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Activation and Functional Characterization of the Mosaic Receptor SorLA/LR11
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Removal of all N-linked glycans by PNGase F resulted in a single band migrating at ~250 kDa, corresponding to the predicted molecular weight of full-length SorLA.
“As previously shown [3, 9], removal of all N-linked glycans by treatment with PNGase F resulted in a single band that migrates at ~ 250 kDa, which corresponds to the predicted molecular weight of the full-length SorLA (SorLAFL) protein (Fig. 2a).”
From Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease (2021) · cites this paper as [3]
In the SorLA localization results (Fig. 8D; page unavailable), the paper reports that PNGase-F deglycosylation of SorLA from transfected cells produced a single band. Our copy does not state that the band migrated at approximately 250 kDa or that this matched the predicted molecular weight of full-length SorLA. (LLM, conf=0.86)
Experimental — accuracy not yet measuredNewly synthesized SorLA molecules follow the constitutive secretory pathway from the ER to the cell surface through the Golgi, and undergo post-translational modifications and maturation, resulting in immature and mature species.
“Newly synthesized SorLA molecules follow the constitutive secretory pathway from the endoplasmic reticulum (ER) to the cell surface, through the Golgi. During their transport through the secretory pathway, SorLA proteins are subjected to several post-translational modifications, including both N- and O-glycosylation, and maturation processes [3–9], resulting in the presence of immature and mature”
From Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease (2021) · cites this paper as [3]
The Discussion states that SorLA is synthesized as an inactive proreceptor and matures through propeptide cleavage in the late Golgi/TGN. The results also show differential glycosylation and about 10% of full-length SorLA at the cell surface. Our copy does not establish O-glycosylation or describe a constitutive ER-to-surface route for newly synthesized SorLA. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe presence of both immature and mature species at the plasma membrane in HEK293 cells could be related to overexpression of SorLA and saturation of the ER quality control system.
“The presence of both species at the plasma membrane in HEK293 cells, which is consistent with the data previously reported by other groups [3, 9], could therefore be related to the overexpression of SorLA and the saturation of the ER quality control system.”
From Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease (2021) · cites this paper as [3]
The cell-surface localization results (Fig. 8, page unavailable) show a double band for SorLA, including in the surface-biotinylated fraction, and identify differential glycosylation. This is consistent with two surface species, but the experiments used CHO cells, not HEK293 cells, and do not identify the bands as immature and mature. The proposed ER-quality-control explanation is the citing authors’ inference, not a finding attributed to this source. (LLM, conf=0.82)
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Metadata
- Authors
- Jacobsen, L., Madsen, P., Jacobsen, C., Nielsen, M. S., Gliemann, J., & Petersen, C. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2001-06
- Volume
- 276
- Issue
- 25
- Pages
- 22788-22796
- ISSN
- 0021-9258
- Cited by
- 157
- References
- 0
- Language
- en
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