Understanding type 1 diabetes: etiology and models

Acharjee, Satarupa; Ghosh, Bijaya; Al-Dhubiab, Bandar E.; Nair, Anroop B.

doi:10.1016/j.jcjd.2013.05.001

Cited by 118Diabetes and associated disordersPancreatic function and diabetesDiabetes Management and Research

Understanding type 1 diabetes: etiology and models

Acharjee, Satarupa, Ghosh, Bijaya, Al-Dhubiab, Bandar E., Nair, Anroop B.·2013·Canadian Journal of Diabetes

DOI 10.1016/j.jcjd.2013.05.001

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Abstract

Type 1 diabetes is a complex disease involving a combination of factors, such as genetic susceptibility, immunologic dysregulation and exposure to environmental triggers. Animal models serve an important function both in elucidating the pathophysiology and preliminary screening of antidiabetic molecules. Hence, the development of models for type 1 diabetes can be broadly divided into 3 categories, namely: identification of spontaneously developing type 1 diabetes mellitus strains, creating diabetes-prone species through gene transfer techniques and forced destruction of islet cells through chemical or surgical means. This review discusses the models used to study type 1 diabetes with special emphasis on genetics.

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Both obesity and hyperglycemia promote the release of inflammatory mediators, like TNF-α or IL-6, and released mediators stimulate macrophages and other innate immune cells, as well as some apoptosis-related signaling pathways, such as Fas/FasL signaling pathway.
“Both obesity and hyperglycemia promote the release of inflammatory mediators, like TNF-α, or IL-6, released mediators stimulate macrophages and other innate immune cells, as well as some apoptosis-related signaling pathways, such as Fas/FasL signaling pathway (78, 79).”
From Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments (2020) · cites this paper as [78]

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Type 2 Diabetes: Molecular mechanism, Understanding and Prevention
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Authors: Acharjee, S., Ghosh, B., Al-Dhubiab, B. E., & Nair, A. B.
Affiliations: King Faisal University (SA)
Corresponding author: Nair, Anroop B.
ORCID: Acharjee, Satarupa
Nair, Anroop B.
Venue: Canadian Journal of Diabetes
Publisher: Elsevier BV
Published: 2013-08
Volume: 37
Issue: 4
Pages: 269-276
ISSN: 1499-2671 (ISSN-L)
DOI: 10.1016/j.jcjd.2013.05.001
OpenAlex: W2114256982
Cited by: 117
References: 52
Citations by year: 2026: 4 · 2025: 10 · 2024: 16 · 2023: 13 · 2022: 14 · 2021: 20 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 3 · 2015: 5 · 2014: 7 · 2013: 1
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Canadian Journal of Diabetes (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords: type 1 diabetes, etiology, animal models of diabetes, genetic susceptibility, environmental triggers, gene transfer, islet cell destruction, pathophysiology
MeSH terms: Animals, Diabetes Mellitus, Type 1, Disease Models, Animal, Humans, Animals, Genetically Modified, Biomedical Research

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Understanding type 1 diabetes: etiology and models

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