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Cited by 766

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Sarcopenia and Mortality after Liver Transplantation

Open access
Englesbe, Michael J., Patel, Shaun P., He, Kevin, Lynch, Raymond J., Schaubel, Douglas E., Harbaugh, Calista, Holcombe, Sven A., Wang, Stewart C., Segev, Dorry L., Sonnenday, Christopher J.·2010·Journal of the American College of Surgeons
DOI 10.1016/j.jamcollsurg.2010.03.039
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Abstract

BACKGROUND: Surgeons frequently struggle to determine patient suitability for liver transplantation. Objective and comprehensive measures of overall burden of disease, such as sarcopenia, could inform clinicians and help avoid futile transplantations. STUDY DESIGN: The cross-sectional area of the psoas muscle was measured on CT scans of 163 liver transplant recipients. After controlling for donor and recipient characteristics using Cox regression models, we described the relationship between psoas area and post-transplantation mortality. RESULTS: Psoas area correlated poorly with Model for End-Stage Liver Disease score and serum albumin. Cox regression revealed a strong association between psoas area and post-transplantation mortality (hazard ratio = 3.7/1,000 mm(2) decrease in psoas area; p < 0.0001). When stratified into quartiles based on psoas area (holding donor and recipient characteristics constant), 1-year survival ranged from 49.7% for the quartile with the smallest psoas area to 87.0% for the quartile with the largest. Survival at 3 years among these groups was 26.4% and 77.2%, respectively. The impact of psoas area on survival exceeded that of all other covariates in these models. CONCLUSIONS: Central sarcopenia strongly correlates with mortality after liver transplantation. Such objective measures of patient frailty, such as sarcopenia, can inform clinical decision making and, potentially, allocation policy. Additional work is needed develop valid and clinically relevant measures of sarcopenia and frailty in liver transplantation.

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Metadata

Authors
Englesbe, M. J., Patel, S. P., He, K., Lynch, R. J., Schaubel, D. E., Harbaugh, C., Holcombe, S. A., Wang, S. C., Segev, D. L., & Sonnenday, C. J.
Venue
Journal of the American College of Surgeons
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-08
Volume
211
Issue
2
Pages
271-278
ISSN
1072-7515 (ISSN-L)
DOI
10.1016/j.jamcollsurg.2010.03.039
OpenAlex
W2087000019
Cited by
766
References
9
FWCI
11.98
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Sarcopenia and Mortality after Liver Transplantation. https://app.cochat.ai/papers/10.1016/j.jamcollsurg.2010.03.039
The paper
Englesbe, M. J., Patel, S. P., He, K., Lynch, R. J., Schaubel, D. E., Harbaugh, C., Holcombe, S. A., Wang, S. C., Segev, D. L., & Sonnenday, C. J. (2010). Sarcopenia and Mortality after Liver Transplantation. Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2010.03.039

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.