Pathological Tau Disrupts Ongoing Network Activity
Open accessAbstract
Pathological tau leads to dementia and neurodegeneration in tauopathies, including Alzheimer's disease. It has been shown to disrupt cellular and synaptic functions, yet its effects on the function of the intact neocortical network remain unknown. Using in vivo intracellular and extracellular recordings, we measured ongoing activity of neocortical pyramidal cells during various arousal states in the rTg4510 mouse model of tauopathy, prior to significant cell death, when only a fraction of the neurons show pathological tau. In transgenic mice, membrane potential oscillations are slower during slow-wave sleep and under anesthesia. Intracellular recordings revealed that these changes are due to longer Down states and state transitions of membrane potentials. Firing rates of transgenic neurons are reduced, and firing patterns within Up states are altered, with longer latencies and inter-spike intervals. By changing the activity patterns of a subpopulation of affected neurons, pathological tau reduces the activity of the neocortical network.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mouse models indicate alterations in synaptic networks prior to the onset of gross neuronal loss in the cerebral cortex.
“A growing body of evidence in mouse models indicates alterations in synaptic networks, prior to the onset of gross neuronal loss in the cerebral cortex [140, 141].”
From Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau (2021) · cites this paper as [141]
Cites
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Hutton, M., Lendon, C. L., Rizzu, P., Baker, M., Froelich, S., Houlden, H., Pickering-Brown, S., Chakraverty, S., Isaacs, A., Grover, A., et al. (1998) · Nature · doi:10.1038/31508 · Cited by 3,498 · see citing works
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works
Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function
SantaCruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., DeTure, M., Ramsden, M., McGowan, E., et al. (2005) · Science · doi:10.1126/science.1113694 · Cited by 2,014 · see citing works
Self-citationSteriade, M., Nunez, A., & Amzica, F. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03252.1993 · Cited by 1,903 · see citing works
Dynamics of ongoing activity: explanation of the large variability in evoked cortical responses
Arieli, A., Sterkin, A., Grinvald, A., & Aertsen, A. (1996) · Science · doi:10.1126/science.273.5283.1868 · Cited by 1,660 · see citing works
Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., Pitstick, R., Carlson, G. A., Lanier, L. M., Yuan, L.-L., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.030 · Cited by 1,118 · see citing works
Role of tau protein in both physiological and pathological conditions
AVILA, J., LUCAS, J. J., PÉREZ, M., & HERNÁNDEZ, F. (2004) · Physiological Reviews · doi:10.1152/physrev.00024.2003 · Cited by 1,005 · see citing works
Haider, B., Duque, A., Hasenstaub, A. R., & McCormick, D. A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5297-05.2006 · Cited by 962 · see citing works
Gennaro, L. D., & Ferrara, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0252 · Cited by 925 · see citing works
Stamer, K., Vogel, R., Thies, E., Mandelkow, E., & Mandelkow, E.-M. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200108057 · Cited by 885 · see citing works
Cowan, R. L., & Wilson, C. J. (1994) · Journal of Neurophysiology · doi:10.1152/jn.1994.71.1.17 · Cited by 535 · see citing works
Synaptic background activity influences spatiotemporal integration in single pyramidal cells.
Bernander, Ö., Douglas, R. J., Martin, K. A. C., & Koch, C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11569 · Cited by 518 · see citing works
The role of tau in neurodegeneration
Gendron, T. F., & Petrucelli, L. (2009) · Molecular Neurodegeneration · doi:10.1186/1750-1326-4-13 · Cited by 478 · see citing works
Spires, T. L., Orne, J. D., SantaCruz, K., Pitstick, R., Carlson, G. A., Ashe, K. H., & Hyman, B. T. (2006) · The American Journal of Pathology · doi:10.2353/ajpath.2006.050840 · Cited by 401 · see citing works
Self-citationAxonal transport defects: a common theme in neurodegenerative diseases
Roy, S., Zhang, B., Lee, V. M. ‐., & Trojanowski, J. Q. (2005) · Acta Neuropathologica · doi:10.1007/s00401-004-0952-x · Cited by 372 · see citing works
Stern, E. A., Kincaid, A. E., & Wilson, C. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.1697 · Cited by 362 · see citing works
Self-citationThies, E., & Mandelkow, E.-M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4674-06.2007 · Cited by 293 · see citing works
Comparative cytoarchitectonic atlas of the C57BL/6 and 129/Sv mouse brains
Hof, P. R. (2000) · Elsevier eBooks · Cited by 289 · see citing works
Rudolph, M., Pospischil, M., Timofeev, I., & Destexhe, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4652-06.2007 · Cited by 247 · see citing works
Properties of Slow Oscillation during Slow-Wave Sleep and Anesthesia in Cats
Chauvette, S., Crochet, S., Volgushev, M., & Timofeev, I. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2339-11.2011 · Cited by 227 · see citing works
Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo
Kuchibhotla, K. V., Wegmann, S., Kopeikina, K. J., Hawkes, J., Rudinskiy, N., Andermann, M. L., Spires-Jones, T. L., Bacskai, B. J., & Hyman, B. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318807111 · Cited by 193 · see citing works
Self-citationStructural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs
Rocher, A. B., Crimins, J. L., Amatrudo, J. M., Kinson, M. S., Todd-Brown, M. A., Lewis, J., & Luebke, J. I. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2009.07.029 · Cited by 187 · see citing works
Crimins, J. L., Rocher, A. B., & Luebke, J. I. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1038-9 · Cited by 137 · see citing works
Synaptic alterations in the rTg4510 mouse model of tauopathy
Kopeikina, K. J., Polydoro, M., Tai, H., Yaeger, E., Carlson, G. A., Pitstick, R., Hyman, B. T., & Spires‐Jones, T. L. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23234 · Cited by 125 · see citing works
Self-citationSynaptic Integration in Rat Frontal Cortex Shaped by Network Activity
Léger, J., Stern, E. A., Aertsen, A., & Heck, D. H. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00067.2003 · Cited by 114 · see citing works
Self-citationOh, K.-J., Perez, S. E., Lagalwar, S., Vana, L., Binder, L., & Mufson, E. J. (2010) · International Journal of Alzheimer's Disease · doi:10.4061/2010/780102 · Cited by 105 · see citing works
Tau‐Induced Traffic Jams Reflect Organelles Accumulation at Points of Microtubule Polar Mismatching
Shemesh, O. A., Erez, H., Ginzburg, I., & Spira, M. E. (2007) · Traffic · doi:10.1111/j.1600-0854.2007.00695.x · Cited by 72 · see citing works
Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy
Crimins, J. L., Rocher, A. B., Peters, A., Shultz, P. L., Lewis, J. M., & Luebke, J. I. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0877-0 · Cited by 71 · see citing works
Glat, M. J., Skaat, H., Menkes-Caspi, N., Margel, S., & Stern, E. A. (2013) · Journal of Nanobiotechnology · doi:10.1186/1477-3155-11-32 · Cited by 54 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00269-y · Cited by 2,606 · see citing works
The Cellular Phase of Alzheimer’s Disease
De Strooper, B., & Karran, E. (2016) · Cell · doi:10.1016/j.cell.2015.12.056 · Cited by 1,990 · see citing works
Synergy between amyloid-β and tau in Alzheimer’s disease
Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works
PET Imaging of Tau Deposition in the Aging Human Brain
Schöll, M., Lockhart, S. N., Schonhaut, D. R., O’Neil, J. P., Janabi, M., Ossenkoppele, R., Baker, S. L., Vogel, J. W., Faria, J., Schwimmer, H. D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.028 · Cited by 1,214 · see citing works
Mander, B. A., Winer, J. R., & Walker, M. P. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.004 · Cited by 1,214 · see citing works
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer’s disease
Bejanin, A., Schonhaut, D. R., La Joie, R., Kramer, J. H., Baker, S. L., Sosa, N., Ayakta, N., Cantwell, A., Janabi, M., Lauriola, M., et al. (2017) · Brain · doi:10.1093/brain/awx243 · Cited by 778 · see citing works
Synaptic degeneration in Alzheimer disease
Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504 · see citing works
Self-citationMander, B. A., Winer, J. R., Jagust, W. J., & Walker, M. P. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.05.002 · Cited by 467 · see citing works
Tau association with synaptic vesicles causes presynaptic dysfunction
Zhou, L., McInnes, J., Wierda, K., Holt, M., Herrmann, A. G., Jackson, R. J., Wang, Y.-C., Swerts, J., Beyens, J., Miskiewicz, K., et al. (2017) · Nature Communications · doi:10.1038/ncomms15295 · Cited by 434 · see citing works
Self-citationTau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo
Busche, M. A., Wegmann, S., Dujardin, S., Commins, C., Schiantarelli, J., Klickstein, N., Kamath, T. V., Carlson, G. A., Nelken, I., & Hyman, B. T. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0289-8 · Cited by 413 · see citing works
The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease
the Synaptic Health Endpoints Working Group, Colom-Cadena, M., Spires-Jones, T., Zetterberg, H., Blennow, K., Caggiano, A., DeKosky, S. T., Fillit, H., Harrison, J. E., Schneider, L. S., et al. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00588-4 · Cited by 328 · see citing works
Self-citationOssenkoppele, R., Smith, R., Mattsson-Carlgren, N., Groot, C., Leuzy, A., Strandberg, O., Palmqvist, S., Olsson, T., Jögi, J., Stormrud, E., et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.1858 · Cited by 311 · see citing works
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works
Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimer’s disease
Otero-Garcia, M., Mahajani, S. U., Wakhloo, D., Tang, W., Xue, Y.-Q., Morabito, S., Pan, J., Oberhauser, J., Madira, A. E., Shakouri, T., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.06.021 · Cited by 262 · see citing works
Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain
Winer, J. R., Mander, B. A., Helfrich, R. F., Maaß, A., Harrison, T. M., Baker, S. L., Knight, R. T., Jagust, W. J., & Walker, M. P. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.0503-19.2019 · Cited by 259 · see citing works
Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse
Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works
Analyzing dendritic spine pathology in Alzheimer’s disease: Problems and opportunities
Dorostkar, M. M., Zou, C., Blazquez-Llorca, L., & Herms, J. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1449-5 · Cited by 235 · see citing works
Cedernaes, J., Osorio, R. S., Varga, A. W., Kam, K., Schiöth, H. B., & Benedict, C. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.002 · Cited by 200 · see citing works
Meftah, S., & Gan, J. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1129036 · Cited by 197 · see citing works
Updates on mouse models of Alzheimer’s disease
Zhong, M. Z., Peng, T., Duarte, M. L., Wang, M., & Cai, D. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00712-0 · Cited by 189 · see citing works
Caspase-2 cleavage of tau reversibly impairs memory
Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. H. (2016) · Nature Medicine · doi:10.1038/nm.4199 · Cited by 187 · see citing works
Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.044 · Cited by 179 · see citing works
Self-citationNetworks of tau distribution in Alzheimer’s disease
Hoenig, M. C., Bischof, G. N., Seemiller, J., Hammes, J., Kukolja, J., Onur, O. A., Jessen, F., Fließbach, K., Neumaier, B., Fink, G. R., et al. (2017) · Brain · doi:10.1093/brain/awx353 · Cited by 174 · see citing works
Shaping the Default Activity Pattern of the Cortical Network
Sanchez-Vives, M. V., Massimini, M., & Mattia, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.015 · Cited by 167 · see citing works
Harris, S. S., Wolf, F., De Strooper, B., & Busche, M. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.005 · Cited by 161 · see citing works
Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia
Swarup, V., Hinz, F. I., Rexach, J. E., Noguchi, K.-I., Toyoshiba, H., Oda, A., Hirai, K., Sarkar, A., Seyfried, N. T., Cheng, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-018-0223-3 · Cited by 136 · see citing works
Hatch, R. J., Yan, W., Xia, D., & Götz, J. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1674-1 · Cited by 147 · see citing works
Millan, M. J. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.03.004 · Cited by 146 · see citing works
Kazim, S. F., Seo, J. H., Bianchi, R., Larson, C. S., Sharma, A., Wong, R. K. S., Gorbachev, K., & Pereira, A. C. (2021) · eNeuro · doi:10.1523/eneuro.0418-20.2020 · Cited by 113 · see citing works
Systems-based proteomics to resolve the biology of Alzheimer’s disease beyond amyloid and tau
Rayaprolu, S., Higginbotham, L., Bagchi, P., Watson, C. M., Zhang, T., Levey, A. I., Rangaraju, S., & Seyfried, N. T. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-020-00840-3 · Cited by 118 · see citing works
Jackson, R. J., Rudinskiy, N., Herrmann, A. G., Croft, S., Kim, J. M., Petrova, V., Ramos‐Rodríguez, J. J., Pitstick, R., Wegmann, S., Garcı́a-Alloza, M., et al. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13442 · Cited by 109 · see citing works
Self-citationRanasinghe, K. G., Cha, J., Iaccarino, L., Hinkley, L. B. N., Beagle, A. J., Pham, J. Q., Jagust, W. J., Miller, B. L., Rankin, K. P., Rabinovici, G. D., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4069 · Cited by 106 · see citing works
Ossenkoppele, R., Iaccarino, L., Schonhaut, D. R., Brown, J. A., Joie, R. L., O’Neil, J. P., Janabi, M., Baker, S. L., Kramer, J. H., Gorno‐Tempini, M., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101848 · Cited by 103 · see citing works
Synaptic activity and Alzheimer's disease: a critical update
Tampellini, D. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00423 · Cited by 105 · see citing works
Cortex-wide BOLD fMRI activity reflects locally-recorded slow oscillation-associated calcium waves
Schwalm, M., Schmid, F., Wachsmuth, L., Backhaus, H., Kronfeld, A., Aedo-Jury, F., Prouvot, P.-H., Fois, C., Albers, F., van Alst, T. M., et al. (2017) · eLife · doi:10.7554/elife.27602 · Cited by 101 · see citing works
Christensen, J., Yamakawa, G. R., Shultz, S. R., & Mychasiuk, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101917 · Cited by 105 · see citing works
How Can Insulin Resistance Cause Alzheimer’s Disease?
Yoon, J. H., Hwang, J., Son, S. U., Choi, J., You, S.-W., Park, H., Cha, S.-Y., & Maeng, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043506 · Cited by 104 · see citing works
In vivo tau pathology is associated with synaptic loss and altered synaptic function
Coomans, E. M., Schoonhoven, D. N., Tuncel, H., Verfaillie, S. C. J., Wolters, E. E., Boellaard, R., Ossenkoppele, R., den Braber, A., Scheper, W., Schober, P. R., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00772-0 · Cited by 101 · see citing works
Ahnaou, A., Moechars, D., Raeymaekers, L., Biermans, R., Manyakov, N. V., Bottelbergs, A., Wintmolders, C., Van Kolen, K., Van De Casteele, T., Kemp, J. A., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-13839-6 · Cited by 98 · see citing works
Local Sleep and Alzheimer’s Disease Pathophysiology
Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97 · see citing works
Hansson, O., Grothe, M. J., Strandberg, T. O., Ohlsson, T. G., Hägerström, D., Jögi, J., Smith, R. A., & Schöll, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00167 · Cited by 98 · see citing works
A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy
Hernández, I., Luna, G., Rauch, J. N., Reis, S. A., Giroux, M., Karch, C. M. M., Boctor, D., Sibih, Y., Storm, N. J., Díaz, A., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aat3005 · Cited by 95 · see citing works
Modulation of Brain Hyperexcitability: Potential New Therapeutic Approaches in Alzheimer’s Disease
Toniolo, S., Sen, A., & Husain, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239318 · Cited by 94 · see citing works
Mattsson, N., Insel, P. S., Donohue, M., Jögi, J., Ossenkoppele, R., Olsson, T., Schöll, M., Smith, R., & Hansson, O. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.12.001 · Cited by 92 · see citing works
Holland, N., Jones, P. S., Savulich, G., Wiggins, J. K., Hong, Y. T., Fryer, T. D., Manavaki, R., Sephton, S. M., Boros, I., Malpetti, M., et al. (2020) · Movement Disorders · doi:10.1002/mds.28188 · Cited by 93 · see citing works
Amyloid, tau and metabolic PET correlates of cognition in early and late-onset Alzheimer’s disease
Tanner, J. A., Iaccarino, L., Edwards, L., Asken, B. M., Gorno‐Tempini, M. L., Kramer, J. H., Pham, J. Q., Perry, D. C., Possin, K. L., Malpetti, M., et al. (2022) · Brain · doi:10.1093/brain/awac229 · Cited by 88 · see citing works
New Features about Tau Function and Dysfunction
Medina, M., Hernández, F., & Ávila, J. (2016) · Biomolecules · doi:10.3390/biom6020021 · Cited by 92 · see citing works
Ten Years of Tau-Targeted Immunotherapy: The Path Walked and the Roads Ahead
Novak, P., Kontsekova, E., Zilka, N., & Novak, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00798 · Cited by 87 · see citing works
EEG alterations during wake and sleep in mild cognitive impairment and Alzheimer's disease
D’Atri, A., Scarpelli, S., Gorgoni, M., Truglia, I., Lauri, G., Cordone, S., Ferrara, M., Marra, C., Rossini, P. M., & Gennaro, L. D. (2021) · iScience · doi:10.1016/j.isci.2021.102386 · Cited by 92 · see citing works
Chang, C.-W., Evans, M. D., Yu, X., Yu, G.-Q., & Mucke, L. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109855 · Cited by 81 · see citing works
Amyloid and tau PET demonstrate region-specific associations in normal older people
Lockhart, S. N., Schöll, M., Baker, S. L., Ayakta, N., Swinnerton, K. N., Bell, R. K., Mellinger, T. J., Shah, V. D., O’Neil, J. P., Janabi, M., et al. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.02.051 · Cited by 79 · see citing works
Shimojo, M., Takuwa, H., Takado, Y., Tokunaga, M., Tsukamoto, S., Minatohara, K., Ono, M., Seki, C., Maeda, J., Urushihata, T., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2880-19.2020 · Cited by 78 · see citing works
Rodriguez, G. A., Barrett, G., Duff, K., & Hussaini, S. A. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000851 · Cited by 76 · see citing works
Altered Synapse Stability in the Early Stages of Tauopathy
Jackson, J., Witton, J., Johnson, J. D., Ahmed, Z., Ward, M., Randall, A. D., Hutton, M. L., Isaac, J. T. R., O’Neill, M. J., & Ashby, M. C. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.013 · Cited by 71 · see citing works
The Sleep Side of Aging and Alzheimer’s Disease
Romanella, S. M., Roe, D., Tatti, E., Cappon, D., Paciorek, R., Testani, E., Rossi, A., Rossi, S., & Santarnecchi, E. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.05.029 · Cited by 69 · see citing works
In vivoimaging reveals reduced activity of neuronal circuits in a mouse tauopathy model
Marinković, P., Blumenstock, S., Goltstein, P. M., Korzhova, V., Peters, F., Knebl, A., & Herms, J. W. (2019) · Brain · doi:10.1093/brain/awz035 · Cited by 63 · see citing works
Morrone, C. D., Raghuraman, R., Hussaini, S. A., & Yu, W. H. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00617-4 · Cited by 64 · see citing works
Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease
Ossenkoppele, R., & Hansson, O. (2021) · Alzheimer's & Dementia · doi:10.1002/alz.12356 · Cited by 62 · see citing works
Tau neurotoxicity and rescue in animal models of human Tauopathies
Krüger, L., & Mandelkow, E. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.09.004 · Cited by 60 · see citing works
Personalized brain models identify neurotransmitter receptor changes in Alzheimer's disease
Khan, A. F., Adewale, Q., Baumeister, T. R., Carbonell, F., Zilles, K., Palomero‐Gallagher, N., Iturria‐Medina, Y., & Initiative, A. D. N. (2021) · Brain · doi:10.1093/brain/awab375 · Cited by 58 · see citing works
Angulo, S. L., Orman, R., Neymotin, S. A., Liu, L., Buitrago, L., Cepeda-Prado, E., Stefanov, D. G., Lytton, W. W., Stewart, M., Small, S. A., et al. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.015 · Cited by 56 · see citing works
Winer, J. R., Morehouse, A. B., Fenton, L. E., Harrison, T. M., Ayangma, L., Reed, M. E., Kumar, S., Baker, S. L., Jagust, W. J., & Walker, M. P. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0353-21.2021 · Cited by 52 · see citing works
Florenzano, F., Corsetti, V., Ciasca, G., Ciotti, M. T., Pittaluga, A., Olivero, G., Feligioni, M., Iannuzzi, F., Latina, V., Sciacca, M. F. M., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.17371 · Cited by 52 · see citing works
Fjell, A. M., Idland, A., Sala‐Llonch, R., Watne, L. O., Borza, T., Brækhus, A., Lona, T., Zetterberg, H., Blennow, K., Wyller, T. B., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx157 · Cited by 52 · see citing works
Late-in-life neurodegeneration after chronic sleep loss in young adult mice
Owen, J. E., Zhu, Y., Fenik, P., Zhan, G., Bell, P., Liu, X. C., & Veasey, S. C. (2021) · SLEEP · doi:10.1093/sleep/zsab057 · Cited by 48 · see citing works
Vanderlinden, G., Ceccarini, J., Vande Casteele, T., Michiels, L., Lemmens, R., Triau, E., Serdons, K., Tournoy, J., Koole, M., Vandenbulcke, M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01672-x · Cited by 47 · see citing works
Adenosine A 1 receptor antagonist rolofylline alleviates axonopathy caused by human Tau ΔK280
Dennissen, F. J. A., Anglada‐Huguet, M., Sydow, A., Mandelkow�, E., & Mandelkow, E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603119113 · Cited by 46 · see citing works
Cordone, S., Scarpelli, S., Alfonsi, V., Gennaro, L. D., & Gorgoni, M. (2021) · Pharmaceuticals · doi:10.3390/ph14040383 · Cited by 49 · see citing works
Mehak, S. F., Shivakumar, A. B., Kumari, S., Muralidharan, B., & Gangadharan, G. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104628 · Cited by 42 · see citing works
The A/T/N model applied through imaging biomarkers in a memory clinic
Dodich, A., Mendes, A., Assal, F., Chicherio, C., Rakotomiaramanana, B., Andryszak, P., Festari, C., Ribaldi, F., Scheffler, M., Schibli, R., et al. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04536-9 · Cited by 42 · see citing works
Gerstner, J. R., Lenz, O., Vanderheyden, W. M., Chan, M. T., Pfeiffenberger, C., & Pack, A. I. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23778 · Cited by 40 · see citing works
CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume
Düzel, E., Berron, D., Schütze, H., Cárdenas‐Blanco, A., Metzger, C. D., Betts, M. J., Ziegler, G., Chen, Y., Dobisch, L., Bittner, D., et al. (2018) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.10.003 · Cited by 37 · see citing works
Molecular pathology and synaptic loss in primary tauopathies: an 18F-AV-1451 and 11C-UCB-J PET study
Holland, N., Malpetti, M., Rittman, T., Mak, E. E., Passamonti, L., Kaalund, S. S., Hezemans, F. H., Jones, P. S., Savulich, G., Hong, Y. T., et al. (2022) · Brain · doi:10.1093/brain/awab282 · Cited by 39 · see citing works
Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease
Deng, Y., Bi, M., Delerue, F., Forrest, S. L., Chan, G., van der Hoven, J., van Hummel, A., Feiten, A., Lee, S., Martínez-Valbuena, I., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-022-02457-w · Cited by 39 · see citing works
Green, C., Sydow, A., Vogel, S. N., Anglada‐Huguet, M., Wiedermann, D., Mandelkow�, E., Mandelkow, E., & Hoehn, M. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0316-6 · Cited by 38 · see citing works
Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration
Holton, C. M., Hanley, N., Shanks, E., Oxley, P., McCarthy, A. P., Eastwood, B. J., Murray, T. K., Nickerson, A. P., & Wafford, K. A. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00651-0 · Cited by 38 · see citing works
Insulin Resistance as a Common Link Between Current Alzheimer’s Disease Hypotheses
Alves, S. S., da Silva-Júnior, R. M. P., Servilha‐Menezes, G., Homolak, J., Šalković‐Petrišić, M., & Garcia‐Cairasco, N. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210234 · Cited by 38 · see citing works
Walsh, C., Drinkenburg, W. H. I. M., & Ahnaou, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.020 · Cited by 35 · see citing works
A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer’s disease
Alexandersen, C. G., de Haan, W., Bick, C., & Goriely, A. (2023) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0607 · Cited by 36 · see citing works
Viney, T. J., Sárkány, B., Ozdemir, A. T., Hartwich, K., Schweimer, J. V., Bannerman, D. M., & Somogyi, P. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111646 · Cited by 34 · see citing works
Novel PET Biomarkers to Disentangle Molecular Pathways across Age-Related Neurodegenerative Diseases
Wilson, H., Politis, M., Rabiner, E. A., & Middleton, L. T. (2020) · Cells · doi:10.3390/cells9122581 · Cited by 34 · see citing works
Ranasinghe, K. G., Petersen, C., Kudo, K., Mizuiri, D., Rankin, K. P., Rabinovici, G. D., Gorno‐Tempini, M., Seeley, W. W., Spina, S., Miller, B. L., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12349 · Cited by 33 · see citing works
Amyloid pathology but notAPOEε4 status is permissive for tau-related hippocampal dysfunction
Düzel, E., Ziegler, G., Berron, D., Maaß, A., Schütze, H., Cárdenas‐Blanco, A., Glanz, W., Metzger, C. D., Dobisch, L., Reuter, M., et al. (2021) · Brain · doi:10.1093/brain/awab405 · Cited by 30 · see citing works
Wakhloo, D., Mahajani, S. U., Oberhauser, J., & Madira, A. E. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.336138 · Cited by 37 · see citing works
Astrocytes restore connectivity and synchronization in dysfunctional cerebellar networks
Kanner, S., Goldin, M. M., Galron, R., Jacob, E. B., Bonifazi, P., & Barzilai, A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718582115 · Cited by 32 · see citing works
Circuitry and Synaptic Dysfunction in Alzheimer’s Disease: A New Tau Hypothesis
Mondragón‐Rodríguez, S., Salgado, H., & Peña‐Ortega, F. (2020) · Neural Plasticity · doi:10.1155/2020/2960343 · Cited by 32 · see citing works
Kong, W., Zheng, Y., Xu, W., Gu, H., & Wu, J. (2020) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-020-05948-2 · Cited by 31 · see citing works
Epigenetic treatment of behavioral and physiological deficits in a tauopathy mouse model
Wang, W., Cao, Q., Tan, T., Yang, F., Williams, J. B., & Yan, Z. (2021) · Aging Cell · doi:10.1111/acel.13456 · Cited by 29 · see citing works
Trease, A. J., George, J. W., Roland, N. J., Lichter, E. Z., Emanuel, K. M., Totusek, S., Fox, H. S., & Stauch, K. L. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.852368 · Cited by 30 · see citing works
Tau-related grey matter network breakdown across the Alzheimer’s disease continuum
Pelkmans, W., Ossenkoppele, R., Dicks, E., Strandberg, O. T., Barkhof, F., Tijms, B. M., Pereira, J. B., & Hansson, O. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00876-7 · Cited by 25 · see citing works
Peña‐Ortega, F., Robles-Gómez, Á. A., & Cueva, L. X. (2022) · Cells · doi:10.3390/cells11060923 · Cited by 27 · see citing works
Przybyla, M., van Eersel, J., van Hummel, A., van der Hoven, J., Sabale, M., Harasta, A. E., Müller, J., Gajwani, M., Prikas, E., Mueller, T., et al. (2020) · Brain · doi:10.1093/brain/awaa133 · Cited by 27 · see citing works
Kam, K., Vetter, K., Tejiram, R. A., Pettibone, W. D., Shim, K., Audrain, M., Yu, L., Daehn, I. S., Ehrlich, M. E., & Varga, A. W. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1828-22.2023 · Cited by 25 · see citing works
Kopach, O., Esteras, N., Wray, S., Rusakov, D. A., & Abramov, A. Y. (2020) · Journal of Cell Science · doi:10.1242/jcs.241687 · Cited by 27 · see citing works
Kopach, O., Esteras, N., Wray, S., Abramov, A. Y., & Rusakov, D. A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04007-w · Cited by 26 · see citing works
Capilla-López, M. D., Deprada-Fernandez, Á., Andrade‐Talavera, Y., Martínez‐Gallego, I., Coatl-Cuaya, H., Sotillo, P. S., Rodrı́guez-Álvarez, J., Moreno, A. R., Parra‐Damas, A., & Saura, C. A. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02901-9 · Cited by 29 · see citing works
Slow and Fast Neocortical Oscillations in the Senescence-Accelerated Mouse Model SAMP8
Castano-Prat, P., Pérez‐Zabalza, M., Perez-Mendez, L., Escorihuela, R. M., & Sanchez-Vives, M. V. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00141 · Cited by 25 · see citing works
Düzel, E., Costagli, M., Donatelli, G., Speck, O., & Cosottini, M. (2021) · European Radiology Experimental · doi:10.1186/s41747-021-00221-5 · Cited by 28 · see citing works
The Role of miR-128 in Neurodegenerative Diseases
Lanza, M., Cuzzocrea, S., Oddo, S., Esposito, E., & Casili, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076024 · Cited by 25 · see citing works
Molecular imaging of beta-amyloid deposition in late-life depression
Smith, G. S., Kuwabara, H., Nandi, A., Gould, N. F., Nassery, N., Savonenko, A. V., Joo, J. H., Kraut, M. A., Brašić, J. R., Holt, D. P., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.002 · Cited by 25 · see citing works
- Authors
- Menkes-Caspi, N., Yamin, H. G., Kellner, V., Spires-Jones, T. L., Cohen, D., & Stern, E. A.
- Affiliations
- Bar-Ilan University (IL)
- Corresponding author
- Stern, Edward A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 85
- Issue
- 5
- Pages
- 959-966
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2163349796
- Cited by
- 184
- References
- 29
- Citations by year
- 2026: 15 · 2025: 11 · 2024: 11 · 2023: 15 · 2022: 17 · 2021: 28 · 2020: 28 · 2019: 12 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 5
- FWCI
- 11.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc-nd)
- Funders
- Versus Arthritis
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- pathological tau, tauopathy, Alzheimer's disease, membrane potential oscillations, slow-wave sleep, anesthesia, neuronal firing patterns, pyramidal neurons, arousal
- MeSH terms
- Action Potentials, Animals, Female, Humans, Male, Mice, Transgenic, Nerve Net, tau Proteins, Neocortex, Tauopathies, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review