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Alzheimer's vulnerable brain region relies on a distinct retromer core dedicated to endosomal recycling

Simoes, Sabrina, Guo, Jia, Buitrago, Luna, Qureshi, Yasir H., Feng, Xinyang, Kothiya, Milankumar, Cortes, Etty, Patel, Vivek, Kannan, Suvarnambiga, Kim, Young-Hyun, Chang, Kyu-Tae, Hussaini, S. Abid, Moreno, Herman, Di Paolo, Gilbert, Andersen, Olav M., Small, Scott A.·2021·Cell Reports
DOI 10.1016/j.celrep.2021.110182PMC PMC8792909
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  • The endosomal network is a key biological pathway affected in neurodegenerative pathology.

    “These studies, alongside clinical evidence [8][9][10][11][12][13][14], highlight the endosomal network as a key biological pathway affected in neurodegenerative pathology.”

    From Global identification of neuronal and astrocytic integral membrane proteins that require Retromer for their endosomal recycling (2026) · cites this paper as [12]

    The Introduction identifies endosomal trafficking as a pathogenic pathway in Alzheimer’s disease, and the Discussion links impaired endosomal recycling to its pathology. The claim extends that finding to neurodegenerative pathology generally; the paper’s substantive discussion here is specific to Alzheimer’s disease. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • Deletion of a neuron-specific VPS26 isoform (VPS26b) in mouse brain is associated with decreased total and cell-surface SORLA levels, as well as increased murine brain Aβ and CSF tau.

    “Interestingly, deletion of a neuron-specific VPS26 isoform (VPS26b) in mouse brain is associated with decreased total and cell-surface SORLA levels, as well as increased murine brain Aβ and CSF tau (Simoes, Guo et al. 2021), implicating interdependent roles for retromer, SORLA and AD pathology.”

    From SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain (2026) · cites this paper as Simoes, Guo et al. 2021

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Research works printed but not linked: 66

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Metadata

Authors
Simoes, S., Guo, J., Buitrago, L., Qureshi, Y. H., Feng, X., Kothiya, M., Cortes, E., Patel, V., Kannan, S., Kim, Y.-H., Chang, K.-T., Hussaini, S. A., Moreno, H., Di Paolo, G., Andersen, O. M., & Small, S. A.
Venue
Cell Reports
Publisher
Elsevier BV
Published
2021-12
Volume
37
Issue
13
Pages
110182
ISSN
2211-1247
DOI
10.1016/j.celrep.2021.110182
PMC
PMC8792909
Cited by
68
References
9
Language
en
Licence
Funders
  • Eli Lilly and Company
  • Denali Therapeutics
  • Genentech
  • H. Lundbeck A/S
  • Merck
  • Janssen Research and Development
  • Northern California Institute for Research and Education
  • National Institute of Biomedical Imaging and Bioengineering
  • Fujirebio US
  • GE Healthcare
  • National Institutes of Health (AG034618, AG035015, AG051556, NS056049, P30AG066462, U01 AG024904)
  • F. Hoffmann-La Roche
  • DOD (W81XWH-12-2-0012)
  • Alzheimer's Disease Neuroimaging Initiative
  • National Institute on Aging
  • University of Southern California
  • Alzheimer's Disease Research Center, Emory University

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