Cardiac dysautonomia in depression – heart rate variability biofeedback as a potential add-on therapy
Open accessAbstract
Depressive disorders are among the most important health problems and are predicted to constitute the leading cause of disease burden by the year 2030. Aside significant impact on quality of life, psychosocial well-being and socioeconomic status of affected patients, depression is associated with impaired cardiovascular health and increased mortality. The link between affective and cardiovascular disease has largely been attributed to dysregulation of the autonomic nervous system resulting in a chronic shift toward increased sympathetic and decreased parasympathetic activity and, consecutively, cardiac dysautonomia. Among proposed surrogate parameters to capture and quantitatively analyze this shift, heart rate variability (HRV) and baroreflex sensitivity have emerged as reliable tools. Attenuation of these parameters is frequently seen in patients suffering from depression and is closely linked to cardiovascular morbidity and mortality. Therefore, diagnostic and therapeutic strategies were designed to assess and counteract cardiac dysautonomia. While psychopharmacological treatment can effectively improve affective symptoms of depression, its effect on cardiac dysautonomia is limited. HRV biofeedback is a non-invasive technique which is based on a metronomic breathing technique to increase parasympathetic tone. While some small studies observed beneficial effects of HRV biofeedback on dysautonomia in patients with depressive disorders, larger confirmatory trials are lacking. We reviewed the current literature on cardiac dysautonomia in patients suffering from depression with a focus on the underlying pathophysiology as well as diagnostic workup and treatment.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
ANS function is purportedly modulated by the core-ICNs and one of the most robust ANS disturbances found in IDs is cardiac dysautonomia in the form of reduced HRV.
“ANS function is purportedly modulated by the core-ICNs and one of the most robust ANS disturbances found in IDs is cardiac dysautonomia in the form of reduced HRV [52, 96, 103, 280, 282–293].”
From Infraslow closed-loop brain training for anxiety and depression (ISAD): a protocol for a randomized, double-blind, sham-controlled pilot trial in adult females with internalizing disorders (2022) · cites this paper as [103]
The section on impairment of HRV in depressive disorders reports reduced HRV in 14 of 18 studies, supporting cardiac dysautonomia in depression. The paper describes a central autonomic network involved in autonomic responses, but it does not identify that network as the core-ICNs or establish reduced HRV across IDs more broadly. Page numbers were not available in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090 · see citing works
Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal
Ndiaye, M., Lespez, L., Tribolo, C., Rassé, M., Hadjas, I., Davidoux, S., Huysecom, É., & Douze, K. (2024) · Monash University Research Portal (Monash University) · doi:10.3929/ethz-b-000667478 · Cited by 24,015 · see citing works
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Zhang, Q., Wang, C., Zheng, M., Li, Y., Li, J., Zhang, L., Shang, X., & Yan, C. (2014) · Cerebrovascular Diseases · doi:10.1159/000369778 · Cited by 11,609 · see citing works
Projections of Global Mortality and Burden of Disease from 2002 to 2030
Mathers, C. D., & Loncar, D. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030442 · Cited by 11,386 · see citing works
Selective Cortical Undercutting As a Means of Modifying and Studying Frontal Lobe Function in Man
Scoville, W. B. (1949) · Journal of neurosurgery · doi:10.3171/jns.1949.6.1.0065 · Cited by 7,373 · see citing works
Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study
Murray, C. J., & Lopez, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07495-8 · Cited by 4,492 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Kleiger, R. E., Miller, J. P., Bigger, J. T., & Moss, A. J. (1987) · The American Journal of Cardiology · doi:10.1016/0002-9149(87)90795-8 · Cited by 3,995 · see citing works
Neural systems supporting interoceptive awareness
Critchley, H. D., Wiens, S., Rotshtein, P., Öhman, A., & Dolan, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1176 · Cited by 3,406 · cited 1× · see citing works
“Insular cortex is a site of multimodal integration, provides emotional related functions, conscious interoceptive awareness and mediates arousal-states in the autonomic divisions.(49) Neuroimaging studies revealed alterations in insular cortex activity in major depressive disorder.”
BackgroundRovere, M. T. L., Bigger, J. T., Marcus, F. I., Mortara, A., & Schwartz, P. J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)11144-8 · Cited by 3,120 · see citing works
A model of neurovisceral integration in emotion regulation and dysregulation
Thayer, J. F., & Lane, R. D. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00338-4 · Cited by 3,092 · see citing works
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117 · see citing works
Heart rate variability as an index of regulated emotional responding
Appelhans, B. M., & Luecken, L. J. (2006) · Review of General Psychology · doi:10.1037/1089-2680.10.3.229 · Cited by 1,893 · see citing works
Thayer, J. F., Hansen, A. L., Saus-Rose, E., & Johnsen, B. H. (2009) · Annals of Behavioral Medicine · doi:10.1007/s12160-009-9101-z · Cited by 1,872 · see citing works
Shaffer, F., McCraty, R., & Zerr, C. L. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01040 · Cited by 1,866 · see citing works
The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
Greenberg, P. E., Fournier, A.-A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09298 · Cited by 1,779 · see citing works
The Central Autonomic Network: Functional Organization, Dysfunction, and Perspective
BENARROCH, E. E. (1993) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)62272-1 · Cited by 1,534 · see citing works
Diagnostic and Statistical Manual of Mental Disorders
Davey, G. (2013) · Encyclopedia of Women in Today's World · doi:10.4135/9781412995962.n207 · Cited by 1,485 · see citing works
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397 · see citing works
Kemp, A. H., Quintana, D. S., Gray, M. A., Felmingham, K. L., Brown, K., & Gatt, J. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.012 · Cited by 1,286 · see citing works
Depression and risk of developing dementia
Byers, A. L., & Yaffe, K. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.60 · Cited by 1,265 · see citing works
The increasing burden of depression
Briley, M., & Lépine (2011) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s19617 · Cited by 1,222 · see citing works
Lichtman, J. H., Froelicher, E. S., Blumenthal, J. A., Carney, R. M., Doering, L. V., Frasure-Smith, N., Freedland, K. E., Jaffe, A. S., Leifheit-Limson, E. C., Sheps, D. S., et al. (2014) · Circulation · doi:10.1161/cir.0000000000000019 · Cited by 1,208 · cited 2× · see citing works
“The authors concluded that the preponderance of evidence had indicated that depression was associated with adverse medical outcomes after ACS.(13) Having this clinical perspective in mind, understanding underlying mechanisms mediating these comorbid disorders might help identify therapeutic targets.”
BackgroundNolan, J., Batin, P. D., Andrews, R., Lindsay, S. J., Brooksby, P., Mullen, M., Baig, W., Flapan, A. D., Cowley, A., Prescott, R. J., et al. (1998) · Circulation · doi:10.1161/01.cir.98.15.1510 · Cited by 1,179 · see citing works
Neuropsychiatric Disease and Treatment
(2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt · Cited by 1,179 · see citing works
Visceral influences on brain and behavior
Critchley, H. D., & Harrison, N. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.008 · Cited by 1,177 · cited 1× · see citing works
“Afferent input from baroreceptors in the heart and the carotid-aortic arch contributes to visceroaffective integration, further highlighting the bidirectional link between autonomic and affective neural systems.(61,62) Conversely, functional magnetic resonance imaging (fMRI) studies have revealed that baroreceptor aff…”
BackgroundDepression and cardiac mortality: results from a community-based longitudinal study.
Penninx, B., Beekman, A., Honig, A., Deeg, D., Schoevers, R., van Eijk, J., & van Tilburg, W. V. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.3.221 · Cited by 983 · see citing works
Heart rate variability biofeedback: how and why does it work?
Lehrer, P. M., & Gevirtz, R. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00756 · Cited by 883 · see citing works
Affective disorders and suicide risk: a reexamination
Bostwick, J. M., & Pankratz, V. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.12.1925 · Cited by 878 · see citing works
Symptoms of depression, acute myocardial infarction, and total mortality in a community sample
Barefoot, J. C., & Schroll, M. (1996) · Circulation · doi:10.1161/01.cir.93.11.1976 · Cited by 850 · see citing works
Depression as a Risk Factor for Coronary Artery Disease: Evidence, Mechanisms, and Treatment
Lett, H. S., Blumenthal, J. A., Babyak, M. A., Sherwood, A., Strauman, T., Robins, C., & Newman, M. F. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000126207.43307.c0 · Cited by 849 · see citing works
Depression, Heart Rate Variability, and Acute Myocardial Infarction
Carney, R. M., Blumenthal, J. A., Stein, P. K., Watkins, L. L., Catellier, D., Berkman, L. F., Czajkowski, S. M., O’Connor, C. M., Stone, P. H., & Freedland, K. E. (2001) · Circulation · doi:10.1161/hc4201.097834 · Cited by 755 · see citing works
Prefrontal mechanisms in extinction of conditioned fear
Quirk, G. J., Garcia, R., & González-Lima, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.010 · Cited by 682 · see citing works
Depression and the Course of Coronary Artery Disease
Glassman, A. H., & Shapiro, P. A. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.1.4 · Cited by 671 · see citing works
Baroreflex Sensitivity: Measurement and Clinical Implications
Rovere, M. T. L., Pinna, G. D., & Raczak, G. (2008) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2008.00219.x · Cited by 663 · see citing works
Lehrer, P. M., Vaschillo, E. G., & Vaschillo, B. (2000) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1009554825745 · Cited by 636 · see citing works
The effect of heart rate variability biofeedback training on stress and anxiety: a meta-analysis
Goessl, V. C., Curtiss, J. E., & Hofmann, S. G. (2017) · Psychological Medicine · doi:10.1017/s0033291717001003 · Cited by 632 · see citing works
Diminished Baroreflex Sensitivity in High Blood Pressure
Bristow, J. D., Honour, A. J., Pickering, G. W., Sleight, P., & Smyth, H. S. (1969) · Circulation · doi:10.1161/01.cir.39.1.48 · Cited by 569 · see citing works
Reduced Heart Rate Variability and New-Onset Hypertension
Singh, J. P., Larson, M. G., Tsuji, H., Evans, J. C., O’Donnell, C. J., & Levy, D. A. (1998) · Hypertension · doi:10.1161/01.hyp.32.2.293 · Cited by 561 · see citing works
Antelmi, I., De Paula, R. S., Shinzato, A. R., Peres, C. A., Mansur, A. J., & Grupi, C. J. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2003.09.065 · Cited by 555 · see citing works
Sobocki, P., Jönsson, B., Angst, J., & Rehnberg, C. (2006) · PubMed · Cited by 533 · see citing works
Meng, L., Chen, D., Yang, Y., Zheng, Y., & Hui, R. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835080b7 · Cited by 526 · see citing works
Depression and cardiovascular disease: mechanisms of interaction
Joynt, K. E., Whellan, D. J., & O’Connor, C. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00568-7 · Cited by 508 · see citing works
Ponikowski, P. P., Anker, S. D., Chua, T. P., Szełemej, R., Piepoli, M. F., Adamopoulos, S. N., Webb-Peploe, K., Harrington, D., Banasiak, W., Wrabec, K., et al. (1997) · The American Journal of Cardiology · doi:10.1016/s0002-9149(97)00215-4 · Cited by 492 · see citing works
Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies
Hamilton, J. P., Siemer, M., & Gotlib, I. H. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.57 · Cited by 492 · see citing works
Gehi, A., Haas, D., Pipkin, S., & Whooley, M. A. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.21.2508 · Cited by 488 · see citing works
Drevets, W. C., Price, J. L., Bardgett, M. E., Reich, T., Todd, R. D., & Raichle, M. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00687-6 · Cited by 457 · see citing works
Ventromedial Prefrontal Cortex Is Critical for the Regulation of Amygdala Activity in Humans
Motzkin, J. C., Philippi, C. L., Wolf, R. C., Baskaya, M. K., & Koenigs, M. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.02.014 · Cited by 454 · see citing works
Arterial Baroreflex Modulation of Heart Rate in Chronic Heart Failure
Mortara, A., Rovere, M. T. L., Pinna, G. D., Prpa, A., Maestri, R., Febo, O., Pozzoli, M., Opasich, C., & Tavazzi, L. (1997) · Circulation · doi:10.1161/01.cir.96.10.3450 · Cited by 443 · see citing works
Avery, J. A., Drevets, W. C., Moseman, S. E., Bodurka, J., Barcalow, J. C., & Simmons, W. K. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.027 · Cited by 442 · see citing works
Karavidas, M. K., Lehrer, P. M., Vaschillo, E., Vaschillo, B., Marin, H., Buyske, S., Malinovsky, I., Radvanski, D., & Hassett, A. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-006-9029-z · Cited by 440 · see citing works
Schwartz, P. J., Billman, G. E., & STONE, H. L. (1984) · Circulation · doi:10.1161/01.cir.69.4.790 · Cited by 434 · see citing works
Characteristics of Resonance in Heart Rate Variability Stimulated by Biofeedback
Vaschillo, E. G., Vaschillo, B., & Lehrer, P. M. (2006) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-006-9009-3 · Cited by 431 · see citing works
Quintana, D. S., Alvares, G. A., & Heathers, J. A. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.73 · Cited by 420 · see citing works
Depression and the Link with Cardiovascular Disease
Dhar, A. K., & Barton, D. A. (2016) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2016.00033 · Cited by 404 · see citing works
Autonomic dysfunction and heart rate variability in depression
Sgoifo, A., Carnevali, L., Alfonso, M. D. L. A. P., & Amore, M. (2015) · Stress · doi:10.3109/10253890.2015.1045868 · Cited by 342 · see citing works
Fear from the heart: sensitivity to fear stimuli depends on individual heartbeats
Garfinkel, S. N., Minati, L., Gray, M. A., Seth, A. K., Dolan, R. J., & Critchley, H. D. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3507-13.2014 · Cited by 338 · see citing works
Relationship of Heart Rate Variability to Parasympathetic Effect
Goldberger, J. J., Challapalli, S., Tung, R. H., Parker, M. A., & Kadish, A. H. (2001) · Circulation · doi:10.1161/01.cir.103.15.1977 · Cited by 329 · see citing works
The insular cortex and cardiovascular system: a new insight into the brain-heart axis
Nagai, M., Hoshide, S., & Kario, K. (2010) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2010.05.001 · Cited by 328 · see citing works
Heart rate variability (HRV) and posttraumatic stress disorder (PTSD): a pilot study
Tan, G., Dao, T. K., Farmer, L., Sutherland, R. J., & Gevirtz, R. (2011) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-010-9141-y · Cited by 319 · see citing works
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
Bertinieri, G., DiRienzo, M., Cavallazzi, A., Ferrari, A. U., Pedotti, A., & Mancia, G. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.255.6.1-a · Cited by 315 · see citing works
Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats
Bertinieri, G., Rienzo, M. D., Cavallazzi, A., Ferrari, A. U., Pedotti, A., & Mancia, G. (1988) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1988.254.2.h377 · Cited by 312 · see citing works
DSM-5 Criteria and Depression Severity: Implications for Clinical Practice
Tolentino, J. C., & Schmidt, S. L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00450 · Cited by 311 · see citing works
Vaschillo, E. G., Lehrer, P. M., Rishe, N. D., & Konstantinov, M. (2002) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1014587304314 · Cited by 297 · see citing works
The effects of specific respiratory rates on heart rate and heart rate variability
Song, H.-S., & Lehrer, P. M. (2003) · Applied Psychophysiology and Biofeedback · doi:10.1023/a:1022312815649 · Cited by 292 · see citing works
Hassett, A. L., Radvanski, D. C., Vaschillo, E. G., Vaschillo, B., Sigal, L. H., Karavidas, M. K., Buyske, S. G., & Lehrer, P. M. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-006-9028-0 · Cited by 282 · see citing works
Siepmann, M., Aykac, V., Unterdörfer, J., Petrowski, K., & Mueck-Weymann, M. (2008) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-008-9064-z · Cited by 265 · see citing works
Self-citationMental Disorders Top The List Of The Most Costly Conditions In The United States: $201 Billion
Roehrig, C. (2016) · Health Affairs · doi:10.1377/hlthaff.2015.1659 · Cited by 246 · see citing works
Kronish, I. M., Rieckmann, N., Halm, E. A., Shimbo, D., Vorchheimer, D. A., Haas, D. C., & Davidson, K. W. (2006) · Journal of General Internal Medicine · doi:10.1111/j.1525-1497.2006.00586.x · Cited by 241 · see citing works
Heartbeat evoked potentials mirror altered body perception in depressed patients
Terhaar, J., Viola, F. C., Bär, K., & Debener, S. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.02.086 · Cited by 238 · see citing works
Cardiac Baroreceptor Sensitivity Predicts Long-Term Outcome After Acute Ischemic Stroke
Robinson, T. G., Dawson, S., Eames, P. J., Panerai, R. B., & Potter, J. F. (2003) · Stroke · doi:10.1161/01.str.0000058493.94875.9f · Cited by 234 · see citing works
Sliz, D., & Hayley, S. P. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2012.00323 · Cited by 224 · see citing works
Steffen, P. R., Austin, T. A., DeBarros, A., & Brown, T. (2017) · Frontiers in Public Health · doi:10.3389/fpubh.2017.00222 · Cited by 221 · see citing works
Nolan, R. P., Kamath, M. V., Floras, J. S., Stanley, J., Pang, C., Picton, P., & Young, Q. R. (2005) · American Heart Journal · doi:10.1016/j.ahj.2005.03.015 · Cited by 219 · see citing works
Meijer, A., Conradi, H. J., Bos, E. H., Anselmino, M., Carney, R. M., Denollet, J., Doyle, F., Freedland, K. E., Grace, S. L., Hosseini, S. H., et al. (2013) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.112.111195 · Cited by 219 · see citing works
Protocol for Heart Rate Variability Biofeedback Training
Lehrer, P. M., Vaschillo, B., Zucker, T., Graves, J., Karavidas, M. K., Aviles‐Velez, M., & Wamboldt, F. S. (2013) · Biofeedback · doi:10.5298/1081-5937-41.3.08 · Cited by 215 · see citing works
Martín-Subero, M., Anderson, G., Kanchanatawan, B., Berk, M., & Maes, M. H. J. (2015) · CNS Spectrums · doi:10.1017/s1092852915000449 · Cited by 196 · see citing works
Effect of Heart Rate Variability Biofeedback on Sport Performance, a Systematic Review
Morgan, S. J., & Mora, J. A. M. (2017) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-017-9364-2 · Cited by 195 · see citing works
Gartlehner, G., Wagner, G., Matyas, N., Titscher, V., Greimel, J., Lux, L., Gaynes, B. N., Viswanathan, M., Patel, S., & Lohr, K. N. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-014912 · Cited by 192 · see citing works
Kemp, A. H., Brunoni, A. R., Santos, I. S., Nunes, M. A., Dantas, E. M., Carvalho de Figueiredo, R., Pereira, A. C., Ribeiro, A. L. P., Mill, J. G., Andreão, R. V., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121605 · Cited by 189 · see citing works
Coronary artery disease and depression
Zellweger, M. J. (2003) · European Heart Journal · doi:10.1016/j.ehj.2003.09.009 · Cited by 183 · see citing works
Depression and cardiac risk: present status and future directions
Frasure-smith, N., & Lespérance, F. (2009) · Postgraduate medical journal · doi:10.1136/hrt.2009.186957 · Cited by 180 · see citing works
Hallman, D., Olsson, E. M. G., von Schéele, B., Melin, L., & Lyskov, E. (2011) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-011-9147-0 · Cited by 174 · see citing works
Hautala, A. J., Mäkikallio, T. H., Kiviniemi, A., Laukkanen, R. T., Nissilä, S., Huikuri, H. V., & Tulppo, M. P. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00202.2003 · Cited by 167 · see citing works
Del Pozo, J. M., Gevirtz, R. N., Scher, B., & Guarneri, E. (2004) · American Heart Journal · doi:10.1016/j.ahj.2003.08.013 · Cited by 165 · see citing works
Emotional appraisal is influenced by cardiac afferent information
Gray, M. A., Beacher, F. D., Minati, L., Nagai, Y., Kemp, A. H., Harrison, N. A., & Critchley, H. D. (2012) · Emotion · doi:10.1037/a0025083 · Cited by 163 · see citing works
New hope for correctional officers: an innovative program for reducing stress and health risks
McCraty, R., Atkinson, M., Lipsenthal, L., & Arguelles, L. (2009) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-009-9087-0 · Cited by 160 · see citing works
Tsui-Caldwell, Y. H. W., & Steffen, P. R. (2018) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2018.01.001 · Cited by 160 · see citing works
Prefrontal Cortex Stimulation Enhances Fear Extinction Memory in Humans
Raij, T., Nummenmaa, A., Marin, M.-F., Porter, D., Furtak, S., Setsompop, K., & Milad, M. R. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.10.022 · Cited by 156 · see citing works
Pizzi, C., Manzoli, L., Mancini, S., & Costa, G. M. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn137 · Cited by 152 · see citing works
Autonomic Neural Regulation of the Immune System
Abboud, F. M., Harwani, S. C., & Chapleau, M. W. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.186833 · Cited by 151 · see citing works
Bär, K., Greiner, W., Jochum, T., Friedrich, M., Wagner, G., & Sauer, H. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2003.12.016 · Cited by 149 · see citing works
Brunoni, A. R., Kemp, A. H., Dantas, E. M., Goulart, A. C., Nunes, M. A., Boggio, P. S., Mill, J. G., Lotufo, P. A., Fregni, F., & Benseñor, I. M. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000497 · Cited by 149 · see citing works
Luskin, F., Reitz, M., Newell, K., Quinn, T. G., & Haskell, W. L. (2002) · Preventive Cardiology · doi:10.1111/j.1520.037x.2002.01029.x · Cited by 141 · see citing works
Henriques, G. R., Keffer, S. L., Abrahamson, C., & Horst, S. J. (2011) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-011-9151-4 · Cited by 139 · see citing works
Lin, G., Xiang, Q., Fu, X., Wang, S., Wang, S., Chen, S., Shao, L., Zhao, Y., & Wang, T. (2012) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2010.0607 · Cited by 136 · see citing works
Heart Rate Variability Biofeedback
Lehrer, P., Vaschillo, E., Lu, S.-E., Eckberg, D., Vaschillo, B., Scardella, A., & Habib, R. (2006) · Chest · doi:10.1378/chest.129.2.278 · Cited by 136 · see citing works
Gruzelier, J. H., Thompson, T., Redding, E., Brandt, R., & Steffert, T. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.05.004 · Cited by 135 · see citing works
Giardino, N. D., Chan, L. E., & Soo Borson, B. (2004) · Applied Psychophysiology and Biofeedback · doi:10.1023/b:apbi.0000026638.64386.89 · Cited by 129 · see citing works
Altered cardiac autonomic nervous function in depression
Wang, Y., Zhao, X., O'Neil, A. E., Turner, A., Liu, X., & Berk, M. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-187 · Cited by 123 · see citing works
Depression and cardiovascular comorbidity
Glassman, A. H. (2007) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2007.9.1/ahglassman · Cited by 123 · see citing works
Moon, E., Lee, S., Kim, D.-H., & Hwang, B. (2013) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2013.11.3.137 · Cited by 120 · see citing works
Stapelberg, N. J. C., Neumann, D. L., Shum, D., McConnell, H. W., & Hamilton‐Craig, I. R. (2011) · Australian & New Zealand Journal of Psychiatry · doi:10.3109/00048674.2011.570427 · Cited by 119 · see citing works
Usui, H., & Nishida, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182611 · Cited by 116 · see citing works
How Does Heart Rate Variability Biofeedback Work? Resonance, the Baroreflex, and Other Mechanisms
Lehrer, P. M. (2013) · Biofeedback · doi:10.5298/1081-5937-41.1.02 · Cited by 115 · see citing works
A literature review of heart rate variability in depressive and bipolar disorders
Bassett, D. L. (2015) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867415622689 · Cited by 110 · see citing works
Eddie, D., Kim, C. D., Lehrer, P. M., Deneke, E., & Bates, M. E. (2014) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-014-9251-z · Cited by 107 · see citing works
Neurobiology of Depression and Anxiety in Parkinson's Disease
Kano, O., Ikeda, K., Cridebring, D., Takazawa, T., Yoshii, Y., & Iwasaki, Y. (2011) · Parkinson s Disease · doi:10.4061/2011/143547 · Cited by 107 · see citing works
Cardiovascular considerations in antidepressant therapy: an evidence-based review.
Yekehtaz, H., Farokhnia, M., & Akhondzadeh, S. (2013) · PubMed Central · Cited by 107 · see citing works
Heart Rate Variability as a Marker of Self-Regulation
Reynard, A. K., Gevirtz, R., Berlow, R., Brown, M., & Boutelle, K. N. (2011) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-011-9162-1 · Cited by 104 · see citing works
Depression and cardiovascular disease: an update on how course of illness may influence risk
Fiedorowicz, J. G. (2014) · Current Psychiatry Reports · doi:10.1007/s11920-014-0492-6 · Cited by 103 · see citing works
Lehrer, P. M., & Eddie, D. (2013) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-013-9217-6 · Cited by 101 · see citing works
Serafini, G., Pompili, M., Belvederi Murri, M., Respino, M., Ghio, L., Girardi, P., Fitzgerald, P. B., & Amore, M. (2015) · Neuropsychobiology · doi:10.1159/000381351 · Cited by 101 · see citing works
Stapelberg, N. J. C., Hamilton‐Craig, I. R., Neumann, D. L., Shum, D., & McConnell, H. W. (2012) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867412444624 · Cited by 99 · see citing works
Fiedorowicz, J. G., He, J., & Merikangas, K. R. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.07.010 · Cited by 98 · see citing works
The altered complexity of cardiovascular regulation in depressed patients
Schulz, S., Koschke, M., Bär, K., & Voss, A. (2010) · Physiological Measurement · doi:10.1088/0967-3334/31/3/003 · Cited by 97 · see citing works
The human nociceptive flexion reflex threshold is higher during systole than diastole
Edwards, L., McIntyre, D., Carroll, D., Ring, C., & Martin, U. (2002) · Psychophysiology · doi:10.1111/1469-8986.3950678 · Cited by 96 · see citing works
Lee, B.-T., Cho, S. W., Khang, H. S., Lee, B.-C., Choi, I.-G., Lyoo, I. K., & Ham, B.-J. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.06.030 · Cited by 94 · see citing works
Kemp, A. H., Quintana, D. S., Quinn, C. R., Hopkinson, P., & Harris, A. W. F. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.01387 · Cited by 94 · see citing works
Bobo, W. V., Angleró, G. C., Jenkins, G. D., Hall‐Flavin, D. K., Weinshilboum, R. M., & Biernacka, J. M. (2016) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.2526 · Cited by 94 · see citing works
Interactions between visceral afferent signaling and stimulus processing
Critchley, H. D., & Garfinkel, S. N. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00286 · Cited by 89 · see citing works
MacKinnon, S., Gevirtz, R., McCraty, R., & Brown, M. (2013) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-013-9226-5 · Cited by 87 · see citing works
Effect of Depression on Prognosis in Heart Failure
Freedland, K. E., Carney, R. M., & Rich, M. W. (2010) · Heart Failure Clinics · doi:10.1016/j.hfc.2010.08.003 · Cited by 86 · see citing works
Interplay of Amygdala and Cingulate Plasticity in Emotional Fear
Toyoda, H., Li, X., Wu, L., Zhao, M., Descalzi, G., Chen, T., Koga, K., & Zhuo, M. (2011) · Neural Plasticity · doi:10.1155/2011/813749 · Cited by 85 · see citing works
Heart Rate Variability Biofeedback Reduces Food Cravings in High Food Cravers
Meule, A., Freund, R., Skirde, A. K., Vögele, C., & Kübler, A. (2012) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-012-9197-y · Cited by 81 · see citing works
Eddie, D., Vaschillo, E. G., Vaschillo, B., & Lehrer, P. M. (2015) · Addiction Research & Theory · doi:10.3109/16066359.2015.1011625 · Cited by 76 · see citing works
Thurber, M. R., Bodenhamer-Davis, E., Johnson, M., Chesky, K., & Chandler, C. K. (2010) · Biofeedback · doi:10.5298/1081-5937-38.1.28 · Cited by 74 · see citing works
Baroreflex Sensitivity Is Reduced in Depression
Broadley, A., Frenneaux, M. P., Moskvina, V., Jones, C. J. H., & Korszun, A. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000170829.91643.24 · Cited by 74 · see citing works
Patron, E., Messerotti Benvenuti, S., Favretto, G., Valfrè, C., Bonfà, C., Gasparotto, R., & Palomba, D. (2013) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-012-9202-5 · Cited by 70 · see citing works
Kudo, N., Shinohara, H., & Kodama, H. (2014) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-014-9259-4 · Cited by 70 · see citing works
Chang, H., Chang, C.-C., Kuo, T. B. J., & Huang, S. (2015) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2015.1017606 · Cited by 64 · see citing works
Penzlin, A. I., Siepmann, T., Illigens, B. M. W., Weidner, K., & Siepmann, M. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s84798 · Cited by 59 · see citing works
Self-citationNonlinear broad band dynamics are less complex in major depression
Boettger, S., Hoyer, D., Falkenhahn, K., Kaatz, M., Yeragani, V. K., & Bär, K. (2008) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00503.x · Cited by 56 · see citing works
Peira, N., Fredrikson, M. G., & Pourtois, G. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.12.008 · Cited by 54 · see citing works
Rottenberg, J. A., Chambers, A. S., Allen, J. J. B., & Manber, R. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.01.028 · Cited by 54 · see citing works
Gender-dependent impact of major depression on autonomic cardiovascular modulation
Voss, A., Boettger, M. K., Schulz, S., Gross, K., & Bär, K. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.015 · Cited by 52 · see citing works
Biofeedback therapy in cardiovascular disease: rationale and research overview.
Moravec, C. S. (2008) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.75.suppl_2.s35 · Cited by 52 · see citing works
Chen, S., Sun, P., Wang, S., Lin, G., & Wang, T. (2015) · Journal of Human Hypertension · doi:10.1038/jhh.2015.27 · Cited by 49 · see citing works
Relation between baroreflex sensitivity and cardiac vagal tone in humans
Kollai, M., Jokkel, G., Bonyhay, I., Tomcsányi, J., & Naszlady, A. (1994) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1994.266.1.h21 · Cited by 47 · see citing works
Karavidas, M. K., Lehrer, P. M., Escobar, J. I., Gara, M. A., Kotay, A., & Liu, R. (2011) · Psychosomatics · doi:10.1016/j.psym.2011.01.015 · Cited by 47 · see citing works
Penzlin, A. I., Barlinn, K., Illigens, B. M. W., Weidner, K., Siepmann, M., & Siepmann, T. (2017) · BMC Psychiatry · doi:10.1186/s12888-017-1480-2 · Cited by 47 · see citing works
Self-citationCosts of Chronic Diseases at the State Level: The Chronic Disease Cost Calculator
Trogdon, J. G., Murphy, L. B., Khavjou, O., Li, R., Maylahn, C., Tangka, F. K. L., Nurmagambetov, T., Ekwueme, D. U., Nwaise, I. A., Chapman, D. P., et al. (2015) · Preventing Chronic Disease · doi:10.5888/pcd12.150131 · Cited by 46 · see citing works
Hughes, J. W., Dennis, M. F., & Beckham, J. C. (2007) · Journal of Traumatic Stress · doi:10.1002/jts.20285 · Cited by 45 · see citing works
Hilimire, M. R., Mayberg, H. S., Holtzheimer, P. E., Broadway, J. M., Parks, N. A., DeVylder, J. E., & Corballis, P. M. (2015) · Brain Stimulation · doi:10.1016/j.brs.2014.11.010 · Cited by 42 · see citing works
Vasudev, A., O'Brien, J. T., Tan, M. P., Parry, S. W., & Thomas, A. J. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2010.11.001 · Cited by 41 · see citing works
Mortara, A., Rovere, M. T. L., Pinna, G. D., PARZIALE, P., Maestri, R., Capomolla, S., Opasich, C., Cobelli, F., & Tavazzi, L. (1997) · American Heart Journal · doi:10.1016/s0002-8703(97)80011-7 · Cited by 41 · see citing works
Reduced heart rate variability in remitted bipolar disorder and recurrent depression
Bassett, D. L., Bear, N., Nutt, D., Hood, S. D., Bassett, S., & Hans, D. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416652734 · Cited by 41 · see citing works
Maestri, R., Raczak, G., Daniłowicz‐Szymanowicz, L., Toruński, A., Sukiennik, A., Kubica, J., Rovere, M. T. L., & Pinna, G. D. (2009) · Clinical Science · doi:10.1042/cs20090183 · Cited by 39 · see citing works
Heart rate variability in drug-naive patients with panic disorder and major depressive disorder
Kikuchi, M., Hanaoka, A., Kidani, T., Remijn, G. B., Minabe, Y., Munesue, T., & Koshino, Y. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.08.002 · Cited by 39 · see citing works
Udupa, K., Thirthalli, J., Sathyaprabha, T. N., Kishore, K., Raju, T. R., & Gangadhar, B. N. (2011) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2011.02.006 · Cited by 37 · see citing works
Biofeedback to treat anxiety in young people at clinical high risk for developing psychosis
McAusland, L., & Addington, J. (2018) · Early Intervention in Psychiatry · doi:10.1111/eip.12368 · Cited by 37 · see citing works
Short-term heart rate variability in older patients with newly diagnosed depression
Ha, J. H., Park, S., Yoon, D., & Kim, B. (2015) · Psychiatry Research · doi:10.1016/j.psychres.2015.02.005 · Cited by 36 · see citing works
Shah, A. P., Carreno, F. R., & Frazer, A. (2014) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2014.12.2.83 · Cited by 35 · see citing works
Heart Rate Variability During Antidepressant Treatment With Venlafaxine and Mirtazapine
Terhardt, J., Lederbogen, F., Feuerhack, A., Weber-Hamann, B., Gilles, M., Schilling, C., Lecei, O., & Deuschle, M. (2013) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3182a76fbb · Cited by 34 · see citing works
Learned Cardiac Control with Heart Rate Biofeedback Transfers to Emotional Reactions
Peira, N., Pourtois, G., & Fredrikson, M. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070004 · Cited by 32 · see citing works
Heart Rate Variability and the Efficacy of Biofeedback in Heroin Users with Depressive Symptoms
Lin, I., Ko, J.-M., Fan, S., & Yen, C. (2016) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.2016.14.2.168 · Cited by 30 · see citing works
Low cardiac vagal tone index by heart rate variability differentiates bipolar from major depression
Hage, B., Britton, B., Daniels, D., Heilman, K., Porges, S., & Halaris, A. (2019) · World Journal of Biological Psychiatry · doi:10.1080/15622975.2017.1376113 · Cited by 29 · see citing works
Depression and cardiovascular disease: co-occurrence or shared genetic substrates?
Licinio, J., Yıldız, B. O., & Wong, M.-L. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001293 · Cited by 27 · see citing works
Agelink, M. W., Ullrich, H., Baumann, B., Strum, S., & Majewski, T. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1146-7 · Cited by 25 · see citing works
McIntyre, D. B., Kavussanu, M., & Ring, C. (2007) · Pain · doi:10.1016/j.pain.2007.10.018 · Cited by 24 · see citing works
The Effects of Heart Rate Variability Biofeedback in Patients with Preterm Labour
Siepmann, M., HENNIG, U., Siepmann, T., Nitzsche, K. I., Mück-Weymann, M., Petrowski, K., & Weidner, K. (2013) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-013-9238-1 · Cited by 23 · see citing works
Self-citationDefective Nitric Oxide–Cyclic Guanosine Monophosphate Signaling in Patients With Bipolar Disorder
Fontoura, P. C., Pinto, V. L. M., Matsuura, C., Resende, Â. C., de Bem, G. F., Ferraz, M. R., Cheniaux, E., Brunini, T. M. C., & Mendes‐Ribeiro, A. C. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3182689460 · Cited by 20 · see citing works
Dauphinot, V., Rouch, I., Kossovsky, M. P., Pichot, V., Dorey, J., Krolak‐Salmon, P., Laurent, B., Roche, F., & Barthélemy, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.045 · Cited by 19 · see citing works
Herbell, K., & Zauszniewski, J. A. (2019) · Journal of Holistic Nursing · doi:10.1177/0898010118783030 · Cited by 16 · see citing works
Heart Rate Variability Biofeedback Stress Relief Program for Depression
Hartogs, B. M. A., Bartels‐Velthuis, A. A., der Ploeg, K. M. V., & Bos, E. H. (2017) · Methods of Information in Medicine · doi:10.3414/me16-02-0033 · Cited by 15 · see citing works
Psychophysiologic Remodeling of the Failing Human Heart
Moravec, C. S., & McKee, M. G. (2013) · Biofeedback · doi:10.5298/1081-5937-41.1.04 · Cited by 14 · see citing works
Effects of Heart Rate Variability Biofeedback Therapy on Patients with Poststroke Depression
Li, X., Zhang, T., Song, L.-P., Zhang, Y., Zhang, G.-G., Xing, C., & Chen, H. (2015) · Chinese Medical Journal · doi:10.4103/0366-6999.164986 · Cited by 14 · see citing works
A smartphone based cardiac coherence biofeedback system
Jonckheere, J. D., Ibarissene, I., Flocteil, M., & Logier, R. (2014) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/embc.2014.6944695 · Cited by 14 · see citing works
Arterial baroreflex dysfunction in major depressive disorder
Johansson, M., Ehnvall, A., Friberg, P., & Myredal, A. (2010) · Clinical Autonomic Research · doi:10.1007/s10286-010-0053-y · Cited by 13 · see citing works
Biofeedback of baroreflex sensitivity in patients with mild essential hypertension
Overhaus, S., Rüddel, H., Curio, I., Mussgay, L., & Scholz, O. B. (2003) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm1001_06 · Cited by 7 · see citing works
B-65Heart Rate Variability as an Index of Stress Resilience
An, E., Nolty, A., Rensberger, J. K., Hennig, N., Amano, S. S., & Buckwalter, J. G. (2016) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acw043.140 · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 177 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Traylor, C. S., Johnson, J., Kimmel, M., & Manuck, T. A. (2020) · American Journal of Obstetrics & Gynecology MFM · doi:10.1016/j.ajogmf.2020.100229 · Cited by 322 · see citing works
Laborde, S., Allen, M. S., Borges, U., Dosseville, F., Hosang, T. J., Iskra, M., Mosley, E., Salvotti, C., Spolverato, L., Zammit, N., et al. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104711 · Cited by 272 · see citing works
Cardiovascular disease and depression: a narrative review
Li, X., Zhou, J., Wang, M., Yang, C., & Sun, G. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1274595 · Cited by 101 · see citing works
Methods for Heart Rate Variability Biofeedback (HRVB): A Systematic Review and Guidelines
Lalanza, J. F., Lorente, S., Bullich, R., García, C., Losilla, J.-M., & Capdevila, L. (2023) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-023-09582-6 · Cited by 102 · see citing works
Depression and coronary heart disease: mechanisms, interventions, and treatments
Xu, L., Zhai, X., Shi, D.-Z., & Zhang, Y. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1328048 · Cited by 72 · see citing works
Autonomic Dysfunction in Preeclampsia: A Systematic Review
Yousif, D., Bellos, I., Penzlin, A. I., Hijazi, M. M., Illigens, B. M. W., Pintér, A., & Siepmann, T. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00816 · Cited by 63 · see citing works
Self-citationМельников, М. Е. (2021) · Neural Plasticity · doi:10.1155/2021/8878857 · Cited by 67 · see citing works
Siepmann, M., Weidner, K., Petrowski, K., & Siepmann, T. (2022) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-022-09572-0 · Cited by 61 · see citing works
Self-citationSzulczewski, M. T. (2021) · Neuromodulation Technology at the Neural Interface · doi:10.1111/ner.13458 · Cited by 33 · see citing works
Feature of Heart Rate Variability and Metabolic Mechanism in Female College Students with Depression
Zhao, S., Chi, A., Yan, J., & Yao, C. (2020) · BioMed Research International · doi:10.1155/2020/5246350 · Cited by 26 · see citing works
Lung, S. C., Chen, N., Hwang, J., Hu, S., Wang, W. V., Wen, T.-Y. J., & Chun-hu, L. (2020) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-020-0254-y · Cited by 26 · see citing works
Zhou, H., Dai, Z., Hua, L., Jiang, H., Tian, S., Han, Y., Lin, P., Wang, H., Lü, Q., & Yao, Z. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00989 · Cited by 24 · see citing works
Adolescent athletes and suicide: A model for treatment and prevention
Edmonds, W. A., Craig, L. L., Christopher, R., Kennedy, T. D., & Mann, D. T. Y. (2021) · Aggression and Violent Behavior · doi:10.1016/j.avb.2021.101580 · Cited by 21 · see citing works
Interaction and mechanisms of depression and cardiovascular disease: a mini-review
Huang, L., Zhang, L., Liu, C., Xu, Q., & Qiu, K. (2025) · PeerJ · doi:10.7717/peerj.20148 · Cited by 19 · see citing works
Impaired Modulation of the Autonomic Nervous System in Adult Patients with Major Depressive Disorder
Böttcher, E., Schreiber, L. S., Wozniak, D., Scheller, E., Schmidt, F. M., & Pelz, J. O. (2024) · Biomedicines · doi:10.3390/biomedicines12061268 · Cited by 13 · see citing works
Idrobo-Ávila, E., Correa, H. L., Muñoz-Bolaños, F., van Noorden, L., & Vargas-Cañas, R. (2021) · Biomedical Signal Processing and Control · doi:10.1016/j.bspc.2021.103095 · Cited by 15 · see citing works
Biosensors and Biofeedback in Clinical Psychology
Mancuso, V., Stramba-Badiale, C., Cavedoni, S., & Cipresso, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818697-8.00002-9 · Cited by 13 · see citing works
Gutlapalli, S. D., Farhat, H., Irfan, H., Muthiah, K., Pallipamu, N., Taheri, S., Thiagaraj, S. S., Shukla, T. S., Giva, S., & Penumetcha, S. S. (2022) · Cureus · doi:10.7759/cureus.32323 · Cited by 13 · see citing works
Lung, S. C., Chen, N., Hwang, J., Hu, S., Wang, W. V., Wen, T.-Y. J., & Chun-hu, L. (2020) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-020-00263-8 · Cited by 11 · see citing works
Lenger, M., Dalkner, N., Schwalsberger, K., Hagendorfer, B., Schönthaler, E. M. D., Rieger, A., Maget, A., Fellendorf, F. T., Hamm, C., Gramer, M., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123277 · Cited by 10 · see citing works
Wei, L., Liang, H., Mo, M., Liu, Z., Ye, R., Ye, H., Ouyang, W., Yu, W., Zhao, W., & Zhang, X. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102541 · Cited by 10 · see citing works
Perez, T. M., Glue, P., Adhia, D. B., Navid, M. S., Zeng, J., Dillingham, P., Smith, M., Niazi, I. K., Young, C. K., & De Ridder, D. (2022) · Trials · doi:10.1186/s13063-022-06863-z · Cited by 8 · see citing works
Tian, Q.-Q., Cheng, C., Liu, P., Yin, Z.-X., Zhang, M.-K., Cui, Y.-P., Zhao, R., Deng, H., Lu, L., Tang, C., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1133964 · Cited by 9 · see citing works
Schnekenberg, L. G., Sedghi, A., Schoene, D., Pallesen, L., Barlinn, J., Woitek, F. J., Linke, A. H.-P., Puetz, V., Barlinn, K., Mangner, N., et al. (2023) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd10070297 · Cited by 10 · see citing works
Self-citationGutlapalli, S. D., Prakash, K., Swarnakari, K. M., Bai, M., Manoharan, M. P., Raja, R., Jamil, A., Csendes, D., Desai, A., Desai, D. M., et al. (2022) · Cureus · doi:10.7759/cureus.28946 · Cited by 11 · see citing works
Stress-related dysautonomias and neurocardiology-based treatment approaches
Gurel, N. Z., Hadaya, J. E., & Ardell, J. L. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.102944 · Cited by 7 · see citing works
Brupbacher, G., Zander-Schellenberg, T., Straus, D., Porschke, H., Infanger, D., Gerber, M., von Känel, R., & Schmidt‐Trucksäss, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10174028 · Cited by 7 · see citing works
The Significance of Sleep Disorders in Post-myocardial Infarction Depression
Gutlapalli, S. D., Pu, J., Zaidi, M. F., Patel, M., Atluri, L. M., Gonzalez, N. A., Sakhamuri, N., Athiyaman, S., Randhi, B., & Penumetcha, S. S. (2022) · Cureus · doi:10.7759/cureus.30899 · Cited by 6 · see citing works
Utilizing language models for advanced electrocardiogram analysis
Pang, J., Wang, Y., Özyurt, F., Doğan, Ş., Tuncer, T., & Lei, Y. (2024) · Alexandria Engineering Journal · doi:10.1016/j.aej.2024.07.086 · Cited by 6 · see citing works
Gutlapalli, S. D., Chaudhuri, D., Khan, K. I., Shouli, R. A., Allakky, A., Ferguson, A. A., Khan, A. I., Abuzainah, B., & Mohammed, L. (2022) · Cureus · doi:10.7759/cureus.32331 · Cited by 5 · see citing works
Cardiac autonomic function is preserved in young adults with major depressive disorder
Darling, A. M., Dominguez, C. M., Skow, R. J., Mogle, J. A., Saunders, E. F. H., Fadel, P. J., & Greaney, J. L. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00762.2023 · Cited by 6 · see citing works
Yoo, S. D., & Park, E. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010104 · Cited by 5 · see citing works
Perez, T. M., Mathew, J., Glue, P., Adhia, D. B., & Ridder, D. D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.821136 · Cited by 3 · see citing works
Luo, X. W., Wang, R., Zhou, Y., & Xie, W. Q. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298998 · Cited by 4 · see citing works
Perez, T. M., Glue, P., Adhia, D. B., Mathew, J., & Ridder, D. D. (2021) · NeuroRegulation · doi:10.15540/nr.8.1.22 · Cited by 2 · see citing works
Gutlapalli, S. D., Lavu, V. K., Abdelwahab, R. A. M., Huang, R., Potla, S., Bhalla, S., AlQabandi, Y., Nandula, S. A., Boddepalli, C. S., & Hamid, P. (2022) · Cureus · doi:10.7759/cureus.29107 · Cited by 3 · see citing works
Galin, S., Nagy, L., Turan, C., Laczkó, D., Szabó, B., Hegyi, P. J., Molnár, Z., & Keri, S. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121388 · Cited by 2 · see citing works
Coleman, R., Trites, K., Parker, B., & Benson, N. F. (2023) · Research in Autism · doi:10.1016/j.rasd.2023.102300 · Cited by 2 · see citing works
Developing of a Biofeedback-Based System for Restoring Cardiorespiratory Interaction
Egorov, D. A., & Alekseev, B. E. (2021) · IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering · doi:10.1109/elconrus51938.2021.9396266 · Cited by 2 · see citing works
Cui, X., Cao, J., Rafanelli, C., Zhu, B., & Gostoli, S. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-051295 · Cited by 2 · see citing works
Challenges and Prospects for Research on Autonomic Regulation in Various Types of Depression
Antipova, O. S. (2019) · Doctor Ru · doi:10.31550/1727-2378-2019-161-6-42-46 · Cited by 1 · see citing works
Perez, T. M., Adhia, D. B., Glue, P., Zeng, J., Dillingham, P. W., Navid, M. S., Niazi, I. K., Young, C. K., Smith, M. L., & Ridder, D. J. M. K. D. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01279-z · Cited by 2 · see citing works
Herzratenvariabilitäts(HRV)-Biofeedback
Siepmann, M. (2021) · Ärztliche Psychotherapie · doi:10.21706/aep-16-3-133
Self-citationAl-Shura, A. N. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817572-9.00013-6
Possibility of using biofeedback as a therapeutic tool
Yamamoto, C. H., Fukushima, A. R., & Nicoletti, M. A. (2023) · International Journal of Health Science · doi:10.22533/at.ed.1593252303045
Veiga, D., Peralta, M., Gouveia, É. R., Nascimento, M. D. M., de Carvalho, L. L., Encantado, J., & Marques, A. (2024) · Geriatrics · doi:10.3390/geriatrics9020036
Liu, X., Shi, X., Zhao, H., Hou, J., Zhao, W., & Ding, W. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305428
Knowledge mapping of biofeedback for depression from 1999 to 2023: A bibliometric analysis
Cheng, J., Tang, Z., Wang, Y., Rehman, S., Ren, Z., Ju, Y., Liu, J., Wang, M., Liu, B., & Zhang, Y. (2025) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2025.100946
Luo, C., Jiang, C., & Du, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-6808275/v1
Luo, C., Wang, C., Jiang, C., Wang, Y., He, Y., & Du, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-7509404/v1
Kundnani, N. R., Mogos, A., Barbu, L. A., Mogoș, G. F. R., Buciu, V., Caraba, A., Borza, C., & Huţ, E. F. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15113995
Tu, Q., He, Z.-X., Duan, Y., Jiang, X.-J., Dong, H., & Zou, Y. (2026) · Global Heart · doi:10.5334/gh.1565
- Authors
- Pinter, A., Szatmari Jr, S., Horvath, T., Penzlin, A. I., Barlinn, K., Siepmann, M., & Siepmann, T.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- University Hospital Carl Gustav Carus (DE)
- Dresden International University (DE)
- Corresponding author
- Siepmann, Timo
- Venue
- Neuropsychiatric Disease and Treatment
- Publisher
- Informa UK Limited
- Published
- 2019-05
- Volume
- Volume 15
- Pages
- 1287-1310
- ISSN
- 1176-6328 (ISSN-L)
- 1178-2021
- PMC
- PMC6529729
- OpenAlex
- W2944887095
- Cited by
- 53
- References
- 177
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 8 · 2020: 7 · 2019: 4
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Neuropsychiatric Disease and Treatment (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Keywords
- cardiac autonomic dysfunction, depression, heart rate variability biofeedback, baroreflex sensitivity, autonomic dysfunction, parasympathetic activity, sympathetic activity, adjunctive therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
