Cited by 1,561RNA Interference and Gene DeliveryNanoparticle-Based Drug DeliveryCellular transport and secretion

The DOI matches its Crossref record; 148 of the 151 references it cites were found in a registry or an index.

Endosomal escape pathways for delivery of biologicals

Open access

Varkouhi, Amir K., Scholte, Marije, Storm, Gert, Haisma, Hidde J.·2011·Journal of Controlled Release

DOI 10.1016/j.jconrel.2010.11.004

Open this paper in CoChat — free account

Abstract

Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue in biological treatments such as protein and gene therapy. The endocytic pathway is the major uptake mechanism of cells and any biological agents, such as DNA, siRNA and proteins. These agents become entrapped in endosomes and are degraded by specific enzymes in the lysosome. Thus, a limiting step in achieving an effective biological based therapy is to facilitate the endosomal escape and ensure cytosolic delivery of the therapeutics. Bacteria and viruses are pathogens which use different mechanisms to penetrate the membranes of their target cells and escape the endosomal pathway. Different mechanisms such as pore formation in the endosomal membrane, pH-buffering effect of protonable groups and fusion into the lipid bilayer of endosomes have been proposed to facilitate the endosomal escape. Several viral and bacterial proteins have been identified that are involved in this process. In addition, chemical agents and photochemical methods to rupture the endosomal membrane have been described. New synthetic biomimetic peptides and polymers with high efficacy in facilitating the endosomal escape, low pathogenicity and toxicity have been developed. Each strategy has different characteristics and challenges for designing the best agents and techniques to facilitate the endosomal escape are ongoing. In this review, several mechanisms and agents which are involved in endosomal escape are introduced.

Integrity signals

Registry

Crossref · 10.1016/j.jconrel.2010.11.004

Cites

148 of 148 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine.
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Peptide Antimicrobial Agents
Jenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,605
ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS
Mellman, I., Fuchs, R., & Helenius, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003311 · Cited by 2,045
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
Kay, M., Glorioso, J., & Naldini, L. (2001) · Nature Medicine · doi:10.1038/83324 · Cited by 1,444
THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS
Wiley, D. C., & Skehel, J. J. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002053 · Cited by 1,413
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., & Prochiantz, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18188 · Cited by 1,073
The actions of melittin on membranes
Dempsey, C. E. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90006-x · Cited by 852
Stepwise dismantling of adenovirus 2 during entry into cells
Greber, U. F., Willetts, M., Webster, P. C., & Helenius, A. (1993) · Cell · doi:10.1016/0092-8674(93)90382-z · Cited by 811
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Al-Dosari, M. S., & Gao, X. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9143-y · Cited by 706

Show all 151 references

Sorted by citations

Items 401–500 of 1,000

Nanoparticle formulations for therapeutic delivery, pathogen imaging and theranostic applications in bacterial infections
Jiang, L., Ding, L., & Liu, G. (2023) · Theranostics · doi:10.7150/thno.82790 · Cited by 65
Strategies for the Nuclear Delivery of Metal Complexes to Cancer Cells
Huynh, M., Vinck, R., Gibert, B., & Gasser, G. (2024) · Advanced Materials · doi:10.1002/adma.202311437 · Cited by 59
Efficient Intracellular Delivery of Molecules with High Cell Viability Using Nanosecond-Pulsed Laser-Activated Carbon Nanoparticles
Sengupta, A., Kelly, S. C., Dwivedi, N., Thadhani, N. N., & Prausnitz, M. R. (2014) · ACS Nano · doi:10.1021/nn500100x · Cited by 59
A Programmable Sensor to Probe the Internalization of Proteins and Nanoparticles in Live Cells
Liu, H., & Johnston, A. P. R. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201301243 · Cited by 59
Bactericidal and Anti-biofilm Effects of Polyhexamethylene Biguanide in Models of Intracellular and Biofilm of Staphylococcus aureus Isolated from Bovine Mastitis
Kamaruzzaman, N. F., Chong, S. Q. Y., Edmondson-Brown, K. M., Ntow‐Boahene, W., Bardiau, M., & Good, L. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01518 · Cited by 59
siRNA in ovarian cancer – Delivery strategies and targets for therapy
van den Brand, D., Mertens, V., Massuger, L. F. A. G., & Brock, R. E. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.05.012 · Cited by 60
Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood–brain barrier transport
Díaz‐Perlas, C., Oller‐Salvia, B., Sánchez‐Navarro, M., Teixidò, M., & Giralt, E. (2018) · Chemical Science · doi:10.1039/c8sc02415d · Cited by 59
Intracellular Routing and Recognition of Lipid-Based mRNA Nanoparticles
Delehedde, C., Even, L., Midoux, P., Pichon, C., & Perche, F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070945 · Cited by 60
Precise and systematic end group chemistry modifications on PAMAM and poly(l-lysine) dendrimers to improve cytosolic delivery of mRNA
Joubert, F., Munson, M. J., Sabirsh, A., England, R., Hemmerling, M., Alexander, C., & Ashford, M. B. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.03.011 · Cited by 58
Nanobiomaterial vectors for improving gene editing and gene therapy
Hu, S. W., Ding, T., Tang, H., Guo, H., Cui, W., & Shu, Y. (2023) · Materials Today · doi:10.1016/j.mattod.2023.04.011 · Cited by 58
Bioactive Vanadium Disulfide Nanostructure with “Dual” Antitumor Effects of Vanadate and Gas for Immune-Checkpoint Blockade-Enhanced Cancer Immunotherapy
Pei, Z., Lei, H., Wu, J., Tang, W., Wei, K., Wang, L., Gong, F., Yang, N., Liu, L., Yang, Y., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c04767 · Cited by 58
Intracellular probes for imaging oxygen concentration: how good are they?
Dmitriev, R. I., & Papkovsky, D. B. (2015) · Methods and Applications in Fluorescence · doi:10.1088/2050-6120/3/3/034001 · Cited by 62
Dual-functionalized graphene oxide for enhanced siRNA delivery to breast cancer cells
Imani, R., Shao, W., Taherkhani, S., Emami, S. H., Prakash, S., & Faghihi, S. (2016) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2016.08.015 · Cited by 58
Glycosylated Triterpenoids as Endosomal Escape Enhancers in Targeted Tumor Therapies
Fuchs, H., Niesler, N., Trautner, A., Sama, S., Jerz, G., Panjideh, H., & Weng, A. (2017) · Biomedicines · doi:10.3390/biomedicines5020014 · Cited by 59
From Endocytosis to Nonendocytosis: The Emerging Era of Gene Delivery
Zhou, J. J., Shao, Z., Liu, J., Duan, Q., Wang, X., Li, J., & Yang, H. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b01131 · Cited by 59
Caproic acid grafted chitosan cationic nanocomplexes for enhanced gene delivery: Effect of degree of substitution
Layek, B., & Singh, J. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.02.052 · Cited by 57
Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function
Uzhytchak, M., Smolková, B., Lunová, M., Frtús, A., Jirsa, M., Dejneka, A., & Lunov, O. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114828 · Cited by 61
Chondroitin/Lactoferrin-dual functionalized pterostilbene-solid lipid nanoparticles as targeted breast cancer therapy
Aly, S., El-Kamel, A. H., Sheta, E., & El-Habashy, S. E. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123163 · Cited by 57
Overcoming Biological Barriers in Cancer Therapy: Cell Membrane-Based Nanocarrier Strategies for Precision Delivery
Li, Y., Sun, H., Cao, D. S., Guo, Y., Wu, D., Yang, M., Wang, H., Shao, X., Li, Y., & Liang, Y. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s497510 · Cited by 60
Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells
Higuchi, Y., Wu, C., Chang, K., Irie, K., Kawakami, S., Yamashita, F., & Hashida, M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.076 · Cited by 57
Endosomal pH-activatable magnetic nanoparticle-capped mesoporous silica for intracellular controlled release
Gan, Q., Lu, X., Dong, W., Yuan, Y., Qian, J., Li, Y., Shi, J., & Liu, C. (2012) · Journal of Materials Chemistry · doi:10.1039/c2jm32020g · Cited by 57
Understanding nano-bio interactions to improve nanocarriers for drug delivery
Pearson, R. M., Hsu, H.-J., Bugno, J., & Hong, S. (2014) · MRS Bulletin · doi:10.1557/mrs.2014.9 · Cited by 57
Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference
Lin, G., Zhang, Y., Zhang, L., Wang, J., Tian, Y., Cai, W., Tang, S., Chu, C., Zhou, J., Mi, P., et al. (2020) · Nano Research · doi:10.1007/s12274-019-2606-2 · Cited by 57
pH‐Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin
Herranz‐Blanco, B., Shahbazi, M., Correia, A. M. R., Balasubramanian, V., Kohout, T., Hirvonen, J. J., & Santos, H. A. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600160 · Cited by 57
Endosomal escape for cell-targeted proteins. Going out after going in
Voltà‐Durán, E., Parladé, E., Serna, N., Villaverde, A., Vázquez, E., & Unzueta, U. (2023) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108103 · Cited by 56
Delivery of Methoprene-Tolerant dsRNA to Improve RNAi Efficiency by Modified Liposomes for Pest Control
Su, C., Liu, S., Sun, M., Yu, Q., Li, C., Graham, R. I., Wang, X., Wang, X., Xu, P., & Ren, G. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c20151 · Cited by 56
Identification of the endosomal sorting complex required for transport-I (ESCRT-I) as an important modulator of anti-miR uptake by cancer cells
Wagenaar, T. R., Tolstykh, T., Shi, C., Jiang, L., Zhang, J., Li, Z., Yu, Q., Qu, H., Sun, F., Cao, H., et al. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku1367 · Cited by 54
Hydroxychloroquine-conjugated gold nanoparticles for improved siRNA activity
Perche, F., Yi, Y., Hespel, L., Mi, P., Dirisala, A., Cabral, H., Miyata, K., & Kataoka, K. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.027 · Cited by 56
Biomechanics and Thermodynamics of Nanoparticle Interactions with Plasma and Endosomal Membrane Lipids in Cellular Uptake and Endosomal Escape
Peetla, C., Jin, S.-H., Weimer, J. M., Elegbede, A. I., & Labhasetwar, V. D. (2014) · Langmuir · doi:10.1021/la5015219 · Cited by 56
Heat shock proteins and cancer: How can nanomedicine be harnessed?
Sauvage, F., Messaoudi, S., Fattal, E., BARRATT, G. M., & Vergnaud, J. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.013 · Cited by 56
Nasal vaccination with r4M2e.HSP70c antigen encapsulated into N-trimethyl chitosan (TMC) nanoparticulate systems: Preparation and immunogenicity in a mouse model
Dabaghian, M., Latifi, A. M., Tebianian, M., Najminejad, H., & Ebrahimi, S. M. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.02.072 · Cited by 56
Redox-Responsive Polycondensate Neoepitope for Enhanced Personalized Cancer Vaccine
Wei, L., Zhao, Y., Hu, X., & Tang, L. (2020) · ACS Central Science · doi:10.1021/acscentsci.9b01174 · Cited by 57
Photosensitizer-Doped and Plasma Membrane-Responsive Liposomes for Nuclear Drug Delivery and Multidrug Resistance Reversal
Zhu, Y., Jia, H., Duan, Q., Liu, X., Yang, J., Liu, Y., & Wu, F. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c09110 · Cited by 56
Potential therapies and diagnosis based on Golgi-targeted nano drug delivery systems
Zhang, M., Xu, N., Xu, W., Ling, G., & Zhang, P. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105861 · Cited by 54
Recent advancements in lipid–mRNA nanoparticles as a treatment option for cancer immunotherapy
Karmacharya, P., Patil, B. R., & Kim, J. O. (2022) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-022-00569-9 · Cited by 54
Intelligent nanotherapeutic strategies for the delivery of CRISPR system
Chen, C., Zhong, W., Du, S., Li, Y., Zeng, Y., Liu, K., Yang, J., Guan, X., & Han, X. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.12.013 · Cited by 56
A potential paradigm in CRISPR/Cas systems delivery: at the crossroad of microalgal gene editing and algal-mediated nanoparticles
Feng, S., Xie, X., Liu, J., Li, A., Wang, Q., Guo, D., Li, S., Li, Y., Wang, Z., Guo, T., et al. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02139-z · Cited by 59
Light-Controlled Delivery of Monoclonal Antibodies for Targeted Photoinactivation of Ki-67
Wang, S., Hüttmann, G., Zhang, Z., Vogel, A., Birngruber, R., Tangutoori, S., Hasan, T. G., & Rahmanzadeh, R. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00260 · Cited by 54
Polymer nanocarriers for MicroRNA delivery
Kapadia, C. H., Luo, B., Dang, M. N., Irvin-Choy, N. S., Valcourt, D. M., & Day, E. S. (2019) · Journal of Applied Polymer Science · doi:10.1002/app.48651 · Cited by 60
Micelleplexes as nucleic acid delivery systems for cancer-targeted therapies
Pereira‐Silva, M., Jarak, I., Alvarez‐Lorenzo, C., Concheiro, Á., Paiva‐Santos, A. C., Veiga, F., & Figueiras, A. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.041 · Cited by 56
Base-modified aptamers obtained by cell-internalization SELEX facilitate cellular uptake of an antisense oligonucleotide
Tanaka, K., Okuda, T., Kasahara, Y., & Obika, S. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2020.11.016 · Cited by 54
Niosomal delivery of simvastatin to MDA-MB-231 cancer cells
Akbarzadeh, I., Poor, A. S., Yaghmaei, S., Norouzian, D., Noorbazargan, H., Saffar, S., Cohan, R. A., & Bakhshandeh, H. (2020) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2020.1810269 · Cited by 53
Delivery systems of therapeutic nucleic acids for the treatment of acute lung injury/acute respiratory distress syndrome
Zhuang, C., Kang, M., & Lee, M. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.06.018 · Cited by 54
Membrane-Embedded Nanoparticles Induce Lipid Rearrangements Similar to Those Exhibited by Biological Membrane Proteins
Lehn, R. C. V., & Alexander‐Katz, A. (2014) · The Journal of Physical Chemistry B · doi:10.1021/jp506239p · Cited by 53
Endosomal escape kinetics of mesoporous silica-based system for efficient siRNA delivery
Wang, M., Xu, L., Ma, Y., & Gu, H. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.03.022 · Cited by 54
Length-Controlled Synthesis of Calcium Phosphate Nanorod and Nanowire and Application in Intracellular Protein Delivery
Das, P., & Jana, N. R. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b01667 · Cited by 53
Transmission electron microscopy for nanomedicine: novel applications for long-established techniques
Malatesta, M. (2016) · European Journal of Histochemistry · doi:10.4081/ejh.2016.2751 · Cited by 53
Dequalinium-based functional nanosomes show increased mitochondria targeting and anticancer effect
Bae, Y., Jung, M. K., Lee, S., Song, S. J., Mun, J. Y., Green, E. S., Han, J., Ko, K. S., & Choi, J. S. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.12.013 · Cited by 53
Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy
Vermeulen, L. M. P., Brans, T., Smedt, S. C. D., Remaut, K., & Braeckmans, K. (2018) · Nano Today · doi:10.1016/j.nantod.2018.06.007 · Cited by 54
Bioresponsive peptide-polysaccharide nanogels — A versatile delivery system to augment the utility of bioactive cargo
Simonson, A. W., Lawanprasert, A., Goralski, T. D. P., Keiler, K. C., & Medina, S. H. (2018) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2018.10.008 · Cited by 53
Cytosolic Delivery of Macromolecules in Live Human Cells Using the Combined Endosomal Escape Activities of a Small Molecule and Cell Penetrating Peptides
Allen, J. K., Najjar, K., Erazo‐Oliveras, A., Kondow-McConaghy, H. M., Brock, D. J., Graham, K. D., Hager, E. C., Marschall, A. L. J., Dübel, S., Juliano, R. L., et al. (2019) · ACS Chemical Biology · doi:10.1021/acschembio.9b00585 · Cited by 56
Delivery of Cas9/sgRNA Ribonucleoprotein Complexes via Hydroxystearyl Oligoamino Amides
Kuhn, J., Lin, Y., Levačić, A. K., Danaf, N. A., Peng, L., Höhn, M., Lamb, D. C., Wagner, E., & Lächelt, U. (2020) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00853 · Cited by 54
Multifunctional envelope-type nano device for controlled intracellular trafficking and selective targeting in vivo
Kajimoto, K., Sato, Y., Nakamura, T., Yamada, Y., & Harashima, H. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.03.058 · Cited by 52
Application of chloroquine as an endosomal escape enhancing agent: new frontiers for an old drug
Hajimolaali, M., Mohammadian, H., Torabi, A., Shirini, A., Shal, M. K., Nezhad, H. B., Iranpour, S., Eftekhari, R. B., & Dorkoosh, F. A. (2021) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2021.1873272 · Cited by 56
Smart Polymeric Nanoparticles with pH-Responsive and PEG-Detachable Properties (II): Co-Delivery of Paclitaxel and VEGF siRNA for Synergistic Breast Cancer Therapy in Mice
Jin, M., Hou, Y., Quan, X., Chen, L., Gao, Z., & Huang, W. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s313339 · Cited by 52
Nanozyme‐Based Artificial Organelles: An Emerging Direction for Artificial Organelles
Zhang, S., Zhang, R., Yan, X., & Fan, K. (2022) · Small · doi:10.1002/smll.202202294 · Cited by 52
Rescuing Nucleus Pulposus Cells from ROS Toxic Microenvironment via Mitochondria‐Targeted Carbon Dot‐Supported Prussian Blue to Alleviate Intervertebral Disc Degeneration
Shi, Y., Bu, W., Chu, D., Lin, W., Li, K., Huang, X., Wang, X., Wu, Y., Wu, S., Li, D., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202303206 · Cited by 53
The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides
Ming, X., Carver, K. A., FISHER, M. S., Noël, R., Cintrat, J., Gillet, D., Barbier, J., Cao, C., Bauman, J. A., & Juliano, R. L. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt066 · Cited by 52
Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells
Wang, W., Sreekumar, P. G., Valluripalli, V., Shi, P., Wang, J., Lin, Y., Cui, H., Kannan, R., Hinton, D. R., & MacKay, J. A. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.028 · Cited by 52
Mechanistic Insights into LDL Nanoparticle-Mediated siRNA Delivery
Jin, H., Lovell, J. F., Chen, J., Lin, Q., Ding, L., Ng, K. K., Pandey, R. K., Manoharan, M., Zhang, Z., & Zheng, G. (2011) · Bioconjugate Chemistry · doi:10.1021/bc200233n · Cited by 52
Smart Nanosystems for Overcoming Multiple Biological Barriers in Cancer Nanomedicines Transport: Design Principles, Progress, and Challenges
Lin, G., Zhou, J., Cheng, H., & Liu, G. (2023) · Small · doi:10.1002/smll.202207973 · Cited by 52
Green synthesis of highly fluorescent carbon quantum dots from almond resin for advanced theranostics in biomedical applications
Praseetha, P. K., Litany, R. I. J., Alharbi, H. M., Khojah, A. A., Akash, S., Bourhia, M., Mengistie, A. A., & Shazly, G. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-75333-0 · Cited by 51
pH-sensitive oncolytic adenovirus hybrid targeting acidic tumor microenvironment and angiogenesis
Choi, J.-W., Jung, S.-J., Kasala, D., Hwang, J. K., Hu, J., Bae, Y. H., & Yun, C. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.01.005 · Cited by 51
pH-Reversible Cationic RNase A Conjugates for Enhanced Cellular Delivery and Tumor Cell Killing
Liu, X., Zhang, P., He, D., Rödl, W., Preiß, T., Rädler, J. O., Wagner, E., & Lächelt, U. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01289 · Cited by 51
Enhanced endosomal escape by photothermal activation for improved small interfering RNA delivery and antitumor effect
Yang, X., Fan, B., Gao, W., Li, L., Li, T., Sun, J., Peng, X., Li, X., Wang, Z., Wang, B., et al. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s161908 · Cited by 52
Ingestion of bacteria expressing dsRNA to maggots produces severe mortality and deformities in fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)
Mohanpuria, P., Govindaswamy, M., Sidhu, G. S., Singh, S., Kaur, S., & Chhuneja, P. (2021) · Egyptian Journal of Biological Pest Control · doi:10.1186/s41938-020-00345-7 · Cited by 51
Metal–Organic Framework Nanoparticles Power DNAzyme Logic Circuits for Aberrant MicroRNA Imaging
Zhang, J., Fu, H., & Chu, X. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c02878 · Cited by 50
The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells
Kim, Y., Kim, H., Kim, E. H., Jang, H., Jang, Y., Chi, S.-G., Yang, Y., & Kim, S. H. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061271 · Cited by 50
‘Smart’ nanoparticles as drug delivery systems for applications in tumor therapy
Fang, Z., Wan, L., Chu, L., Zhang, Y., & Wu, J. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2015.1071352 · Cited by 50
Polyplexes based on cationic polymers with strong nucleic acid binding properties
Varkouhi, A. K., Mountrichas, G., Schiffelers, R. M., Lammers, T., Storm, G., Pispas, S., & Hennink, W. E. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.09.002 · Cited by 50
Self-citation
Dioctadecyldimethylammonium:Monoolein Nanocarriers for Efficient in Vitro Gene Silencing
Oliveira, A. C., Martens, T., Raemdonck, K., Adati, R. D., Feitosa, E., Botelho, C., Gomes, A. C., Braeckmans, K., & Oliveira, M. E. C. D. R. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am500793y · Cited by 50
Nanocarriers as Potential Targeted Drug Delivery for Cancer Therapy
Singhvi, G., Rapalli, V. K., Nagpal, S., Dubey, S. K., & Saha, R. N. (2020) · Environmental chemistry for a sustainable world · doi:10.1007/978-3-030-29207-2_2 · Cited by 50
Charge reversible hyaluronic acid-modified dendrimer-based nanoparticles for siMDR-1 and doxorubicin co-delivery
Zhang, X., Pan, J., Yao, M., Mendes, L. P., Sarısözen, C., Mao, S., & Torchilin, V. P. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.06.019 · Cited by 50
Considerations for the delivery of STING ligands in cancer immunotherapy
Petrovic, M., Borchard, G., & Jordan, O. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.09.033 · Cited by 51
Sequential delivery of VEGF siRNA and paclitaxel for PVN destruction, anti-angiogenesis, and tumor cell apoptosis procedurally via a multi-functional polymer micelle
Yang, Y., Meng, Y., Ye, J., Xia, X., Wang, H., Li, L., Dong, W., Jin, D., & Liu, Y. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.08.028 · Cited by 49
RGD peptide-based lipids for targeted mRNA delivery and gene editing applications
Qin, J., Xue, L., Gong, N., Zhang, H., Shepherd, S. J., Haley, R. M., Swingle, K. L., & Mitchell, M. J. (2022) · RSC Advances · doi:10.1039/d2ra02771b · Cited by 54
Comprehensive analysis of lipid nanoparticle formulation and preparation for RNA delivery
Haque, M. A., Shrestha, A., Mikelis, C. M., & Mattheolabakis, G. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100283 · Cited by 52
The Fate of Nanocarriers As Nanomedicines In Vivo: Important Considerations and Biological Barriers to Overcome
Moros, M., Mitchell, S. G., Grazú, V., & de la Fuente, J. M. (2013) · Current Medicinal Chemistry · doi:10.2174/0929867311320220003 · Cited by 49
Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound
Yoon, S., Wang, P., Qin, P., Wang, Y., & Shung, K. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-05722-1 · Cited by 49
State of the Art of Stimuli-Responsive Liposomes for Cancer Therapy.
Heidarli, E., Dadashzadeh, S., & Haeri, A. (2017) · PubMed Central · Cited by 49
Mimicking Pathogenic Invasion with the Complexes of Au22(SG)18-Engineered Assemblies and Folic Acid
Zhang, C., Zhang, A., Hou, W., Li, T., Wang, K., Zhang, Q., de la Fuente, J. M., Jin, W., & Cui, D. (2018) · ACS Nano · doi:10.1021/acsnano.8b00196 · Cited by 49
Graphene oxide as a 2D platform for complexation and intracellular delivery of siRNA
de Lázaro, I., Vranic, S., Marson, D., Rodrigues, A. F., Buggio, M., Esteban-Arranz, A., Mazza, M., Posocco, P., & Kostarelos, K. (2019) · Nanoscale · doi:10.1039/c9nr02301a · Cited by 49
Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery
Wei, W., Sun, J., Guo, X., Chen, X., Wang, R., Qiu, C., Zhang, H., Pang, W.-H., Wang, J., & Zhang, Q. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b22781 · Cited by 49
Nucleic acid nanotechnology for cancer treatment
Jin, J., Kim, G., Hwang, J., Han, K. H., Kwak, M., & Lee, P. C.-W. (2020) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2020.188377 · Cited by 49
Shape matters: Morphologically biomimetic particles for improved drug delivery
Wang, J., Li, Q., Xue, J., Chen, W., Zhang, R., & Xing, D. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.127849 · Cited by 49
Hyaluronic acid-based multifunctional carriers for applications in regenerative medicine: A review
An, C., Li, H., Zhao, Y., Zhang, S., Zhao, Y., Zhang, Y., Yang, J., Zhang, L., Ren, C., Zhang, Y., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123307 · Cited by 49
Recent progress in copolymer-mediated siRNA delivery
Wu, Z.-W., Chien, C., Liu, C., Yan, J., & Lin, S. (2012) · Journal of drug targeting · doi:10.3109/1061186x.2012.699057 · Cited by 50
Novel endosomolytic peptides for enhancing gene delivery in nanoparticles
Ahmad, A., Ranjan, S. K., Zhang, W., Zou, J., Pyykkö, I. V., & Kinnunen, P. K. J. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.11.008 · Cited by 49
Tracking the Down‐Regulation of Folate Receptor‐α in Cancer Cells through Target Specific Delivery of Quantum Dots Coupled with Antisense Oligonucleotide and Targeted Peptide
Zhang, M., Yu, Y., Yu, R., Wan, M., Zhang, R., & Zhao, Y. (2013) · Small · doi:10.1002/smll.201300994 · Cited by 48
Molecular bionics – engineering biomaterials at the molecular level using biological principles
Rodríguez‐Arco, L., Poma, A., Ruiz‐Pérez, L., Scarpa, E., Ngamkham, K., & Battaglia, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.044 · Cited by 49
Protamine/DNA/Niosome Ternary Nonviral Vectors for Gene Delivery to the Retina: The Role of Protamine
Puras, G., Martı́nez, G., Mashal, M., Sesma, J. Z., Agirre, M., Ojeda, E., Grijalvo, S., Eritja, R., Díaz‐Tahoces, A., Avilés‐Trigueros, M., et al. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00422 · Cited by 47
Development of a simple, biocompatible and cost-effective Inulin-Diethylenetriamine based siRNA delivery system
Sardo, C., Farra, R., Licciardi, M., Dapas, B., Scialabba, C., Giammona, G., Grassi, M., Grassi, G., & Cavallaro, G. (2015) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2015.03.021 · Cited by 47
Internalized chitosan nanoparticles persist for long time in cultured cells
Malatesta, M., Grecchi, S., Chiesa, E., Cisterna, B., Costanzo, M., & Zancanaro, C. (2015) · European Journal of Histochemistry · doi:10.4081/ejh.2015.2492 · Cited by 47
Live cell imaging of duplex siRNA intracellular trafficking
Hirsch, M., & Helm, M. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv307 · Cited by 46
The toxin component of targeted anti‐tumor toxins determines their efficacy increase by saponins
Weng, A., Thakur, M., Beceren‐Braun, F., Bachran, D., Bachran, C., Riese, S. B., Jenett‐Siems, K., Gilabert‐Oriol, R., Melzig, M. F., & Fuchs, H. (2012) · Molecular Oncology · doi:10.1016/j.molonc.2012.01.004 · Cited by 47
Multi-stage, charge conversional, stimuli-responsive nanogels for therapeutic protein delivery
Zhang, X., Zhang, K., & Haag, R. (2015) · Biomaterials Science · doi:10.1039/c5bm00171d · Cited by 47
Dendron conjugation to graphene oxide using click chemistry for efficient gene delivery
Sarkar, K., Madras, G., & Chatterjee, K. (2015) · RSC Advances · doi:10.1039/c5ra07004j · Cited by 49
Limited Efficiency of Drug Delivery to Specific Intracellular Organelles Using Subcellularly “Targeted” Drug Delivery Systems
Maity, A. R., & Stepensky, D. (2015) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5b00697 · Cited by 47
Repurposing bacterial toxins for intracellular delivery of therapeutic proteins
Beilhartz, G. L., Sugiman‐Marangos, S. N., & Melnyk, R. A. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.04.009 · Cited by 49
Formulation of Nonionic Surfactant Vesicles (NISV) Prepared by Microfluidics for Therapeutic Delivery of siRNA into Cancer Cells
Obeid, M. A., Elburi, A. H. A., Young, L., Mullen, A. B., Tate, R. J., & Ferro, V. A. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00352 · Cited by 47

Authors: Varkouhi, A. K., Scholte, M., Storm, G., & Haisma, H. J.
Affiliations: Utrecht University (NL)
University of Groningen (NL)
Corresponding author: Haisma, Hidde J.
ORCID: Varkouhi, Amir K.
Storm, Gert
Haisma, Hidde J.
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2011-05
Volume: 151
Issue: 3
Pages: 220-228
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2010.11.004
OpenAlex: W2008028087
Cited by: 1,561
References: 151
Citations by year: 2026: 82 · 2025: 82 · 2024: 90 · 2023: 94 · 2022: 122 · 2021: 100 · 2020: 123 · 2019: 120 · 2018: 137 · 2017: 111 · 2016: 127 · 2015: 116 · 2014: 98 · 2013: 90 · 2012: 51
FWCI: 4.32
Type: journal article
Language: en
Open access: green
research.wur.nl
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Data Archiving and Networked Services (DANS) (submittedVersion)
Funders: European Commission
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: endosomal escape, endocytosis, lysosomal degradation, protein delivery, gene delivery, siRNA delivery, viral fusion, pH buffering, biomimetic peptides, polymers, biologic therapy
MeSH terms: Animals, Cytosol, DNA, Drug Carriers, Endocytosis, Humans, Intracellular Membranes, Membrane Fusion, Models, Biological, Proteins, Endosomes, RNA, Small Interfering

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Endosomal escape pathways for delivery of biologicals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks