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Beneficial Effects of Olive Oil and the Mediterranean Diet on Alzheimer’s Disease and Vascular Dementia: A Review

González-Cidad, Aitor, García-Moncó, Juan Carlos, Román, Gustavo C.·2026·Medicina
DOI 10.3390/medicina62040696
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Abstract

Background and Objectives: During the past 25 years, a significant body of research has been conducted reporting on the salutary effects of the Mediterranean diet and extra-virgin olive oil, one of its main components. The initial studies were epidemiological observations on populations with very low mortality rates due to significant reductions in myocardial infarction fatalities. Population-based studies demonstrated that the Mediterranean diet with olive oil consumption is associated with a lower prevalence of cardiovascular and cerebrovascular disease, obesity, arthritis, and cancer. Materials and Methods: In this narrative review, we present recent studies on the effects of extra-virgin olive oil and the Mediterranean diet—compared with various other diets—on several vascular risk factors, including hypertension, hyperlipidemia, type 2 diabetes mellitus, and obesity, as well as their impact on cognitive decline and dementia. Results: This diet has been shown to improve cognitive function in patients with mild cognitive impairment, Alzheimer’s disease, vascular cognitive impairment, and vascular dementia. The main mechanisms responsible for cognitive improvement include control of arterial hypertension by reducing systolic and diastolic blood pressure, lowering triglycerides and low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol, along with improvement in fasting glucose, insulin levels, and hemoglobin A1c in subjects with type 2 diabetes mellitus, as well as lowering body mass index and obesity. Conclusions: The Mediterranean diet and olive oil induce—along with prevention of cardiovascular disease and stroke—a significant improvement of vascular risk factors, slowing the progression of both vascular dementia and Alzheimer’s disease. There is a need for additional placebo-controlled clinical trials to confirm the supportive nutritional role of extra-virgin olive oil in age-associated cognitive decline in the elderly.

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  1. Jackson, 2019, Extra-virgin olive oil for potential prevention of Alzheimer disease, Rev. Neurol., 175, 705, 10.1016/j.neurol.2019.07.017 · DOI
  2. Jackson, 2019, Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease, Rev. Neurol., 175, 724, 10.1016/j.neurol.2019.08.005 · DOI
  3. Jones, 2024, Potentially modifiable risk factors for dementia and Mild Cognitive Impairment: An umbrella review and meta-analysis, Dement. Geriatr. Cogn. Disord., 53, 91, 10.1159/000536643 · DOI
  4. Ng, 2025, Updates on vascular dementia, Stroke Vasc. Neurol., 10, e004048, 10.1136/svn-2025-004048 · DOI
  5. Duron, 2008, Vascular risk factors, cognitive decline, and dementia, Vasc. Health Risk Manag., 4, 363, 10.2147/VHRM.S1839 · DOI
  6. Vijayan, 2016, Stroke, vascular dementia, and Alzheimer’s disease: Molecular links, J. Alzheimers Dis., 54, 427, 10.3233/JAD-160527 · DOI
  7. Zuliani, 2026, Efficacy of Mediterranean diet for the prevention of neurological diseases: A systematic review and meta-analysis featured in the Italian National Guidelines “La Dieta Mediterranea”, Nutrition, 132, 112990, 10.1016/j.nut.2025.112990 · DOI
  8. Wang, 2025, Mediterranean diet and dementia: MRI marker evidence from meta-analysis, Eur. J. Med. Res., 30, 32, 10.1186/s40001-025-02276-1 · DOI
  9. Sachdev, 2025, Revised diagnostic criteria for vascular cognitive impairment and dementia: The VasCog-2-WSO Criteria, JAMA Neurol., 82, 1103, 10.1001/jamaneurol.2025.3242 · DOI
  10. Sarhan, 2025, The pathophysiology of mixed Alzheimer’s disease and vascular dementia, Theranostics, 15, 9793, 10.7150/thno.118737 · DOI
  11. Estruch, 2018, Primary prevention of cardiovascular disease with a Mediterranean diet supplemented with extra-virgin olive oil or nuts, N. Engl. J. Med., 378, e34, 10.1056/NEJMoa1800389 · DOI · Paper page
  12. Fuentes, 2022, Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): A randomised controlled trial, Lancet, 399, 1876, 10.1016/S0140-6736(22)00122-2 · DOI · Paper page
  13. Landolfo, M., Stella, L., Gezzi, A., Spannella, F., Turri, P., Sabbatini, L., Cecchi, S., Lucchetti, B., Petrelli, M., and Sarzani, R. (2025). Low-Calorie, High-Protein Ketogenic Diet versus Low-Calorie, Low-Sodium, and High-Potassium Mediterranean diet in overweight patients and patients with obesity with high-normal blood pressure or Grade I hypertension: The Keto–Salt Pilot Study. Nutrients, 17. · DOI
  14. Asoudeh, 2023, The effect of Mediterranean diet on inflammatory biomarkers and components of metabolic syndrome in adolescent girls, J. Endocrinol. Investig., 46, 1995, 10.1007/s40618-023-02027-1 · DOI
  15. Kales, 2023, Mediterranean diet-based interventions to improve anthropometric and obesity indicators in children and adolescents: A systematic review with meta-analysis of randomized controlled trials, Adv. Nutr., 14, 858, 10.1016/j.advnut.2023.04.011 · DOI
  16. Dominguez, 2023, Mediterranean diet in the management and prevention of obesity, Exp. Gerontol., 174, 112121, 10.1016/j.exger.2023.112121 · DOI
  17. Osorio-Conles, Ó., Olbeyra, R., Moizé, V., Ibarzabal, A., Giró, O., Viaplana, J., Jiménez, A., Vidal, J., and de Hollanda, A. (2022). Positive effects of a Mediterranean diet supplemented with almonds on female adipose tissue biology in severe obesity. Nutrients, 14. · DOI
  18. Barrea, 2024, Sex-differences in Mediterranean diet: A key piece to explain sex-related cardiovascular risk in obesity? A cross-sectional study, J. Transl. Med., 22, 48, 10.1186/s12967-023-04814-z · DOI
  19. Lotfi, 2022, Adherence to the Mediterranean diet, five-year weight change, and risk of overweight and obesity: A systematic review and dose-response meta-analysis of prospective cohort studies, Adv. Nutr., 13, 152, 10.1093/advances/nmab092 · DOI
  20. Filippou, 2021, Mediterranean diet and blood pressure reduction in adults with and without hypertension: A systematic review and meta-analysis of randomized controlled trials, Clin. Nutr., 40, 3191, 10.1016/j.clnu.2021.01.030 · DOI
  21. Filippou, 2023, DASH vs. Mediterranean diet on a salt restriction background in adults with high normal blood pressure or grade 1 hypertension: A randomized controlled trial, Clin. Nutr., 42, 1807, 10.1016/j.clnu.2023.08.011 · DOI
  22. Daidone, M., Di Chiara, T., Del Cuore, A., Casuccio, A., Salamone, G., Di Raimondo, D., and Tuttolomondo, A. (2025). Mediterranean diet and hypertension: Relationship between adherence to a Mediterranean diet and arterial hypertension. BMC Nutr., 11. · DOI
  23. Candás-Estébanez, B., Fernández-Cidón, B., Corbella, E., Tebé, C., Fanlo-Maresma, M., Esteve-Luque, V., Salas-Salvadó, J., Fitó, M., Riera-Mestre, A., and Ros, E. (2024). The impact of the Mediterranean diet and lifestyle intervention on lipoprotein subclass profiles among metabolic syndrome patients: Findings of a randomized controlled trial. Int. J. Mol. Sci., 25. · DOI
  24. Domínguez-López, I., Galkina, P., Fernández-Duval, G., Pozzoli, C., Razquin, C., Jáuregui, O., Salas-Salvadó, J., Tojal-Sierra, L., Fitó, M., and Corella, D. (2025). Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: The PREDIMED trial. BMC Med., 24. · DOI
  25. Pourmontaseri, H., Bazmi, S., Sepehrinia, M., Mostafavi, A., Arefnezhad, R., Homayounfar, R., and Vahid, F. (2024). Exploring the application of dietary antioxidant index for disease risk assessment: A comprehensive review. Front. Nutr., 11. · DOI
  26. Li, X., Hu, X., and You, C. (2024). Interactive effects of composite dietary antioxidant index with body mass index for the risk of stroke among U.S. adults: Insight from NHANES 2001–2018. Front. Nutr., 11. · DOI
  27. Zhao, 2024, Association between composite dietary antioxidant index and hyperlipidemia: A cross-sectional study from NHANES (2005–2020), Sci. Rep., 14, 16220
  28. 2024, Dietary antioxidant intake reduces carotid intima-media thickness in coronary heart disease patients: From the CORDIOPREV study, Free Radic. Biol. Med., 210, 221, 10.1016/j.freeradbiomed.2023.11.026 · DOI
  29. Al-Aubaidy, H.A., Dayan, A., Deseo, M.A., Itsiopoulos, C., Jamil, D., Hadi, N.R., and Thomas, C.J. (2021). Twelve-week Mediterranean diet intervention increases citrus bioflavonoid levels and reduces inflammation in people with type 2 diabetes mellitus. Nutrients, 13. · DOI
  30. Barrea, 2023, Adherence to the Mediterranean diet as a possible additional tool to be used for screening the metabolically unhealthy obesity (MUO) phenotype, J. Transl. Med., 21, 454, 10.1186/s12967-023-04546-0 · DOI
  31. Zuk, 2023, Plant bioactive compounds from Mediterranean diet improve risk factors for metabolic syndrome, Int. J. Food Sci. Nutr., 74, 403, 10.1080/09637486.2023.2232949 · DOI
  32. Tuncay, 2020, A systematic review of precision nutrition and Mediterranean Diet: A personalized nutrition approaches for prevention and management of obesity related disorders, Clin. Nutr. ESPEN, 38, 61, 10.1016/j.clnesp.2020.04.005 · DOI
  33. Konieczna, 2020, Longitudinal changes in Mediterranean diet and transition between different obesity phenotypes, Clin. Nutr., 39, 966, 10.1016/j.clnu.2019.04.002 · DOI
  34. Dayi, 2022, Effects of the Mediterranean diet on the components of metabolic syndrome, J. Prev. Med. Hyg., 63, E56
  35. Seidita, A., Soresi, M., Giannitrapani, L., Di Stefano, V., Citarrella, R., Mirarchi, L., Cusimano, A., Augello, G., Carroccio, A., and Iovanna, J.L. (2022). The clinical impact of an extra virgin olive oil enriched Mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach. Front. Nutr., 9. · DOI
  36. Khalil, M., Shanmugam, H., Abdallah, H., John Britto, J.S., Galerati, I., Gómez-Ambrosi, J., Frühbeck, G., and Portincasa, P. (2022). The potential of the Mediterranean diet to improve mitochondrial function in experimental models of obesity and metabolic syndrome. Nutrients, 14. · DOI
  37. Scacco, S., Acquaviva, S., França Vieira e Silva, F., Zhang, J.H., Lo Muzio, L., Corso, G., Caponio, V.C.A., Reveglia, P., Lecce, L., and Bizzoca, M.E. (2025). Bioactivity and neuroprotective effects of extra virgin olive oil in a mouse model of cerebral ischemia: An in vitro and in vivo study. Int. J. Mol. Sci., 26. · DOI
  38. Nazzi, C., Avenanti, A., and Battaglia, S. (2024). The involvement of antioxidants in cognitive decline and neurodegeneration: Mens Sana in Corpore Sano. Antioxidants, 13. · DOI
  39. Pollicino, 2023, Mediterranean diet and mitochondria: New findings, Exp. Gerontol., 176, 112165, 10.1016/j.exger.2023.112165 · DOI
  40. Yammine, A., Nury, T., Vejux, A., Latruffe, N., Vervandier-Fasseur, D., Samadi, M., Greige-Gerges, H., Auezova, L., and Lizard, G. (2020). Prevention of 7-ketocholesterol-induced overproduction of reactive oxygen species, mitochondrial dysfunction and cell death with major nutrients (polyphenols, ω3 and ω9 unsaturated fatty acids) of the Mediterranean diet on N2a neuronal cells. Molecules, 25. · DOI
  41. Mercurio, 2025, A Mediterranean diet-based food mix ameliorates diabetes- and obesity-associated liver alterations through mitochondrial and metabolic reprogramming, Mol. Nutr. Food Res., 69, 2400345, 10.1002/mnfr.70210 · DOI
  42. Pignatelli, 2015, Relationship between Mediterranean diet and time in therapeutic range in atrial fibrillation patients taking vitamin K antagonists, Europace, 17, 1223, 10.1093/europace/euv127 · DOI
  43. Saulle, 2019, A systematic overview of the scientific literature on the association between Mediterranean diet and the stroke prevention, Clin. Ter., 170, e396
  44. Chen, 2019, Adherence to the Mediterranean diet and risk of stroke and stroke subtypes, Eur. J. Epidemiol., 34, 337, 10.1007/s10654-019-00504-7 · DOI
  45. Ungvari, 2025, Impact of adherence to the Mediterranean diet on stroke risk, Geroscience, 47, 3565, 10.1007/s11357-024-01491-8 · DOI
  46. Boughanem, 2025, Mediterranean diet, neutrophil count, and carotid intima-media thickness in secondary prevention: The CORDIOPREV study, Eur. Heart J., 46, 719, 10.1093/eurheartj/ehae836 · DOI
  47. Maiorino, 2017, Effect of a Mediterranean diet on endothelial progenitor cells and carotid intima-media thickness in type 2 diabetes: Follow-up of a randomized trial, Eur. J. Prev. Cardiol., 24, 399, 10.1177/2047487316676133 · DOI · Paper page
  48. Jimenez, 2021, Impact of Mediterranean diet prior to stroke on the prognosis of patients undergoing endovascular treatment, Cerebrovasc. Dis., 50, 303, 10.1159/000514136 · DOI
  49. Razquin, 2021, Metabolomics of the tryptophan–kynurenine degradation pathway and risk of atrial fibrillation and heart failure: Potential modification effect of Mediterranean diet, Am. J. Clin. Nutr., 114, 1646, 10.1093/ajcn/nqab238 · DOI
  50. Bayes, 2023, The effect of the Mediterranean diet on health outcomes in post-stroke adults: A systematic literature review of intervention trials, Eur. J. Clin. Nutr., 77, 551, 10.1038/s41430-022-01212-4 · DOI
  51. Montero, 2023, Yearly attained adherence to Mediterranean diet and incidence of diabetes in a large randomized trial, Cardiovasc. Diabetol., 22, 223
  52. Kotzakioulafi, E., Bakaloudi, D.R., Chrysoula, L., Theodoridis, X., Antza, C., Tirodimos, I., and Chourdakis, M. (2023). High versus low adherence to the Mediterranean diet for prevention of diabetes mellitus type 2: A systematic review and meta-analysis. Metabolites, 13. · DOI
  53. Sarsangi, 2022, Association between adherence to the Mediterranean diet and risk of type 2 diabetes: An updated systematic review and dose–response meta-analysis of prospective cohort studies, Adv. Nutr., 13, 1787, 10.1093/advances/nmac046 · DOI
  54. Bruna-Mejias, A., San Martin, J., Arciniegas-Diaz, D., Meneses-Caroca, T., Salamanca-Cerda, A., Beas-Gambi, A., Paola-Loaiza-Giraldo,, J., Ortiz-Ahumada, C., Nova-Baeza, P., and Oyanedel-Amaro, G. (2025). Comparison of the Mediterranean diet and other therapeutic strategies in metabolic syndrome: A systematic review and meta-analysis. Int. J. Mol. Sci., 26. · DOI
  55. Pavlidou, E., Papadopoulou, S.K., Fasoulas, A., Papaliagkas, V., Alexatou, O., Chatzidimitriou, M., Mentzelou, M., and Giaginis, C. (2024). Diabesity and dietary interventions: Evaluating the impact of Mediterranean diet and other types of diets on obesity and type 2 diabetes management. Nutrients, 16. · DOI
  56. Gioxari, A., Grammatikopoulou, M.G., Katsarou, C., Panagiotakos, D.B., Toutouza, M., Kavouras, S.A., Sidossis, L.S., and Maraki, M.I. (2022). A modified Mediterranean diet improves fasting and postprandial glucoregulation in adults with overweight and obesity: A pilot study. Int. J. Environ. Res. Public Health, 19. · DOI
  57. Suárez-Cuenca, J.A., Díaz-Jiménez, D.E., Pineda-Juárez, J.A., Mendoza-Mota, A.G., Valencia-Aldana, O.D., Núñez-Angeles, S., Vera-Gómez, E., Hernández-Patricio, A., Loeza-Magaña, P., and Lara-Vargas, J.A. (2025). Effect of Mediterranean diet in combination with isokinetic exercise therapy on body composition and cytokine profile in patients with metabolic syndrome. Nutrients, 17. · DOI
  58. Corella, 2025, Comparison of an energy-reduced Mediterranean diet and physical activity versus an ad libitum Mediterranean diet in the prevention of type 2 diabetes—A secondary analysis of a randomized controlled trial, Ann. Intern. Med., 178, 1378
  59. Chooi, Y.C., Magkos, F., Yaligar, J., Michael, N., Sadananthan, S.A., Kway, Y.M., Velan, S.S., Lim, K.J., Lai, X., and Wong,, L.H. (2025). Adherence to a “MediterrAsian” diet is associated with weight loss-independent improvements in liver fat and lipid profile, but not glucoregulation or inflammation: Secondary analysis of a randomized controlled trial. Front. Nutr., 12. · DOI
  60. Florkowski, M., Abiona, E., Frank, K.M., and Brichacek, L.A. (2024). Obesity-associated inflammation countered by a Mediterranean diet: The role of gut-derived metabolites. Front. Nutr., 11. · DOI
  61. Tuccinardi, 2021, The Mediterranean diet increases glucagon-like peptide 1 and oxyntomodulin compared with a vegetarian diet in patients with type 2 diabetes: A randomized controlled cross-over trial, Diabetes Metab. Res. Rev., 37, e3406, 10.1002/dmrr.3406 · DOI
  62. Esposito, 2004, Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: A randomized trial, JAMA, 292, 1440, 10.1001/jama.292.12.1440 · DOI · Paper page
  63. Garza, M.C., Pérez-Calahorra, S., Rodrigo-Carbó, C., Sánchez-Calavera, M.A., Jarauta, E., Mateo-Gallego, R., Gracia-Rubio, I., and Lamiquiz-Moneo, I. (2024). Effect of aromatic herbs and spices present in the Mediterranean diet on the glycemic profile in type 2 diabetes subjects: A systematic review and meta-analysis. Nutrients, 16. · DOI
  64. Barbería-Latasa, M., Martínez-Urbistondo, D., and Martínez-González, M.A. (2025). The role of the Mediterranean diet and alcohol consumption in chronic liver disease prevention: A narrative review. Medicina, 61. · DOI
  65. 2024, Should we remove wine from the Mediterranean diet?: A narrative review, Am. J. Clin. Nutr., 119, 262, 10.1016/j.ajcnut.2023.12.020 · DOI
  66. Muniyappa, 2013, Role of insulin resistance in endothelial dysfunction, Rev. Endocr. Metab. Disord., 14, 5, 10.1007/s11154-012-9229-1 · DOI · Paper page
  67. Gregory, 2023, Mediterranean diet and structural neuroimaging biomarkers of Alzheimer’s and cerebrovascular disease: A systematic review, Exp. Gerontol., 171, 112065, 10.1016/j.exger.2022.112065 · DOI
  68. Godos, J., Ferri, R., Lanza, G., Caraci, F., Vistorte, A.O.R., Yelamos Torres, V., Grosso, G., and Castellano, S. (2024). Mediterranean diet and sleep features: A systematic review of current evidence. Nutrients, 16. · DOI
  69. Patel, 2025, The effect of Mediterranean diet and chrononutrition on sleep quality: A scoping review, Nutr. J., 24, 11, 10.1186/s12937-025-01095-8 · DOI
  70. Fallah, M., Aminianfar, A., and Esmaillzadeh, A. (2024). Mediterranean diet adherence and sleep pattern: A systematic review of observational studies. BMC Nutr., 10. · DOI
  71. Bouloukaki, I., Daskalaki, E., Mavroudi, E., Moniaki, V., Schiza, S.E., and Tsiligianni, I. (2023). A dietary and lifestyle intervention improves treatment adherence and clinical outcomes in overweight and obese patients with obstructive sleep apnea: A randomized, controlled trial. Life, 13. · DOI
  72. Psaltopoulou, 2013, Mediterranean diet, stroke, cognitive impairment, and depression: A meta-analysis, Ann. Neurol., 74, 580, 10.1002/ana.23944 · DOI · Paper page
  73. Godos, J., Guglielmetti, M., Ferraris, C., Frias-Toral, E., Domínguez Azpíroz, I., Lipari, V., Di Mauro, A., Furnari, F., Castellano, S., and Galvano, F. (2025). Mediterranean diet and quality of life in adults: A systematic review. Nutrients, 17. · DOI
  74. Zielińska, M., Łuszczki, E., Michońska, I., and Dereń, K. (2022). The Mediterranean diet and the Western diet in adolescent depression—Current reports. Nutrients, 14. · DOI
  75. Mafe, A.N., and Büsselberg, D. (2025). Could a Mediterranean diet modulate Alzheimer’s disease progression? The role of gut microbiota and metabolite signatures in neurodegeneration. Foods, 14. · DOI
  76. Scoditti, E., Tumolo, M.R., and Garbarino, S. (2022). Mediterranean diet on sleep: A health alliance. Nutrients, 14. · DOI
  77. Perera, 2023, Can the Mediterranean diet decrease the risk of depression in older persons—A systematic review, Psychiatr. Pol., 57, 339, 10.12740/PP/OnlineFirst/140465 · DOI
  78. Georgoulis, 2021, A weight-loss Mediterranean diet/lifestyle intervention ameliorates inflammation and oxidative stress in patients with obstructive sleep apnea: Results of the “MIMOSA” randomized clinical trial, Eur. J. Nutr., 60, 3799, 10.1007/s00394-021-02552-w · DOI
  79. Kerner, 2016, Obstructive sleep apnea is linked to depression and cognitive impairment: Evidence and potential mechanisms, Am. J. Geriatr. Psychiatry, 24, 496, 10.1016/j.jagp.2016.01.134 · DOI
  80. Nucci, 2024, Association between Mediterranean diet and dementia and Alzheimer disease: A systematic review with meta-analysis, Aging Clin. Exp. Res., 36, 73, 10.1007/s40520-024-02718-6 · DOI
  81. García-Casares, N., Fuentes, P.G., Barbancho, M.Á., López-Gigosos, R., García-Rodríguez, A., and Gutiérrez-Bedmar, M. (2021). Alzheimer’s disease, mild cognitive impairment and Mediterranean diet. A systematic review and dose-response meta-analysis. J. Clin. Med., 10. · DOI
  82. Singh, 2014, Association of Mediterranean diet with mild cognitive impairment and Alzheimer’s disease: A systematic review and meta-analysis, J. Alzheimers Dis., 39, 271, 10.3233/JAD-130830 · DOI
  83. Fekete, 2025, The role of the Mediterranean diet in reducing the risk of cognitive impairment, dementia, and Alzheimer’s disease: A meta-analysis, Geroscience, 47, 3111, 10.1007/s11357-024-01488-3 · DOI
  84. Youn, 2025, Association of Mediterranean, high-quality, and anti-inflammatory diet with dementia in UK Biobank cohort, J. Nutr. Health Aging, 29, 100564, 10.1016/j.jnha.2025.100564 · DOI
  85. Corella, 2015, Mediterranean diet and age-related cognitive decline: A randomized clinical trial, JAMA Intern. Med., 175, 1094, 10.1001/jamainternmed.2015.1668 · DOI · Paper page
  86. Devranis, P., Vassilopoulou, Ε., Tsironis, V., Sotiriadis, P.M., Chourdakis, M., Aivaliotis, M., and Tsolaki, M. (2023). Mediterranean diet, ketogenic diet or MIND diet for aging populations with cognitive decline: A systematic review. Life, 13. · DOI
  87. Jennings, A., Shannon, O.M., Gillings, R., Lee, V., Elsworthy, R., Bundy, R., Rao, G., Hanson, S., Hardeman, W., and Paddick, S.M. (2024). Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: The MedEx-UK randomised controlled trial. BMC Med., 22. · DOI
  88. Frisardi, 2010, Nutraceutical properties of mediterranean diet and cognitive decline: Possible underlying mechanisms, J. Alzheimers Dis., 22, 715, 10.3233/JAD-2010-100942 · DOI
  89. Solfrizzi, 2011, Mediterranean diet in predementia and dementia syndromes, Curr. Alzheimer Res., 8, 520, 10.2174/156720511796391809 · DOI
  90. Maggi, 2023, The role of nutrition and the Mediterranean diet on the trajectories of cognitive decline, Exp. Gerontol., 173, 112110, 10.1016/j.exger.2023.112110 · DOI
  91. Fekete, M., Jarecsny, T., Lehoczki, A., Major, D., Fazekas-Pongor, V., Csípő, T., Lipécz, Á., Szappanos, Á., Pázmándi, E.M., and Varga, P. (2025). Mediterranean diet, polyphenols, and neuroprotection: Mechanistic insights into resveratrol and oleuropein. Nutrients, 17. · DOI
  92. Walle, 2011, Bioavailability of resveratrol, Ann. N. Y. Acad. Sci., 1215, 9, 10.1111/j.1749-6632.2010.05842.x · DOI · Paper page
  93. Semba, 2014, Resveratrol levels and all-cause mortality in older community-dwelling adults, JAMA Intern. Med., 174, 1077, 10.1001/jamainternmed.2014.1582 · DOI
  94. Mesquita, A., de Sousa, D., Padrão, P., Costa, A.R., and Moreira, P. (2025). Challenging the wine component in Mediterranean diet scores: Cognitive outcomes in Portuguese adults at high risk of dementia. Nutrients, 17. · DOI
  95. Wanleenuwat, 2019, Alzheimer’s dementia: Pathogenesis and impact of cardiovascular risk factors on cognitive decline, Postgrad. Med., 131, 415, 10.1080/00325481.2019.1657776 · DOI
  96. Miranda, 2017, Dieta Mediterránea y sus efectos benéficos en la prevención de la enfermedad de Alzheimer, Rev. Med. Chil., 145, 501, 10.4067/S0034-98872017000400010 · DOI
  97. Sofi, 2010, Effectiveness of the Mediterranean diet: Can it help delay or prevent Alzheimer’s disease?, J. Alzheimers Dis., 20, 795, 10.3233/JAD-2010-1418 · DOI
  98. Liu, 2025, Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function, Nat. Med., 31, 3790, 10.1038/s41591-025-03891-5 · DOI
  99. Karavasilis, E., Balomenos, V., Christidi, F., Velonakis, G., Angelopoulou, G., Yannakoulia, M., Mamalaki, E., Drouka, A., Brikou, D., and Tsapanou, A. (2024). Mediterranean diet and brain functional connectivity in a population without dementia. Front. Neuroimaging, 3. · DOI
  100. Faulkner, 2025, Greater resting state functional connectivity of the medial prefrontal cortex with the thalamus, caudate, and putamen in individuals who adhere to the Mediterranean style diets, Eur. J. Nutr., 64, 3548, 10.1007/s00394-024-03548-y · DOI
  101. Gaynor, 2022, Diet moderates the effect of resting state functional connectivity on cognitive function, Sci. Rep., 12, 9115, 10.1038/s41598-022-20047-4 · DOI
  102. Armeli, F., Bonucci, A., Maggi, E., Pinto, A., and Businaro, R. (2021). Mediterranean diet and neurodegenerative diseases: The neglected role of nutrition in the modulation of the endocannabinoid system. Biomolecules, 11. · DOI
  103. Namsi, A., Nury, T., Hamdouni, H., Yammine, A., Vejux, A., Vervandier-Fasseur, D., Latruffe, N., Masmoudi-Kouki, O., and Lizard, G. (2018). Induction of neuronal differentiation of murine N2a cells by two polyphenols present in the Mediterranean diet mimicking neurotrophins activities: Resveratrol and apigenin. Diseases, 6. · DOI
  104. Cherian, 2019, Mediterranean-dash intervention for neurodegenerative delay (MIND) diet slows cognitive decline after stroke, J. Prev. Alzheimers Dis., 6, 267, 10.14283/jpad.2019.28 · DOI
  105. Berendsen, 2019, The Mediterranean, dietary approaches to stop hypertension (DASH), and Mediterranean-DASH intervention for neurodegenerative delay (MIND) diets are associated with less cognitive decline and a lower risk of Alzheimer’s disease—A review, Adv. Nutr., 10, 1040, 10.1093/advances/nmz054 · DOI · Paper page
  106. Strazzabosco, C., Storti, B., Marinoni, G., Carolina, D.T., Canavero, I., Rifino, N., Boncoraglio, G., Zacarias, E., Francia, A., and Pollaci, G. (2025). Impact of the Mediterranean diet on stroke incidence and cognitive impairment in CADASIL and CAA patients: The DIETETICA study. Front. Nutr., 12. · DOI
  107. Vinters, 2018, Review: Vascular dementia: Clinicopathologic and genetic considerations, Neuropathol. Appl. Neurobiol., 44, 247, 10.1111/nan.12472 · DOI
  108. Woodside, 2014, Mediterranean diet interventions to prevent cognitive decline-opportunities and challenges, Eur. J. Clin. Nutr., 68, 1241, 10.1038/ejcn.2014.178 · DOI
  109. Lourida, 2013, Mediterranean diet, cognitive function, and dementia: A systematic review, Epidemiology, 24, 479, 10.1097/EDE.0b013e3182944410 · DOI · Paper page
  110. Shannon, 2021, Feasibility and acceptability of a multi-domain intervention to increase Mediterranean diet adherence and physical activity in older UK adults at risk of dementia: Protocol for the MedEx-UK randomised controlled trial, BMJ Open, 11, e042823, 10.1136/bmjopen-2020-042823 · DOI
  111. Pipingas, 2023, A Mediterranean diet and walking intervention to reduce cognitive decline and dementia risk in independently living older Australians: The MedWalk randomized controlled trial experimental protocol, Including COVID-19 related modifications and baseline characteristics, J. Alzheimers Dis., 96, 409, 10.3233/JAD-230641 · DOI
  112. Drehmer, 2018, Improvement of main cognitive functions in patients with Alzheimer’s disease after treatment with coconut oil enriched Mediterranean diet: A pilot study, J. Alzheimers Dis., 65, 577, 10.3233/JAD-180184 · DOI · Paper page
  113. Vollrath, 2025, Efficacy of an avocado-based Mediterranean diet on serum lipids for secondary prevention after ischemic stroke: A randomized phase 2 controlled pilot trial, Lipids Health Dis., 24, 37, 10.1186/s12944-025-02454-4 · DOI
  114. Gardner, 2022, Effect of a ketogenic diet versus Mediterranean diet on glycated hemoglobin in individuals with prediabetes and type 2 diabetes mellitus: The interventional Keto-Med randomized crossover trial, Am. J. Clin. Nutr., 116, 640, 10.1093/ajcn/nqac154 · DOI · Paper page
  115. Tettamanzi, F., Bagnardi, V., Louca, P., Nogal, A., Monti, G.S., Mambrini, S.P., Lucchetti, E., Maestrini, S., Mazza, S., and Rodriguez-Mateos, A. (2021). A high protein diet is more effective in improving insulin resistance and glycemic variability compared to a Mediterranean diet—A cross-over controlled inpatient dietary study. Nutrients, 13. · DOI
  116. Filippou, 2022, Overview of salt restriction in the Dietary Approaches to Stop Hypertension (DASH) and the Mediterranean diet for blood pressure reduction, Rev. Cardiovasc. Med., 23, 1036, 10.31083/j.rcm2301036 · DOI
  117. Tangney, 2014, Relation of DASH-and Mediterranean-like dietary patterns to cognitive decline in older persons, Am. J. Clin. Nutr., 99, 136
  118. Stefaniak, O., Dobrzyńska, M., Drzymała-Czyż, S., and Przysławski, J. (2022). Diet in the prevention of Alzheimer’s disease: Current knowledge and future research requirements. Nutrients, 14. · DOI
  119. Qin, P., Ho, F.K., Celis-Morales, C.A., and Pell, J.P. (2026). Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias. BMC Med., 24. · DOI
  120. Hosking, 2019, MIND not Mediterranean diet related to 12-year incidence of cognitive impairment in an Australian longitudinal cohort study, Alzheimers Dement., 15, 581, 10.1016/j.jalz.2018.12.011 · DOI
  121. Du, 2025, Effect of olive oil consumption on diabetes risk: A dose-response meta-analysis, J. Health Popul. Nutr., 44, 866, 10.1186/s41043-025-00866-7 · DOI · Paper page
  122. Munteanu, C., Kotova, P., and Schwartz, B. (2025). Impact of olive oil components on the expression of genes related to type 2 diabetes mellitus. Nutrients, 17. · DOI
  123. De Matteis, C., Crudele, L., Di Buduo, E., Cantatore, S., Novielli, F., Cultrera, S., Tricase, A.F., Arconzo, M., Florio, M., and Gadaleta, R.M. (2025). Regular extra-virgin olive oil intake independently associates with lower abdominal obesity. Front. Nutr., 12. · DOI
  124. Storniolo, 2014, Polyphenol fraction of extra virgin olive oil protects against endothelial dysfunction induced by high glucose and free fatty acids through modulation of nitric oxide and endothelin-1, Redox Biol., 2, 971, 10.1016/j.redox.2014.07.001 · DOI · Paper page
  125. Salvo, A., and Tuttolomondo, A. (2025). The role of olive oil in cardiometabolic risk. Metabolites, 15. · DOI
  126. Silva-Soto, M.Á., Carrillo-Fernández, P., Saez Lancellotti, E.T., Medina-Jiménez, E., Mogaburo Alba, J.F., Catena-Granados, N., López-Carmona, M.D., Pérez-Belmonte, L.M., Prieto Lain, N., and Gómez Hernández, A.I. (2025). Extra virgin olive oil phenolic compounds: Modulating mitochondrial function and protecting against chronic diseases—A narrative review. Nutrients, 17. · DOI
  127. Visioli, 2005, Virgin Olive Oil Study (VOLOS): Vasoprotective potential of extra virgin olive oil in mildly dyslipidemic patients, Eur. J. Nutr., 44, 121, 10.1007/s00394-004-0504-0 · DOI
  128. de Souza, P.A.L., Marcadenti, A., and Portal, V.L. (2017). Effects of olive oil phenolic compounds on inflammation in the prevention and treatment of coronary artery disease. Nutrients, 9. · DOI
  129. Perona, 2006, The role of virgin olive oil components in the modulation of endothelial function, J. Nutr. Biochem., 17, 429, 10.1016/j.jnutbio.2005.11.007 · DOI
  130. Valderas-Martinez, P., Chiva-Blanch, G., Casas, R., Arranz, S., Martínez-Huélamo, M., Urpi-Sarda, M., Torrado, X., Corella, D., Lamuela-Raventós, R.M., and Estruch, R. (2016). Tomato sauce enriched with olive oil exerts greater effects on cardiovascular disease risk factors than raw tomato and tomato sauce: A randomized trial. Nutrients, 8. · DOI
  131. Covas, 2007, Olive oil and the cardiovascular system, Pharmacol. Res., 55, 175, 10.1016/j.phrs.2007.01.010 · DOI
  132. Milena, E., and Maurizio, M. (2025). Exploring the cardiovascular benefits of extra virgin olive oil: Insights into mechanisms and therapeutic potential. Biomolecules, 15. · DOI
  133. Sarapis, K., Thomas, C.J., Hoskin, J., George, E.S., Marx, W., Mayr, H.L., Kennedy, G., Pipingas, A., Willcox, J.C., and Prendergast, L.A. (2020). The effect of high polyphenol extra virgin olive oil on blood pressure and arterial stiffness in healthy Australian adults: A randomized, controlled, cross-over study. Nutrients, 12. · DOI
  134. Ussia, S., Ritorto, G., Mollace, R., Serra, M., Tavernese, A., Altomare, C., Muscoli, C., Fini, M., Barillà, F., and Indolfi, C. (2025). Exploring the benefits of extra virgin olive oil on cardiovascular health enhancement and disease prevention: A systematic review. Nutrients, 17. · DOI · Paper page
  135. Fuentes, 2008, Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with α-linolenic acid on postprandial endothelial function in healthy men, Br. J. Nutr., 100, 159, 10.1017/S0007114508888708 · DOI
  136. Antonopoulou, S., and Demopoulos, C.A. (2023). Protective effect of olive oil microconstituents in atherosclerosis: Emphasis on PAF implicated atherosclerosis theory. Biomolecules, 13. · DOI
  137. Alkhalifa, A.E., Al-Ghraiybah, N.F., and Kaddoumi, A. (2024). Extra-virgin olive oil in Alzheimer’s disease: A comprehensive review of cellular, animal, and clinical studies. Int. J. Mol. Sci., 25. · DOI
  138. Delgado, 2021, Neuroinflammation in Alzheimer’s disease and beneficial action of luteolin, BioFactors, 47, 207, 10.1002/biof.1714 · DOI
  139. Omar, S.H. (2019). Mediterranean and MIND diets containing olive biophenols reduces the prevalence of Alzheimer’s disease. Int. J. Mol. Sci., 20. · DOI
  140. Rigacci, 2015, Olive oil phenols as promising multi-targeting agents against Alzheimer’s disease, Adv. Exp. Med. Biol., 863, 1, 10.1007/978-3-319-18365-7_1 · DOI
  141. Casamenti, 2015, Oleuropein aglycone: A possible drug against degenerative conditions. In vivo evidence of its effectiveness against Alzheimer’s disease, J. Alzheimers Dis., 45, 679, 10.3233/JAD-142850 · DOI
  142. Zupo, 2025, Alzheimer’s disease may benefit from olive oil polyphenols: A systematic review on preclinical evidence supporting the effect of oleocanthal on amyloid-β load, Curr. Neuropharmacol., 23, 1249, 10.2174/011570159X327650241021115228 · DOI
  143. Kheiri, 2019, Role of p38/MAPKs in Alzheimer’s disease: Implications for amyloid beta toxicity targeted therapy, Rev. Neurosci., 30, 9, 10.1515/revneuro-2018-0008 · DOI · Paper page
  144. Cordero, 2018, Benefit of oleuropein aglycone for Alzheimer’s disease by promoting autophagy, Oxid. Med. Cell. Longev., 2018, 5010741, 10.1155/2018/5010741 · DOI
  145. Fazlollahi, A., Motlagh Asghari, K., Aslan, C., Noori, M., Nejadghaderi, S.A., Araj-Khodaei, M., Sullman, , M.J.M., Karamzad,, N., Kolahi, A.A., and Safiri, S. (2023). The effects of olive oil consumption on cognitive performance: A systematic review. Front. Nutr., 10. · DOI
  146. Kaddoumi, A., Denney, T.S., Deshpande, G., Robinson, J.L., Beyers, R.J., Redden, D.T., Praticò, D., Kyriakides, T.C., Lu, , B., and Kirby, A.N. (2022). Extra-virgin olive oil enhances the blood–brain barrier function in mild cognitive impairment: A randomized controlled trial. Nutrients, 14. · DOI
  147. 2025, Olive polyphenols as modulators of amyloid aggregation: Mechanisms and implications for neurodegenerative diseases, Food Funct., 16, 8658, 10.1039/D5FO03331D · DOI
  148. Wei, L., Li, Z., Shi, M., Song, W., Teng, Z., and Zhang, C. (2025). Neuroprotective properties of extra virgin olive oil polyphenols in Alzheimer’s disease: A multi-target mechanistic review. Front. Nutr., 12. · DOI
  149. Stavrinou, P.S., Andreou, E., Aphamis, G., Pantzaris, M., Ioannou, M., Patrikios, I.S., and Giannaki, C.D. (2020). The effects of a 6-month high dose omega-3 and omega-6 polyunsaturated fatty acids and antioxidant vitamins supplementation on cognitive function and functional capacity in older adults with mild cognitive impairment. Nutrients, 12. · DOI
  150. Christodoulou, C.C., Pitsillides, M., Hadjisavvas, A., and Zamba-Papanicolaou, E. (2025). Dietary Intake, Mediterranean and Nordic diet adherence in Alzheimer’s disease and dementia: A systematic review. Nutrients, 17. · DOI
  151. Clavero, 2013, Virgin olive oil supplementation and long-term cognition: The Predimed-Navarra randomized, trial, J. Nutr. Health Aging, 17, 544, 10.1007/s12603-013-0027-6 · DOI
  152. Mazza, 2018, Effect of the replacement of dietary vegetable oils with a low dose of extra-virgin olive oil in the Mediterranean diet on cognitive functions in the elderly, J. Transl. Med., 16, 10, 10.1186/s12967-018-1386-x · DOI
  153. Tsolaki, 2020, A randomized clinical trial of Greek high phenolic early harvest extra virgin olive oil in mild cognitive impairment: The MICOIL pilot study, J. Alzheimers Dis., 78, 801, 10.3233/JAD-200405 · DOI

Metadata

Authors
González-Cidad, A., García-Moncó, J. C., & Román, G. C.
Venue
Medicina
Publisher
MDPI AG
Published
2026-04-04
Volume
62
Issue
4
Pages
696
ISSN
1648-9144
DOI
10.3390/medicina62040696
Cited by
1
References
10
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
Jack S. Blanton Distinguished Endowed Chair for the Study of Neurological Disease

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