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Cited by 27Nutrition, Genetics, and DiseasePharmacogenetics and Drug MetabolismDietetics, Nutrition, and Education

Effect of Incorporating Genetic Testing Results into Nutrition Counseling and Care on Health Outcomes: An Evidence Analysis Center Systematic Review—Part II

Ellis, Amy, Rozga, Mary, Braakhuis, Andrea, Monnard, Cathriona R., Robinson, Katie, Sinley, Rachel, Wanner, Amanda, Vargas, Ashley J.·2021·Journal of the Academy of Nutrition and Dietetics
DOI 10.1016/j.jand.2020.02.009
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Abstract

In recent years, literature examining implementation of nutritional genomics into clinical practice has increased, including publication of several randomized controlled trials (RCTs). This systematic review addressed the following question: In children and adults, what is the effect of incorporating results of genetic testing into nutrition counseling and care compared with an alternative intervention or control group, on nutrition-related health outcomes? A literature search of MEDLINE, Embase, PsycINFO, CINAHL, and other databases was conducted for peer-reviewed RCTs published from January 2008 until December 2018. An international workgroup consisting of registered dietitian nutritionists, systematic review methodologists, and evidence analysts screened and reviewed articles, summarized data, conducted meta-analyses, and graded conclusion statements. The second in a two-part series, this article specifically summarizes evidence from RCTs that examined health outcomes (ie, quality of life, disease incidence and prevention of disease progression, or mortality), intermediate health outcomes (ie, anthropometric measures, body composition, or relevant laboratory measures routinely collected in practice), and adverse events as reported by study authors. Analysis of 11 articles from nine RCTs resulted in 16 graded conclusion statements. Among participants with nonalcoholic fatty liver disease, a diet tailored to genotype resulted in a greater reduction of percent body fat compar…

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  • Overall evidence on the effectiveness of integrating genotyping into nutritional counseling remains limited and of variable quality.

    “However, overall evidence on the effectiveness of integrating genotyping into nutritional counseling remains limited and of variable quality [141].”

    From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [141]

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Authors
Ellis, A., Rozga, M., Braakhuis, A., Monnard, C. R., Robinson, K., Sinley, R., Wanner, A., & Vargas, A. J.
Affiliations
  • University of Alabama (US)
  • Academy of Nutrition and Dietetics (US)
  • University of Auckland (NZ)
  • University of Fribourg (CH)
  • University of Iowa (US)
  • Metropolitan State University of Denver (US)
  • National Institutes of Health (US)
Corresponding author
Rozga, Mary
ORCID
Venue
Journal of the Academy of Nutrition and Dietetics
Publisher
Elsevier BV
Published
2021-03
Volume
121
Issue
3
Pages
582-605.e17
ISSN
2212-2672 (ISSN-L)
DOI
10.1016/j.jand.2020.02.009
OpenAlex
W3036386313
Cited by
27
References
11
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 4 · 2021: 4 · 2020: 3
FWCI
0.68
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of the Academy of Nutrition and Dietetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Academy of Nutrition and Dietetics
  • Academy of Nutrition and Dietetics Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Health Sciences › Health Professions › Health Information Management › Dietetics, Nutrition, and Education
Keywords
nutrigenomics, genetic testing, nutrition counseling, personalized nutrition, non-alcoholic fatty liver disease, fat loss, Nutrition Care Process, quality of life, disease prevention, adverse events, body composition, cholesterol, body mass index
MeSH terms
Adult, Child, Counseling, Diet, Dietetics, Female, Genetic Testing, Genotype, Humans, Male, Nutritional Physiological Phenomena, Randomized Controlled Trials as Topic, Treatment Outcome, Evidence-Based Medicine, Nutrition Therapy, Nutrigenomics

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