The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Formulation of Poloxamers for Drug Delivery
Open accessAbstract
Poloxamers, also known as Pluronics®, are block copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO), which have an amphiphilic character and useful association and adsorption properties emanating from this. Poloxamers find use in many applications that require solubilization or stabilization of compounds and also have notable physiological properties, including low toxicity. Accordingly, poloxamers serve well as excipients for pharmaceuticals. Current challenges facing nanomedicine revolve around the transport of typically water-insoluble drugs throughout the body, followed by targeted delivery. Judicious design of drug delivery systems leads to improved bioavailability, patient compliance and therapeutic outcomes. The rich phase behavior (micelles, hydrogels, lyotropic liquid crystals, etc.) of poloxamers makes them amenable to multiple types of processing and various product forms. In this review, we first present the general solution behavior of poloxamers, focusing on their self-assembly properties. This is followed by a discussion of how the self-assembly properties of poloxamers can be leveraged to encapsulate drugs using an array of processing techniques including direct solubilization, solvent displacement methods, emulsification and preparation of kinetically-frozen nanoparticles. Finally, we conclude with a summary and perspective.
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PubChem Substance and Compound databases
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Pluronic® block copolymers as novel polymer therapeutics for drug and gene delivery
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Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004
Drug self-delivery systems for cancer therapy
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Cited by
Lombardo, D., Kiselev, M. A., & Caccamo, M. T. (2019) · Journal of Nanomaterials · doi:10.1155/2019/3702518 · Cited by 864
Poloxamer: A versatile tri-block copolymer for biomedical applications
Zarrintaj, P., Ramsey, J. D., Samadi, A., Atoufi, Z., Yazdi, M. K., Ganjali, M. R., Amirabad, L. M., Zangene, E., Farokhi, M., Formela, K., et al. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.04.028 · Cited by 404
Kwon, M., Lim, D. Y., Lee, C. H., Jeon, J.-H., Choi, M.-K., & Song, I.-S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12090882 · Cited by 76
Ch, S., Padaga, S. G., Ghosh, B., Roy, S., & Biswas, S. (2023) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2023.120822 · Cited by 40
RetractedKumar, S., Yadav, A., Verma, R. K., Kumar, A., Gupta, P. K., & Shukla, R. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c00386 · Cited by 14
Metadata
- Authors
- Bodratti, A., & Alexandridis, P.
- Venue
- Journal of Functional Biomaterials
- Publisher
- MDPI AG
- Published
- 2018-01-18
- Volume
- 9
- Issue
- 1
- Pages
- 11
- ISSN
- 2079-4983 (ISSN-L)
- OpenAlex
- W2793276275
- Cited by
- 589
- References
- 8
- FWCI
- 23.26
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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