Disclosure of genetic information and change in dietary intake: a randomized controlled trial
Open accessAbstract
BACKGROUND: Proponents of consumer genetic tests claim that the information can positively impact health behaviors and aid in chronic disease prevention. However, the effects of disclosing genetic information on dietary intake behavior are not clear. METHODS: A double-blinded, parallel group, 2:1 online randomized controlled trial was conducted to determine the short- and long-term effects of disclosing nutrition-related genetic information for personalized nutrition on dietary intakes of caffeine, vitamin C, added sugars, and sodium. Participants were healthy men and women aged 20-35 years (n = 138). The intervention group (n = 92) received personalized DNA-based dietary advice for 12-months and the control group (n = 46) received general dietary recommendations with no genetic information for 12-months. Food frequency questionnaires were collected at baseline and 3- and 12-months after the intervention to assess dietary intakes. General linear models were used to compare changes in intakes between those receiving general dietary advice and those receiving DNA-based dietary advice. RESULTS: Compared to the control group, no significant changes to dietary intakes of the nutrients were observed at 3-months. At 12-months, participants in the intervention group who possessed a risk version of the ACE gene, and were advised to limit their sodium intake, significantly reduced their sodium intake (mg/day) compared to the control group (-287.3 ± 114.1 vs. 129.8 ± 118.2, p = 0.008). Those who had the non-risk version of ACE did not significantly change their sodium intake compared to the control group (12-months: -244.2 ± 150.2, p = 0.11). Among those with the risk version of the ACE gene, the proportion who met the targeted recommendation of 1500 mg/day increased from 19% at baseline to 34% after 12 months (p = 0.06). CONCLUSIONS: These findings demonstrate that disclosing genetic information for personalized nutrition results in greater changes in intake for some dietary components compared to general population-based dietary advice. TRIAL REGISTRATION: ClinicalTrials.gov NCT01353014.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Some studies identify genetic variants related to lipid, caffeine, and sodium metabolism.
“Some studies identify variants related to lipid, caffeine, and sodium metabolism [145,146].”
From The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review (2026) · cites this paper as [145]
Materials and Methods (Dietary Reports and Recommendations; page unavailable) identifies variants affecting caffeine metabolism (CYP1A2) and sodium sensitivity (ACE). The paper does not identify a variant related to lipid metabolism, so it supports only two of the three components attributed to it. (LLM, conf=0.88)
Experimental — accuracy not yet measuredEarlier PN interventions improved sodium intake in people at higher genotypic risk.
“Previous PN interventions have achieved improvements in sodium intake in individuals at higher genotypic-based risk (20), however, the Food4Me PoP study was the first to examine the effect of including genotype-based PN on overall patterns of healthy eating.”
From Effect of an Internet-based, personalized nutrition randomized trial on dietary changes associated with the Mediterranean diet: the Food4Me Study (2016) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Genetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
Projected effect of dietary salt reductions on future cardiovascular disease
Bibbins-Domingo, K., Chertow, G. M., Coxson, P. G., Moran, A., Lightwood, J. M., Pletcher, M. J., & Goldman, L. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0907355 · Cited by 1,253 · see citing works
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199 · see citing works
Charting a course for genomic medicine from base pairs to bedside
Green, E. D., & Guyer, M. S. (2011) · Nature · doi:10.1038/nature09764 · Cited by 901 · see citing works
Medeiros, D. M. (2007) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.924 · Cited by 763 · see citing works
Nishida, C., Uauy, R., Kumanyika, S., & Shetty, P. (2004) · Public Health Nutrition · doi:10.1079/phn2003592 · Cited by 744 · see citing works
Effect of Direct-to-Consumer Genomewide Profiling to Assess Disease Risk
Bloss, C. S., Schork, N. J., & Topol, E. J. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011893 · Cited by 565 · see citing works
Coffee, CYP1A2 genotype, and risk of myocardial infarction
Cornelis, M. C., El-Sohemy, A., Kabagambe, E. K., & Campos, H. (2006) · JAMA · doi:10.1001/jama.295.10.1135 · Cited by 490 · see citing works
Sodium Intake in Populations: Assessment of Evidence
Strom, B. L., Yaktine, A. L., Oria, M. P., & Nutrition Board (2013) · Cited by 274 · see citing works
Effects of communicating DNA-based disease risk estimates on risk-reducing behaviours
Marteau, T. M., French, D., Griffin, S. J., Prevost, A. T., Sutton, S. R., Watkinson, C., Attwood, S., & Hollands, G. J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007275.pub2 · Cited by 269 · see citing works
Health Behavior Changes After Genetic Risk Assessment for Alzheimer Disease: The REVEAL Study
Chao, S. H.-L., Roberts, J. S., Marteau, T. M., Silliman, R. A., Cupples, L. A., & Green, R. C. (2008) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31815a9dcc · Cited by 243 · see citing works
McBride, C. M., Koehly, L. M., Sanderson, S. C., & Kaphingst, K. A. (2010) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.012809.103532 · Cited by 243 · see citing works
CYP1A2 genotype modifies the association between coffee intake and the risk of hypertension
Palatini, P., Ceolotto, G., Ragazzo, F., Dorigatti, F., Saladini, F., Papparella, I., Mos, L., Zanata, G., & Santonastaso, M. (2009) · Journal of Hypertension · doi:10.1097/hjh.0b013e32832ba850 · Cited by 230 · see citing works
Cornelis, M. C., Monda, K. L., Yu, K., Paynter, N., Azzato, E. M., Bennett, S. N., Berndt, S. I., Boerwinkle, E., Chanock, S., Chatterjee, N., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002033 · Cited by 228 · see citing works
Hamza, T. H., Chen, H., Hill-Burns, E. M., Rhodes, S. L., Montimurro, J., Kay, D. M., Tenesa, A., Kusel, V. I., Sheehan, P., Eaaswarkhanth, M., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002237 · Cited by 218 · see citing works
Molecular Basis of Salt Sensitivity in Human Hypertension
Poch, E., González, D., Galvañ, V. G., Bragulat, E., Coca, A., & de la Sierra, A. (2001) · Hypertension · doi:10.1161/hy1101.099479 · Cited by 202 · see citing works
Kaufman, D., Bollinger, J. M., Dvoskin, R. L., & Scott, J. A. (2012) · Journal of Genetic Counseling · doi:10.1007/s10897-012-9483-0 · Cited by 180 · see citing works
Gollust, S. E., Gordon, E. S., Zayac, C., Griffin, G., Christman, M. F., Pyeritz, R. E., Wawak, L., & Bernhardt, B. A. (2011) · Public Health Genomics · doi:10.1159/000327296 · Cited by 174 · see citing works
Improved weight management using genetic information to personalize a calorie controlled diet
Arkadianos, I., Valdes, A. M., Marinos, E., Florou, A., Gill, R. D., & Grimaldi, K. A. (2007) · Nutrition Journal · doi:10.1186/1475-2891-6-29 · Cited by 167 · see citing works
Eny, K. M., Wolever, T. M. S., Corey, P., & El‐Sohemy, A. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29836 · Cited by 166 · see citing works
Self-citationDirect-to-consumer genetic testing
Horton, R., Crawford, G., Freeman, L., Fenwick, A., Wright, C. F., & Lucassen, A. (2019) · BMJ · doi:10.1136/bmj.l5688 · Cited by 151 · see citing works
Personalized Genetic Risk Counseling to Motivate Diabetes Prevention
Grant, R. W., OʼBrien, K., Waxler, J. L., Vassy, J. L., Delahanty, L. M., Bissett, L., Green, R. C., Stember, K. G., Guiducci, C., Park, E. R., et al. (2012) · Diabetes Care · doi:10.2337/dc12-0884 · Cited by 142 · see citing works
Nutrigenomics research for personalized nutrition and medicine
Kaput, J. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.02.005 · Cited by 136 · see citing works
The General Public’s Understanding and Perception of Direct-to-Consumer Genetic Test Results
Leighton, J. W., Valverde, K. D., & Bernhardt, B. A. (2011) · Public Health Genomics · doi:10.1159/000327159 · Cited by 135 · see citing works
Renin-Angiotensin System Genetic Polymorphisms and Salt Sensitivity in Essential Hypertension
Galvañ, V. G., Poch, E., Bragulat, E., Oriola, J., González, D., Coca, A., & de la Sierra, A. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.512 · Cited by 133 · see citing works
Direct-to-Consumer Genetic Testing: Perceptions, Problems, and Policy Responses
Caulfield, T., & McGuire, A. L. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-062110-123753 · Cited by 126 · see citing works
Stewart-Knox, B. J., Bunting, B. P., Gilpin, S., Parr, H. J., Pinhão, S., Strain, J., de Almeida, M. D. V., & Gibney, M. J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508055657 · Cited by 117 · see citing works
A Survey of UK Public Interest in Internet-Based Personal Genome Testing
Cherkas, L. F., Harris, J. M., Levinson, E., Spector, T. D., & Prainsack, B. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013473 · Cited by 109 · see citing works
A randomized trial of genetic information for personalized nutrition
Nielsen, D. E., & El‐Sohemy, A. (2012) · Genes & Nutrition · doi:10.1007/s12263-012-0290-x · Cited by 96 · see citing works
Self-citationHe, J., Kelly, T. N., Zhao, Q., Li, H., Huang, J., Wang, L., Jaquish, C. E., Sung, Y. J., Shimmin, L. C., Lu, F., et al. (2013) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000307 · Cited by 79 · see citing works
Cahill, L. E., Fontaine‐Bisson, B., & El‐Sohemy, A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28327 · Cited by 72 · see citing works
Self-citationMcGuire, S. (2014) · Advances in Nutrition · doi:10.3945/an.113.005033 · Cited by 71 · see citing works
Health Behavior Change: Can Genomics Improve Behavioral Adherence?
McBride, C. M., Bryan, A. D., Bray, M. S., Swan, G. E., & Green, E. D. (2012) · American Journal of Public Health · doi:10.2105/ajph.2011.300513 · Cited by 56 · see citing works
Genomic Information as a Behavioral Health Intervention: Can it Work?
Bloss, C. S., Madlensky, L., Schork, N. J., & Topol, E. J. (2011) · Personalized Medicine · doi:10.2217/pme.11.73 · Cited by 49 · see citing works
Kolor, K., Duquette, D. A., Zlot, A. I., Foland, J., Anderson, B., Giles, R. T., Wrathall, J., & Khoury, M. J. (2012) · Genetics in Medicine · doi:10.1038/gim.2012.67 · Cited by 48 · see citing works
Goddard, K. A. B., Duquette, D. A., Zlot, A. I., Johnson, J., Annis, A., Lee, P. W. K., Bland, M. P., Edwards, K. L., Oehlke, K. P., Giles, R. T., et al. (2008) · American Journal of Public Health · doi:10.2105/ajph.2007.131631 · Cited by 43 · see citing works
Eny, K. M., Corey, P., & El‐Sohemy, A. (2009) · Lifestyle Genomics · doi:10.1159/000276991 · Cited by 34 · see citing works
Self-citationDesroches, S., Lapointe, A., Ratté, S., Gravel, K., Légaré, F., & Thirsk, J. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-111 · Cited by 26 · see citing works
Applying Genomics to Nutrition and Lifestyle Modification
Nielsen, D. E., & El‐Sohemy, A. (2012) · Personalized Medicine · doi:10.2217/pme.12.79 · Cited by 16 · see citing works
Self-citationNature readers flirt with personal genomics
Maher, B. (2011) · Nature · doi:10.1038/478019a · Cited by 15 · see citing works
How Could Disclosing Incidental Information from Whole-Genome Sequencing Affect Patient Behavior?
Christensen, K. D., & Green, R. C. (2013) · Personalized Medicine · doi:10.2217/pme.13.24 · Cited by 14 · see citing works
Research in nutrigenomics and potential applications to practice
Ferguson, L. R., & Barnett, M. P. G. (2012) · Nutrition & Dietetics · doi:10.1111/j.1747-0080.2012.01623.x · Cited by 9 · see citing works
Predisposed to risk but not change
Collier, R. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.109-4157 · Cited by 3 · see citing works
Direct-to-consumer genetic testing
Wesselius, A., & Zeegers, M. (2013) · OA Epidemiology · doi:10.13172/2053-079x-1-1-582 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [26]National Research Council (2006) Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. The National Academies Press: Washington, DC.
Cited by
Sorted by citations
International Society of Sports Nutrition Position Stand: Caffeine and Exercise Performance
Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N. D. M., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., et al. (2021) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00383-4 · Cited by 665 · see citing works
Personalised nutrition and health
Ordovás, J. M., Ferguson, L. R., Tai, E. S., & Mathers, J. C. (2018) · BMJ · doi:10.1136/bmj.k2173 · Cited by 634 · see citing works
de Toro‐Martín, J., Arsenault, B. J., Després, J., & Vohl, M. (2017) · Nutrients · doi:10.3390/nu9080913 · Cited by 511 · see citing works
Hollands, G. J., French, D., Griffin, S. J., Prevost, A. T., Sutton, S. R., King, S., & Marteau, T. M. (2016) · BMJ · doi:10.1136/bmj.i1102 · Cited by 483 · see citing works
Celis-Morales, C., Livingstone, K. M., Marsaux, C. F. M., Macready, A. L., Fallaize, R., O’Donovan, C. B., Woolhead, C., Forster, H., Walsh, M. C., Navas-Carretero, S., et al. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyw186 · Cited by 399 · see citing works
Toward the Definition of Personalized Nutrition: A Proposal by The American Nutrition Association
Bush, C. L., Blumberg, J. B., El‐Sohemy, A., Minich, D. M., Ordovás, J. M., Reed, D. G., & Behm, V. A. Y. (2019) · Journal of the American College of Nutrition · doi:10.1080/07315724.2019.1685332 · Cited by 259 · see citing works
Self-citationSport Nutrigenomics: Personalized Nutrition for Athletic Performance
Guest, N. S., Horne, J. R., Vanderhout, S. M., & El‐Sohemy, A. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00008 · Cited by 184 · see citing works
Self-citationRamos-López, O., Milagro, F. I., Allayee, H., Chmurzyńska, A., Choi, M. S., Curi, R., Caterina, R. D., Ferguson, L. R., Goñi, L., Kang, J. X., et al. (2017) · Lifestyle Genomics · doi:10.1159/000477729 · Cited by 172 · see citing works
Jinnette, R., Narita, A., Manning, B., McNaughton, S. A., Mathers, J. C., & Livingstone, K. M. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa144 · Cited by 152 · see citing works
Chamoun, E., Mutch, D. M., Allen‐Vercoe, E., Buchholz, A. C., Duncan, A. M., Spriet, L. L., Haines, J., David, W. L., & Study, O. B. O. T. G. F. H. (2016) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2016.1152229 · Cited by 150 · see citing works
Paving the Way to Precision Nutrition Through Metabolomics
Tebani, A., & Bekri, S. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00041 · Cited by 143 · see citing works
Lagoumintzis, G., & Patrinos, G. P. (2023) · Human Genomics · doi:10.1186/s40246-023-00561-w · Cited by 132 · see citing works
Precision nutrition: A review of current approaches and future endeavors
Livingstone, K. M., Ramos-López, O., Përusse, L., Kato, H., Ordovás, J. M., & Martínez, J. A. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.08.017 · Cited by 136 · see citing works
Ferguson, J. F., Allayee, H., Gerszten, R. E., Ideraabdullah, F., Kris‐Etherton, P. M., Ordovás, J. M., Rimm, E. B., Wang, T. J., & Bennett, B. J. (2016) · Circulation Cardiovascular Genetics · doi:10.1161/hcg.0000000000000030 · Cited by 126 · see citing works
Kohlmeier, M., Caterina, R. D., Ferguson, L. R., Görman, U., Allayee, H., Prasad, C., Kang, J. X., Nicoletti, C. F., & Martínez, J. A. (2016) · Lifestyle Genomics · doi:10.1159/000446347 · Cited by 117 · see citing works
Livingstone, K. M., Celis-Morales, C., Navas-Carretero, S., San-Cristobal, R., Macready, A. L., Fallaize, R., Forster, H., Woolhead, C., O’Donovan, C. B., Marsaux, C. F., et al. (2016) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.129049 · Cited by 115 · see citing works
Can Genetic Testing Identify Talent for Sport?
Pickering, C., Kiely, J., Grgić, J., Lucía, A., & Coso, J. D. (2019) · Genes · doi:10.3390/genes10120972 · Cited by 112 · see citing works
Nutrigenomics in the modern era
Mathers, J. C. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s002966511600080x · Cited by 111 · see citing works
Horne, J. R., Madill, J., O’Connor, C. P., Shelley, J., & Gilliland, J. (2018) · Lifestyle Genomics · doi:10.1159/000488086 · Cited by 94 · see citing works
Palmnäs, M. S. A., Brunius, C. F., Shi, L. S., Rostgaard-Hansen, A., Estanyol-Torres, N., González‐Domínguez, R., Zamora‐Ros, R., Ye, Y. L., Halkjær, J., Tjønneland, A. M., et al. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz121 · Cited by 88 · see citing works
Choudhary, N. S., & Duseja, A. K. (2020) · Translational Gastroenterology and Hepatology · doi:10.21037/tgh.2019.09.06 · Cited by 80 · see citing works
Shyam, S., Lee, K. X., Tan, A. S. W., Khoo, T. A., Harikrishnan, S., Lalani, S. A., & Ramadas, A. (2022) · Nutrients · doi:10.3390/nu14194104 · Cited by 76 · see citing works
Blumberg, J. B., Bailey, R. L., Sesso, H. D., & Ulrich, C. M. (2018) · Nutrients · doi:10.3390/nu10020248 · Cited by 76 · see citing works
Li, S. X., Ye, Z., Whelan, K., & Truby, H. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002488 · Cited by 66 · see citing works
Horne, J., Gilliland, J., O'Connor, C., Seabrook, J., & Madill, J. (2020) · BMJ Nutrition, Prevention & Health · doi:10.1136/bmjnph-2020-000073 · Cited by 65 · see citing works
Fallaize, R., Celis-Morales, C. A., Macready, A. L., Marsaux, C. F. M., Forster, H., O’Donovan, C. B., Woolhead, C., San-Cristóbal, R., Kolossa, S., Hallmann, J., et al. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.135012 · Cited by 66 · see citing works
Livingstone, K. M., Celis-Morales, C. A., Navas‐Carretero, S., San-Cristóbal, R., Forster, H., Woolhead, C., O’Donovan, C. B., Moschonis, G., Μanios, Y., Traczyk, I., et al. (2021) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/s12966-021-01136-5 · Cited by 62 · see citing works
Marsaux, C. F. M., Celis-Morales, C. A., Livingstone, K. M., Fallaize, R., Kolossa, S., Hallmann, J., San-Cristóbal, R., Navas‐Carretero, S., O’Donovan, C. B., Woolhead, C., et al. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5198 · Cited by 59 · see citing works
Goals in Nutrition Science 2020-2025
Bassaganya-Riera, J., Berry, E. M., Blaak, E. E., Burlingame, B., le Coutre, J., van Eden, W., El‐Sohemy, A., German, J. B., Knorr, D., Lacroix, C., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2020.606378 · Cited by 65 · see citing works
Self-citationPaving the way to better population health through personalised nutrition
Mathers, J. C. (2019) · EFSA Journal · doi:10.2903/j.efsa.2019.e170713 · Cited by 52 · see citing works
A Scientific Perspective of Personalised Gene-Based Dietary Recommendations for Weight Management
Drabsch, T., & Holzapfel, C. (2019) · Nutrients · doi:10.3390/nu11030617 · Cited by 51 · see citing works
Precision Nutrition to Improve Risk Factors of Obesity and Type 2 Diabetes
Antwi, J. (2023) · Current Nutrition Reports · doi:10.1007/s13668-023-00491-y · Cited by 50 · see citing works
van den Brink, W. J., van den Broek, T. J., Palmisano, S., Wopereis, S., & de Hoogh, I. M. (2022) · Nutrients · doi:10.3390/nu14214465 · Cited by 49 · see citing works
de Hoogh, I. M., Winters, B., Nieman, K. M., Bijlsma, S., Krone, T., van den Broek, T. J., Anderson, B. D., Caspers, M. P. M., Anthony, J. C., & Wopereis, S. (2021) · Nutrients · doi:10.3390/nu13061763 · Cited by 40 · see citing works
The Evolution of Science and Regulation of Dietary Supplements: Past, Present, and Future
Coates, P. M., Bailey, R. L., Blumberg, J. B., El‐Sohemy, A., Floyd, Z. E., Goldenberg, J. Z., Shunney, A. G., Holscher, H. D., Nkrumah-Elie, Y. M., Rai, D., et al. (2024) · Journal of Nutrition · doi:10.1016/j.tjnut.2024.06.017 · Cited by 38 · see citing works
Self-citationLipidomics: An omics discipline with a key role in nutrition
de Castro, M. D. L., & Quiles-Zafra, R. (2020) · Talanta · doi:10.1016/j.talanta.2020.121197 · Cited by 37 · see citing works
Genetics and Epigenetics in Personalized Nutrition: Evidence, Expectations, and Experiences
Holzapfel, C., Waldenberger, M., Lorkowski, S., Daniel, H., & the Working Group “Personalized Nutrition” of the German Nutrition Society (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200077 · Cited by 37 · see citing works
Components, prospects and challenges of personalized prevention
Jaskulski, S., Nuszbaum, C., & Michels, K. B. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1075076 · Cited by 35 · see citing works
Roke, K., Walton, K., Klingel, S. L., Harnett, A., Subedi, S. D., Haines, J., & Mutch, D. M. (2017) · Nutrients · doi:10.3390/nu9030240 · Cited by 34 · see citing works
Knowing your genes: does this impact behaviour change?
O’Donovan, C. B., Walsh, M. C., Gibney, M. J., Brennan, L., & Gibney, E. R. (2017) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116002949 · Cited by 33 · see citing works
Diet and exercise changes following direct-to-consumer personal genomic testing
for the PGen Study Group, Nielsen, D. E., Carere, D. A., Wang, C., Roberts, J. S., & Green, R. C. (2017) · BMC Medical Genomics · doi:10.1186/s12920-017-0258-1 · Cited by 32 · see citing works
Self-citationCan metabotyping help deliver the promise of personalised nutrition?
O’Donovan, C. B., Walsh, M. C., Gibney, M. J., Gibney, E. R., & Brennan, L. (2015) · Proceedings of The Nutrition Society · doi:10.1017/s0029665115002347 · Cited by 31 · see citing works
Reprint of: Precision nutrition: A review of current approaches and future endeavors
Livingstone, K. M., Ramos-López, O., Përusse, L., Kato, H., Ordovás, J. M., & Martínez, J. A. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.10.010 · Cited by 30 · see citing works
Horne, J. R., Nielsen, D. E., Madill, J., Robitaille, J., Vohl, M.-C., & Mutch, D. M. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.02.008 · Cited by 29 · see citing works
Self-citationBraakhuis, A., Monnard, C. R., Ellis, A., & Rozga, M. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.04.002 · Cited by 29 · see citing works
Livingstone, K. M., Celis-Morales, C. A., Navas‐Carretero, S., San-Cristóbal, R., Forster, H., Woolhead, C., O’Donovan, C. B., Moschonis, G., Μanios, Y., Traczyk, I., et al. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000653 · Cited by 27 · see citing works
Kan, J., Ni, J., Xue, K., Wang, F., Zheng, J., Cheng, J., Wu, P., Runyon, M. K., Guo, H. Z., & Du, J. C. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.919882 · Cited by 27 · see citing works
Höchsmann, C., Yang, S., Ordovás, J. M., Dorling, J. L., Champagne, C. M., Apolzan, J. W., Greenway, F. L., Cardel, M. I., Foster, G. D., & Martin, C. K. (2023) · Nature Communications · doi:10.1038/s41467-023-41969-1 · Cited by 26 · see citing works
Abrahams, M., Frewer, L. J., Bryant, E. J., & Stewart-Knox, B. J. (2016) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2016.11.005 · Cited by 26 · see citing works
Leveraging Genomic Associations in Precision Digital Care for Weight Loss: Cohort Study
Sinha, R., Kachru, D., Ricchetti, R. R., Singh-Rambiritch, S., Muthukumar, K., Singaravel, V., Irudayanathan, C., Reddy-Sinha, C., Junaid, I., Sharma, G., et al. (2021) · Journal of Medical Internet Research · doi:10.2196/25401 · Cited by 29 · see citing works
Horne, J. R., Madill, J., & Gilliland, J. (2017) · Personalized Medicine · doi:10.2217/pme-2017-0038 · Cited by 23 · see citing works
Livingstone, K. M., Celis-Morales, C. A., Macready, A. L., Fallaize, R., Forster, H., Woolhead, C., O’Donovan, C. B., Marsaux, C. F. M., Navas‐Carretero, S., San-Cristóbal, R., et al. (2016) · Public Health Nutrition · doi:10.1017/s1368980016002020 · Cited by 21 · see citing works
Hillesheim, E., Yin, X., Sundaramoorthy, G. P., & Brennan, L. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202200620 · Cited by 20 · see citing works
Fallaize, R., Franco, R. Z., Hwang, F., & Lovegrove, J. A. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214931 · Cited by 20 · see citing works
Calderón-Pérez, L., Escoté, X., Companys, J., Alcaide‐Hidalgo, J. M., Bosch, M., Rabassa, M., Crescenti, A., Valls, R. M., Pedret, A., Solà, R., et al. (2024) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2024.04.004 · Cited by 19 · see citing works
Nutrigenetics, Nutrigenomics and Precision Nutrition
Meiliana, A., & Wijaya, A. (2020) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v12i3.1158 · Cited by 18 · see citing works
Ellis, A., Rozga, M., Braakhuis, A., Monnard, C. R., Robinson, K., Sinley, R., Wanner, A., & Vargas, A. J. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.02.009 · Cited by 27 · see citing works
Robinson, K., Rozga, M., Braakhuis, A., Ellis, A., Monnard, C. R., Sinley, R., Wanner, A., & Vargas, A. J. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.04.001 · Cited by 20 · see citing works
Vrânceanu, M., Pickering, C., Filip, L. A., Pralea, I.-E., Sundaram, S. K., AlSaleh, A. F. F., Popa, D., & Grimaldi, K. A. (2020) · BMC Nutrition · doi:10.1186/s40795-020-00370-7 · Cited by 16 · see citing works
O’Donovan, C. B., Walsh, M. C., Forster, H., Woolhead, C., Celis-Morales, C. A., Fallaize, R., Macready, A. L., Marsaux, C. F. M., Navas‐Carretero, S., San-Cristóbal, R., et al. (2016) · Genes & Nutrition · doi:10.1186/s12263-016-0539-x · Cited by 15 · see citing works
Recent advances and current controversies in genetic testing for personalized nutrition
García‐Bailo, B., & El‐Sohemy, A. (2021) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000763 · Cited by 16 · see citing works
Self-citationMetabotyping: a tool for identifying subgroups for tailored nutrition advice
Hillesheim, E., & Brennan, L. (2023) · Proceedings of The Nutrition Society · doi:10.1017/s0029665123000058 · Cited by 15 · see citing works
Hachiya, T., Narita, A., Ohmomo, H., Sutoh, Y., Komaki, S., Tanno, K., Satoh, M., Sakata, K., Hitomi, J., Nakamura, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-32074-1 · Cited by 15 · see citing works
Ethical Considerations in the Implementation of Nutrigenetics/Nutrigenomics
Hurlimann, T., Robitaille, J., Vohl, M., & Godard, B. (2016) · Personalized Medicine · doi:10.2217/pme-2016-0035 · Cited by 14 · see citing works
Nutritional Genomics in Precision Nutrition: An Evidence Analysis Center Scoping Review
Rozga, M., & Handu, D. (2018) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2018.05.022 · Cited by 14 · see citing works
Horne, J. R., Gilliland, J., Vohl, M., & Madill, J. (2020) · Nutrients · doi:10.3390/nu12123768 · Cited by 13 · see citing works
Teimouri-Korani, H., Hemmatinafar, M., Willems, M. E. T., Rezaei, R., & Imanian, B. (2025) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2025.2495228 · Cited by 11 · see citing works
Almeida, V. A., Littlejohn, P. T., Cop, I., Brown, E., Afroze, R., & Davison, K. (2019) · Journal of Medical Internet Research · doi:10.2196/12580 · Cited by 11 · see citing works
Allen, C. G., Peterson, S. R., Khoury, M. J., Brody, L. C., & McBride, C. M. (2020) · Translational Behavioral Medicine · doi:10.1093/tbm/ibaa076 · Cited by 11 · see citing works
Han, H. Y., Paquet, C., Dubé, L., & Nielsen, D. E. (2020) · Nutrients · doi:10.3390/nu12113349 · Cited by 11 · see citing works
Self-citationLivingstone, K. M., Celis-Morales, C. A., Lara, J., Woolhead, C., O’Donovan, C. B., Forster, H., Marsaux, C. F. M., Macready, A. L., Fallaize, R., Navas‐Carretero, S., et al. (2016) · Public Health Nutrition · doi:10.1017/s1368980016001932 · Cited by 12 · see citing works
O’Hara, C., O’Sullivan, A. M., & Gibney, E. R. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac151 · Cited by 11 · see citing works
Nutrigenomic Information in the openEHR Data Set
Maranhao, P. A., Bacelar-Silva, G. M., Ferreira, D., Calhau, C., Vieira‐Marques, P., & Cruz-Correia, R. J. (2018) · Applied Clinical Informatics · doi:10.1055/s-0038-1635115 · Cited by 10 · see citing works
King, A., Graham, C., Glaister, M., Anastacio, V. D. S., Pilić, L., & Mavrommatis, Y. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad001 · Cited by 10 · see citing works
Hietaranta-Luoma, H.-L., Tringham, M., Karjalainen, H., Tanner, L. M., Vähäkangas, K., Pietilä, A., Åkerman, K. K., Puolijoki, H., Tahvonen, R., & Hopia, A. (2018) · Lifestyle Genomics · doi:10.1159/000500199 · Cited by 8 · see citing works
Genetic test for the prescription of diets in support of physical activity.
Naureen, Z., Miggiano, G. A. D., Aquilanti, B., Velluti, V., Matera, G., Gagliardi, L., Zulian, A., Romanelli, R., & Bertelli, M. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i13-s.10584 · Cited by 11 · see citing works
Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition
Lee, G. Y., & Han, S. N. (2021) · Clinical Nutrition Research · doi:10.7762/cnr.2021.10.4.279 · Cited by 8 · see citing works
Exploring genetic modifiers influencing adult eating behaviour: A scoping review
Brown, J. E., Morton, L. C., & Braakhuis, A. J. (2025) · Appetite · doi:10.1016/j.appet.2025.108193 · Cited by 7 · see citing works
Nacis, J. S., Labrador, J. P. H., Ronquillo, D. G. D., Rodriguez, M. P., Dablo, A. M. F. D., Frane, R. D., Madrid, M. L., Santos, N. L. C., Carrillo, J. J. V., Fernandez, M. G., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1238234 · Cited by 7 · see citing works
David, D., Gherman, A., Podina, I. R., Mogoaşe, C., Sucala, M. L., & Voinescu, B. (2016) · Journal of Rational-Emotive & Cognitive-Behavior Therapy · doi:10.1007/s10942-016-0245-z · Cited by 7 · see citing works
Roke, K. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0700 · Cited by 7 · see citing works
Burnell, M., Gaba, F., Sobočan, M., Desai, R., Sanderson, S. C., Loggenberg, K., Gessler, S., Side, L. E., Brady, A. F., Dorkins, H. R., et al. (2022) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.17253 · Cited by 6 · see citing works
The Seven Methods for the Evaluation of Nutritional Status—ABCDEFG: Narrative Review
Zambrano-Villacres, R., Arteaga-Pazmiño, C., Guevara Castillo, W. D., Herrera-Fontana, M. E., Domínguez Brito, L. D., Becerra Granados, L. M., Recoba-Obregón, P. E., Rodríguez-Veintimilla, D., Bressi, V., Andrade-Molina, D., et al. (2026) · Applied Sciences · doi:10.3390/app16020845 · Cited by 5 · see citing works
Characterizing Precision Nutrition Discourse on Twitter: Quantitative Content Analysis
Batheja, S., Schopp, E. M., Pappas, S., Ravuri, S. C., & Persky, S. (2023) · Journal of Medical Internet Research · doi:10.2196/43701 · Cited by 5 · see citing works
Littlejohn, P. T., Cop, I., Brown, E., Afroze, R., & Davison, K. (2018) · JMIR Research Protocols · doi:10.2196/resprot.9846 · Cited by 5 · see citing works
Miyamoto, K., Iwakuma, M., & Nakayama, T. (2016) · Journal of Clinical Hypertension · doi:10.1111/jch.12897 · Cited by 5 · see citing works
Sodium Reduction Program Incorporating Genetic Profile and an AI-Based App
Sato, K., Inoue, K., Yamaguchi, T., Yagi, M., Ebisawa, M., Mizuno, S., Yanagisawa, T., Akiyama, N., Node, K., Kondo, N., et al. (2025) · JAMA Network Open · doi:10.1001/jamanetworkopen.2025.37540 · Cited by 4 · see citing works
King, A., Saifi, S., Smith, J., Pilić, L., Graham, C., Anastacio, V. D. S., Glaister, M., & Mavrommatis, Y. (2021) · Nutrition and Health · doi:10.1177/02601060211032882 · Cited by 4 · see citing works
Lee, G. Y., Chung, K., Lee, J., Kim, J.-H., & Han, S. N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0291052 · Cited by 4 · see citing works
Kapellou, A., Silva, G. V., Pilić, L., & Mavrommatis, Y. (2021) · Nutrition and Health · doi:10.1177/02601060211026834 · Cited by 4 · see citing works
Assessing the Impact of Developments in Genetic Testing on Insurers' Risk Exposure
Rodriguez-Rincon, D., Parkinson, S., Hocking, L., Evans, H., Hudson, E., & Morley, K. I. (2022) · Rand health quarterly · doi:10.7249/rhq-09-04-05 · Cited by 4 · see citing works
Healthcare Professional Clinical Actions following Nutrigenomics Testing in Practice
Karamanoglu, I., & Nielsen, D. E. (2020) · Public Health Genomics · doi:10.1159/000511785 · Cited by 4 · see citing works
Self-citationOkayama, M., Takeshima, T., Harada, M., Ae, R., & Kajii, E. (2016) · International Journal of General Medicine · doi:10.2147/ijgm.s111337 · Cited by 4 · see citing works
Genetic determinants of beverage consumption: Implications for nutrition and health
Cornelis, M. C. (2019) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2019.03.001 · Cited by 4 · see citing works
Weitzman, E. R., Blakemore, L. M., Pierce, S. E., Kossowsky, J., & Levy, S. (2024) · AJPM Focus · doi:10.1016/j.focus.2023.100153 · Cited by 3 · see citing works
Key evidence for personalised nutrition: a review of randomised controlled trials
Martinsen, T., & Brennan, L. (2025) · Food & Function · doi:10.1039/d5fo02969d · Cited by 3 · see citing works
King, A., Glaister, M., Lawrence, K., Pilić, L., & Mavrommatis, Y. (2024) · Journal of Nutritional Science · doi:10.1017/jns.2024.50 · Cited by 3 · see citing works
Lee, G. Y., Lee, J., Kim, J., Chung, K., & Han, S. N. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03713-x · Cited by 3 · see citing works
Nacis, J. S., Labrador, J. P. H., Ronquillo, D. G. D., Rementilla, J. C., Rodriguez, M. P., Madrid, M. L., Frane, R. D., Santos, N. L., Dablo, A. M. F. D., Carrillo, J. J. V., et al. (2026) · Genes & Nutrition · doi:10.1186/s12263-026-00794-z · Cited by 2 · see citing works
Nakashita, C., Fujiwara, Y., Lu, X., Hisada, A., Miyazaki, W., & Katoh, T. (2016) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.71.133 · Cited by 2 · see citing works
- Authors
- Nielsen, D. E., & El-Sohemy, A.
- Affiliations
- University of Toronto (CA)
- ORCID
- Nielsen, Daiva E.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-11-14
- Volume
- 9
- Issue
- 11
- Pages
- e112665
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4232422
- OpenAlex
- W1989879035
- Cited by
- 157
- References
- 44
- Citations by year
- 2026: 12 · 2025: 11 · 2024: 9 · 2023: 11 · 2022: 11 · 2021: 23 · 2020: 19 · 2019: 16 · 2018: 11 · 2017: 11 · 2016: 20 · 2015: 3
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Advanced Foods and Materials Network
- Canadian Institutes of Health Research (89829_1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
- Keywords
- genetic information disclosure, consumer genetic testing, personalized nutrition, ACE gene, sodium intake, caffeine consumption, vitamin C intake, added sugars, chronic disease prevention
- MeSH terms
- Adult, Diet, Female, Genetic Testing, Humans, Male, Linear Models, Disclosure, Nutrigenomics, Precision Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review