Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
Open accessAbstract
Bone cancers are characterised by the development of tumour cells in bone sites, associated with a dysregulation of their environment. In the last two decades, numerous therapeutic strategies have been developed to target the cancer cells or tumour niche. As the crosstalk between these two entities is tightly controlled by the release of polypeptide mediators activating signalling pathways through several receptor tyrosine kinases (RTKs), RTK inhibitors have been designed. These inhibitors have shown exciting clinical impacts, such as imatinib mesylate, which has become a reference treatment for chronic myeloid leukaemia and gastrointestinal tumours. The present review gives an overview of the main molecular and functional characteristics of RTKs, and focuses on the clinical applications that are envisaged and already assessed for the treatment of bone sarcomas and bone metastases.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
One proposal is that osteosarcoma begins when osteoblastic lineage cells transform malignantly at different differentiation stages, with pathways including Notch, Wnt, and RTK promoting uncontrolled proliferation.
“Osteosarcoma cells are thought to originate from the malignant transformation of cells within the osteoblastic lineage at any stage of differentiation, which is controlled by numerous cellular signalling pathways (for example, Notch, Wnt and RTK) that can initiate uncontrolled proliferation 202,203,204,205 .”
From Osteosarcoma (2022) · cites this paper as [204]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Lynch, T. J., Bell, D. W., Sordella, R., Gurubhagavatula, S., Okimoto, R. A., Brannigan, B. W., Harris, P. L., Haserlat, S. M., Supko, J. G., Haluska, F. G., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa040938 · Cited by 11,486 · see citing works
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929 · see citing works
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738 · see citing works
Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., & Roux, P. P. (2011) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-10 · Cited by 3,274 · see citing works
Met, metastasis, motility and more
Birchmeier, C., Birchmeier, W., Gherardi, E., & Woude, G. V. (2003) · Nature reviews. Molecular cell biology · doi:10.1038/nrm1261 · Cited by 2,667 · see citing works
The activation of Akt/PKB signaling pathway and cell survival
Song, G., Ouyang, G., & Bao, S. (2005) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2005.tb00337.x · Cited by 1,891 · see citing works
ERK1/2 MAP kinases: Structure, function, and regulation
Roskoski, R. J. (2012) · Pharmacological Research · doi:10.1016/j.phrs.2012.04.005 · Cited by 1,642 · see citing works
Differential regulation and properties of MAPKs
Raman, M., Chen, W., & Cobb, M. H. (2007) · Oncogene · doi:10.1038/sj.onc.1210392 · Cited by 1,430 · see citing works
MET signalling: principles and functions in development, organ regeneration and cancer
Trusolino, L., Bertotti, A., & Comoglio, P. M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3012 · Cited by 1,244 · see citing works
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains
Ogiso, H., Ishitani, R., Nureki, O., Fukai, S., Yamanaka, M., Kim, J.-H., Saito, K., Sakamoto, A., Inoue, M., Shirouzu, M., et al. (2002) · Cell · doi:10.1016/s0092-8674(02)00963-7 · Cited by 1,227 · see citing works
The protein tyrosine kinase family of the human genome
Robinson, D. R., Wu, Y., & Lin, S. (2000) · Oncogene · doi:10.1038/sj.onc.1203957 · Cited by 1,179 · see citing works
Protein Tyrosine Kinase Structure and Function
Hubbard, S. R., & Till, J. H. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.373 · Cited by 1,176 · see citing works
Activating HER2 Mutations in HER2 Gene Amplification Negative Breast Cancer
Bose, R., Kavuri, S. M., Searleman, A. C., Shen, W., Shen, D., Koboldt, D. C., Monsey, J. D., Goel, N. J., Aronson, A. B., Li, S., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0349 · Cited by 869 · see citing works
Liao, W., Lin, J., & Leonard, W. J. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.08.003 · Cited by 744 · see citing works
Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 710 · see citing works
Biscardi, J. S., Maa, M.-C., Tice, D. A., Cox, M. E., Leu, T.-H., & Parsons, S. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.8335 · Cited by 649 · see citing works
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
Santos, S. D. M., Verveer, P. J., & Bastiaens, P. I. H. (2007) · Nature Cell Biology · doi:10.1038/ncb1543 · Cited by 609 · see citing works
Decoding signalling networks by mass spectrometry-based proteomics
Choudhary, C., & Mann, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2900 · Cited by 575 · see citing works
Receptor tyrosine kinases: mechanisms of activation and signaling
Hubbard, S. R., & Miller, W. T. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.010 · Cited by 535 · see citing works
Feedback control of intercellular signalling in development
Freeman, M. (2000) · Nature · doi:10.1038/35042500 · Cited by 534 · see citing works
The Bone Marrow Microenvironment as a Tumor Sanctuary and Contributor to Drug Resistance
Meads, M. B., Hazlehurst, L., & Dalton, W. S. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2223 · Cited by 519 · see citing works
A module of negative feedback regulators defines growth factor signaling
Amit, I., Citri, A., Shay, T., Lu, Y., Katz, M., Zhang, F., Tarcic, G., Siwak, D. R., Lahad, J. P., Jacob‐Hirsch, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1987 · Cited by 488 · see citing works
The interplay between Src family kinases and receptor tyrosine kinases
Bromann, P. A., Körkaya, H., & Courtneidge, S. A. (2004) · Oncogene · doi:10.1038/sj.onc.1208079 · Cited by 451 · see citing works
Smith, D. C., Smith, M. R., Sweeney, C. J., Elfiky, A. A., Logothetis, C. J., Corn, P. G., Vogelzang, N. J., Small, E. J., Harzstark, A. L., Gordon, M. S., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.0494 · Cited by 446 · see citing works
VEGF: an Essential Mediator of Both Angiogenesis and Endochondral Ossification
Dai, J., & Rabie, A. B. M. (2007) · Journal of Dental Research · doi:10.1177/154405910708601006 · Cited by 403 · see citing works
Role of protein ubiquitylation in regulating endocytosis of receptor tyrosine kinases
Marmor, M. D., & Yarden, Y. (2004) · Oncogene · doi:10.1038/sj.onc.1207390 · Cited by 382 · see citing works
Moro, L., Dolce, L., Cabodi, S., Bergatto, E., Erba, E. B., Smeriglio, M., Turco, E., Retta, S. F., Giuffrida, M. G., Venturino, M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109101200 · Cited by 378 · see citing works
Grignani, G., Palmerini, E., Dileo, P., Asaftei, S. D., D’Ambrosio, L., Pignochino, Y., Mercuri, M., Picci, P., Fagioli, F., Casali, P. G., et al. (2012) · Annals of Oncology · doi:10.1093/annonc/mdr151 · Cited by 359 · see citing works
Dikič, I., & Giordano, S. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00004-8 · Cited by 342 · see citing works
Moriki, T., Maruyama, H., & MARUYAMA, I. N. (2001) · Journal of Molecular Biology · doi:10.1006/jmbi.2001.4923 · Cited by 337 · see citing works
Hepatocyte growth factor and its receptor (c-MET) in prostatic carcinoma.
Humphrey, P. A., Zhu, X., Zarnegar, R., et al. (1995) · PubMed · Cited by 332 · see citing works
Lu, Z., Jiang, G., Blume‐Jensen, P., & Hunter, T. R. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.12.4016-4031.2001 · Cited by 330 · see citing works
Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits
Jiang, X., Huang, F., Marusyk, A., & Sorkin, A. D. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-08-0532 · Cited by 322 · see citing works
Uehara, H., Kim, S. J., Karashima, T., Shepherd, D. L., Fan, D., Tsan, R., Killion, J. J., Logothetis, C. J., Mathew, P. F., & Fidler, I. J. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/95.6.458 · Cited by 280 · see citing works
C-met Proto-Oncogene Expression in Benign and Malignant Human Prostate Tissues
Pisters, L. L., Troncoso, P., Zhau, H. E., Li, W., von Eschenbach, A. C., & Chung, L. W. K. (1995) · The Journal of Urology · doi:10.1016/s0022-5347(01)67297-5 · Cited by 269 · see citing works
Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma.
Tuck, A. B., Park, M., Sterns, E. E., Boag, A., & Elliott, B. E. (1996) · Europe PMC (PubMed Central) · Cited by 244 · see citing works
Ebb, D., Meyers, P., Grier, H., Bernstein, M., Gorlick, R., Lipshultz, S. E., Krailo, M., Devidas, M., Barkauskas, D. A., Siegal, G. P., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.37.4546 · Cited by 243 · see citing works
Chugh, R. K., Wathen, J. K., Maki, R. G., Benjamin, R. S., PATEL, S. R., Myers, P. A., Priebat, D. A., Reinke, D. K., Thomas, D. G., Keohan, M. L., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.20.5054 · Cited by 232 · see citing works
Araujo, J. C., Trudel, G. C., Fred Saad, C., Armstrong, A. J., Yu, E. Y., Joaquim Bellmunt, B., Wilding, G., McCaffrey, J., Serrano, S. V., Matveev, V. B., et al. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70479-0 · Cited by 231 · see citing works
Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia
Meshinchi, S., & Appelbaum, F. R. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1123 · Cited by 224 · see citing works
The dual role of IL-6-type cytokines on bone remodeling and bone tumors
Blanchard, F., Duplomb, L., Baud’huin, M., & Royer, B. B.-L. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.11.004 · Cited by 221 · see citing works
Phase II Study of Dasatinib in Patients with Metastatic Castration-Resistant Prostate Cancer
Yu, E. Y., Wilding, G., Posadas, E. M., Gross, M. E., Culine, S., Massard, C., Morris, M. J., Hudes, G. R., Calabrò, F., Cheng, S., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1691 · Cited by 219 · see citing works
Bond, M. C., Bernstein, M. L., Pappo, A. S., Schultz, K. R., Krailo, M., Blaney, S. M., & Adamson, P. C. (2007) · Pediatric Blood & Cancer · doi:10.1002/pbc.21132 · Cited by 210 · see citing works
Ponzo, M. G., Lesurf, R., Petkiewicz, S., O’Malley, F. P., Pinnaduwage, D., Andrulis, I. L., Bull, S. B., Chughtai, N., Zuo, D., Souleimanova, M., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810402106 · Cited by 204 · see citing works
Ralston, R., & Bishop, J. M. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.23.7845 · Cited by 203 · see citing works
Liu, Y., & Rohrschneider, L. R. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)02425-0 · Cited by 199 · see citing works
Michaelson, M. D., Oudard, S. M., Ou, Y.-C., Sengeløv, L., Fred Saad, C., Houédé, N., Ostler, P. J., Stenzl, A., Daugaard, G., Jones, R. J., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.48.5268 · Cited by 194 · see citing works
The Class II cytokine receptor (CRF2) family: overview and patterns of receptor–ligand interactions
Langer, J. A., Cutrone, E. C., & Kotenko, S. V. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2003.10.001 · Cited by 193 · see citing works
A Phase II Clinical Trial of Sorafenib in Androgen-Independent Prostate Cancer
Dahut, W. L., Scripture, C. D., Posadas, E. M., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1355 · Cited by 182 · see citing works
Pignochino, Y., Grignani, G., Cavalloni, G., Motta, M., Tapparo, M., Bruno, S., Bottos, A., Gammaitoni, L., Migliardi, G., Camussi, G., et al. (2009) · Molecular Cancer · doi:10.1186/1476-4598-8-118 · Cited by 180 · see citing works
Osborne, C. K., Neven, P., Dirix, L. Y., Mackey, J. R., Robert, J., Underhill, C. R., Schiff, R., Gutiérrez, C., Migliaccio, I., Anagnostou, V., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1869 · Cited by 179 · see citing works
Bender, J. G., Lee, A., Reid, J. M., et al. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.47.0914 · Cited by 168 · see citing works
Bone cell interactions through Eph/ephrin: Bone modeling, remodeling and associated diseases
Matsuo, K., & Otaki, N. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20888 · Cited by 167 · see citing works
Cristofanilli, M., Valero, V., Mangalik, A., Royce, M., Rabinowitz, I., Arena, F. P., Kroener, J. F., Curcio, E., Watkins, C. L., Bacus, S. S., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-2282 · Cited by 156 · see citing works
Evolution of Class I cytokine receptors
Liongue, C., & Ward, A. C. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-120 · Cited by 150 · see citing works
Beuselinck, B., Oudard, S. M., Rixe, O., et al. (2010) · Annals of Oncology · doi:10.1093/annonc/mdq554 · Cited by 149 · see citing works
Dysregulation of bone remodeling by imatinib mesylate
Vandyke, K., Fitter, S., Dewar, A. L., Hughes, T. P., & Zannettino, A. C. W. (2009) · Blood · doi:10.1182/blood-2009-08-237404 · Cited by 138 · see citing works
Sonpavde, G., Periman, P., Bernold, D. M., Weckstein, D. J., Fleming, M. T., Galsky, M. D., Berry, W. R., Zhan, F., Boehm, K. A., Asmar, L., et al. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp323 · Cited by 137 · see citing works
Function of matrix IGF-1 in coupling bone resorption and formation
Crane, J. L., & Cao, X. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1084-3 · Cited by 133 · see citing works
VEGF and bone cell signalling: an essential vessel for communication?
Clarkin, C., & Gerstenfeld, L. C. (2012) · Cell Biochemistry and Function · doi:10.1002/cbf.2911 · Cited by 130 · see citing works
Small GTP-binding protein-coupled receptors
Bhattacharya, M., Babwah, A. V., & Ferguson, S. S. G. (2004) · Biochemical Society Transactions · doi:10.1042/bst0321040 · Cited by 130 · see citing works
Smith, M. R., Sweeney, C. J., Corn, P. G., Rathkopf, D. E., Smith, D. C., Hussain, M., George, D. J., Higano, C. S., Harzstark, A. L., Sartor, O. A., et al. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2013.54.5954 · Cited by 129 · see citing works
An EGF receptor/Ral‐GTPase signaling cascade regulates c‐Src activity and substrate specificity
Goi, T., Shipitsin, M. V., Lu, Z., Foster, D. A., Klinz, S. G., & Feig, L. A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.4.623 · Cited by 129 · see citing works
Mathew, P. F., Thall, P. F., JONES, D. M., Perez, C. A., Bucana, C. D., Troncoso, P., Kim, S.-J., Fidler, I. J., & Logothetis, C. J. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.10.116 · Cited by 125 · see citing works
The GIST paradigm: lessons for other kinase‐driven cancers
Antonescu, C. R. (2010) · The Journal of Pathology · doi:10.1002/path.2798 · Cited by 123 · see citing works
Aplenc, R., Blaney, S. M., Strauss, L. C., Balis, F. M., Shusterman, S., Ingle, A. M., Agrawal, S., Sun, J., Wright, J. J., & Adamson, P. C. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.7231 · Cited by 122 · see citing works
Aragon‐Ching, J. B., Jain, L., Gulley, J. L., Arlen, P. M., Wright, J. J., Steinberg, S. M., Draper, D., Venitz, J., Jones, E. C., Chen, C. C., et al. (2009) · British Journal of Urology · doi:10.1111/j.1464-410x.2008.08327.x · Cited by 118 · see citing works
Garbers, D. L., Koesling, D., & Schultz, G. (1994) · Molecular Biology of the Cell · doi:10.1091/mbc.5.1.1 · Cited by 114 · see citing works
McGary, E. C., WEBER, K. L., Mills, L., Doucet, M., Lewis, V., Lev, D. C., Fidler, I. J., & Bar‐Eli, M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1101 · Cited by 113 · see citing works
DuBois, S. G., Shusterman, S., Ingle, A. M., Ahern, C. H., Reid, J. M., Wu, B. H., Baruchel, S., Bender, J. G., Ivy, P. S., Grier, H. E., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0237 · Cited by 112 · see citing works
Han, J., Tian, R., Yong, B., Luo, C., Tan, P., Shen, J., & Peng, T. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.05.019 · Cited by 109 · see citing works
Liu, Y., Karaca, M., Zhang, Z., Gioeli, D., Earp, H. S., & Whang, Y. E. (2010) · Oncogene · doi:10.1038/onc.2010.103 · Cited by 106 · see citing works
“RAF” neighborhood: Protein–protein interaction in the Raf/Mek/Erk pathway
Cseh, B., Doma, E., & Baccarini, M. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.06.025 · Cited by 104 · see citing works
Neia, C. P., Migliardi, G., Grand, M. M., et al. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-31 · Cited by 98 · see citing works
Wan, X., Corn, P. G., Yang, J., Palanisamy, N., Starbuck, M. W., Efstathiou, E., Tapia, E. M. L. N., Zurita, A. J., Aparicio, A. M., Ravoori, M. K., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009332 · Cited by 96 · see citing works
IR/IGF1R signaling as potential target for treatment of high-grade osteosarcoma
Kuijjer, M. L., Peterse, E. F. P., van den Akker, B. E., Bruijn, I. H. B., Serra, M., Meza‐Zepeda, L. A., Myklebost, O., Hassan, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-245 · Cited by 95 · see citing works
Kim, S.-J., Uehara, H., Yazıcı, S., Busby, J. E., Nakamura, T., He, J., Maya, M., Logothetis, C. J., Mathew, P. F., Wang, X., et al. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj211 · Cited by 94 · see citing works
Koreckij, T. D., Nguyen, H. M., Brown, L. G., Yu, E. Y., Vessella, R. L., & Corey, E. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605178 · Cited by 92 · see citing works
Yu, E. Y., Massard, C., Gross, M. E., et al. (2011) · Urology · doi:10.1016/j.urology.2011.01.006 · Cited by 91 · see citing works
Whang, Y. E., Armstrong, A. J., Rathmell, W. K., Godley, P. A., Kim, W. Y., Pruthi, R. S., Wallen, E., Crane, J. M., Moore, D. T., Grigson, G., et al. (2011) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2010.09.018 · Cited by 89 · see citing works
Vandyke, K., Dewar, A. L., Diamond, P., Fitter, S., Schultz, C. G., Sims, N. A., & Zannettino, A. C. W. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.85 · Cited by 89 · see citing works
Mathew, P. F., Thall, P. F., Bucana, C. D., Oh, W. K., Morris, M. J., JONES, D. M., Johnson, M. M., Wen, S., Pagliaro, L. C., Tannir, N. M., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-1269 · Cited by 89 · see citing works
Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program
Maris, J. M., Courtright, J., Houghton, P. J., et al. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21535 · Cited by 85 · see citing works
Gross, M. E., Higano, C. S., Pantuck, A. J., Castellanos, O. O., Green, E., NGUYEN, K. N., & Agus, D. B. (2007) · BMC Cancer · doi:10.1186/1471-2407-7-142 · Cited by 85 · see citing works
Duan, Z., Choy, E., Harmon, D. C., Cao, Y., Ryu, K., Schwab, J. H., Mankin, H. J., & Hornicek, F. J. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0115 · Cited by 84 · see citing works
Kumar, S., Mokhtari, R. B., Sheikh, R., Wu, B. H., Zhang, L., Xu, P., Man, S., Oliveira, I. D., Yeger, H., Kerbel, R. S., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0078 · Cited by 83 · see citing works
Signaling Pathways Affecting Skeletal Health
Marie, P. J. (2012) · Current Osteoporosis Reports · doi:10.1007/s11914-012-0109-0 · Cited by 81 · see citing works
Nakajima, H., Ishikawa, Y., Furuya, M., et al. (2012) · Breast Cancer · doi:10.1007/s12282-012-0354-1 · Cited by 80 · see citing works
Fibroblast growth factor signaling controlling bone formation: An update
Marie, P. J. (2012) · Gene · doi:10.1016/j.gene.2012.01.086 · Cited by 80 · see citing works
González, I., Andreu, E. J., Panizo, A., et al. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-0778-03 · Cited by 79 · see citing works
Dasatinib as a Bone-Modifying Agent: Anabolic and Anti-Resorptive Effects
García-Gómez, A., Ocio, E. M., Crusoé, E. D. Q., Santamaría, C., Hernández‐Campo, P. M., Blanco, J. F., Sanchez-Guijo, F. M., Hernández‐Iglesias, T., Briñón, J. G., Fisac-Herrero, R. M., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034914 · Cited by 76 · see citing works
Sridhar, S. S., Hotte, S. J., Chin, J. L., et al. (2010) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e3181beac33 · Cited by 76 · see citing works
CYTOKINES, GROWTH FACTORS AND OSTEOCLASTS
Heymann, D., Guicheux, J., Gouin, F., Passuti, N., & Daculsi, G. (1998) · Cytokine · doi:10.1006/cyto.1997.0277 · Cited by 75 · see citing works
Self-citationNavid, F., Baker, S. D., McCarville, M. B., et al. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-1897 · Cited by 75 · see citing works
Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery
PosthumaDeBoer, J., Piersma, S. R., Pham, T. V., van Egmond, P. W., Knol, J. C., Cleton-Jansen, A. M., van Geer, M. A., van Beusechem, V. W., Kaspers, G. J. L., van Royen, B. J., et al. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.578 · Cited by 73 · see citing works
Lee, R. J., Saylor, P. J., Michaelson, M. D., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0319 · Cited by 73 · see citing works
Graham, T. J., Box, G., Tunariu, N., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju033 · Cited by 72 · see citing works
David, E., Blanchard, F., Heymann, M., Pinieux, G. D. B. D., Gouin, F., Rédiní, F., & Heymann, D. (2011) · Sarcoma · doi:10.1155/2011/932451 · Cited by 70 · see citing works
Self-citationRyan, C. J., Stadler, W. M., Roth, B. J., et al. (2007) · Investigational New Drugs · doi:10.1007/s10637-007-9050-y · Cited by 70 · see citing works
Fritsche‐Guenther, R., Noske, A., Ungethüm, U., Kuban, R., Schlag, P. M., Tunn, P., Karle, J., Krenn, V., Dietel, M., & Sers, C. (2010) · Histopathology · doi:10.1111/j.1365-2559.2010.03713.x · Cited by 69 · see citing works
Nguyen, H. M., Ruppender, N. S., Zhang, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078881 · Cited by 69 · see citing works
Hingorani, P., Zhang, W., Gorlick, R. G., & Kolb, E. A. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1657 · Cited by 68 · see citing works
Dib, I. E. H., Gallet, M., Mentaverri, R., et al. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.007 · Cited by 61 · see citing works
Expression and clinical relevance of MET and ALK in Ewing sarcomas
Fleuren, E. D. G., Roeffen, M. H. S., Leenders, W. P. J., et al. (2013) · International Journal of Cancer · doi:10.1002/ijc.28047 · Cited by 60 · see citing works
Sgambato, A., Camerini, A., Faraglia, B., et al. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20045 · Cited by 59 · see citing works
Previdi, S., Abbadessa, G., Dalò, F., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0277 · Cited by 58 · see citing works
Arkin, I. T. (2002) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(02)00580-1 · Cited by 57 · see citing works
Nabhan, C., Lestingi, T. M., Galvez, A. G., Tolzien, K., Kelby, S. K., Tsarwhas, D., Newman, S. B., & Bitran, J. D. (2009) · Urology · doi:10.1016/j.urology.2009.05.016 · Cited by 56 · see citing works
Hepatocyte growth factor/scatter factor expression and c-met in primary breast cancer
Nagy, J., Curry, G., Hillan, K. J., McKay, I. C., Mallon, E., Purushotham, A. D., & George, W. D. (1996) · Surgical Oncology · doi:10.1016/s0960-7404(96)80017-x · Cited by 55 · see citing works
Chao, J., Budd, G. T., Chu, P. G., et al. (2010) · PubMed · Cited by 55 · see citing works
Keizman, D., Ish‐Shalom, M., Пили, Р., et al. (2012) · European Journal of Cancer · doi:10.1016/j.ejca.2012.02.050 · Cited by 54 · see citing works
Truitt, L., & Freywald, A. (2011) · Biochemistry and Cell Biology · doi:10.1139/o10-145 · Cited by 54 · see citing works
Autoinhibitory mechanisms in receptor tyrosine kinases
Hubbard, S. R. (2002) · Frontiers in bioscience · doi:10.2741/a778 · Cited by 51 · see citing works
Erlotinib inhibits osteolytic bone invasion of human non-small-cell lung cancer cell line NCI-H292
Furugaki, K., Moriya, Y., Iwai, T., Yorozu, K., Yanagisawa, M., Kondoh, K., Fujimoto-Ouchi, K., & Mori, K. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9398-4 · Cited by 51 · see citing works
Pezaro, C. J., Rosenthal, M. A., Gurney, H., Davis, I. D., Underhill, C. R., Boyer, M. J., Kotasek, D., Solomon, B., & Toner, G. C. (2009) · American Journal of Clinical Oncology · doi:10.1097/coc.0b013e31818b946b · Cited by 51 · see citing works
Sampson, E. R., Martin, B., Morris, A. E., et al. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.336 · Cited by 50 · see citing works
Gobin, B., Moriceau, G., Ory, B., Charrier, C., Brion, R., Blanchard, F., Rédiní, F., & Heymann, D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090795 · Cited by 49 · see citing works
Self-citationYin, J. J., Zhang, L., Munasinghe, J., Linnoila, R. I., & Kelly, K. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1435 · Cited by 48 · see citing works
Fleuren, E. D. G., Hillebrandt-Roeffen, M. H. S., Flucke, U. E., Loo, D. M. W. M. T., Boerman, O. C., van der Graaf, W. T. A., & Versleijen‐Jonkers, Y. M. H. (2014) · Oncotarget · doi:10.18632/oncotarget.2648 · Cited by 47 · see citing works
Importance of Wnt Signaling in the Tumor Stroma Microenvironment
Macheda, M. L., & Stacker, S. A. (2008) · Current Cancer Drug Targets · doi:10.2174/156800908785699324 · Cited by 47 · see citing works
Araujo, J. C., Poblenz, A. T., Parikh, N. U., Starbuck, M. W., Thompson, J. T., Lee, F. Y., Logothetis, C. J., & Darnay, B. G. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.22.9770 · Cited by 46 · see citing works
Insulin-Like Growth Factor 1 Receptor and Response to Anti-IGF1R Antibody Therapy in Osteosarcoma
Cao, Y., Roth, M. E., Piperdi, S., Montoya, K., Sowers, R. S., Rao, P. H., Geller, D., Houghton, P. J., Kolb, E. A., Gill, J. B., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106249 · Cited by 45 · see citing works
The skeletal effects of the tyrosine kinase inhibitor nilotinib
O’Sullivan, S., Lin, J., Watson, M., Callon, K. E., Tong, P. C., Naot, D., Horne, A. M., Aati, O., Porteous, F., Gamble, G. D., et al. (2011) · Bone · doi:10.1016/j.bone.2011.04.014 · Cited by 45 · see citing works
Clemons, M. J., Cochrane, B., Pond, G. R., Califaretti, N., Chia, S., Dent, R. A., Song, X., Robidoux, A., Parpia, S., Warr, D. G., et al. (2014) · Breast Cancer Research and Treatment · doi:10.1007/s10549-014-3015-6 · Cited by 45 · see citing works
Merz, M., Komljenovic, D., Zwick, S., Semmler, W., & Bäuerle, T. (2010) · European Journal of Cancer · doi:10.1016/j.ejca.2010.08.019 · Cited by 45 · see citing works
Basch, E., Autio, K. A., Smith, M. R., Bennett, A. V., Weitzman, A., Scheffold, C., Sweeney, C. J., Rathkopf, D. E., Smith, D. C., George, D. J., et al. (2014) · European Urology · doi:10.1016/j.eururo.2014.02.013 · Cited by 43 · see citing works
Ligand-gated ion channel interacting proteins and their role in neuroprotection
Li, S., Wong, A. H. C., & Liu, F. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00125 · Cited by 43 · see citing works
D’Alessio, A., Luca, A. D., Maiello, M. R., et al. (2009) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0649-x · Cited by 43 · see citing works
Timeus, F. S., Crescenzio, N., Fandi, A., et al. (2008) · Oncology Reports · doi:10.3892/or.19.2.353 · Cited by 42 · see citing works
Targeted therapies for bone sarcomas
Heymann, D., & Rédiní, F. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.112 · Cited by 42 · see citing works
Self-citationSalzberg, M. O., Rochlitz, C. F., Morant, R., et al. (2007) · Oncology Research and Treatment · doi:10.1159/000102452 · Cited by 42 · see citing works
Epidermal Growth Factor Receptor: Is It a Feasible Target for the Treatment of Osteosarcoma?
Lee, J. A., Ko, Y., Kim, D. H., Lim, J. S., Kong, C., Cho, W. H., Jeon, D., Lee, S., & Koh, J.-S. (2012) · Cancer Research and Treatment · doi:10.4143/crt.2012.44.3.202 · Cited by 41 · see citing works
Carlson, R. W., O’Neill, A., Vidaurre, T., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-1997-5 · Cited by 41 · see citing works
Keir, S. T., Morton, C. L., Wu, J., et al. (2011) · Pediatric Blood & Cancer · doi:10.1002/pbc.24016 · Cited by 37 · see citing works
Imatinib mesylate and zoledronic acid in androgen-independent prostate cancer
Tiffany, N. M., Wersinger, E. M., Garzotto, M. G., et al. (2004) · Urology · doi:10.1016/j.urology.2003.12.022 · Cited by 36 · see citing works
Borghese, C., Cattaruzza, L., Pivetta, E., Normanno, N., Luca, A. D., Mazzucato, M., Celegato, M., Colombatti, A., & Aldinucci, D. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24456 · Cited by 35 · see citing works
Azad, A., Beardsley, E. K., Hotte, S. J., et al. (2014) · Investigational New Drugs · doi:10.1007/s10637-014-0091-8 · Cited by 33 · see citing works
Zwolak, P., Jasiński, P., Terai, K., et al. (2008) · European Journal of Cancer · doi:10.1016/j.ejca.2008.07.011 · Cited by 32 · see citing works
Receptor Tyrosine Kinases in Osteosarcoma: Not Just the Usual Suspects
Rettew, A. N., Getty, P. J., & Greenfield, E. M. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_3 · Cited by 30 · see citing works
Zhang, Y., Tang, Y.-J., Man, Y., Pan, F., Li, Z.-H., & Jia, L.-S. (2013) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201302600117 · Cited by 30 · see citing works
The role of the insulin-like growth factor (IGF) axis in osteogenic and odontogenic differentiation
Alkharobi, H. E., El-Gendy, R., DeVine, D., et al. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1508-9 · Cited by 29 · see citing works
Bachelier, R., Confavreux, C. B., Peyruchaud, O., Croset, M., Goehrig, D., van der Pluijm, G., & Clézardin, P. (2014) · International Journal of Cancer · doi:10.1002/ijc.28787 · Cited by 28 · see citing works
Bachelot, T., García-Sáenz, J. Á., Verma, S., et al. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-166 · Cited by 27 · see citing works
Receptor tyrosine kinase signaling mechanisms: Devolving TrkA responses with phosphoproteomics
Bradshaw, R. A., Chalkley, R. J., Biarc, J., et al. (2012) · Advances in Biological Regulation · doi:10.1016/j.jbior.2012.10.006 · Cited by 27 · see citing works
Bone Sarcomas: From Biology to Targeted Therapies
Gaspar, N., Giannatale, A. D., Geoerger, B., Rédiní, F., Corradini, N., Entz‐Werlé, N., Tirode, F., Marec‐Bérard, P., Gentet, J., Laurence, V., et al. (2012) · Sarcoma · doi:10.1155/2012/301975 · Cited by 27 · see citing works
Boccardo, F., RUBAGOTTI, A., Conti, G. N., et al. (2008) · Oncology · doi:10.1159/000151391 · Cited by 25 · see citing works
Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts.
Pinski, J., Weeraratna, A. T., Uzgare, A. R., et al. (2002) · PubMed · Cited by 25 · see citing works
Phase I study of dasatinib (BMS‐354825) in Japanese patients with solid tumors
Takahashi, S., Miyazaki, M., Okamoto, I., Ito, Y., Ueda, K., Seriu, T., Nakagawa, K., & Hatake, K. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.02041.x · Cited by 24 · see citing works
Somlo, G., Martel, C. L., Lau, S. K., Frankel, P. H., Ruel, C., Gu, L., Hurria, A., Chung, C. T., Luu, T., Morgan, R. J., et al. (2011) · Breast Cancer Research and Treatment · doi:10.1007/s10549-011-1850-2 · Cited by 24 · see citing works
Autoinhibitory mechanisms in receptor tyrosine kinases
Stevan, R. H. (2002) · Frontiers in bioscience · doi:10.2741/hubbard · Cited by 24 · see citing works
Bone sarcomas: pathogenesis and new therapeutic approaches
Heymann, D., & Rédiní, F. (2011) · IBMS BoneKEy · doi:10.1138/20110531 · Cited by 23 · see citing works
Self-citationIkeda, A. K., Judelson, D. R., Federman, N. C., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0812 · Cited by 20 · see citing works
Oncogenic activation of the PDGF β receptor by the transmembrane domain of p185neu*
Petti, L. M., Irusta, P. M., & DiMaio, D. (1998) · Oncogene · doi:10.1038/sj.onc.1201590 · Cited by 20 · see citing works
Previdi, S., Scolari, F., Chilà, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079101 · Cited by 17 · see citing works
HER-2 Involvement in Osteosarcoma
Gill, J. B., Geller, D., & Gorlick, R. G. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-04843-7_9 · Cited by 15 · see citing works
Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa)
Fu, M., Zhang, Y., Shan, L., et al. (2014) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-014-1566-x · Cited by 15 · see citing works
Managing GIST in the imatinib era: optimization of adjuvant therapy
Trent, J. C., & Subramanian, M. (2014) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.2014.952284 · Cited by 14 · see citing works
Pircher, M., Mlineritsch, B., Fridrik, M., et al. (2015) · PubMed · Cited by 13 · see citing works
Vallo, S., Mani, J., Stastny, M., Makarević, J., Juengel, E., Tsaur, I., Bartsch, G. C., Haferkamp, A., & Blaheta, R. A. (2012) · Investigational New Drugs · doi:10.1007/s10637-012-9851-5 · Cited by 11 · see citing works
Cabozantinib and Prostate Cancer: Inhibiting Seed and Disrupting Soil?
Lee, R. J., & Smith, M. R. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-2636 · Cited by 10 · see citing works
Adjuvant Therapy with Sorafenib in Bone Metastases Bilateral Renal Carcinoma: A Case Report
Sciarra, A., Gomez, A. M. A., Gentilucci, A., et al. (2007) · European Urology · doi:10.1016/j.eururo.2007.03.083 · Cited by 8 · see citing works
Bao, N., Lü, M., Bin, F.-W., Chang, Z.-Y., Meng, J., Zhou, L., Guo, T., & Zhao, J.-N. (2013) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Clézardin, P. (2013) · Bulletin du Cancer · doi:10.1684/bdc.2013.1836 · Cited by 5 · see citing works
Sorafenib inhibits in vitro osteoclastogenesis by down-modulating Mcl-1
Rimondi, E., Secchiero, P., Melloni, E., et al. (2012) · Investigational New Drugs · doi:10.1007/s10637-012-9903-x · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- [8]Bone cancer, primary bone cancers and bone metastases Heymann D. 2nd ed. 2014 Academic Press San Diego, USA
- [87]Rettew A.N. Getty P.J. Greenfield E.M. Receptor tyrosine kinases in osteosarcoma: not just the usual suspects Adv Exp Med Biol 804 2014 47 66 24924168
- [137]Previdi S. Scolari F. Chilà R. Ricci F. Abbadessa G. Broggini M. Combination of the c-Met inhibitor tivantinib and zoledronic acid prevents tumor bone engraftment and inhibits progression of established bone metastases in a breast xenograft model PLoS One 8 2013 e79101 24260160 PMC3832513
Cited by
Sorted by citations
Beird, H. C., Bielack, S. S., Flanagan, A. M., Gill, J., Heymann, D., Janeway, K. A., Livingston, J. A., Roberts, R. D., Strauss, S. J., & Gorlick, R. (2022) · Nature Reviews Disease Primers · doi:10.1038/s41572-022-00409-y · Cited by 660 · see citing works
Self-citationBiology of Bone Sarcomas and New Therapeutic Developments
Brown, H. K., Schiavone, K., Gouin, F., Heymann, M.-F., & Heymann, D. (2018) · Calcified Tissue International · doi:10.1007/s00223-017-0372-2 · Cited by 163 · see citing works
Self-citation
- Authors
- Ségaliny, A. I., Tellez-Gabriel, M., Heymann, M.-F., & Heymann, D.
- Affiliations
- Inserm (FR)
- Corresponding author
- Heymann, Marie-Françoise
- Heymann, Dominique
- Venue
- Journal of Bone Oncology
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 4
- Issue
- 1
- Pages
- 1-12
- ISSN
- 2212-1366 (ISSN-L)
- 2212-1374
- PMC
- PMC4620971
- OpenAlex
- W2045756126
- Cited by
- 164
- References
- 164
- Citations by year
- 2026: 2 · 2025: 16 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 21 · 2020: 20 · 2019: 29 · 2018: 13 · 2017: 14 · 2016: 8 · 2015: 4
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of bone oncology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
- HAL (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Seventh Framework Programme (FP7/2007-2013, 264817-BONE-NET)
- Region des Pays de la Loire
- Ligue Nationale Contre le Cancer
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
- Keywords
- receptor tyrosine kinase, receptor tyrosine kinase inhibitors, bone cancer, bone sarcoma, bone metastasis, tumor microenvironment, imatinib, signaling pathways, cancer therapy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review