Predicting diagnosis and cognition with 18 F‐AV‐1451 tau PET and structural MRI in Alzheimer's disease
Open accessAbstract
Introduction: The relative importance of structural magnetic resonance imaging (MRI) and tau positron emission tomography (PET) to predict diagnosis and cognition in Alzheimer's disease (AD) is unclear. Methods: We tested 56 cognitively unimpaired controls (including 27 preclinical AD), 32 patients with prodromal AD, and 39 patients with AD dementia. Optimal classifiers were constructed using the least absolute shrinkage and selection operator with 18 F‐AV‐1451 (tau) PET and structural MRI data (regional cortical thickness and subcortical volumes). Results: 18 F‐AV‐1451 in the amygdala, entorhinal cortex, parahippocampal gyrus, fusiform, and inferior parietal lobule had 93% diagnostic accuracy for AD (prodromal or dementia). The MRI classifier involved partly the same regions plus the hippocampus, with 83% accuracy, but did not improve upon the tau classifier. 18 F‐AV‐1451 retention and MRI were independently associated with cognition. Discussion: Optimized tau PET classifiers may diagnose AD with high accuracy, but both tau PET and structural brain MRI capture partly unique information relevant for the clinical deterioration in AD.
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- Authors
- Mattsson, N., Insel, P. S., Donohue, M., Jögi, J., Ossenkoppele, R., Olsson, T., Schöll, M., Smith, R., & Hansson, O.
- Affiliations
- Lund University (SE)
- San Francisco VA Medical Center (US)
- University of Southern California (US)
- Skåne University Hospital (SE)
- Corresponding author
- Mattsson, Niklas
- ORCID
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2019-01-09
- Volume
- 15
- Issue
- 4
- Pages
- 570-580
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- OpenAlex
- W2911001278
- Cited by
- 92
- References
- 35
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 9 · 2023: 12 · 2022: 12 · 2021: 13 · 2020: 26 · 2019: 4
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- H2020 European Research Council
- Vetenskapsrådet
- Marianne and Marcus Wallenberg Foundation
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- Alzheimer's disease, 18F-AV-1451
- MeSH terms
- Aged, Alzheimer Disease, Brain, Carbolines, Cognition, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Sweden, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography, Prodromal Symptoms
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