The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
Alopecia areata: A multifactorial autoimmune condition
Open accessAbstract
Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is clinically characterised by small patches of baldness on the scalp and/or around the body. It can later progress to total loss of scalp hair (Alopecia totalis) and/or total loss of all body hair (Alopecia universalis). The rapid rate of hair loss and disfiguration caused by the condition causes anxiety on patients and increases the risks of developing psychological and psychiatric complications. Hair loss in alopecia areata is caused by lymphocytic infiltrations around the hair follicles and IFN-γ. IgG antibodies against the hair follicle cells are also found in alopecia areata sufferers. In addition, the disease coexists with other autoimmune disorders and can come secondary to infections or inflammation. However, despite the growing knowledge about alopecia areata, the aetiology and pathophysiology of disease are not well defined. In this review we discuss various genetic and environmental factors that cause autoimmunity and describe the immune mechanisms that lead to hair loss in alopecia areata patients.
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Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition
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Cited by
Mahmud, M. R., Akter, S., Tamanna, S. K., Mazumder, L., Esti, I. Z., Banerjee, S., Akter, S., Hasan, M. R., Acharjee, M., Hossain, M. S., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2096995 · Cited by 466
The Human Skin Microbiome in Selected Cutaneous Diseases
Carmona-Cruz, S., Orozco-Covarrubias, L., & Sáez-de-Ocariz, M. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.834135 · Cited by 170
Xie, W.-R., Yang, X.-Y., Xia, H. H.-X., Wu, L.-H., & He, X.-X. (2019) · World Journal of Clinical Cases · doi:10.12998/wjcc.v7.i19.3074 · Cited by 67
Carambia, A., Gottwick, C., Schwinge, D., Stein, S., Digigow, R., Şeleci, M., Mungalpara, D., Heine, M., Schuran, F. A., Corban, C., et al. (2021) · Immunology · doi:10.1111/imm.13298 · Cited by 30
Kim, K., Jang, H., Kim, E., Kim, H., & Sung, G. Y. (2023) · Experimental Dermatology · doi:10.1111/exd.14940 · Cited by 24
Metadata
- Authors
- Simakou, T., Butcher, J. P., Reid, S., & Henriquez, F. L.
- Venue
- Journal of Autoimmunity
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 98
- Pages
- 74-85
- ISSN
- 0896-8411 (ISSN-L)
- OpenAlex
- W2903645751
- Cited by
- 309
- References
- 92
- FWCI
- 14.97
- Type
- journal article
- Language
- en
- Open access
- green
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