Cited by 894Chronic Disease Management StrategiesHealth Systems, Economic Evaluations, Quality of LifeHealthcare Policy and Management

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The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients

Charlson, Mary E., Charlson, Robert E., Peterson, Janey C., Marinopoulos, Spyridon S., Briggs, William M., Hollenberg, James P.·2008·Journal of Clinical Epidemiology

DOI 10.1016/j.jclinepi.2008.01.006

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Abstract

Objective (1) To determine chronic illness costs for large cohort of primary care patients, (2) to develop prospective model predicting total costs over one year, using demographic and clinical information including widely used comorbidity index.Study design and setting Data including diagnostic, medication, and resource utilization were obtained for 5,861 patients from practice-based computer system over a 1-year period beginning December 1, 1993, for retrospective analysis. Hospital cost data were obtained from hospital cost accounting system.Results Average annual per patient cost was $2,655. Older patients and those with Medicare or Medicaid had higher costs. Hospital costs were $1,558, accounting for 58.7% of total costs. In the predictive model, individuals with higher comorbidity incurred exponentially higher annual costs, from $4,317 with comorbidity score of two, to $5,986 with score of three, to $13,326 with scores greater than seven. To use an adapted comorbidity index to predict total yearly costs, four conditions should be added to the index: hypertension, depression, and use of warfarin with a weight of one, skin ulcers/cellulitis, a weight of two.Conclusion The adapted comorbidity index can be used to predict resource utilization. Predictive models may help to identify targets for reducing high costs, by prospectively identifying those at high risk.

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Method
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Method
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Method
Patient Frailty: Key Considerations, Definitions and Practical Implications
Cohen, M. S., Paul, E., Nuschke, J., Tolentino, J. C., Mendez, A. V. C., Mira, A.-E. A., Baxter, R. A., & Stawicki, S. P. (2016) · InTech eBooks · doi:10.5772/64296 · Cited by 16
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Background
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Moskowitz, E. J., Paulucci, D. J., Reddy, B., Blum, K. A., Rosen, D. C., Abaza, R. M. D., Eun, D., Hemal, A. K., Krane, L. S., & Badani, K. K. (2016) · Journal of Endourology · doi:10.1089/end.2016.0217 · Cited by 15
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“Comorbidity was assessed with the Charlson Comorbidity Index age-adjusted score (CCI; Charlson et al., 1987, 2008); this measure records the presence of any of 23 chronic conditions (e.g., hypertension), each of which is assigned a weighted score indicating the associated mortality risk, with the…”
Method
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“due to late presentation); and differences in co-morbidity, resulting in additional treatment costs through poorer functional impairment or presenting contra-indications to standard therapies (Charlson et al., 2008; Cunic et al., 2014).”
Background
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“a Charlson comorbidity index is a validated instrument that applies weights for different levels of vascular diseases, (myocardial infarction, congestive heart failure, peripheral vascular disease, cerebrovascular disease); endocrine disorders (diabetes with or without end-organ damage including retinopathy, neuropath…”
Background
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BackgroundMethodResultInfluential
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“, gender, age at cohort entry, type of inhaled long-acting bronchodilator received at therapy start, and Charlson’s co-morbidity index (16) calculated from inpa-”
Method
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Mehta, H. B., Sura, S. D., Sharma, M., Johnson, M. L., & Riall, T. S. (2016) · Medical Care · doi:10.1097/mlr.0000000000000517 · Cited by 13
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Background
Difference in the trajectory of change in bone geometry as measured by hip structural analysis in the narrow neck, intertrochanteric region, and femoral shaft between men and women following hip fracture
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Method
Mediators of Weight Loss Maintenance in the Keep It Off Trial
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“Exclusion criteria included anorexia nervosa history, bariatric surgery, modified Charlson [31] score ≥3, non-skin cancer, congestive heart failure, use of a phone-based weight loss program to achieve their recent weight loss, or current participation in another weight management study.”
Background
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Method
Benzodiazepine and unhealthy alcohol use among adult outpatients.
Hirschtritt, M. E., Palzes, V. A., Kline‐Simon, A. H., Kroenke, K., Campbell, C. I., & Sterling, S. (2019) · PubMed · Cited by 13
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Authors: Charlson, M. E., Charlson, R. E., Peterson, J. C., Marinopoulos, S. S., Briggs, W. M., & Hollenberg, J. P.
Affiliations: Weill Cornell Medicine (US)
Yale New Haven Hospital (US)
Johns Hopkins University (US)
Central Michigan University (US)
Corresponding author: Charlson, Mary E.
ORCID: Charlson, Mary E.
Marinopoulos, Spyridon S.
Briggs, William M.
Venue: Journal of Clinical Epidemiology
Publisher: Elsevier BV
Published: 2008-12
Volume: 61
Issue: 12
Pages: 1234-1240
ISSN: 0895-4356 (ISSN-L)
DOI: 10.1016/j.jclinepi.2008.01.006
OpenAlex: W2110548428
Cited by: 894
References: 38
Citations by year: 2026: 35 · 2025: 52 · 2024: 79 · 2023: 74 · 2022: 80 · 2021: 77 · 2020: 81 · 2019: 66 · 2018: 83 · 2017: 56 · 2016: 42 · 2015: 51 · 2014: 37 · 2013: 21 · 2012: 22
FWCI: 9.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Clinical Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Chronic Disease Management Strategies
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Healthcare Policy and Management
Keywords: Charlson Comorbidity Index, chronic disease costs, health care costs, primary care patients, cost prediction model, hospital costs, resource utilization (health care), hypertension, depression, warfarin, skin ulcers, cellulitis, Medicare and Medicaid, elderly patients
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Chronic Disease, Epidemiologic Methods, Female, Health Resources, Health Services Research, Hospitalization, Humans, Male, Middle Aged, New York City, Primary Health Care, Prognosis, Drug Costs, Health Care Costs, Hospital Costs, Young Adult

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The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients

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