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Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease
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INTRODUCTION: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. METHODS: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. RESULTS: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P = .0046). DISCUSSION: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.
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“For these reasons, PART is unlikely to explain our findings in the TSC cohort.”
From Tuberous sclerosis complex is a novel, amyloid-independent tauopathy associated with elevated phosphorylated 3R/4R tau aggregation (2022) · cites this paper as [2]
Experimental — accuracy not yet measuredIn the citing paper
“However, an isolated amnestic syndrome of the hippocampal type with only tau biomarker positivity can occur in primary age-related tauopathy37,38 or in atypical presentations of mixed 3 repeat or 4 repeat tau frontotemporal lobar degeneration100,102 (appendix p 2).”
From Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group (2021) · cites this paper as [38]
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Clinical diagnosis of Alzheimer’s disease: Recommendations of the International Working Group
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“On the other hand, an isolated amnestic syndrome of the hippocampal type with only tau biomarker positivity can be encountered in primary age-related tauopathy (PART) 77,78 or in atypical presentations of mixed 3R/4R frontotemporal lobar degeneration (FTLD) tau 75,79 (Supplementary Figure 1).”
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Metadata
- Authors
- Bell, W. R., An, Y., Kageyama, Y., English, C., Rudow, G. L., Pletnikova, O., Thambisetty, M., O'Brien, R., Moghekar, A. R., Albert, M. S., Rabins, P. V., Resnick, S. M., & Troncoso, J. C.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Department of Pathology Division of Neuropathology Johns Hopkins University School of Medicine Baltimore MD USA
- Department of Neurology Duke University School of Medicine Durham NC USA
- Corresponding author
- Troncoso, Juan C.
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2018-11-19
- Volume
- 15
- Issue
- 1
- Pages
- 8-16
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC6542566
- OpenAlex
- W2900909585
- Cited by
- 111
- References
- 47
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 17 · 2023: 14 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 10
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- Hall Family Foundation
- BrightFocus Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- primary age-related tauopathy, Alzheimer's disease
- MeSH terms
- Neuropathology, Aged, 80 and over, Aging, Alzheimer Disease, Autopsy, Brain, Genotype, Humans, Longitudinal Studies, Memory, Neuropsychological Tests, Baltimore, Tauopathies, Apolipoprotein E4, Cognitive Dysfunction
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