Bone cell interactions through Eph/ephrin: Bone modeling, remodeling and associated diseases

Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts

Takayanagi, H., Kim, S., Koga, T., Nishina, H., Isshiki, M., Yoshida, H., Saiura, A., Isobe, M., Yokochi, T., Inoue, J.-I., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00369-6 · Cited by 2,701 · see citing works

The amazing osteocyte

Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works

Molecular Distinction and Angiogenic Interaction between Embryonic Arteries and Veins Revealed by ephrin-B2 and Its Receptor Eph-B4

Wang, H. U., Chen, Z., & Anderson, D. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81436-1 · Cited by 1,678 · see citing works

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

Tian, E., Zhan, F., Walker, R. C., Rasmussen, E., Ma, Y., Barlogie, B., & Shaughnessy, J. D. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030847 · Cited by 1,499 · see citing works

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Wang, Y., Nakayama, M., Pitulescu, M. E., Schmidt, T., Bochenek, M. L., Sakakibara, A., Adams, S., Davy, A., Deutsch, U., Lüthi, U., et al. (2010) · Nature · doi:10.1038/nature09002 · Cited by 1,276 · see citing works

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

Pasquale, E. B. (2008) · Cell · doi:10.1016/j.cell.2008.03.011 · Cited by 1,251 · see citing works

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

Pasquale, E. B. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2806 · Cited by 1,216 · see citing works

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165 · see citing works

Building strong bones: molecular regulation of the osteoblast lineage

Long, F. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3254 · Cited by 1,149 · see citing works

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesisPreprint

Adams, R. H., Wilkinson, G. A., Weiss, C., Diella, F., Gale, N. W., Deutsch, U., Risau, W., & Klein, R. (1999) · Genes & Development · doi:10.1101/gad.13.3.295 · Cited by 1,024 · see citing works

Osteoblast Precursors, but Not Mature Osteoblasts, Move into Developing and Fractured Bones along with Invading Blood Vessels

Maes, C., Kobayashi, T., Selig, M. K., Torrekens, S., Roth, S. I., Mackem, S., Carmeliet, G., & Kronenberg, H. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.010 · Cited by 940 · see citing works

Cellular mechanisms of bone remodeling

Eriksen, E. F. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9153-1 · Cited by 824 · see citing works

Osteoclast–osteoblast communication

Matsuo, K., & Irie, N. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.03.027 · Cited by 780 · see citing works

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777 · see citing works

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

Gerety, S. S., Wang, H. U., Chen, Z., & Anderson, D. J. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80342-1 · Cited by 707 · see citing works

Nuclear Factor of Activated T-cells (NFAT) Rescues Osteoclastogenesis in Precursors Lacking c-Fos

Matsuo, K., Galson, D. L., Chen, Z., Peng, L., Laplace, C., Wang, K. Z. Q., Bachler, M. A., Amano, H., Aburatani, H., Ishikawa, H., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313973200 · Cited by 569 · see citing works

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556 · see citing works

The contribution of bone to whole-organism physiology

Karsenty, G., & Ferron, M. (2012) · Nature · doi:10.1038/nature10763 · Cited by 537 · see citing works

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

Sawamiphak, S., Seidel, S., Essmann, C. L., Wilkinson, G. A., Pitulescu, M. E., Acker, T., & Acker‐Palmer, A. (2010) · Nature · doi:10.1038/nature08995 · Cited by 532 · see citing works

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

Sims, N. A., & Gooi, J. H. (2008) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2008.07.016 · Cited by 513 · see citing works

Craniosynostosis

Johnson, D., & Wilkie, A. O. M. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2010.235 · Cited by 499 · see citing works

Suppression of bone formation by osteoclastic expression of semaphorin 4D

Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498 · see citing works

PDZ interaction site in ephrinB2 is required for the remodeling of lymphatic vasculaturePreprint

Mäkinen, T., Adams, R. H., Bailey, J., Lü, Q., Ziemiecki, A., Alitalo, K. K., Klein, R., & Wilkinson, G. A. (2005) · Genes & Development · doi:10.1101/gad.330105 · Cited by 461 · see citing works

The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar-Gutter, W., Saftig, P., & Beertsen, W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.77 · Cited by 411 · see citing works

Bidirectional Eph–ephrin signaling during axon guidance

Egea, J., & Klein, R. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.03.004 · Cited by 394 · see citing works

Osteoblasts are target cells for transformation in c-fos transgenic mice

Grigoriadis, A. E., Schellander, K., Wang, Z., & Wagner, E. F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.3.685 · Cited by 349 · see citing works

Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2

Oshima, T., Abe, M., Asano, J., Hara, T., Kitazoe, K.-I., Sekimoto, E., Tanaka, Y., Shibata, H., Hashimoto, T., Ozaki, S., et al. (2005) · Blood · doi:10.1182/blood-2004-12-4940 · Cited by 344 · see citing works

Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling

Hattner, R. S., Epker, B. N., & Frost, H. M. (1965) · Nature · doi:10.1038/206489a0 · Cited by 343 · see citing works

Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation

Matsuo, K., Owens, J., Tonko, M., Elliott, C., Chambers, T. J., & Wagner, E. F. (2000) · Nature Genetics · doi:10.1038/72855 · Cited by 341 · see citing works

Mutations of ephrin-B1 ( EFNB1 ), a marker of tissue boundary formation, cause craniofrontonasal syndrome

Twigg, S. R. F., Kan, R., Babbs, C., Bochukova, E. G., Robertson, S. P., Wall, S. A., Morriss‐Kay, G. M., & Wilkie, A. O. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402819101 · Cited by 341 · see citing works

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

Orioli, D., Henkemeyer, M. J., Lemke, G., Klein, R., & Pawson, T. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00992.x · Cited by 333 · see citing works

Localization of RANKL (receptor activator of NFκB ligand) mRNA and protein in skeletal and extraskeletal tissues

Kartsogiannis, V., Zhou, H., Horwood, N. J., Thomas, R. J., Hards, D. K., Quinn, J. M. W., Niforas, P., Ng, K. W., Martin, T. J., & Gillespie, M. T. (1999) · Bone · doi:10.1016/s8756-3282(99)00214-8 · Cited by 324 · see citing works

Ephrin-B1 forward and reverse signaling are required during mouse developmentPreprint

Davy, A., Aubin, J., & Soriano, P. M. (2004) · Genes & Development · doi:10.1101/gad.1171704 · Cited by 288 · see citing works

Local communication on and within bone controls bone remodeling

Henriksen, K., Neutzsky-Wulff, A. V., Bonewald, L. F., & Karsdal, M. A. (2009) · Bone · doi:10.1016/j.bone.2009.03.671 · Cited by 284 · see citing works

Skeletal Renewal and Metabolic Bone Disease

Harris, W. H., & Heaney, R. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196901232800405 · Cited by 279 · see citing works

Eph/ephrin molecules—a hub for signaling and endocytosisPreprint

Pitulescu, M. E., & Adams, R. H. (2010) · Genes & Development · doi:10.1101/gad.1973910 · Cited by 275 · see citing works

Dynamic histomorphometry of alveolar bone remodeling in the adult rat

Vignery, A., & Baron, R. (1980) · The Anatomical Record · doi:10.1002/ar.1091960210 · Cited by 260 · see citing works

Kinase-Dependent and Kinase-Independent Functions of EphA4 Receptors in Major Axon Tract Formation In Vivo

Kullander, K., Mather, N. K., Diella, F., Dottori, M., Boyd, A., & Klein, R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00181-7 · Cited by 258 · see citing works

Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma

Qiang, Y., Chen, Y., Stephens, O., Brown, N., Chen, B., Epstein, J., Barlogie, B., & Shaughnessy, J. D. (2008) · Blood · doi:10.1182/blood-2008-01-132134 · Cited by 249 · see citing works

Mutations of the Ephrin-B1 Gene Cause Craniofrontonasal Syndrome

Wieland, I., Jakubiczka, S., Muschke, P., Cohen, M. Y., Thiele, H., Gerlach, K. L., Adams, R. H., & Wieacker, P. F. (2004) · The American Journal of Human Genetics · doi:10.1086/421532 · Cited by 243 · see citing works

The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity

Morimoto, M., Takahashi, Y., Endo, M., & Saga, Y. (2005) · Nature · doi:10.1038/nature03591 · Cited by 234 · see citing works

Advances in osteoclast biology: old findings and new insights from mouse models

Edwards, J., & Mundy, G. R. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.23 · Cited by 232 · see citing works

Control of Skeletal Patterning by EphrinB1-EphB Interactions

Compagni, A., Logan, M., Klein, R., & Adams, R. H. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00198-9 · Cited by 231 · see citing works

Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease

Vallet, S., Mukherjee, S., Vaghela, N., Hideshima, T., Fulciniti, M., Pozzi, S., Santo, L., Cirstea, D. D., Patel, K. J., Sohani, A. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911929107 · Cited by 230 · see citing works

Ephrin signaling in vivo: Look both ways

Davy, A., & Soriano, P. M. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20200 · Cited by 207 · see citing works

EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

Allan, E. H., Häusler, K. D., Wei, T., Gooi, J. H., Quinn, J. M., Crimeen-Irwin, B., Pompolo, S., Sims, N. A., Gillespie, M. T., Onyia, J. E., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080324 · Cited by 199 · see citing works

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J., & Sims, N. A. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080706 · Cited by 190 · see citing works

The pathogenesis of the bone disease of multiple myeloma

Edwards, C. M., Zhuang, J., & Mundy, G. R. (2008) · Bone · doi:10.1016/j.bone.2008.01.027 · Cited by 185 · see citing works

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 175 · see citing works

Regulatory mechanism of NFATc1 in RANKL‐induced osteoclast activation

Song, I., Kim, J. H., Kim, K., Jin, H. M., Youn, B. U., & Kim, N. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.06.047 · Cited by 159 · see citing works

Cellular kinetics of the bone remodeling sequence in the rat

Van, P. T., Vignery, A., & Baron, R. (1982) · The Anatomical Record · doi:10.1002/ar.1092020403 · Cited by 158 · see citing works

Eph/Ephrin Signaling Regulates the Mesenchymal-to-Epithelial Transition of the Paraxial Mesoderm during Somite Morphogenesis

Barrios, A., Poole, R. J., Durbin, L., Brennan, C. H., Holder, N., & Wilson, S. W. (2003) · Current Biology · doi:10.1016/j.cub.2003.08.030 · Cited by 154 · see citing works

Loss ofEph-receptorexpression correlates with loss of cell adhesion and chondrogenic capacity inHoxa13mutant limbs

Stadler, H. S., Higgins, K. M., & Capecchi, M. R. (2001) · Development · doi:10.1242/dev.128.21.4177 · Cited by 152 · see citing works

Inhibition of Gap Junction Communication at Ectopic Eph/ephrin Boundaries Underlies Craniofrontonasal Syndrome

Davy, A., Bush, J. O., & Soriano, P. M. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040315 · Cited by 151 · see citing works

Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression

Yasuhiko, Y., Haraguchi, S., Kitajima, S., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508238103 · Cited by 135 · see citing works

Preferential Induction of EphB4 over EphB2 and Its Implication in Colorectal Cancer Progression

Kumar, S. R., Scehnet, J. S., Ley, E. J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3232 · Cited by 133 · see citing works

Boning up on Ephrin Signaling

Mundy, G. R., & Elefteriou, F. (2006) · Cell · doi:10.1016/j.cell.2006.07.015 · Cited by 111 · see citing works

Detection of osteoprotegerin (OPG) and its ligand (RANKL) mRNA and protein in femur and tibia of the rat

Silvestrini, G., Ballanti, P., Patacchioli, F. R., Leopizzi, M., Gualtieri, N., Monnazzi, P., Tremante, E., Sardella, D., & BONUCCI, E. (2005) · The Histochemical Journal · doi:10.1007/s10735-004-3839-1 · Cited by 105 · see citing works

Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph–ephrin boundariesPreprint

Bush, J. O., & Soriano, P. M. (2010) · Genes & Development · doi:10.1101/gad.1963210 · Cited by 101 · see citing works

Ephrin B1 Regulates Bone Marrow Stromal Cell Differentiation and Bone Formation by Influencing TAZ Transactivation via Complex Formation with NHERF1

Xing, W., Kim, J.-H., Wergedal, J. E., Chen, S., & Mohan, S. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00610-09 · Cited by 99 · see citing works

The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth

Pennisi, A., Ling, W., Li, X., Khan, S., Shaughnessy, J. D., Barlogie, B., & Yaccoby, S. (2009) · Blood · doi:10.1182/blood-2009-01-201954 · Cited by 96 · see citing works

EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation

Arthur, A., Zannettino, A. C. W., Panagopoulos, R. A., Koblar, S. A., Sims, N. A., Stylianou, C., Matsuo, K., & Gronthos, S. (2010) · Bone · doi:10.1016/j.bone.2010.10.180 · Cited by 93 · see citing works

EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation

Watanabe, T., Sato, Y., Saito, D., Tadokoro, R., & Takahashi, Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902859106 · Cited by 88 · see citing works

Conditional deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, increasing volume of remodeling bone in mice

Okamoto, M., Murai, J., Imai, Y., Ikegami, D., Kamiya, N., Kato, S., Mishina, Y. M., Yoshikawa, H., & Tsumaki, N. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.477 · Cited by 80 · see citing works

Communication Between EphrinB2 and EphB4 Within the Osteoblast Lineage

Martin, T. J., Allan, E. H., Ho, P. W. M., Gooi, J. H., Quinn, J. M. W., Gillespie, M. T., Krasnoperov, V. G., & Sims, N. A. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1050-9_6 · Cited by 77 · see citing works

EphB/Ephrin-B Interaction Mediates Adult Stem Cell Attachment, Spreading, and Migration: Implications for Dental Tissue Repair

Stokowski, A., Shi, S., Sun, T., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2006-0373 · Cited by 75 · see citing works

Osteoblast function in myeloma

Roodman, G. D. (2010) · Bone · doi:10.1016/j.bone.2010.06.016 · Cited by 75 · see citing works

Skeletal Renewal and Metabolic Bone Disease

Harris, W. H., & Heaney, R. P. (1969) · New England Journal of Medicine · doi:10.1056/nejm196901302800507 · Cited by 75 · see citing works

Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes

Pfaff, D., Héroult, M., Riedel, M., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.030627 · Cited by 70 · see citing works

<i>De novo</i> expression of EphA2 in osteosarcoma modulates activation of the mitogenic signalling pathway

Fritsche‐Guenther, R., Noske, A., Ungethüm, U., Kuban, R., Schlag, P. M., Tunn, P., Karle, J., Krenn, V., Dietel, M., & Sers, C. (2010) · Histopathology · doi:10.1111/j.1365-2559.2010.03713.x · Cited by 69 · see citing works

Clinical and genetic aspects of craniofrontonasal syndrome: Towards resolving a genetic paradox

Wieacker, P., & Wieland, I. (2005) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2005.07.017 · Cited by 69 · see citing works

Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2

Nakajima, Y., Morimoto, M., Takahashi, Y., et al. (2006) · Development · doi:10.1242/dev.02422 · Cited by 68 · see citing works

Human osteosarcoma expresses specific ephrin profiles

Varelias, A., Koblar, S. A., Cowled, P. A., Carter, C. D., & Clayer, M. (2002) · Cancer · doi:10.1002/cncr.10749 · Cited by 67 · see citing works

Intermittent PTH Administration Stimulates Pre-Osteoblastic Proliferation Without Leading to Enhanced Bone Formation in Osteoclast-Less c-fos−/− Mice

de Freitas, P. H. L., Li, M., Ninomiya, T., Nakamura, M., Sobhan, U., Oda, K., Udagawa, N., Maeda, T., Takagi, R., & Amizuka, N. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090413 · Cited by 66 · see citing works

ADAM8 is a negative regulator of retinal neovascularization and of the growth of heterotopically injected tumor cells in mice

Guaiquil, V. H., Swendeman, S. L., Zhou, W., Guaiquil, P., Weskamp, G., Bartsch, J. W., & Blobel, C. (2010) · Journal of Molecular Medicine · doi:10.1007/s00109-010-0591-8 · Cited by 60 · see citing works

Enhancement of lymphocyte migration and cytokine production by ephrinB1 system in rheumatoid arthritis

Kitamura, T., Kabuyama, Y., Kamataki, A., et al. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00314.2007 · Cited by 60 · see citing works

MAPping Out Arteries and Veins

Lamont, R. E., & Childs, S. J. (2006) · Science s STKE · doi:10.1126/stke.3552006pe39 · Cited by 57 · see citing works

Expression and regulation of Cek-8, a cell to cell signalling receptor in developing chick limb buds

Patel, K. J., Nittenberg, R., D’Souza, D., et al. (1996) · Development · doi:10.1242/dev.122.4.1147 · Cited by 55 · see citing works

Endothelial EphrinB2 Is Controlled by Microenvironmental Determinants and Associates Context-Dependently With CD31

Korff, T., Dandekar, G., Pfaff, D., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000200081.42064.e7 · Cited by 52 · see citing works

EphB2 and EphB3 forward signalling are required for palate development

Risley, M. D., Garrod, D. R., Henkemeyer, M. J., & McLean, W. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.10.009 · Cited by 51 · see citing works

Activation of the receptor EphB4 by its specific ligand ephrin B2 in human osteoarthritic subchondral bone osteoblasts

Tat, S. K., Pelletier, J., Amiable, N., Boileau, C., Lajeunesse, D., Duval, N., & Martel‐Pelletier, J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24029 · Cited by 50 · see citing works

Targeted Disruption of Ephrin B1 in Cells of Myeloid Lineage Increases Osteoclast Differentiation and Bone Resorption in Mice

Cheng, S., Zhao, S. L., Nelson, B., Kesavan, C., Qin, X., Wergedal, J. E., Mohan, S., & Xing, W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032887 · Cited by 41 · see citing works

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes

Tat, S. K., Pelletier, J., Amiable, N., Boileau, C., Lavigne, M. J. F., & Martel‐Pelletier, J. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2782 · Cited by 38 · see citing works

Diverse Clinical and Genetic Aspects of Craniofrontonasal Syndrome

Zafeiriou, D., Pavlidou, E., & Vargìami, E. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2010.10.012 · Cited by 27 · see citing works

Impaired Vibration of Auditory Ossicles in Osteopetrotic Mice

Kanzaki, S., Takada, Y., Niida, S., Takeda, Y., Udagawa, N., Ogawa, K., Nango, N., Momose, A., & Matsuo, K. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2010.11.063 · Cited by 27 · see citing works

3 Patterning and Differentiation of the Vertebrate SpinePreprint

Chal, J., & Pourquié, O. (2009) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969825.53.41 · Cited by 19 · see citing works

Down-regulation of ephrin-A5, a gene product of normal cartilage, in chondrosarcoma

Kalinski, T., Röpke, A., Sel, S., Kouznetsova, I., Röpke, M., & Roessner, A. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.03.024 · Cited by 19 · see citing works

Distribution, gene expression, and functional role of EphA4 during ossification

Kuroda, C., Kubota, S., Kawata, K., Aoyama, E., Sumiyoshi, K., Oka, M., Inoue, M., Minagi, S., & Takigawa, M. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.089 · Cited by 18 · see citing works

Microsomal Prostaglandin E Synthase‐1, Ephrins, and Ephrin Kinases as Suspected Therapeutic Targets in Arthritis

Romanovsky, A. A., Ivanov, A. I., & Petersen, S. R. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1351.016 · Cited by 15 · see citing works

Preliminary identification of potential PDZ-domain proteins downstream of ephrin B2 during osteoclast differentiation of RAW264.7 cells.

Mao, Y., Huang, X., Zhao, J., & Gu, Z. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.639 · Cited by 13 · see citing works

EPHs and ephrins: Many pathways to regulate osteoblasts and osteoclasts

Sims, N. A. (2010) · IBMS BoneKEy · doi:10.1138/20100463 · Cited by 11 · see citing works

Ephrin A4 expression in osteosarcoma, impact on prognosis, and patient outcome

Abdou, A. G., El-Wahed, M. A., Asaad, N., et al. (2010) · Indian Journal of Cancer · doi:10.4103/0019-509x.58859 · Cited by 11 · see citing works

Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone

Martin, T. J., Sims, N. A., & Quinn, J. M. W. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-375670-1.10008-1 · Cited by 10 · see citing works

β-Arrestin2 Regulates RANKL and Ephrins Gene Expression in Response to Bone Remodeling in Mice

Pierroz, D. D., Rufo, A., Bianchi, E. N., Glatt, V., Capulli, M., Rucci, N., Cavat, F., Rizzoli, R., Teti, A. M., Bouxsein, M., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.081237

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works

Osteoclasts: more than ‘bone eaters’

Charles, J. F., & Aliprantis, A. O. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.06.001 · Cited by 391 · see citing works

Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers

Ségaliny, A. I., Tellez-Gabriel, M., Heymann, M.-F., & Heymann, D. (2015) · Journal of Bone Oncology · doi:10.1016/j.jbo.2015.01.001 · Cited by 164 · see citing works

Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts

Abdelgawad, M. E., Delaisse, J.-M., Hinge, M., Jensen, P. R., Alnaimi, R. W., Rolighed, L., Engelholm, L. H., Marcussen, N., & Andersen, T. L. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1414-y · Cited by 76 · see citing works

Promiscuous and specific recognition among ephrins and Eph receptors

Dai, D., Huang, Q., Nussinov, R., & Ma, B. (2014) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2014.07.002 · Cited by 51 · see citing works

RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales

Tazaki, Y., Sugitani, K., Ogai, K., Kobayashi, I., Kawasaki, H., Aoyama, T., Suzuki, N., Tabuchi, Y., Hattori, A., & Kitamura, K.-I. (2018) · Comparative Biochemistry and Physiology Part A: Molecular &amp; Integrative Physiology · doi:10.1016/j.cbpa.2018.06.011 · Cited by 15 · see citing works

May EPH/Ephrin Targeting Revolutionize Lung Cancer Treatment?

Psilopatis, I., Karniadakis, I., Danos, K. S., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010093 · Cited by 14 · see citing works

Erythropoietin-Producing Hepatocellular Receptors A: Ephrin A1, Ephrin A2 and Ephrin A3

Salajegheh, A. (2016) · Springer eBooks · doi:10.1007/978-3-319-28140-7_14

Roles of EphA1/A2 and ephrin‐A1 in cancer

Ieguchi, K., & Maru, Y. (2019) · Cancer Science · doi:10.1111/cas.13942 · Cited by 66 · see citing works

Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer

Efazat, G., Novak, M., Kaminskyy, V. O., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11219 · Cited by 26 · see citing works

Lithocholic Acid Is an Eph-ephrin Ligand Interfering with Eph-kinase Activation

Giorgio, C., Mohamed, I. H., Flammini, L., Barocelli, E., Incerti, M., Lodola, A., & Tognolini, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018128 · Cited by 84 · see citing works