Cited by 500SARS-CoV-2 and COVID-19 ResearchCellular transport and secretionSARS-CoV-2 detection and testing

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SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis

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Bayati, Armin, Kumar, Rahul, Francis, Vincent, McPherson, Peter S.·2021·Journal of Biological Chemistry

DOI 10.1016/j.jbc.2021.100306PMC PMC7816624

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of COVID-19, so understanding its biology and infection mechanisms is critical to facing this major medical challenge. SARS-CoV-2 is known to use its spike glycoprotein to interact with the cell surface as a first step in the infection process. As for other coronaviruses, it is likely that SARS-CoV-2 next undergoes endocytosis, but whether or not this is required for infectivity and the precise endocytic mechanism used are unknown. Using purified spike glycoprotein and lentivirus pseudotyped with spike glycoprotein, a common model of SARS-CoV-2 infectivity, we now demonstrate that after engagement with the plasma membrane, SARS-CoV-2 undergoes rapid, clathrin-mediated endocytosis. This suggests that transfer of viral RNA to the cell cytosol occurs from the lumen of the endosomal system. Importantly, we further demonstrate that knockdown of clathrin heavy chain, which blocks clathrin-mediated endocytosis, reduces viral infectivity. These discoveries reveal that SARS-CoV-2 uses clathrin-mediated endocytosis to gain access into cells and suggests that this process is a key aspect of virus infectivity.

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Additional file 6 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
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Additional file 2 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
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Additional file 7 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
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Additional file 4 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
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Additional file 1 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
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Additional file 5 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
Cheng, F.-J., Ho, C.-Y., Li, T.-S., Chen, Y., Yeh, Y.-L., Wei, Y.-L., Huynh, T. K., Chen, B.-R., Ko, H.-Y., Hsueh, C.-S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23597398
Additional file 3 of Umbelliferone and eriodictyol suppress the cellular entry of SARS-CoV-2
Cheng, F.-J., Ho, C.-Y., Li, T.-S., Chen, Y., Yeh, Y.-L., Wei, Y.-L., Huynh, T. K., Chen, B.-R., Ko, H.-Y., Hsueh, C.-S., et al. (2023) · Figshare · doi:10.6084/m9.figshare.23597392
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Authors: Bayati, A., Kumar, R., Francis, V., & McPherson, P. S.
Affiliations: Montreal Neurological Institute and Hospital (CA)
Corresponding author: McPherson, Peter S.
ORCID: Bayati, Armin
Kumar, Rahul
Francis, Vincent
McPherson, Peter S.
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 2021-01
Volume: 296
Pages: 100306
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/j.jbc.2021.100306
PMC: PMC7816624
OpenAlex: W3121790907
Cited by: 499
References: 55
Citations by year: 2026: 28 · 2025: 53 · 2024: 87 · 2023: 106 · 2022: 150 · 2021: 70
FWCI: 32.78
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 15 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Natural Sciences and Engineering Research Council of Canada
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
Keywords: SARS-CoV-2, clathrin-mediated endocytosis, viral entry, spike protein, clathrin heavy chain, endosomal escape, COVID-19 pandemic, infection mechanism
MeSH terms: A549 Cells, Angiotensin-Converting Enzyme 2, SARS-CoV-2, Animals, Chlorocebus aethiops, Endocytosis, Gene Expression Regulation, Genetic Vectors, Humans, Hydrazones, Protein Binding, Endosomes, Sulfonamides, Vero Cells, Signal Transduction, Lentivirus, Clathrin Heavy Chains, RNA, Small Interfering, Virus Internalization, Thiazolidines, Host-Pathogen Interactions, HEK293 Cells, Spike Glycoprotein, Coronavirus

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SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis

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