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Cited by 517

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease

Open access
Calvert, Patrick A., Obaid, Daniel R., O'Sullivan, Michael, Shapiro, Leonard M., McNab, Duncan, Densem, Cameron G., Schofield, Peter M., Braganza, Denise, Clarke, Sarah C., Ray, Kausik K., West, Nick E.J., Bennett, Martin R.·2011·JACC: Cardiovascular Imaging
DOI 10.1016/j.jcmg.2011.05.005
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Abstract

OBJECTIVES The purpose of this study was to determine whether thin-capped fibroatheromata (TCFA) identified by virtual histology intravascular ultrasound (VH-IVUS) are associated with major adverse cardiac events (MACE) on individual plaque or whole patient analysis. BACKGROUND Post-mortem studies have identified TCFA as the substrate for most myocardial infarctions. However, little is known about the natural history of individual TCFA and their link with MACE. VH-IVUS provides a method of identifying plaques in vivo that are similar (although not identical) to histologically defined TCFA, and has been validated in human atherectomy and post-mortem studies. METHODS One hundred seventy patients with stable angina or troponin-positive acute coronary syndrome referred for percutaneous coronary intervention (PCI) were prospectively enrolled and underwent 3-vessel VH-IVUS pre-PCI and also post-PCI in the culprit vessel. MACE consisted of death, myocardial infarction, or unplanned revascularization. RESULTS In all, 30,372 mm of VH-IVUS were analyzed. Eighteen MACE occurred in 16 patients over a median follow-up of 625 days (interquartile range: 463 to 990 days); 1,096 plaques were classified, and 19 lesions resulted in MACE (13 nonculprit lesions and 6 culprit lesions). Nonculprit lesion factors associated with nonrestenotic MACE included VHTCFA (hazard ratio [HR]: 7.53, p = 0.038) and plaque burden >70% (HR: 8.13, p = 0.011). VHTCFA (HR: 8.16, p = 0.007), plaque burden >70% (HR: 7.48, p < 0.001), and minimum luminal area <4 mm(2) (HR: 2.91, p = 0.036) were associated with total MACE. On patient-based analysis, the only factor associated with nonrestenotic MACE was 3-vessel noncalcified VHTCFA (HR: 1.79, p = 0.004). CONCLUSIONS VH-IVUS TCFA was associated with nonrestenotic and total MACE on individual plaque analysis, and noncalcified VHTCFA was associated with nonrestenotic and total MACE on whole-patient analysis, demonstrating that VH-IVUS can identify plaques at increased risk of subsequent events. The preservation of the association between VHTCFA and MACE despite various analyses emphasizes its biological importance.

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Metadata

Authors
Calvert, P. A., Obaid, D. R., O'Sullivan, M., Shapiro, L. M., McNab, D., Densem, C. G., Schofield, P. M., Braganza, D., Clarke, S. C., Ray, K. K., West, N. E. J., & Bennett, M. R.
Venue
JACC: Cardiovascular Imaging
Publisher
Elsevier BV
Published
2011-08
Volume
4
Issue
8
Pages
894-901
ISSN
  • 1876-7591 (ISSN-L)
  • 1936-878X
DOI
10.1016/j.jcmg.2011.05.005
OpenAlex
W174836541
Cited by
517
References
12
FWCI
27.72
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease. https://app.cochat.ai/papers/10.1016/j.jcmg.2011.05.005
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Calvert, P. A., Obaid, D. R., O'Sullivan, M., Shapiro, L. M., McNab, D., Densem, C. G., Schofield, P. M., Braganza, D., Clarke, S. C., Ray, K. K., West, N. E. J., & Bennett, M. R. (2011). Association Between IVUS Findings and Adverse Outcomes in Patients With Coronary Artery Disease. JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2011.05.005

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.