Management of Sarcopenia: A Network Meta-Analysis of Randomized Controlled Trials
Abstract
Objective This study aimed to determine the comparative effectiveness of interventions in treatment of sarcopenia. The primary outcome was the measure of treatment effect on muscle mass, and secondary outcomes were the treatment effect on muscle strength and physical performance.Design Systematic review and network meta-analysis (NMA).Setting and participants Participants with sarcopenia receiving interventions targeting sarcopenia in any setting.Methods Data sources: Relevant RCTs were identified by a systematic search of several electronic databases, including CINAHL, Embase, MEDLINE, and the Cochrane Central Registry of Controlled Trials (CENTRAL) from January 1995 to July 2019. Duplicate title and abstract and full-text screening, data extraction, and risk of bias assessment were performed.Data extraction All RCTs examining sarcopenia interventions [mixed exercise (combined aerobic and resistance exercise), aerobic exercise, resistance exercise, balance exercise, physical activity and protein or nutrition supplementation, acupuncture, whole-body vibration, protein supplement or interventions to increase protein intake, any nutritional intervention other than protein, and pharmacotherapy] were included. Comparators were standard care, placebo, or another intervention.Data synthesis We performed Bayesian NMA; continuous outcome data were pooled using the standardized mean difference effect size. Interventions were ranked using the surface under the cumulative ranking curve (SUCRA) for each outcome.Results A total of 59 RCTs were included after screening of 4315 citations and 313 full-text articles. Network meta-analysis of muscle mass outcome (including 46 RCTs, 3649 participants, 11 interventions) suggested that mixed exercise were the most effective intervention (SUCRA = 93.94%) to increase muscle mass. Physical activity and protein or nutrition supplementation, and aerobic exercise were the most effective interventions to improve muscle strength and physical performance, respectively. Overall, mixed exercise is the most effective intervention in increasing muscle mass and was one of the 3 most effective interventions in increasing muscle strength and physical performance.Conclusions and implications Mixed exercise and physical activity with nutritional supplementation are the most effective sarcopenia interventions. Most of the included studies have a high risk of bias. More robust RCTs are needed to increase the confidence of our NMA results and the quality of evidence.
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Another review reported that aerobic exercise was most effective to improve muscle strength and physical performance.
“whereas another review reported that aerobic exercise was most effective to improve muscle strength and physical performance. 23”
From Exercise for sarcopenia in older people: A systematic review and network meta‐analysis (2023) · cites this paper as [23]
The two previously published network meta-analyses did not provide the overall quality of evidence.
“The two reviews and NMAs did not provide the overall quality of evidence. 23 , 25”
From Exercise for sarcopenia in older people: A systematic review and network meta‐analysis (2023) · cites this paper as [23]
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Prokopidis, K., Ispoglou, T., Thompson, T., Sánchez‐Rodríguez, D., Herghelegiu, A. M., Balcı, C., Alves, M., Pizzol, D., McLean, J., Soysal, P., et al. (2026) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.70276 · Cited by 1 · see citing works
Akut inmede nütrisyon: Sorunlar ve çözüm yolları
Güngör, L. (2022) · Turkish Journal of Cerebrovascular Diseases · doi:10.5505/tbdhd.2022.15013 · Cited by 1 · see citing works
Lapaeva, A., Tabakov, R., Tabakov, S., Miroshnikov, A. B., & Smolenskiy, A. V. (2023) · Voprosy Pitaniya · doi:10.33029/0042-8833-2023-92-2-87-96 · Cited by 1 · see citing works
ADVANCES IN SARCOPENIA TREATMENT FOR A HEALTHIER FUTURE
Eyigör, S., & Kutsal, Y. G. (2025) · The Turkish Journal of Geriatrics · doi:10.29400/tjgeri.2025.428 · Cited by 1 · see citing works
Translation of Research on Sarcopenia Into Clinical Practice
Cesari, M., Calvani, R., Canevelli, M., & Marzetti, E. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.03.006
- Authors
- Negm, A. M., Lee, J., Hamidian, R., Jones, C. A., & Khadaroo, R. G.
- Affiliations
- University of Alberta (CA)
- McMaster University (CA)
- Corresponding author
- Negm, Ahmed M.
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 23
- Issue
- 5
- Pages
- 707-714
- ISSN
- 1525-8610 (ISSN-L)
- OpenAlex
- W4213260343
- Cited by
- 137
- References
- 95
- Citations by year
- 2026: 26 · 2025: 37 · 2024: 39 · 2023: 25 · 2022: 10
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Medical Directors Association (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Alberta Innovates
- Alaska Historical Society
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- sarcopenia, muscle mass, muscle strength, physical performance, exercise intervention, resistance training, aerobic exercise, protein supplementation, dietary supplementation, physical activity, whole-body vibration, acupuncture, pharmacotherapy, comparative effectiveness
- MeSH terms
- Network Meta-Analysis as Topic, Network Meta-Analysis, Bayes Theorem, Humans, Randomized Controlled Trials as Topic, Muscle Strength, Sarcopenia
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