The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Early Platelet Dysfunction: An Unrecognized Role in the Acute Coagulopathy of Trauma
Open accessAbstract
BACKGROUND: Our aim was to determine the prevalence of platelet dysfunction using an end point of assembly into a stable thrombus after severe injury. Although the current debate on acute traumatic coagulopathy has focused on the consumption or inhibition of coagulation factors, the question of early platelet dysfunction in this setting remains unclear. STUDY DESIGN: Prospective platelet function in assembly and stability of the thrombus was determined within 30 minutes of injury using whole blood samples from trauma patients at the point of care using thrombelastography-based platelet functional analysis. RESULTS: There were 51 patients in the study. There were significant differences in the platelet response between trauma patients and healthy volunteers, such that there was impaired aggregation to these agonists. In trauma patients, the median ADP inhibition of platelet function was 86.1% (interquartile range [IQR] 38.6% to 97.7%) compared with 4.2 % (IQR 0 to 18.2%) in healthy volunteers. After trauma, the impairment of platelet function in response to arachidonic acid was 44.9% (IQR 26.6% to 59.3%) compared with 0.5% (IQR 0 to 3.02%) in volunteers (Wilcoxon nonparametric test, p < 0.0001 for both tests). CONCLUSIONS: In this study, we show that platelet dysfunction is manifest after major trauma and before substantial fluid or blood administration. These data suggest a potential role for early platelet transfusion in severely injured patients at risk for postinjury coagulopathy.
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Cites
Epidemiology of Trauma Deaths: A Reassessment
Sauaia, A., Moore, F. A., Moore, E. E., Moser, K. S., Brennan, R., Read, R. A., & Pons, P. T. (1995) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/00005373-199502000-00006 · Cited by 1,879
Self-citationA Cell-based Model of Hemostasis
Monroe, D., & Hoffman, M. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615947 · Cited by 1,542
Holcomb, J. B., Wade, C. E., Michalek, J. E., Chisholm, G. B., Zarzabal, L. A., Schreiber, M. A., Gonzalez, E. A., Pomper, G. J., Perkins, J. G., Spinella, P. C., et al. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e318185a9ad · Cited by 1,087
Acute Traumatic Coagulopathy: Initiated by Hypoperfusion: Modulated Through the Protein C Pathway?
Brohi, K., Cohen, M. J., Ganter, M. T., Matthay, M. A., Mackersie, R. C., & Pittet, J.-F. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000256862.79374.31 · Cited by 736
Acute Coagulopathy of Trauma: Hypoperfusion Induces Systemic Anticoagulation and Hyperfibrinolysis
Brohi, K., Cohen, M. J., Ganter, M. T., Schultz, M. J., Levi, M., Mackersie, R. C., & Pittet, J.-F. (2008) · Journal of Trauma: Injury, Infection & Critical Care · doi:10.1097/ta.0b013e318169cd3c · Cited by 733
Ganter, M. T., & Hofer, C. K. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318168b367 · Cited by 677
Blood Transfusion: An Independent Risk Factor for Postinjury Multiple Organ Failure
Moore, F. A. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430300062013 · Cited by 562
Ciavarella, D., Reed, R. L., Counts, R. B., Baron, L., Pavlin, E., Heimbach, D. M., & Carrico, C. J. (1987) · British Journal of Haematology · doi:10.1111/j.1365-2141.1987.tb02359.x · Cited by 298
Primary Fibrinolysis Is Integral in the Pathogenesis of the Acute Coagulopathy of Trauma
Kashuk, J. L., Moore, E. E., Sawyer, M., Wohlauer, M., Pezold, M., Barnett, C., Biffl, W. L., Burlew, C. C., Johnson, J. L., & Sauaia, A. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181f09191 · Cited by 295
Self-citationImpact of Plasma Transfusion in Trauma Patients Who Do Not Require Massive Transfusion
Inaba, K., Branco, B. C., Rhee, P., Blackbourne, L. H., Holcomb, J. B., Teixeira, P. G. R., Shulman, I., Nelson, J., & Demetriades, D. (2010) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2010.01.031 · Cited by 272
Cited by
Guidelines for the use of platelet transfusions
Estcourt, L. J., Birchall, J., Allard, S., Bassey, S. J., Hersey, P., Kerr, J. P., Mumford, A. D., Stanworth, S. J., Tinegate, H., & the British Committee for Standards in Haematology (2017) · British Journal of Haematology · doi:10.1111/bjh.14423 · Cited by 648
Moore, H. B., Moore, E. E., Liras, I. N., Gonzalez, E., Harvin, J. A., Holcomb, J. B., Sauaia, A., & Cotton, B. A. (2016) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2016.01.006 · Cited by 295
Self-citationAdvances in the understanding of trauma-induced coagulopathy
Chang, R., Cardenas, J. C., Wade, C. E., & Holcomb, J. B. (2016) · Blood · doi:10.1182/blood-2016-01-636423 · Cited by 287
Walsh, M., Fritz, S., Hake, D., Son, M., Greve, S., Jbara, M., Chitta, S., Fritz, B., Miller, A., K Bader, M., et al. (2016) · Current Drug Targets · doi:10.2174/1389450117666160310153211 · Cited by 58
Metadata
- Authors
- Wohlauer, M. V., Moore, E. E., Thomas, S., Sauaia, A., Evans, E., Harr, J., Silliman, C. C., Ploplis, V., Castellino, F. J., & Walsh, M.
- Venue
- Journal of the American College of Surgeons
- Published
- 2012-05
- Volume
- 214
- Issue
- 5
- Pages
- 739-746
- ISSN
- 1072-7515 (ISSN-L)
- OpenAlex
- W1970569414
- Cited by
- 291
- References
- 30
- FWCI
- 15.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Wohlauer, M. V., Moore, E. E., Thomas, S., Sauaia, A., Evans, E., Harr, J., Silliman, C. C., Ploplis, V., Castellino, F. J., & Walsh, M. (2012). Early Platelet Dysfunction: An Unrecognized Role in the Acute Coagulopathy of Trauma. Journal of the American College of Surgeons. https://doi.org/10.1016/j.jamcollsurg.2012.01.050
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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