The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Physical Activity, Fitness, and Obesity in Heart Failure With Preserved Ejection Fraction
Open accessAbstract
Heart failure with preserved ejection fraction (HFpEF) is common, increasing in prevalence, and refractory to available pharmacotherapies. Our understanding of HFpEF has evolved from a disorder of diastolic dysfunction to a constellation of physiologic impairments that lead to elevated left ventricular filling pressures and exercise intolerance. Accordingly, the therapeutic and preventive focus has shifted to identifying lifestyle factors that may have more pleotropic effects on the pathophysiologic mechanisms that define HFpEF. Recent studies have demonstrated that physical inactivity, low fitness, and obesity are potential modifiable targets for prevention as well as management of HFpEF. In this review, we have discussed the emerging epidemiological, mechanistic, and clinical evidence that support the role of these lifestyle factors as key determinants of development and progression of HFpEF. We also summarize the available evidence and major knowledge gaps with regard to developing exercise training and weight loss as unique and effective therapeutic strategies for management of HFpEF.
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Citations
Cites
Obesity and the risk of heart failure
Kenchaiah, S., Evans, J. C., Levy, D., Wilson, P. W. F., Benjamin, E. J., Larson, M. G., Kannel, W. B., & Vasan, R. S. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa020245 · Cited by 3,093
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908
Spironolactone for heart failure with preserved ejection fraction
Pitt, B., Pfeffer, M. A., Assmann, S. F., Boineau, R., Anand, I. S., Claggett, B., Clausell, N., Desai, A. S., Diaz, R., Fleg, J. L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1313731 · Cited by 2,809
Obokata, M., Reddy, Y. N. V., Pislaru, S. V., Melenovsky, V., & Borlaug, B. A. (2017) · Circulation · doi:10.1161/circulationaha.116.026807 · Cited by 1,179
Kitzman, D. W., Brubaker, P., Morgan, T., Haykowsky, M., Hundley, G., Kraus, W. E., Eggebeen, J., & Nicklas, B. J. (2016) · JAMA · doi:10.1001/jama.2015.17346 · Cited by 921
Self-citationRelationship between physical activity, body mass index, and risk of heart failure
Pandey, A., LaMonte, M., Klein, L., Ayers, C., Psaty, B. M., Eaton, C. B., Allen, N. B., de Lemos, J. A., Carnethon, M., Greenland, P., et al. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.081 · Cited by 398
Self-citationDose–Response Relationship Between Physical Activity and Risk of Heart Failure: A Meta-Analysis
Pandey, A., Garg, S., Khunger, M., Darden, D., Ayers, C., Kumbhani, D. J., Mayo, H. G., de Lemos, J. A., & Berry, J. D. (2015) · Circulation · doi:10.1161/circulationaha.115.015853 · Cited by 272
Self-citationPatel, V. B., Shah, S., Verma, S., & Oudit, G. Y. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9644-1 · Cited by 218
Mechanisms of Abnormal Renal Sodium Handling in Obesity Hypertension
Hall, J. (1997) · American Journal of Hypertension · doi:10.1016/s0895-7061(97)00075-7 · Cited by 213
Haykowsky, M. J., Nicklas, B. J., Brubaker, P. H., Hundley, W. G., Brinkley, T. E., Upadhya, B., Becton, J. T., Nelson, M. D., Chen, H., & Kitzman, D. W. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2018.06.002 · Cited by 179
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Cited by
Obesity and cardiovascular disease: a scientific statement from the American Heart Association
Powell-Wiley, T. M., Poirier, P., Burke, L. E., Després, J.-P., Gordon-Larsen, P., Lavie, C. J., Lear, S. A., Ndumele, C. E., Neeland, I. J., Sanders, P., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000973 · Cited by 3,691
Self-citationEvaluation and management of heart failure with preserved ejection fraction
Borlaug, B. A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0363-2 · Cited by 675
Exercise Intolerance in Patients With Heart Failure
Del Buono, M. G., Arena, R., Borlaug, B. A., Carbone, S., Canada, J. M., Kirkman, D. L., Garten, R., Rodriguez-Miguelez, P., Guazzi, M., Lavie, C. J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.072 · Cited by 477
Self-citationMetabolic inflammation in heart failure with preserved ejection fraction
Schiattarella, G. G., Rodolico, D., & Hill, J. A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa217 · Cited by 284
Exercise and cardiovascular health: A state-of-the-art review
Isath, A., Koziol, K. J., Martinez, M. W., Garber, C. E., Martinez, M. N., Emery, M. S., Baggish, A. L., Naidu, S. S., Lavie, C. J., Arena, R., et al. (2023) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2023.04.008 · Cited by 176
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Metadata
- Authors
- Pandey, A., Patel, K. V., Vaduganathan, M., Sarma, S., Haykowsky, M. J., Berry, J. D., & Lavie, C. J.
- Venue
- JACC: Heart Failure
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 6
- Issue
- 12
- Pages
- 975-982
- ISSN
- 2213-1779 (ISSN-L)
- OpenAlex
- W2902480205
- Cited by
- 201
- References
- 12
- FWCI
- 19.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Pandey, A., Patel, K. V., Vaduganathan, M., Sarma, S., Haykowsky, M. J., Berry, J. D., & Lavie, C. J. (2018). Physical Activity, Fitness, and Obesity in Heart Failure With Preserved Ejection Fraction. JACC: Heart Failure. https://doi.org/10.1016/j.jchf.2018.09.006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
