Cited by 23Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesIntensive Care Unit Cognitive Disorders

New-onset dementia among survivors of pneumonia associated With severe acute respiratory syndrome coronavirus 2 infection

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Qureshi, Adnan I, Baskett, William I, Huang, Wei, Naqvi, S Hasan, Shyu, Chi-Ren·2022·Open Forum Infectious Diseases

Abstract

Background: Case series without control groups suggest that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in cognitive deficits and dementia in the postinfectious period. Methods: Adult pneumonia patients with SARS-CoV-2 infection (index hospitalization) and age-, gender-, and race/ethnicity-matched contemporary control pneumonia patients without SARS-CoV-2 infection were identified from 110 healthcare facilities in United States. The risk of new diagnosis of dementia following >30 days after the index hospitalization event without any previous history of dementia was identified using logistic regression analysis to adjust for potential confounders. Results: Among 10 403 patients with pneumonia associated with SARS-CoV-2 infection, 312 patients (3% [95% confidence interval {CI}, 2.7%-3.4%]) developed new-onset dementia over a median period of 182 days (quartile 1 = 113 days, quartile 3 = 277 days). After adjustment for age, gender, race/ethnicity, hypertension, diabetes mellitus, hyperlipidemia, nicotine dependence/tobacco use, alcohol use/abuse, atrial fibrillation, previous stroke, and congestive heart failure, the risk of new-onset dementia was significantly higher with pneumonia associated with SARS-CoV-2 infection compared with pneumonia unrelated to SARS-CoV-2 infection (odds ratio [OR], 1.3 [95% CI, 1.1-1.5]). The association remained significant after further adjustment for occurrence of stroke, septic shock, and intubation/mechanical ventilation during index hospitalization (OR, 1.3 [95% CI, 1.1-1.5]). Conclusions: Approximately 3% of patients with pneumonia associated with SARS-CoV-2 infection developed new-onset dementia, which was significantly higher than the rate seen with other pneumonias.

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  • The neurological sequelae of SARS-CoV-2 infection are proving to be both common and debilitating.

    “It is thus not surprising that the neurological sequelae of SARS-CoV-2 infection are proving to be both common and debilitating (Nasserie et al., 2021; Mazza et al., 2021; Qureshi et al., 2022; Becker et al., 2021; Tabacof et al., 2022).”

    From Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation (2022) · cites this paper as Qureshi et al., 2022

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Authors
Qureshi, A. I., Baskett, W. I., Huang, W., Naqvi, S. H., & Shyu, C.-R.
Affiliations
University of Missouri (US)
Corresponding author
Qureshi, Adnan I
Venue
Open Forum Infectious Diseases
Published
2022-03-07
Volume
9
Issue
4
Pages
ofac115-ofac115
ISSN
2328-8957 (ISSN-L)
OpenAlex
W4220760193
Cited by
23
References
48
Citations by year
2025: 5 · 2024: 4 · 2023: 7 · 2022: 7
FWCI
3.03
Type
journal article
Language
en
Open access
Locations
  • Open Forum Infectious Diseases (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (5T32LM012410)
Topics
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
COVID-19 pandemic, pneumonia, long COVID, stroke, septic shock, mechanical ventilation, intubation

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