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SORL1 is a receptor for tau that promotes tau seeding

Cooper, Joanna M., Lathuiliere, Aurelien, Su, Enming J., Song, Yuyu, Torrente, Daniel, Jo, Youhwa, Weinrich, Nicholas, Sales, Jennifer Diaz, Migliorini, Mary, Sisson, Thomas H., Lawrence, Daniel A., Hyman, Bradley T., Strickland, Dudley K.·2024·Journal of Biological Chemistry
DOI 10.1016/j.jbc.2024.107313PMC PMC11145553
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  • Short-term modulation of SORLA in a human cell line may have differing effects on exogenously internalized tau compared to global SORLA modulation in aged PS19 mouse brain.

    “This suggests that short-term modulation of SORLA in a human cell line may have differing effects on exogenously internalized tau (Cooper, Lathuiliere et al. 2024) compared to global SORLA modulation in aged PS19 mouse brain.”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Cooper, Lathuiliere et al. 2024

  • Observations that SORLA can potentially enhance intracellular tau seeding from exogenous tau exposure are so far only seen in cultured cell lines.

    “While observations that SORLA can potentially enhance intracellular tau seeding from exogenous tau exposure are interesting, these effects are so far only seen in cultured cell lines (Cooper, Lathuiliere et al. 2024).”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Cooper, Lathuiliere et al. 2024

  • SORLA can interact directly with tau through interactions with the N-terminal SORLA VSP10 domain, and SORLA can promote tau aggregation and seeding from tau-enriched fractions in AD brain samples in an HEK293 tau-RD FRET biosensor model.

    “recent evidence suggests that SORLA can interact directly with tau through interactions with the N-terminal SORLA VSP10 domain, and SORLA can promote tau aggregation and seeding from tau-enriched fractions in AD brain samples in an HEK293 tau-RD FRET biosensor model (Cooper, Lathuiliere et al. 2024)”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Cooper, Lathuiliere et al. 2024

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Research works printed but not linked: 50

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Metadata

Authors
Cooper, J. M., Lathuiliere, A., Su, E. J., Song, Y., Torrente, D., Jo, Y., Weinrich, N., Sales, J. D., Migliorini, M., Sisson, T. H., Lawrence, D. A., Hyman, B. T., & Strickland, D. K.
ORCID
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
2024-06
Volume
300
Issue
6
Pages
107313
ISSN
0021-9258
DOI
10.1016/j.jbc.2024.107313
PMC
PMC11145553
Cited by
25
References
9
Language
en
Licence
Funders
  • Alzheimer's Association
  • NHLBI
  • NIA

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