Cited by 111Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAmyotrophic Lateral Sclerosis Research

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Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

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Bell, W. Robert, An, Yang, Kageyama, Yusuke, English, Collin, Rudow, Gay L., Pletnikova, Olga, Thambisetty, Madhav, O'Brien, Richard, Moghekar, Abhay R., Albert, Marilyn S., Rabins, Peter V., Resnick, Susan M., Troncoso, Juan C.·2019·Alzheimer's & Dementia

DOI 10.1016/j.jalz.2018.07.215PMC PMC6542566

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Abstract

INTRODUCTION: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. METHODS: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. RESULTS: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P = .0046). DISCUSSION: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

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Authors: Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M. S., Rabins, P. V., Resnick, S. M., & Troncoso, J. C.
Affiliations: Johns Hopkins University (US)
National Institutes of Health (US)
Department of Pathology Division of Neuropathology Johns Hopkins University School of Medicine Baltimore MD USA
Department of Neurology Duke University School of Medicine Durham NC USA
Corresponding author: Troncoso, Juan C.
ORCID: An, Yang
Kageyama, Yusuke
English, Collin
Thambisetty, Madhav
Moghekar, Abhay R.
Albert, Marilyn S.
Resnick, Susan M.
Troncoso, Juan C.
Venue: Alzheimer's & Dementia
Publisher: Wiley
Published: 2018-11-19
Volume: 15
Issue: 1
Pages: 8-16
ISSN: 1552-5260 (ISSN-L)
1552-5279
DOI: 10.1016/j.jalz.2018.07.215
PMC: PMC6542566
OpenAlex: W2900909585
Cited by: 111
References: 47
Citations by year: 2026: 8 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 10
FWCI: 7.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Alzheimer s & Dementia (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
Hall Family Foundation
BrightFocus Foundation
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
Keywords: primary age-related tauopathy, Alzheimer's disease
MeSH terms: Neuropathology, Aged, 80 and over, Aging, Alzheimer Disease, Autopsy, Brain, Genotype, Humans, Longitudinal Studies, Memory, Neuropsychological Tests, Baltimore, Tauopathies, Apolipoprotein E4, Cognitive Dysfunction

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Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease

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