The insular cortex and cardiovascular system: a new insight into the brain-heart axis

Circuitry and functional aspects of the insular lobe in primates including humans

AUGUSTINE, J. (1996) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00011-2 · Cited by 1,776 · see citing works

The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective

BENARROCH, E. E. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62272-1 · Cited by 1,534 · see citing works

Cardiovascular effects of human insular cortex stimulation

Oppenheimer, S. M., Gelb, A., Girvin, J. P., & Hachinski, V. C. (1992) · Neurology · doi:10.1212/wnl.42.9.1727 · Cited by 1,272 · see citing works

[Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases].

Dote, K., Sato, H., Tateishi, H., Uchida, T., & Ishihara, M. (1991) · PubMed · Cited by 1,229 · see citing works

Neural correlates of heart rate variability during emotion

Lane, R. D., Kateri Mcrae, A., Reiman, E. M., Chen, K., Ahern, G. L., & Thayer, J. F. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.07.056 · Cited by 687 · see citing works

Effects of Stroke Localization on Cardiac Autonomic Balance and Sudden Death

Tokgözoglu, S. L., Batur, M. K., Topçuoğlu, M. A., Sarıbaş, O., Kes, S., & Oto, A. (1999) · Stroke · doi:10.1161/01.str.30.7.1307 · Cited by 392 · see citing works

Brain correlates of autonomic modulation: Combining heart rate variability with fMRI

Napadow, V., Dhond, R. P., Conti, G., Makris, N., Brown, E. N., & Barbieri, R. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.04.238 · Cited by 347 · see citing works

Activity in the human brain predicting differential heart rate responses to emotional facial expressions

Critchley, H. D., Rotshtein, P., Nagai, Y., O'Doherty, J., Mathias, C. J., & Dolan, R. J. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.10.013 · Cited by 340 · see citing works

Cardiac Autonomic Derangement and Arrhythmias in Right-Sided Stroke With Insular Involvement

Colivicchi, F., Bassi, A., Santini, M., & Caltagirone, C. (2004) · Stroke · doi:10.1161/01.str.0000138452.81003.4c · Cited by 335 · see citing works

New insights into central cardiovascular control during exercise in humans: a central command update

WILLIAMSON, J. W., Fadel, P. J., & Mitchell, J. H. (2005) · Experimental Physiology · doi:10.1113/expphysiol.2005.032037 · Cited by 325 · see citing works

Insular cortex stimulation produces lethal cardiac arrhythmias: a mechanism of sudden death?

Oppenheimer, S. M., Wilson, J. X., Guiraudon, C., & Cechetto, D. F. (1991) · Brain Research · doi:10.1016/0006-8993(91)90412-o · Cited by 298 · see citing works

Lateralization in autononic dysfunction in ischemic stroke involving the insular cortex

Meyer, S., Strittmatter, M., Fischer, C., Georg, T., & Schmitz, B. (2004) · Neuroreport · doi:10.1097/00001756-200402090-00029 · Cited by 277 · see citing works

Neuroanatomic correlates of stroke-related myocardial injury

Ay, H., Koroshetz, W. J., Benner, T., Vangel, M. G., Melinosky, C., Arsava, E. M., Ayata, C., Zhu, M., Schwamm, L. H., & Sorensen, A. G. (2006) · Neurology · doi:10.1212/01.wnl.0000206077.13705.6d · Cited by 273 · see citing works

Cardiac chronotropic organization of the rat insular cortex

Oppenheimer, S. M., & Cechetto, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91796-j · Cited by 270 · see citing works

Unilateral cerebral inactivation produces differential left/right heart rate responses

ZAMRINI, E. Y., Meador, K. J., Loring, D. W., Nichols, F. T., Lee, G. P., Figueroa, R. E., & Thompson, W. O. (1990) · Neurology · doi:10.1212/wnl.40.9.1408 · Cited by 252 · see citing works

Takotsubo cardiomyopathy in acute ischemic stroke

Yoshimura, S., Toyoda, Ḱ., Ohara, T., Nagasawa, H., Ohtani, N., Kuwashiro, T., Naritomi, H., & Minematsu, K. (2008) · Annals of Neurology · doi:10.1002/ana.21459 · Cited by 242 · see citing works

Hemispheric influence on autonomic modulation and baroreflex sensitivity

Hilz, M. J., Dütsch, M., Perrine, K., Nelson, P. K., Rauhut, U., & Devinsky, O. (2001) · Annals of Neurology · doi:10.1002/ana.1006 · Cited by 234 · see citing works

Prognostic relevance of pathological sympathetic activation after acute thromboembolic stroke

Sander, D., Winbeck, K., Klingelhöfer, J., Etgen, T., & Conrad, B. (2001) · Neurology · doi:10.1212/wnl.57.5.833 · Cited by 234 · see citing works

The Insula and Cerebrogenic Sudden Death

Cheung, R. T. F., & Hachinski, V. (2000) · Archives of Neurology · doi:10.1001/archneur.57.12.1685 · Cited by 219 · see citing works

Left insular stroke is associated with adverse cardiac outcome

Laowattana, S., Zeger, S. L., Lima, J. A. C., Goodman, S. N., Wittstein, I. S., & Oppenheimer, S. M. (2006) · Neurology · doi:10.1212/01.wnl.0000202684.29640.60 · Cited by 211 · see citing works

Cerebral Hemispheric Lateralization in Cardiac Autonomic Control

Yoon, B.-W., Morillo, C. A., Cechetto, D. F., & Hachinski, V. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550180055012 · Cited by 188 · see citing works

Prognostic Implications of Right-Sided Insular Damage, Cardiac Autonomic Derangement, and Arrhythmias After Acute Ischemic Stroke

Colivicchi, F., Bassi, A., Santini, M., & Caltagirone, C. (2005) · Stroke · doi:10.1161/01.str.0000173400.19346.bd · Cited by 182 · see citing works

Insular lesions, ECG abnormalities, and outcome in acute stroke

Christensen, H. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.037531 · Cited by 181 · see citing works

Insular involvement in brain infarction increases risk for cardiac arrhythmia and death

Abboud, H., Berroir, S., Labreuche, J., Orjuela, K. D., & Amarenco, P. (2006) · Annals of Neurology · doi:10.1002/ana.20806 · Cited by 158 · see citing works

Atrial fibrillation after acute stroke.

Vingerhoets, F., Bogousslavsky, J., Regli, F., & van Melle, G. (1993) · Stroke · doi:10.1161/01.str.24.1.26 · Cited by 140 · see citing works

Changes of circadian blood pressure patterns after hemodynamic and thromboembolic brain infarction.

Sander, D., & Klingelhöfer, J. (1994) · Stroke · doi:10.1161/01.str.25.9.1730 · Cited by 136 · see citing works

Insular Cortical Ischemia Is Independently Associated With Acute Stress Hyperglycemia

Allport, L., Butcher, K., Baird, T. A., MacGregor, L., Desmond, P. M., Tress, B. M., Colman, P. G., & Davis, S. M. (2004) · Stroke · doi:10.1161/01.str.0000133687.33868.71 · Cited by 116 · see citing works

Insular cortex lesions alter baroreceptor sensitivity in the urethane-anesthetized rat

Zhang, Z.-H., Rashba, S., & Oppenheimer, S. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00996-2 · Cited by 115 · see citing works

Heightened Functional Neural Activation to Psychological Stress Covaries With Exaggerated Blood Pressure Reactivity

Gianaros, P. J., Jennings, J. R., Sheu, L. K., Derbyshire, S. W. G., & Matthews, K. A. (2006) · Hypertension · doi:10.1161/01.hyp.0000250984.14992.64 · Cited by 102 · see citing works

Elevated plasma N-terminal pro–brain natriuretic peptide levels in acute ischemic stroke

İltümür, K., Karabulut, A., Apak, İ., et al. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.05.022 · Cited by 99 · see citing works

Impaired Baroreceptor Reflex Sensitivity in Acute Stroke Is Associated With Insular Involvement, But Not With Carotid Atherosclerosis

Sykora, M., Diedler, J., Rupp, A., Turčáni, P., & Steiner, T. (2009) · Stroke · doi:10.1161/strokeaha.108.519967 · Cited by 91 · see citing works

Cardiac Dysfunction After Left Permanent Cerebral Focal Ischemia

Min, J., Farooq, M. U., Greenberg, E. J., Aloka, F., Bhatt, A., Kassab, M. Y., Morgan, J. P., & Majid, A. (2009) · Stroke · doi:10.1161/strokeaha.108.536086 · Cited by 90 · see citing works

Changes of circadian blood pressure patterns after hemodynamic and thromboembolic brain infarction.

DSander, & JKlingelhöfer (1994) · Stroke · Cited by 86 · see citing works

Characterization of baroreceptor-related neurons in the monkey insular cortex

Zhang, Z.-H., Dougherty, P. M., & Oppenheimer, S. M. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00268-6 · Cited by 83 · see citing works

Central Periodic Breathing During Sleep in Acute Ischemic Stroke

Hermann, D. M., Siccoli, M. M., Kirov, P. К., Gugger, M., & Bassetti, C. L. (2007) · Stroke · doi:10.1161/01.str.0000258105.58221.9a · Cited by 79 · see citing works

Effects of convulsants on handling-induced convulsions in mice selected for ethanol withdrawal severity

Crabbe, J. C., Merrill, C. D., & Belknap, J. K. (1991) · Brain Research · doi:10.1016/0006-8993(91)90397-e · Cited by 65 · see citing works

Prolongation of the Frequency-Corrected QT Dispersion following Cerebral Strokes with Involvement of the Insula of Reil

Eckardt, M., Gerlach, L., & Welter, F. (1999) · European Neurology · doi:10.1159/000008105 · Cited by 52 · see citing works

Plasma and organ catecholamine levels following stimulation of the rat insular cortex

Oppenheimer, S. M., Saleh, T. M., Wilson, J. X., et al. (1992) · Brain Research · doi:10.1016/0006-8993(92)90633-k · Cited by 44 · see citing works

N-Acetylaspartate/Creatine and Choline/Creatine Ratios in the Thalami, Insular Cortex and White Matter as Markers of Hypertension and Cognitive Impairment in the Elderly

Salem, D. B., WALKER, P. M., Béjot, Y., Aho, S., Tavernier, B., Rouaud, O., Ricolfi, F., & Brunotte, F. (2008) · Hypertension Research · doi:10.1291/hypres.31.1851 · Cited by 31 · see citing works

Insular Cortex Atrophy as an Independent Determinant of Disrupted Diurnal Rhythm of Ambulatory Blood Pressure in Elderly Hypertension

Nagai, M., Hoshide, S., Ishikawa, J., Shimada, K., & Kario, K. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.71 · Cited by 28 · see citing works

Adolescent neurobiological susceptibility to social context

Schriber, R. A., & Guyer, A. E. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.009 · Cited by 246 · see citing works

Neural control of the heart: Recent concepts and clinical correlations

Palma, J.-A., & Benarroch, E. E. (2014) · Neurology · doi:10.1212/wnl.0000000000000605 · Cited by 237 · see citing works

Brain systems for baroreflex suppression during stress in humans

Gianaros, P. J., Onyewuenyi, I. C., Sheu, L. K., Christie, I. C., & Critchley, H. D. (2012) · Human Brain Mapping · doi:10.1002/hbm.21315 · Cited by 166 · see citing works

The Insula: A “Hub of Activity” in Migraine

Borsook, D., Veggeberg, R., Erpelding, N., Borra, R., Linnman, C., Burstein, R., & Becerra, L. (2016) · The Neuroscientist · doi:10.1177/1073858415601369 · Cited by 146 · see citing works

Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis

de Heus, R. A. A., Tzourio, C., Lee, E. J. L., Opozda, M., Vincent, A. D., Anstey, K. J., Hofman, A., Kario, K., Lattanzi, S., Launer, L. J., et al. (2021) · Hypertension · doi:10.1161/hypertensionaha.121.17797 · Cited by 138 · see citing works

Central control of autonomic function and involvement in neurodegenerative disorders

(2013) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-53491-0.00005-5 · Cited by 129 · see citing works

Blood Pressure Variability and Progression of Clinical Alzheimer Disease

de Heus, R. A. A., Olde Rikkert, M. G. M., Tully, P. J., Lawlor, B. A., Claassen, J. A. H. R., & for the NILVAD Study Group (2019) · Hypertension · doi:10.1161/hypertensionaha.119.13664 · Cited by 88 · see citing works

<p>Cardiac dysautonomia in depression – heart rate variability biofeedback as a potential add-on therapy</p>

Pinter, A., Szatmari Jr, S., Horvath, T., Penzlin, A. I., Barlinn, K., Siepmann, M., & Siepmann, T. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s200360 · Cited by 53 · see citing works

The Heart–Brain Axis in the Artificial Intelligence Era: Integrating Old and New Insights Towards New Targeting and Innovative Neuro- and Cardio-Therapeutics

Palantzas, A., & Anagnostouli, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178217 · Cited by 11 · see citing works

Food Cue Reactivity and the Brain-Heart Axis During Cognitive Stress Following Clinically Relevant Weight Loss

Rauch, H. G. L., Hume, D. J., Howells, F. M., Kroff, J., & Lambert, E. V. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00135 · Cited by 3 · see citing works

Intraperitoneal injection of lithium chloride induces lateralized activation of the insular cortex in adult mice

Qian, K., Liu, J., Cao, Y., Yang, J. H., & Qiu, S. (2021) · Molecular Brain · doi:10.1186/s13041-021-00780-z · Cited by 15 · see citing works

Functional specialization of the male insula during taste perception

Dalenberg, J. R., Hoogeveen, H. R., Renken, R. J., Langers, D. R. M., & Horst, G. J. T. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.062 · Cited by 60 · see citing works

Disproportionate Alterations in the Anterior and Posterior Insular Cortices in Obsessive–Compulsive Disorder

Song, A., Jung, W. H., Jang, J. H., Kim, E., Shim, G., Park, H. Y., Choi, C., & Kwon, J. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022361 · Cited by 32 · see citing works

Functional anatomy of the insula: new insights from imaging

Dupont, S., Bouilleret, V., Hasboun, D., Semah, F., & Baulac, M. (2003) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-003-0103-4 · Cited by 124 · see citing works

Chewing ameliorates the effects of restraint stress on pERK-immunoreactive neurons in the rat insular cortex

Onuki, M., Yamamoto, T., Sasaguri, K., Yamada, K., Okada, N., & Kawata, T. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.008 · Cited by 4 · see citing works