The DOI matches its Crossref record; 148 of the 151 references it cites were found in a registry or an index.
Endosomal escape pathways for delivery of biologicals
Open accessAbstract
Despite continuous improvements in delivery systems, the development of methods for efficient and specific delivery of targeted therapeutic agents still remains an issue in biological treatments such as protein and gene therapy. The endocytic pathway is the major uptake mechanism of cells and any biological agents, such as DNA, siRNA and proteins. These agents become entrapped in endosomes and are degraded by specific enzymes in the lysosome. Thus, a limiting step in achieving an effective biological based therapy is to facilitate the endosomal escape and ensure cytosolic delivery of the therapeutics. Bacteria and viruses are pathogens which use different mechanisms to penetrate the membranes of their target cells and escape the endosomal pathway. Different mechanisms such as pore formation in the endosomal membrane, pH-buffering effect of protonable groups and fusion into the lipid bilayer of endosomes have been proposed to facilitate the endosomal escape. Several viral and bacterial proteins have been identified that are involved in this process. In addition, chemical agents and photochemical methods to rupture the endosomal membrane have been described. New synthetic biomimetic peptides and polymers with high efficacy in facilitating the endosomal escape, low pathogenicity and toxicity have been developed. Each strategy has different characteristics and challenges for designing the best agents and techniques to facilitate the endosomal escape are ongoing. In this review, several mechanisms and agents which are involved in endosomal escape are introduced.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Citations
Cites
Boussif, O., Lezoualc’h, F., Zanta, M. A., Djavaheri‐Mergny, M., Scherman, D., DEMENEIX, B. A., & Behr, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.16.7297 · Cited by 6,256
Jenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,605
ACIDIFICATION OF THE ENDOCYTIC AND EXOCYTIC PATHWAYS
Mellman, I., Fuchs, R., & Helenius, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003311 · Cited by 2,045
Lewin, M., Carlesso, N., Tung, C., Tang, X. S., Cory, D. G., Scadden, D. T., & Weissleder, R. (2000) · Nature Biotechnology · doi:10.1038/74464 · Cited by 1,716
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
Kay, M., Glorioso, J., & Naldini, L. (2001) · Nature Medicine · doi:10.1038/83324 · Cited by 1,444
THE STRUCTURE AND FUNCTION OF THE HEMAGGLUTININ MEMBRANE GLYCOPROTEIN OF INFLUENZA VIRUS
Wiley, D. C., & Skehel, J. J. (1987) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.56.070187.002053 · Cited by 1,413
Cell Internalization of the Third Helix of the Antennapedia Homeodomain Is Receptor-independent
Derossi, D., Calvet, S., Trembleau, A., Brunissen, A., Chassaing, G., & Prochiantz, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18188 · Cited by 1,073
The actions of melittin on membranes
Dempsey, C. E. (1990) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(90)90006-x · Cited by 852
Stepwise dismantling of adenovirus 2 during entry into cells
Greber, U. F., Willetts, M., Webster, P. C., & Helenius, A. (1993) · Cell · doi:10.1016/0092-8674(93)90382-z · Cited by 811
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
Al-Dosari, M. S., & Gao, X. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9143-y · Cited by 706
Flagged first, then by citations
3 of the 151 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 601–700 of 1,000
Byrnes, A. E., Dominguez, S. L., Yen, C.-W., Laufer, B. I., Foreman, O., Reichelt, M., Lin, H., Sagolla, M., Hötzel, K., Ngu, H., et al. (2023) · Molecular Therapy - Nucleic Acids · doi:10.1016/j.omtn.2023.05.005 · Cited by 38
Ramadan, E., Ismeal, A. A. A., & Naguib, Y. W. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14111092 · Cited by 42
Messaoudi, K., Clavreul, A., & Lagarce, F. (2015) · Drug Discovery Today · doi:10.1016/j.drudis.2015.02.014 · Cited by 36
Liu, Q., Jiang, Q., Yi, W.-J., Zhang, J., Zhang, X.-C., Wu, M., Zhang, Y., Zhu, W., & Yu, X. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.048 · Cited by 36
Nanoengineered strategies for siRNA delivery: from target assessment to cancer therapeutic efficacy
Mishra, D. K., Balekar, N., & Mishra, P. K. (2017) · Drug Delivery and Translational Research · doi:10.1007/s13346-016-0352-5 · Cited by 37
Xie, Y., Yu, F., Tang, W., Alade, B. O., Peng, Z., Wang, Y., Li, J., & Oupický, D. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700194 · Cited by 36
Mashal, M., Attia, N., Soto‐Sánchez, C., Martı́nez, G., Fernández, E., Puras, G., & Pedraz, J. L. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.09.038 · Cited by 36
Cholesterol Anchors Enable Efficient Binding and Intracellular Uptake of DNA Nanostructures
Whitehouse, W. L., Noble, J. E., Ryadnov, M. G., & Howorka, S. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00036 · Cited by 36
Overcoming Endocytosis Deficiency by Cubosome Nanocarriers
Prange, J. A., Aleandri, S., Komisarski, M., Luciani, A., Käch, A., Schuh, C., Hall, A. M., Mezzenga, R., Devuyst, O., & Landau, E. M. (2019) · ACS Applied Bio Materials · doi:10.1021/acsabm.9b00187 · Cited by 36
Vocelle, D., Chan, C., & Walton, S. P. (2020) · Nucleic Acid Therapeutics · doi:10.1089/nat.2019.0804 · Cited by 37
Bobbala, S. K. R., Allen, S. D., Yi, S., Vincent, M. P., Frey, M. A., Karabin, N. B., & Scott, E. A. (2020) · Nanoscale · doi:10.1039/c9nr10921h · Cited by 36
Kollenda, S., Kopp, M., Wens, J., Koch, J., Schulze, N., Papadopoulos, C., Pöhler, R., Meyer, H. H., & Epple, M. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.05.014 · Cited by 35
Li, Y., Liu, H., Fei, X., Ma, D., He, X., Tang, Q., Zhao, X., Zou, H., Chen, X., Kong, X., et al. (2021) · Nano Research · doi:10.1007/s12274-021-3616-4 · Cited by 36
Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers
Sevimli, S., Sagnella, S. M., Kavallaris, M., Bulmuş, V., & Davis, T. P. (2012) · Polymer Chemistry · doi:10.1039/c2py20112g · Cited by 36
Kachanov, A., Kostyusheva, A., Brezgin, S., Karandashov, I., Ponomareva, N. I., Tikhonov, A., Lukashev, A. N., Pokrovsky, V. S., Zamyatnin, A. A., Parodi, A., et al. (2024) · Medicinal Research Reviews · doi:10.1002/med.22036 · Cited by 44
Probing Endosomal Escape Using pHlexi Nanoparticles
Kongkatigumjorn, N., Cortez‐Jugo, C., Czuba, E., Wong, A. S. M., Hodgetts, R. Y., Johnston, A. P. R., & Such, G. K. (2016) · Macromolecular Bioscience · doi:10.1002/mabi.201600248 · Cited by 35
Colombani, T., Peuziat, P., Dallet, L., Haudebourg, T., Mével, M., Berchel, M., Lambert, O., Habrant, D., & Pitard, B. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.01.041 · Cited by 36
An overview of nanosomes delivery mechanisms: trafficking, orders, barriers and cellular effects
Harisa, G. I., Badran, M. M., Alanazi, F. K., & Attia, S. M. (2017) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2017.1354301 · Cited by 35
Biocompatible fluorinated poly(β-amino ester)s for safe and efficient gene therapy
Gong, J., Wang, Y., Xing, L., Cui, P., Qiao, J.-B., He, Y., & Jiang, H. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.015 · Cited by 35
Alsaggar, M., & Liu, D. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1437919 · Cited by 38
Role of the endolysosomal pathway and exosome release in tau propagation
Yan, M., & Zheng, T. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.104988 · Cited by 36
Methods for Evaluating Cell-Specific, Cell-Internalizing RNA Aptamers
Hernandez, L. I., Flenker, K. S., Hernández, F. J., Klingelhutz, A. J., McNamara, J. O., & Giangrande, P. H. (2013) · Pharmaceuticals · doi:10.3390/ph6030295 · Cited by 35
Muro, S. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201303188 · Cited by 34
Debele, T. A., Mekuria, S. L., Lin, S., & Tsai, H. (2016) · RSC Advances · doi:10.1039/c5ra25650j · Cited by 35
Heller, P., Hobernik, D., Lächelt, U., Schinnerer, M., Weber, B., Schmidt, M., Wagner, E., Bros, M., & Barz, M. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.05.012 · Cited by 34
Zhang, Y., Li, Y., Ma, J., Wang, X., Yuan, Z., & Wang, W. (2018) · Nano Research · doi:10.1007/s12274-018-2014-z · Cited by 34
Amornwachirabodee, K., Tantimekin, N., Pan-In, P., Palaga, T., Pienpinijtham, P., Pipattanaboon, C., Sukmanee, T., Ritprajak, P., Charoenpat, P., Pitaksajjakul, P., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20650-4 · Cited by 34
Sharma, S., Pukale, S. S., Sahel, D. K., Singh, P., Mittal, A., & Chitkara, D. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112305 · Cited by 34
Joseph, C., Daniels, A. N., Singh, S., & Singh, M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics14010053 · Cited by 34
Endocytosis-like DNA uptake by cell wall-deficient bacteria
Kapteijn, R., Shitut, S., Aschmann, D., Zhang, L., de Beer, M. A., Daviran, D., Roverts, R., Akiva, A., van Wezel, G. P., Kros, A., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33054-w · Cited by 36
Kohno, M., Horibe, T., Ohara, K., Ito, S., & Kawakami, K. (2014) · Chemistry & Biology · doi:10.1016/j.chembiol.2014.09.008 · Cited by 33
Chan, L. Y., Khung, Y. L., & Lin, C.-Y. (2019) · Nanomaterials · doi:10.3390/nano9010067 · Cited by 33
Basic Principles of RNA Interference: Nucleic Acid Types and In Vitro Intracellular Delivery Methods
Isenmann, M., Stoddart, M. J., Schmelzeisen, R., Groß, C., Bella, E. D., & Rothweiler, R. M. (2023) · Micromachines · doi:10.3390/mi14071321 · Cited by 37
Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release
Nazli, A., Khan, M. Z. I., Rácz, Á., & Béni, S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116699 · Cited by 38
Understanding of endo/lysosomal escape of nanomaterials in biomedical application
Wang, X., Li, H., Chen, C., & Liang, Z. (2025) · Smart Molecules · doi:10.1002/smo.20240017 · Cited by 37
Nanoparticle Ligand Presentation for Targeting Solid Tumors
Duskey, J. T., & Rice, K. G. (2014) · AAPS PharmSciTech · doi:10.1208/s12249-014-0143-6 · Cited by 33
Enhancing dendritic cell activation and HIV vaccine effectiveness through nanoparticle vaccination
Glass, J. J., Kent, S. J., & Rose, R. D. (2016) · Expert Review of Vaccines · doi:10.1586/14760584.2016.1141054 · Cited by 34
Smart micelleplexes as a new therapeutic approach for RNA delivery
Pereira, P., Barreira, M., Queiroz, J. A., Veiga, F., de Sousa, F. P., & Figueiras, A. (2016) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2016.1214567 · Cited by 34
Alterations in Cellular Processes Involving Vesicular Trafficking and Implications in Drug Delivery
Muro, S. (2018) · Biomimetics · doi:10.3390/biomimetics3030019 · Cited by 33
Cao, M., Gao, Zhan, M., Qiu, Piao, Zhou, Z., & Shen, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205074 · Cited by 33
Enzian, P., Schell, C., Link, A., Malich, C., Pries, R., Wollenberg, B., & Rahmanzadeh, R. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.9b01173 · Cited by 33
Environment‐Responsive Lipid/siRNA Nanoparticles for Cancer Therapy
Lu, Z., Laney, V. E. A., Hall, R. C. W., & Ayat, N. R. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001294 · Cited by 33
Polymeric Systems for Cancer Immunotherapy: A Review
Le, T. M. D., Yoon, A. R., Thambi, T., & Yun, C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826876 · Cited by 34
Nanocomplexes of doxorubicin and DNA fragments for efficient and safe cancer chemotherapy
Mohammad, S. N., Choi, Y. S., Chung, J. Y., Cedrone, E., Neun, B. W., Dobrovolskaia, M. A., Yang, X., Guo, W., Chew, Y. C., Kim, J., et al. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.048 · Cited by 33
Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles
McCullough, K. C., Milona, P., Thomann, L., Démoulins, T., Englezou, P. C., Suter, R., & Ruggli, N. (2014) · Vaccines · doi:10.3390/vaccines2040735 · Cited by 35
He, M., Potuck, A., Kohn, J. C., Fung, K., Reinhart‐King, C. A., & Chu, C. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b01449 · Cited by 33
Haidary, S. M., Mohammed, A. B., Córcoles, E. P., Ali, N. K., & Ahmad, M. R. (2016) · Microelectronic Engineering · doi:10.1016/j.mee.2016.03.051 · Cited by 33
Lu, M., Zhao, X., Xing, H., Xun, Z., Yang, T., Cai, C., Wang, D., & Ding, P. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.043 · Cited by 33
Cellular Mechanisms in Nanomaterial Internalization, Intracellular Trafficking, and Toxicity
de Jesus, M. B., & Kapila, Y. L. (2013) · Nanomedicine and nanotoxicology · doi:10.1007/978-1-4614-8993-1_9 · Cited by 33
Chen, X., Luo, X., Yin, W., Cui, W., He, Y., Tian, T., & Lin, Y. (2025) · ACS Nano · doi:10.1021/acsnano.5c03945 · Cited by 39
Injectable nanorobots for precision cancer therapy: motion-enhanced drug delivery
Gao, Z., Yang, Z., Xu, W., Luo, M., & Guan, J. (2025) · Chemical Society Reviews · doi:10.1039/d5cs00596e · Cited by 35
Geoghegan, J. C., Gilmore, B. L., & Davidson, B. L. (2012) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2012.43 · Cited by 32
Hasan, M., Nishimoto, A., Ohgita, T., Hama, S., Kashida, H., Asanuma, H., & Kogure, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.048 · Cited by 32
Kolesnikova, T. A., Kiragosyan, G., Le, T. H. N., Springer, S., & Winterhalter, M. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b01313 · Cited by 32
Nanotechnology in Wound Care: One Step Closer to the Clinic
Mozafari, M. (2018) · Molecular Therapy · doi:10.1016/j.ymthe.2018.08.008 · Cited by 32
Hameed, D. S., Sapmaz, A., Gjonaj, L., Merkx, R., & Ovaa, H. (2018) · ChemBioChem · doi:10.1002/cbic.201800649 · Cited by 32
Complex Size and Surface Charge Determine Nucleic Acid Transfer by Fusogenic Liposomes
Hoffmann, M., Hersch, N., Gerlach, S., Dreissen, G., Springer, R., Merkel, R., Csiszár, Á., & Hoffmann, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062244 · Cited by 32
Nadal‐Bufí, F., & Henriques, S. T. (2020) · Peptide Science · doi:10.1002/pep2.24168 · Cited by 33
Laisney, J., Gurusamy, D., Baddar, Z. E., Palli, S. R., & Unrine, J. M. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c06234 · Cited by 36
A novel progress of drug delivery system for organelle targeting in tumour cells
He, Z., Zhang, Y., Khan, A. R., Ji, J., Yu, A., & Zhai, G. (2020) · Journal of drug targeting · doi:10.1080/1061186x.2020.1797051 · Cited by 32
Pre-clinical non-viral vectors exploited for in vivo CRISPR/Cas9 gene editing: an overview
Rouatbi, N., McGlynn, T., & Al‐Jamal, K. T. (2022) · Biomaterials Science · doi:10.1039/d1bm01452h · Cited by 33
Toledo, M. A. S., Janissen, R., Favaro, M. T. D. P., Cotta, M. A., Monteiro, G. A., Prazeres, D. M. F., de Souza, A. P., & Azzoni, A. R. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.01.011 · Cited by 32
Nanomaterials for delivery of nucleic acid to the central nervous system (CNS)
Wang, D., & Wu, L. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.04.011 · Cited by 32
Estrada, L. H., Wu, H., Ling, K., Zhang, G., Sumagin, R., Parkos, C. A., Jones, R. M., Champion, J. A., & Neish, A. S. (2017) · ACS Nano · doi:10.1021/acsnano.7b03239 · Cited by 32
Dendritic peptide bolaamphiphiles for siRNA delivery to primary adipocytes
Eldredge, A. C., Johnson, M. E., Cao, Y., Zhang, L., Zhao, C., Liu, Z., Yang, Q., & Guan, Z. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.024 · Cited by 32
Oligonucleotides‐decorated‐poly(N‐vinyl pyrrolidone) nanogels for gene delivery
Dispenza, C., Adamo, G., Sabatino, M. A., Grimaldi, N., Bulone, D., Bondı̀, M. L., Rigogliuso, S., & Ghersi, G. (2013) · Journal of Applied Polymer Science · doi:10.1002/app.39774 · Cited by 31
Targeted Cytolysins Synergistically Potentiate Cytoplasmic Delivery of Gelonin Immunotoxin
Pirie, C. M., Liu, D. V., & Wittrup, K. D. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-12-1023 · Cited by 31
The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery
Choi, H., Jeena, M. T., Palanikumar, L., Jeong, Y., Park, S., Lee, E. J., & Ryu, J. (2016) · Chemical Communications · doi:10.1039/c6cc00200e · Cited by 31
Hu, J., Liu, G., Wang, C., Liu, T., Zhang, G., & Liu, S. (2014) · Biomacromolecules · doi:10.1021/bm501296d · Cited by 31
Yang, Y., Yang, Y., Xie, X., Xu, X., Xia, X., Wang, H., Li, L., Dong, W., Ma, P., & Liu, Y. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.04.035 · Cited by 31
Inflammation and Cancer: In Medio Stat Nano
Molinaro, R., Corbo, C., Livingston, M. K., Evangelopoulos, M., Parodi, A., Boada, C., Agostini, M., & Tasciotti, E. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867324666170920160030 · Cited by 32
New Mechanism for Release of Endosomal Contents: Osmotic Lysis via Nigericin-Mediated K+/H+ Exchange
Rangasamy, L., Chelvam, V., Kanduluru, A. K., Srinivasarao, M., Bandara, N. A., You, F., Orellana, E. A., Kasinski, A. L., & Low, P. S. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00714 · Cited by 31
A networked swellable dextrin nanogels loading Bcl2 siRNA for melanoma tumor therapy
Li, H., Zhou, Z., Zhang, F., Guo, Y., Yang, X., Jiang, H., Tan, F., Oupický, D., & Sun, M. (2018) · Nano Research · doi:10.1007/s12274-018-2044-6 · Cited by 31
Biswas, A., Chakraborty, K., Dutta, C., Mukherjee, S., Gayen, P., Jan, S., Mallick, A. M., Bhattacharyya, D., & Roy, R. S. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b13794 · Cited by 31
Lee, Y. V., & Tian, B. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00388 · Cited by 33
Cheng, H. B., Yuan, P., Fan, G., Zhao, L., Zheng, R., Yang, B., Qiu, X., Yu, X., Li, S., & Zhang, X. (2019) · Applied Materials Today · doi:10.1016/j.apmt.2019.04.017 · Cited by 31
Rodrigues, L., Schneider, F., Zhang, X., Larsson, E., Moodie, L. W. K., Dietz, H., Papadakis, C. M., Winter, G., Lundmark, R., & Hubert, M. (2019) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2019.06.045 · Cited by 31
Stable Deuterium Labeling of Histidine-Rich Lysine-Based Dendrimers
Sheveleva, N. N., Markelov, D. A., Vovk, M. A., Tarasenko, I. I., Mikhailova, M. E., Ilyash, M., Михайлович, Н. И., & Lähderanta, E. (2019) · Molecules · doi:10.3390/molecules24132481 · Cited by 31
Direct Drug Targeting into Intracellular Compartments: Issues, Limitations, and Future Outlook
Harisa, G. I., & Faris, T. M. (2019) · The Journal of Membrane Biology · doi:10.1007/s00232-019-00082-5 · Cited by 31
Advances on Tumor-Targeting Delivery of Cytotoxic Proteins
Asrorov, A. M., Gu, Z., Min, K. A., Shin, M. C., & Huang, Y. (2019) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.9b00087 · Cited by 31
A Nanoparticle Platform for Accelerated In Vivo Oral Delivery Screening of Nucleic Acids
El-Mayta, R. D., Zhang, R., Shepherd, S. J., Wang, F., Billingsley, M. M., Dudkin, V., Klein, D., Lu, H. D., & Mitchell, M. J. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000111 · Cited by 33
Enzymatic Noncovalent Synthesis for Mitochondrial Genetic Engineering of Cancer Cells
He, H., Lin, X., Wu, D., Wang, J., Guo, J., Green, D. R., Zhang, H., & Xu, B. (2020) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2020.100270 · Cited by 31
Immunological perspectives on spatial and temporal vaccine delivery
Zhu, M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113966 · Cited by 32
Kang, M. A., Fang, J., Paragodaarachchi, A., Kodama, K., Yakobashvili, D., Ichiyanagi, Y., & Matsui, H. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c02691 · Cited by 31
Nonviral gene delivery to T cells with Lipofectamine LTX
Harris, E., Zimmerman, D., Warga, E., Bamezai, A. K., & Elmer, J. J. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27686 · Cited by 32
Cell-penetrating peptides for sustainable agriculture
Patel, P., Benzle, K., Pei, D., & Wang, G. (2024) · Trends in Plant Science · doi:10.1016/j.tplants.2024.05.011 · Cited by 30
Advances and prospects of cell-penetrating peptides in tumor immunotherapy
Yang, D., Liu, B., & Sha, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-86130-8 · Cited by 31
Lipid nanoparticles: a promising tool for nucleic acid delivery in cancer immunotherapy
Abaza, T., Mohamed, E., & Zaky, M. Y. (2025) · Medical Oncology · doi:10.1007/s12032-025-02939-3 · Cited by 35
Improved intracellular delivery of peptide- and lipid-nanoplexes by natural glycosides
Weng, A., Manunta, M., Thakur, M., Gilabert‐Oriol, R., Tagalakis, A. D., Eddaoudi, A., Munye, M. M., Vink, C. A., Wiesner, B., Eichhorst, J., et al. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.03.007 · Cited by 30
Kilchrist, K. V., Evans, B. C., Brophy, C. M., & Duvall, C. L. (2016) · Cellular and Molecular Bioengineering · doi:10.1007/s12195-016-0446-7 · Cited by 30
Chitosan for DNA and gene therapy
Layek, B., & Singh, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-08-100228-5.00008-0 · Cited by 31
Phospholipid–Block Copolymer Hybrid Vesicles with Lysosomal Escape Ability
Zong, W., Thingholm, B., Itel, F., Schattling, P., Brodszkij, E., Mayer, D., Stenger, S., Goldie, K. N., Han, X., & Städler, B. (2018) · Langmuir · doi:10.1021/acs.langmuir.8b01073 · Cited by 30
Herlem, G., Picaud, F., Giŗardet, C., & Micheau, O. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814033-8.00016-3 · Cited by 35
Djemaa, S. B., Hervé-Aubert, K., Lajoie, L., Falanga, A., Galdiero, S., Nédellec, S., Soucé, M., Munnier, E., Chourpa, I., David, S., et al. (2019) · Biomacromolecules · doi:10.1021/acs.biomac.9b00637 · Cited by 30
Khan, A. A., Allemailem, K. S., Almatroudi, A., Almatroodi, S. A., Alsahli, M. A., & Rahmani, A. H. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102315 · Cited by 31
González, L. F., Bevilacqua, L. E., & Naves, R. F. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13122055 · Cited by 31
Defined positive charge patterns created on DNA nanostructures determine cellular uptake efficiency
Shi, Y., Xu, X., Yu, H., Lin, Z., Zuo, H., & Wu, Y. (2022) · Nano Letters · doi:10.1021/acs.nanolett.2c01316 · Cited by 31
Tripathi, S., Singh, V. P., Gupta, K. C., & Kumar, P. (2013) · Journal of Materials Chemistry B · doi:10.1039/c3tb00481c · Cited by 31
Yu, T., Zhuang, W., Su, X., Ma, B., Hu, J. X., He, H., Li, G., & Wang, Y. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00364 · Cited by 30
Frizzell, H., & Woodrow, K. A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201907170 · Cited by 30
Metadata
- Authors
- Varkouhi, A. K., Scholte, M., Storm, G., & Haisma, H. J.
- Affiliations
- Utrecht University (NL)
- University of Groningen (NL)
- Corresponding author
- Haisma, Hidde J.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 151
- Issue
- 3
- Pages
- 220-228
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2008028087
- Cited by
- 1,561
- References
- 151
- Citations by year
- 2026: 82 · 2025: 82 · 2024: 90 · 2023: 94 · 2022: 122 · 2021: 100 · 2020: 123 · 2019: 120 · 2018: 137 · 2017: 111 · 2016: 127 · 2015: 116 · 2014: 98 · 2013: 90 · 2012: 51
- FWCI
- 4.32
- Type
- journal article
- Language
- en
- Open access
- green
- research.wur.nl
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- endosomal escape, endocytosis, lysosomal degradation, protein delivery, gene delivery, siRNA delivery, viral fusion, pH buffering, biomimetic peptides, polymers, biologic therapy
- MeSH terms
- Animals, Cytosol, DNA, Drug Carriers, Endocytosis, Humans, Intracellular Membranes, Membrane Fusion, Models, Biological, Proteins, Endosomes, RNA, Small Interfering
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
