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Cited by 163

The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.

Impacts of High-Protein Oral Nutritional Supplements Among Malnourished Men and Women with Sarcopenia: A Multicenter, Randomized, Double-Blinded, Controlled Trial

Open access
Cramer, Joel T., Cruz-Jentoft, Alfonso J., Landi, Francesco, Hickson, Mary, Zamboni, Mauro, Pereira, Suzette L., Hustead, Deborah S., Mustad, Vikkie A.·2016·Journal of the American Medical Directors Association
DOI 10.1016/j.jamda.2016.08.009
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Abstract

BackgroundRecent evidence suggests that nutritional interventions may improve muscle outcomes in malnutrition and sarcopenia.ObjectivesWe evaluated the effects of 2 high-quality oral nutritional supplements (ONS) differing in amount and type of key nutrients in older adult men and women.DesignA multicenter, randomized, double-blinded, controlled clinical trial.ParticipantsMalnourished and sarcopenic men and women, 65 years and older (n = 330).InterventionA 24-week intervention period with 2 energy-rich (330 kcal) ONS treatment groups: Control ONS (CONS, 14 g protein; 147 IU vitamin D3) versus Experimental ONS (EONS, 20 g protein; 499 IU vitamin D3; 1.5 g CaHMB) taken twice daily. Both ONS also contained other vitamins, minerals, and nutrients in varying amounts.MeasurementsIsokinetic peak torque (PT, Nm) leg strength, grip strength (kg), and gait speed (m·s−1) were assessed at baseline and 12 and 24 weeks. Left and right leg muscle mass (LMM, kg) were assessed by dual-energy x-ray absorptiometry (DXA). Muscle quality (MQ) was leg strength expressed relative to the tested LMM (Nm·kg−1). Subgroup analyses were performed: severe sarcopenia (low skeletal mass index, low grip strength [<30 kg men; <20 kg women], low gait speed [<0.8 m·s−1]) and mild-moderate sarcopenia (low skeletal mass index, normal gait speed, or normal grip strength).ResultsBoth ONS groups (EONS and CONS) improved PT, MQ, grip strength, and gait speed from baseline with no treatment differences. Those with severe sarcopenia (44%) exhibited lower baseline PT and MQ, with no differences in strength improvements between treatments. However, participants with mild-moderate sarcopenia exhibited higher baseline PT and MQ, with differences in strength improvements at 12 weeks (EONS > CONS, P = .032) in those with normal grip strength. There were no treatment differences based on sarcopenic severity for either grip strength or gait speed.ConclusionONS improved strength outcomes in malnourished older adults with sarcopenia. In those with mild-moderate sarcopenia, but not severe sarcopenia, consumption of the EONS improved leg muscle strength and quality compared with the standard CONS.

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Metadata

Authors
Cramer, J. T., Cruz-Jentoft, A. J., Landi, F., Hickson, M., Zamboni, M., Pereira, S. L., Hustead, D. S., & Mustad, V. A.
Venue
Journal of the American Medical Directors Association
Publisher
Elsevier BV
Published
2016-11
Volume
17
Issue
11
Pages
1044-1055
ISSN
1525-8610 (ISSN-L)
DOI
10.1016/j.jamda.2016.08.009
OpenAlex
W2537831197
Cited by
163
References
18
FWCI
10.27
Type
journal article
Language
en
Open access
hybrid

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