Cited by 164Sarcoma Diagnosis and TreatmentCancer Mechanisms and TherapyLung Cancer Treatments and Mutations

Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

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Ségaliny, Aude I., Tellez-Gabriel, Marta, Heymann, Marie-Françoise, Heymann, Dominique·2015·Journal of Bone Oncology

Abstract

Bone cancers are characterised by the development of tumour cells in bone sites, associated with a dysregulation of their environment. In the last two decades, numerous therapeutic strategies have been developed to target the cancer cells or tumour niche. As the crosstalk between these two entities is tightly controlled by the release of polypeptide mediators activating signalling pathways through several receptor tyrosine kinases (RTKs), RTK inhibitors have been designed. These inhibitors have shown exciting clinical impacts, such as imatinib mesylate, which has become a reference treatment for chronic myeloid leukaemia and gastrointestinal tumours. The present review gives an overview of the main molecular and functional characteristics of RTKs, and focuses on the clinical applications that are envisaged and already assessed for the treatment of bone sarcomas and bone metastases.

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Crossref · 10.1016/j.jbo.2015.01.001

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  • One proposal is that osteosarcoma begins when osteoblastic lineage cells transform malignantly at different differentiation stages, with pathways including Notch, Wnt, and RTK promoting uncontrolled proliferation.

    “Osteosarcoma cells are thought to originate from the malignant transformation of cells within the osteoblastic lineage at any stage of differentiation, which is controlled by numerous cellular signalling pathways (for example, Notch, Wnt and RTK) that can initiate uncontrolled proliferation 202,203,204,205 .”

    From Osteosarcoma (2022) · cites this paper as [204]

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Research works printed but not linked: 3

  1. [8]Bone cancer, primary bone cancers and bone metastases Heymann D. 2nd ed. 2014 Academic Press San Diego, USA
  2. [87]Rettew A.N. Getty P.J. Greenfield E.M. Receptor tyrosine kinases in osteosarcoma: not just the usual suspects Adv Exp Med Biol 804 2014 47 66 24924168
  3. [137]Previdi S. Scolari F. Chilà R. Ricci F. Abbadessa G. Broggini M. Combination of the c-Met inhibitor tivantinib and zoledronic acid prevents tumor bone engraftment and inhibits progression of established bone metastases in a breast xenograft model PLoS One 8 2013 e79101 24260160 PMC3832513

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Authors
Ségaliny, A. I., Tellez-Gabriel, M., Heymann, M.-F., & Heymann, D.
Affiliations
Inserm (FR)
Corresponding author
  • Heymann, Marie-Françoise
  • Heymann, Dominique
Venue
Journal of Bone Oncology
Publisher
Elsevier BV
Published
2015-03
Volume
4
Issue
1
Pages
1-12
ISSN
  • 2212-1366 (ISSN-L)
  • 2212-1374
OpenAlex
W2045756126
Cited by
164
References
164
Citations by year
2026: 2 · 2025: 16 · 2024: 14 · 2023: 10 · 2022: 13 · 2021: 21 · 2020: 20 · 2019: 29 · 2018: 13 · 2017: 14 · 2016: 8 · 2015: 4
FWCI
2.36
Type
journal article
Language
en
Open access
Locations
  • Journal of bone oncology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • White Rose Research Online (University of Leeds, The University of Sheffield, University of York) (acceptedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Seventh Framework Programme (FP7/2007-2013, 264817-BONE-NET)
  • Region des Pays de la Loire
  • Ligue Nationale Contre le Cancer
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Keywords
receptor tyrosine kinase, receptor tyrosine kinase inhibitors, bone cancer, bone sarcoma, bone metastasis, tumor microenvironment, imatinib, signaling pathways, cancer therapy

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