Cited by 360Diet, Metabolism, and DiseaseAdipokines, Inflammation, and Metabolic DiseasesGut microbiota and health

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Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

Gao, Xiang, Liu, Xiaofang, Xu, Jie, Xue, Changhu, Xue, Yong, Wang, Yuming·2014·Journal of Bioscience and Bioengineering

DOI 10.1016/j.jbiosc.2014.03.001

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Abstract

Trimethylamine N-oxide (TMAO) is an oxidation product of trimethylamine (TMA) and is present in many aquatic foods. Here, we investigated the effects of TMAO on glucose tolerance in high fat diet (HFD)-fed mice. Male C57BL/6 mice were randomly assigned to the control, high fat (HF), and TMAO groups. The HF group was fed a diet containing 25% fat, and the TMAO group was fed the HFD plus 0.2% TMAO for 4 weeks. After 3 weeks of feeding, oral glucose tolerance tests were performed. Dietary TMAO increased fasting insulin levels and homeostasis model assessment-estimated insulin resistance (HOMA-IR) and exacerbated the impaired glucose tolerance in HFD-fed mice. These effects were associated with the expression of genes related to the insulin signal pathway, glycogen synthesis, gluconeogenesis and glucose transport in liver. mRNA levels of the pro-inflammatory cytokine MCP-1 increased significantly and of the anti-inflammatory cytokine IL-10 greatly decreased in adipose tissue. Our results suggest that dietary TMAO exacerbates impaired glucose tolerance, obstructs the hepatic insulin signaling pathway, and causes adipose tissue inflammation in mice fed a high fat diet.

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Authors: Gao, X., Liu, X., Xu, J., Xue, C., Xue, Y., & Wang, Y.
Affiliations: Ocean University of China (CN)
Corresponding author: Wang, Yuming
ORCID: Gao, Xiang
Liu, Xiaofang
Xu, Jie
Xue, Changhu
Xue, Yong
Wang, Yuming
Venue: Journal of Bioscience and Bioengineering
Publisher: Elsevier BV
Published: 2014-10
Volume: 118
Issue: 4
Pages: 476-481
ISSN: 1347-4421 (ISSN-L)
1389-1723
DOI: 10.1016/j.jbiosc.2014.03.001
OpenAlex: W1965021718
Cited by: 360
References: 44
Citations by year: 2026: 26 · 2025: 40 · 2024: 35 · 2023: 36 · 2022: 42 · 2021: 42 · 2020: 34 · 2019: 33 · 2018: 18 · 2017: 21 · 2016: 19 · 2015: 12 · 2014: 2
FWCI: 14.47
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Bioscience and Bioengineering (publishedVersion)
PubMed (publishedVersion)
Funders: the National Key Technology R&D Program (2012BAD33B07)
National Natural Science Foundation of China (31371757)
Program for Changjiang Scholars and Innovative Research Team in University (IRT1188)
Taishan Scholars Programme of Shandong Province
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: trimethylamine N-oxide, impaired glucose tolerance, high-fat diet, insulin resistance, hepatic insulin signaling, hepatic gluconeogenesis, hepatic glycogen synthesis, adipose tissue inflammation, MCP-1, IL-10, fasting insulin
MeSH terms: Adipose Tissue, Animals, Blood Glucose, Dietary Fats, Fasting, Glucose Tolerance Test, Inflammation, Insulin, Insulin Resistance, Liver, Male, Methylamines, Mice, Inbred C57BL, Interleukin-10, Glucose Intolerance, Chemokine CCL2, Mice, Diet, High-Fat

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Dietary trimethylamine N-oxide exacerbates impaired glucose tolerance in mice fed a high fat diet

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