The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development
Open accessAbstract
Understanding structure-property relationships is critical for the development of new drug delivery systems. This study investigates the properties of Pluronic smart hydrogel formulations for future use as injectable controlled drug carriers. The smart hydrogels promise to enhance patient compliance, decrease side effects and reduce dose and frequency. Pharmaceutically, these systems are attractive due to their unique sol-gel phase transition in the body, biocompatibility, safety and injectability as solutions before transforming into gel matrices at body temperature. We quantify the structural changes of F127 systems under controlled temperature after flow, as experienced during real bodily injection. Empirical formulae combining the coupled thermal and shear dependency are produced to aid future application of these systems. Induced structural transitions measured in-situ by small angle x-ray and neutron scattering reveal mixed oriented structures that can be exploited to tailor the drug release profile.
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Cites
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Cited by
In situ formation of injectable hydrogels for chronic wound healing
Gao, Y., Li, Z., Huang, J., Zhao, M., & Wu, J. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01074j · Cited by 189
Photocrosslinkable silk-based biomaterials for regenerative medicine and healthcare applications
Dey, S., Jaiswal, C., Shome, S., Bhar, B., Bandyopadhyay, A., Manikumar, K., Dadheech, R., & Mandal, B. B. (2023) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-022-00277-8 · Cited by 24
Metadata
- Authors
- Shriky, B., Kelly, A., Isreb, M., Babenko, M., Mahmoudi, N., Rogers, S., Shebanova, O., Snow, T., & Gough, T.
- Venue
- Journal of Colloid and Interface Science
- Publisher
- Elsevier BV
- Published
- 2020-04
- Volume
- 565
- Pages
- 119-130
- ISSN
- 0021-9797 (ISSN-L)
- OpenAlex
- W2998248368
- Cited by
- 299
- References
- 29
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Shriky, B., Kelly, A., Isreb, M., Babenko, M., Mahmoudi, N., Rogers, S., Shebanova, O., Snow, T., & Gough, T. (2020). Pluronic F127 thermosensitive injectable smart hydrogels for controlled drug delivery system development. Journal of Colloid and Interface Science. https://doi.org/10.1016/j.jcis.2019.12.096
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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