The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial
Open accessAbstract
BackgroundRecent evidence suggests that nutritional interventions may improve muscle outcomes in malnutrition and sarcopenia.ObjectivesWe evaluated the effects of 2 high-quality oral nutritional supplements (ONS) differing in amount and type of key nutrients in older adult men and women.DesignA multicenter, randomized, double-blinded, controlled clinical trial.ParticipantsMalnourished and sarcopenic men and women, 65 years and older (n = 330).InterventionA 24-week intervention period with 2 energy-rich (330 kcal) ONS treatment groups: Control ONS (CONS, 14 g protein; 147 IU vitamin D3) versus Experimental ONS (EONS, 20 g protein; 499 IU vitamin D3; 1.5 g CaHMB) taken twice daily. Both ONS also contained other vitamins, minerals, and nutrients in varying amounts.MeasurementsIsokinetic peak torque (PT, Nm) leg strength, grip strength (kg), and gait speed (m·s−1) were assessed at baseline and 12 and 24 weeks. Left and right leg muscle mass (LMM, kg) were assessed by dual-energy x-ray absorptiometry (DXA). Muscle quality (MQ) was leg strength expressed relative to the tested LMM (Nm·kg−1). Subgroup analyses were performed: severe sarcopenia (low skeletal mass index, low grip strength [<30 kg men; <20 kg women], low gait speed [<0.8 m·s−1]) and mild-moderate sarcopenia (low skeletal mass index, normal gait speed, or normal grip strength).ResultsBoth ONS groups (EONS and CONS) improved PT, MQ, grip strength, and gait speed from baseline with no treatment differences. Those with severe sarcopenia (44%) exhibited lower baseline PT and MQ, with no differences in strength improvements between treatments. However, participants with mild-moderate sarcopenia exhibited higher baseline PT and MQ, with differences in strength improvements at 12 weeks (EONS > CONS, P = .032) in those with normal grip strength. There were no treatment differences based on sarcopenic severity for either grip strength or gait speed.ConclusionONS improved strength outcomes in malnourished older adults with sarcopenia. In those with mild-moderate sarcopenia, but not severe sarcopenia, consumption of the EONS improved leg muscle strength and quality compared with the standard CONS.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Self-citationGuralnik, J. M., Simonsick, E. M., Ferrucci, L., Glynn, R. J., Berkman, L. F., Blazer, D. G., Scherr, P. A., & Wallace, R. B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.2.m85 · Cited by 9,792
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
What is subjective global assessment of nutritional status?
Detsky, A., McLaughlin, Baker, J., Johnston, N., Whittaker, S., Mendelson, R., & Jeejeebhoy, K. (1987) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/014860718701100108 · Cited by 3,252
Janssen, I., Heymsfield, S. B., & Ross, R. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50216.x · Cited by 3,139
Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., et al. (2014) · Clinical Nutrition · doi:10.1016/j.clnu.2014.04.007 · Cited by 1,738
Self-citationSarcopenia: alternative definitions and associations with lower extremity function
Newman, A. B., Kupelian, V., Visser, M., Simonsick, E., Goodpaster, B., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Rubin, S. M., Harris, T. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51534.x · Cited by 981
Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study
Landi, F., Liperoti, R., Russo, A., Giovannini, S., Tosato, M., Capoluongo, E., Bernabei, R., & Onder, G. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.02.007 · Cited by 938
Self-citationDelmonico, M. J., Harris, T. B., Lee, J., Visser, M., Nevitt, M., Kritchevsky, S. B., Tylavsky, F. A., Newman, A. B., & for the Health, A. A. B. C. S. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01140.x · Cited by 819
Breen, L., & Phillips, S. M. (2011) · Nutrition & Metabolism · doi:10.1186/1743-7075-8-68 · Cited by 576
Cited by
Cruz-Jentoft, A. J., & Sayer, A. A. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31138-9 · Cited by 3,905
Self-citationDent, E., Morley, J. E., Cruz-Jentoft, A. J., Arai, H., Kritchevsky, S. B., Guralnik, J., Bauer, J. M., Pahor, M., Clark, B. C., Cesari, M., et al. (2018) · The Journal of nutrition, health and aging · doi:10.1007/s12603-018-1139-9 · Cited by 1,130
Self-citationThe Asia-Pacific Clinical Practice Guidelines for the Management of Frailty
Dent, E., Lien, C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., de la Vega, S., Hua Poi, P. J., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.018 · Cited by 631
Self-citationHsu, K.-J., Liao, C.-D., Tsai, M.-W., & Chen, C.-N. (2019) · Nutrients · doi:10.3390/nu11092163 · Cited by 258
Management of Sarcopenia: A Network Meta-Analysis of Randomized Controlled Trials
Negm, A. M., Lee, J., Hamidian, R., Jones, C. A., & Khadaroo, R. G. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.01.057 · Cited by 137
Metadata
- Authors
- Cramer, J. T., Cruz-Jentoft, A. J., Landi, F., Hickson, M., Zamboni, M., Pereira, S. L., Hustead, D. S., & Mustad, V. A.
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 17
- Issue
- 11
- Pages
- 1044-1055
- ISSN
- 1525-8610 (ISSN-L)
- OpenAlex
- W2537831197
- Cited by
- 163
- References
- 18
- FWCI
- 10.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial. https://app.cochat.ai/papers/10.1016/j.jamda.2016.08.009
- The paper
- Cramer, J. T., Cruz-Jentoft, A. J., Landi, F., Hickson, M., Zamboni, M., Pereira, S. L., Hustead, D. S., & Mustad, V. A. (2016). Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial. Journal of the American Medical Directors Association. https://doi.org/10.1016/j.jamda.2016.08.009
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
