In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery
Open accessAbstract
Intravaginal (ivag) delivery, which is a proven way to confer local protection against STDs contracted via the reproductive tract, is complicated by the mucus gel barrier, the hormone cycle, and the harsh mucosal environment that leads to low residence-time for administered agents. Polymer delivery vehicles may be useful in overcoming these barriers. In this study, we explored the fate of nanoparticles (NP) made from poly(lactide-co-glycolide) (PLGA) in the mouse reproductive tract after ivag delivery. The nanoparticles were modified to display avidin (Avid-NP) or 2 kDa PEG (PEG-NP) on their surface. Vaginal retention fractions for both muco-adhesive Avid-NP and stealthy PEG-NP were 5× higher than unmodified PLGA particles (NP). The amount of particles associated with mucus differed across formulations (Avid-NP>NP>PEG-NP). PEG-NP was found at higher concentration in the tissue than Avid-NP and NP up to 6h after delivery, and particles were found within epithelial cells, the underlying submucosal stromal and fibroblast cells of the vaginal tissue. Our results demonstrate that surface properties of nanoparticles can impact their fates following ivag delivery. Moreover, we show that the muco-evasive PEG-modified nanoparticles are the most effective among the delivery vehicles tested for this application.
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In that study, the highest tissue uptake was achieved with PEG-coated nanoparticles; however, tissue uptake was limited to the lower reproductive tract.
“The highest tissue uptake was achieved with PEG-coated nanoparticles; however, tissue uptake was limited to the lower reproductive tract.”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [23]
In a study from the Saltzman group, leakage out of the vaginal tract was highest for uncoated PLGA nanoparticles (~13% of the dose within 0.5 h).
“Leakage out of the vaginal tract was highest for uncoated nanoparticles (~13% of the dose within 0.5 h).”
From Nanotechnology approaches for global infectious diseases (2021) · cites this paper as [23]
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Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435 · see citing works
Cone, R. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.008 · Cited by 1,459 · see citing works
Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
Lai, S. K., O'Hanlon, D. E., Harrold, S., Man, S. T., Wang, Y.-Y., Cone, R., & Hanes, J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608611104 · Cited by 1,050 · see citing works
Mundargi, R. C., Babu, V. R., Rangaswamy, V., Patel, P., & Aminabhavi, T. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.09.013 · Cited by 1,025 · see citing works
Handbook of Mucosal Immunology
(1994) · Elsevier eBooks · doi:10.1016/c2009-1-03796-4 · Cited by 706 · see citing works
Wang, Y., Lai, S. K., Suk, J. S., Pace, A., Cone, R. A., & Hanes, J. S. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200803526 · Cited by 597 · see citing works
Diffusion of Macromolecules and Virus-Like Particles in Human Cervical Mucus
Olmsted, S. S., Padgett, J. L., Yudin, A. I., Whaley, K. J., Moench, T. R., & Cone, R. A. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)75844-4 · Cited by 544 · see citing works
Iwasaki, A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141634 · Cited by 533 · see citing works
Woodrow, K. A., Cu, Y., Booth, C. J., Saucier-Sawyer, J. K., Wood, M. J., & Saltzman, W. M. (2009) · Nature Materials · doi:10.1038/nmat2444 · Cited by 437 · see citing works
Self-citationThe vagina as a route for systemic drug delivery
Hussain, A., & Ahsan, F. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.11.034 · Cited by 437 · see citing works
Shen, H. Y., Ackerman, A. L., Cody, V., Giodini, A., Hinson, E. R., Cresswell, P., Edelson, R. L., Saltzman, W. M., & Hanlon, D. J. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02268.x · Cited by 421 · see citing works
Self-citationYamamoto, H., Kuno, Y., Sugimoto, S., Takeuchi, H., & Kawashimà, Y. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.10.010 · Cited by 389 · see citing works
Behrens, I., Pena, A. I. V., Alonso, M. J., & Kissel, T. (2002) · Pharmaceutical Research · doi:10.1023/a:1019854327540 · Cited by 372 · see citing works
Cu, Y., & Saltzman, W. M. (2008) · Molecular Pharmaceutics · doi:10.1021/mp8001254 · Cited by 267 · see citing works
Self-citationNew strategies for using mucosal vaccination to achieve more effective immunization
Walker, R. I. (1994) · Vaccine · doi:10.1016/0264-410x(94)90112-0 · Cited by 257 · see citing works
Vila, A., Gill, H., McCallion, O. N. M., & Alonso, M. J. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.04.026 · Cited by 249 · see citing works
Enzymatic barriers to peptide and protein absorption.
Lee, V. H. L. (1988) · PubMed · Cited by 211 · see citing works
Mechanistic study of the adjuvant effect of biodegradable nanoparticles in mucosal vaccination
Slütter, B., Plapied, L., Fievez, V., Alonso, M. J., Rieux, A. D., Schneider, Y., van Riet, E., Jiskoot, W., & Véronique Préat, A. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.011 · Cited by 192 · see citing works
Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs
Takeuchi, H., Matsui, Y., Sugihara, H., Yamamoto, H., & Kawashimà, Y. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.06.028 · Cited by 190 · see citing works
Tabata, Y. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00149-1 · Cited by 181 · see citing works
Immunologic Uniqueness of the Genital Tract: Challenge for Vaccine Development
Mestecky, J. F., Moldoveanu, Z., & Russell, M. W. (2005) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2005.00267.x · Cited by 170 · see citing works
Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B
Khatri, K., Goyal, A. K., Gupta, P. N., Mishra, N., & Vyas, S. P. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.027 · Cited by 140 · see citing works
Drug Delivery by the Intravaginal Route
Woolfson, A. D., Malcolm, K. R., & Gallagher, R. (2000) · Critical Reviews in Therapeutic Drug Carrier Systems · doi:10.1615/critrevtherdrugcarriersyst.v17.i5.30 · Cited by 129 · see citing works
Mucoadhesive Microspheres for Gastroretentive Delivery of Acyclovir: In Vitro and In Vivo Evaluation
Dhaliwal, S., Jain, S. K., Singh, H. P., & Tiwary, A. K. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9039-2 · Cited by 124 · see citing works
Yin, Y.-S., Chen, D., Qiao, M., Wei, X., & Hu, H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.06.024 · Cited by 107 · see citing works
Thomas, C., Gupta, V., & Ahsan, F. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.06.006 · Cited by 79 · see citing works
Effects of menstrual cycle on gene transfection through mouse vagina for DNA vaccine
Kanazawa, T., Takashima, Y., Hirayama, S., & Okada, H. (2008) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2008.04.038 · Cited by 35 · see citing works
Residence half-life of IgG administered topically to the mouse vagina
Sherwood, J. K. (1996) · Biology of Reproduction · doi:10.1095/biolreprod54.1.264 · Cited by 30 · see citing works
Haller, P. K., Cu, Y., Blum, J. S., Appleton, J. A., & Saltzman, W. M. (2010) · Molecular Pharmaceutics · doi:10.1021/mp100009e · Cited by 24 · see citing works
Self-citationRetention and distribution of two 99mTc-DTPA labelled vaginal dosage forms
Chatterton, B. E., Penglis, S., Kovacs, J. C., Presnell, B., & Hunt, B. (2003) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2003.11.006 · Cited by 24 · see citing works
Mucosal or systemic administration of rE2 glycoprotein antigen loaded PLGA microspheres
Brandhonneur, N., Loizel, C., Chevanne, F., Wakeley, P. R., Jestin, A., Potier, M. F. L., & Corre, P. L. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.01.020 · Cited by 10 · see citing works
SAKAGUCHI, M., SAKAI, T., ADACHI, Y., KAWASHIMA, T., & AWATA, N. (1992) · Journal of Pharmacobio-Dynamics · doi:10.1248/bpb1978.15.67 · Cited by 7 · see citing works
Synthesis of novel iodinated derivatives of nonoxynol-9 and their bioavailability in rats
Fowler, P. T., Matsumoto, K., Page, R. C., & Digenis, G. A. (2002) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(02)00334-7 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
Suk, J. S., Xu, Q., Kim, N., Hanes, J., & Ensign, L. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.09.012 · Cited by 4,523 · see citing works
Synthetic Nanoparticles for Vaccines and Immunotherapy
Irvine, D. J., Hanson, M. C., Rakhra, K., & Tokatlian, T. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00109 · Cited by 770 · see citing works
Engineering synthetic vaccines using cues from natural immunity
Irvine, D. J., Swartz, M. A., & Szeto, G. L. (2013) · Nature Materials · doi:10.1038/nmat3775 · Cited by 596 · see citing works
Nanotechnology approaches for global infectious diseases
Kirtane, A. R., Verma, M., Karandikar, P., Furin, J., Langer, R., & Traverso, G. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00866-8 · Cited by 520 · see citing works
Sosnik, A., das Neves, J., & Sarmento, B. F. C. C. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2014.07.010 · Cited by 489 · see citing works
A holistic approach to targeting disease with polymeric nanoparticles
Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480 · see citing works
Self-citationEngineering Nano‐ and Microparticles to Tune Immunity
Moon, J. J., Huang, B., & Irvine, D. J. (2012) · Advanced Materials · doi:10.1002/adma.201200446 · Cited by 402 · see citing works
Mucus-Penetrating Nanoparticles for Vaginal Drug Delivery Protect Against Herpes Simplex Virus
Ensign, L. M., Tang, B. C., Wang, Y.-Y., Tse, T. A., Hoen, T., Cone, R., & Hanes, J. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003453 · Cited by 368 · see citing works
Functionalizing PLGA and PLGA Derivatives for Drug Delivery and Tissue Regeneration Applications
Martins, C., Sousa, F., Araújo, F., & Sarmento, B. F. C. C. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201701035 · Cited by 366 · see citing works
Mucoadhesive vs. mucopenetrating particulate drug delivery
Netsomboon, K., & Bernkop‐Schnürch, A. (2015) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2015.11.003 · Cited by 319 · see citing works
The principles and applications of avidin-based nanoparticles in drug delivery and diagnosis
Jain, A., & Cheng, K. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.11.016 · Cited by 306 · see citing works
Mucoadhesive and thermogelling systems for vaginal drug delivery
Caramella, C. M., Rossi, S., Ferrari, F., Bonferoni, M. C., & Sandri, G. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.02.001 · Cited by 269 · see citing works
Nanoparticle-based drug delivery to the vagina: A review
Ensign, L. M., Cone, R. A., & Hanes, J. S. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.033 · Cited by 250 · see citing works
Controlled release for local delivery of drugs: barriers and models
Weiser, J. R., & Saltzman, W. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.048 · Cited by 224 · see citing works
Self-citationRecent Advances in Polymer-Based Vaginal Drug Delivery Systems
Osmałek, T. Z., Froelich, A., Jadach, B., Tatarek, A., Gadziński, P., Falana, A., Gralińska, K., Ekert, M., Puri, V., Wrotyńska-Barczyńska, J., et al. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13060884 · Cited by 145 · see citing works
Polymer-based nanocarriers for vaginal drug delivery
das Neves, J., Nunes, R., Machado, A., & Sarmento, B. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.12.004 · Cited by 138 · see citing works
Approaches in Polymeric Nanoparticles for Vaginal Drug Delivery: A Review of the State of the Art
Leyva‐Gómez, G., Piñón‐Segundo, E., Mendoza‐Muñoz, N., Zambrano‐Zaragoza, M. L., Mendoza-Elvira, S. E., & Quintanar‐Guerrero, D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19061549 · Cited by 117 · see citing works
Nanopharmaceuticals for improved topical vaginal therapy: Can they deliver?
Vanić, Ž., & Škalko‐Basnet, N. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.04.035 · Cited by 114 · see citing works
Advances in Therapeutic Cancer Vaccines
Wong, K. K. W., Li, A. W., Mooney, D. J., & Dranoff, G. (2016) · Advances in immunology · doi:10.1016/bs.ai.2015.12.001 · Cited by 113 · see citing works
Steinbach-Rankins, J. M., Seo, Y.-E., & Saltzman, W. M. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.11.029 · Cited by 109 · see citing works
Self-citationYang, M., Yu, T., Wang, Y., Lai, S. K., Zeng, Q., Miao, B., Tang, B. C., Simons, B. W., Ensign, L. M., Liu, G., et al. (2013) · Advanced Healthcare Materials · doi:10.1002/adhm.201300519 · Cited by 106 · see citing works
Ensign, L. M., Henning, A., Schneider, C. S., Maisel, K., Wang, Y.-Y., Porosoff, M. D., Cone, R. A., & Hanes, J. S. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400087y · Cited by 103 · see citing works
Nanoparticles-in-film for the combined vaginal delivery of anti-HIV microbicide drugs
Cunha-Reis, C., Machado, A., Barreiros, L., Araújo, F., Nunes, R., Seabra, V., Ferreira, D., Segundo, M. A., Sarmento, B., & das Neves, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.020 · Cited by 95 · see citing works
Polymer nanotechnology based approaches in mucosal vaccine delivery: Challenges and opportunities
Sharma, R. K., Agrawal, U., Mody, N., & Vyas, S. P. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2014.12.004 · Cited by 91 · see citing works
Surface modified poly(β amino ester)-containing nanoparticles for plasmid DNA delivery
Fields, R. J., Cheng, C. J., Quijano, E., Weller, C. E., Kristofik, N. J., Duong, N. T., Hoimes, C. J., Egan, M. E., & Saltzman, W. M. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.020 · Cited by 88 · see citing works
Self-citationOptimizing pharmacokinetics of intravesical chemotherapy for bladder cancer
Joice, G., Bivalacqua, T., & Kates, M. (2019) · Nature reviews. Urology · doi:10.1038/s41585-019-0220-4 · Cited by 74 · see citing works
Kovarova, M., Council, O. D., Date, A. A., Long, J. M., Nochii, T., Belshan, M., Shibata, A., Vincent, H., Baker, C. E., Thayer, W. O., et al. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005075 · Cited by 77 · see citing works
Metal organic frameworks in biomedicine: Innovations in drug delivery
Benny, A., Pai, S. D. K. R., Pinheiro, D., & Chundattu, S. J. (2024) · Results in Chemistry · doi:10.1016/j.rechem.2024.101414 · Cited by 77 · see citing works
Advances in intravesical drug delivery systems to treat bladder cancer
Kolawole, O. M., Lau, W. M., Mostafid, H. A., & Khutoryanskiy, V. V. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.08.120 · Cited by 77 · see citing works
A review of nanotechnological approaches for the prophylaxis of HIV/AIDS
Date, A. A., & Destache, C. J. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.05.012 · Cited by 74 · see citing works
das Neves, J., Araújo, F., Andrade, F., Amiji, M. M., Bahia, M. F., & Sarmento, B. F. C. C. (2014) · Pharmaceutical Research · doi:10.1007/s11095-013-1287-x · Cited by 72 · see citing works
Vaginal drug delivery: strategies and concerns in polymeric nanoparticle development
Wong, T. W., Dhanawat, M., & Rathbone, M. J. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.924499 · Cited by 72 · see citing works
Enhanced uptake and transport of PLGA-modified nanoparticles in cervical cancer
Sims, L. B., Curtis, L. T., Frieboes, H. B., & Steinbach-Rankins, J. M. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0185-x · Cited by 72 · see citing works
Nanoparticle-releasing nanofiber composites for enhanced in vivo vaginal retention
Krogstad, E. A., Ramanathan, R., Nhan, C., Kraft, J. C., Blakney, A. K., Cao, S., Ho, R. J. Y., & Woodrow, K. A. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.07.034 · Cited by 69 · see citing works
Mohideen, M., Quijano, E., Song, E., Deng, Y., Panse, G., Zhang, W., Clark, M. R., & Saltzman, W. M. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.08.029 · Cited by 69 · see citing works
Self-citationBhavana, V., Thakor, P., Phuse, R., Dalvi, M., Kharat, P., Kumar, A., Panwar, D., Singh, S. B., Pastorin, G., & Mehra, N. K. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2022.103162 · Cited by 67 · see citing works
Delivery technologies for women’s health applications
Swingle, K. L., Ricciardi, A. S., Peranteau, W. H., & Mitchell, M. J. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00040-w · Cited by 64 · see citing works
Martin, D. T., Hoimes, C. J., Kaimakliotis, H. Z., Cheng, C. J., Zhang, K., Liu, J., Wheeler, M. A., Kelly, W. K., Tew, G., Saltzman, W. M., et al. (2013) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2013.05.017 · Cited by 59 · see citing works
Self-citationNanomedicine in the development of anti-HIV microbicides
das Neves, J., Nunes, R., Rodrigues, F., & Sarmento, B. F. C. C. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.01.017 · Cited by 59 · see citing works
Nanoparticle delivery systems, general approaches, and their implementation in multiple myeloma
de la Puente, P., & Azab, A. K. (2017) · European Journal Of Haematology · doi:10.1111/ejh.12870 · Cited by 54 · see citing works
Zhou, J., Frank, M. A., Yang, Y., Boccaccini, A. R., & Virtanen, S. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.08.066 · Cited by 54 · see citing works
Vaginal Mucosa and Drug Delivery
das Neves, J., Palmeira‐de‐Oliveira, R., Palmeira‐de‐Oliveira, A., Rodrigues, F., & Sarmento, B. F. C. C. (2014) · Wiley eBooks · doi:10.1002/9781118794203.ch05 · Cited by 54 · see citing works
In vitro and ex vivo models for evaluating vaginal drug delivery systems
Shapiro, R. L., DeLong, K., Zulfiqar, F., Carter, D. M., Better, M., & Ensign, L. M. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114543 · Cited by 53 · see citing works
Enabling sublingual peptide immunization with molecular self-assemblies
Kelly, S. H., Wu, Y., Varadhan, A. K., Curvino, E. J., Chong, A. S., & Collier, J. H. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.119903 · Cited by 53 · see citing works
Recent advances in PLGA particulate systems for drug delivery
Choi, J., Seo, K., & Yoo, J. (2012) · Journal of Pharmaceutical Investigation · doi:10.1007/s40005-012-0024-5 · Cited by 53 · see citing works
Poly Lactic‐Co‐Glycolic Acid (PLGA) Copolymer and Its Pharmaceutical Application
Pandey, A. P., & Jain, D. S. (2015) · doi:10.1002/9781119041412.ch6 · Cited by 51 · see citing works
Immunology‐Guided Biomaterial Design for Mucosal Cancer Vaccines
Ferber, S., Gonzalez, R. J., Cryer, A. M., von Andrian, U. H., & Artzi, N. (2019) · Advanced Materials · doi:10.1002/adma.201903847 · Cited by 49 · see citing works
Fields, R. J., Quijano, E., McNeer, N. A., Caputo, C. R., Bahal, R., Anandalingam, K. K., Egan, M. E., Glazer, P. M., & Saltzman, W. M. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201400355 · Cited by 45 · see citing works
Self-citationPolysaccharide-based nanogels for biomedical applications: A comprehensive review
Damiri, F., Rojekar, S. V., Bachra, Y., Varma, R. S., Andra, S., Balu, S. K., Pardeshi, C. V., Patel, P. J., Patel, H. M., Paiva‐Santos, A. C., et al. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104447 · Cited by 43 · see citing works
Sims, L. B., Huss, M. K., Frieboes, H. B., & Steinbach-Rankins, J. M. (2017) · Journal of Nanobiotechnology · doi:10.1186/s12951-017-0298-x · Cited by 43 · see citing works
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Tyo, K. M., Lasnik, A. B., Zhang, L., Mahmoud, M. Y., Jenson, A. B., Fuqua, J. L., Palmer, K. E., & Steinbach-Rankins, J. M. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.02.006 · Cited by 43 · see citing works
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da Silva, P. B., Ramos, M. A. D. S., Bonifácio, B. V., Negri, K. M. S., Sato, M. R., Bauab, T. M., & Chorilli, M. (2014) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2014.1890 · Cited by 41 · see citing works
Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA
Du, X., Li, W., Gao, X., West, M., Saltzman, W. M., Cheng, C. J., Stewart, C. A., Zheng, J., Cheng, W., & Kopke, R. D. (2013) · Hearing Research · doi:10.1016/j.heares.2013.06.011 · Cited by 41 · see citing works
Self-citationMelo, M., Nunes, R., Sarmento, B. F. C. C., & das Neves, J. (2019) · Biomaterials Science · doi:10.1039/c9bm00759h · Cited by 40 · see citing works
Recent advances on anti-HIV vaginal delivery systems development
Antimisiaris, S. G., & Mourtas, S. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.03.015 · Cited by 40 · see citing works
Awaad, A. (2015) · The Journal of Basic and Applied Zoology · doi:10.1016/j.jobaz.2015.03.003 · Cited by 39 · see citing works
Potential Applications of Nanotechnology in Urological Cancer
He, M., Chen, L., Zheng, T., Tu, Y., He, Q., Fu, H., Lin, J., Zhang, W., Shu, G., He, L., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00745 · Cited by 37 · see citing works
Nunes, R., Araújo, F., Tavares, J., Sarmento, B. F. C. C., & das Neves, J. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.06.029 · Cited by 36 · see citing works
Protein and oligonucleotide delivery systems for vaginal microbicides against viral STIs
Steinbach-Rankins, J. M. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1756-3 · Cited by 35 · see citing works
Design of nanomaterials for applications in maternal/fetal medicine
Irvin-Choy, N. S., Nelson, K. M., Gleghorn, J. P., & Day, E. S. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00612b · Cited by 35 · see citing works
Lechanteur, A., Furst, T., Évrard, B., Delvenne, P., Piel, G., & Hubert, P. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b01154 · Cited by 34 · see citing works
Nanocarriers For Vaginal Drug Delivery
Iqbal, Z., & Dilnawaz, F. (2019) · Recent Patents on Drug Delivery & Formulation · doi:10.2174/1872211313666190215141507 · Cited by 32 · see citing works
Feeney, O. M., Gracia, G., Brundel, D. H. S., Trevaskis, N. L., Cao, E., Kaminskas, L. M., & Porter, C. J. H. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.10.002 · Cited by 30 · see citing works
Functional Nanocarrier for Drug and Gene Delivery Via Local Administration in Mucosal Tissues
Wang, L., Zhou, Y., Wu, M., Wu, M., Li, X., Gong, X., Chang, J. K., & Zhang, X. (2017) · Nanomedicine · doi:10.2217/nnm-2017-0143 · Cited by 31 · see citing works
Nanocrystal Formulation Improves Vaginal Delivery of CSIC for HIV Prevention
Gong, T., Patel, S. K., Parniak, M. A., Ballou, B. T., & Rohan, L. C. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1503-z · Cited by 27 · see citing works
Nanoparticle Transport from Mouse Vagina to Adjacent Lymph Nodes
Ballou, B. T., Andreko, S. K., Osuna-Highley, E., McRaven, M. D., Catalone, T., Bruchez, M. P., Hope, T. J., & Labib, M. E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051995 · Cited by 27 · see citing works
Wagner, R. D., Johnson, S. J., Danielsen, Z. Y., Jin-Hee, L., Mudalige, T., & Linder, S. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175250 · Cited by 26 · see citing works
Innovations in bioadhesive vaginal drug delivery system
Bassi, P., & Kaur, G. (2012) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2012.714369 · Cited by 25 · see citing works
Park, J., Ramanathan, R., Pham, L., & Woodrow, K. A. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.04.012 · Cited by 24 · see citing works
Progresses in Nano-Enabled Platforms for the Treatment of Vaginal Disorders
Patel, R., Yadav, B. K., & Patel, G. C. (2022) · Recent Patents on Nanotechnology · doi:10.2174/1872210516666220628150447 · Cited by 24 · see citing works
Lin, J., Li, Y., Li, Y., Cui, F., Yu, F., Wu, H., Xie, L., 罗芳洪, 侯振清, & Lin, C. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00724k · Cited by 23 · see citing works
Howe, S. E., & Konjufca, V. H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0114601 · Cited by 23 · see citing works
Efficacy of Surface-Modified PLGA Nanoparticles as a Function of Cervical Cancer Type
Sims, L. B., Curry, K. C., Parupalli, S., Horner, G., Frieboes, H. B., & Steinbach-Rankins, J. M. (2019) · Pharmaceutical Research · doi:10.1007/s11095-019-2602-y · Cited by 22 · see citing works
Core–shell nanocarriers for cancer therapy. Part I: biologically oriented design rules
d’Angelo, I., Conte, C., Miro, A., Quaglia, F., & Ungaro, F. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.868881 · Cited by 21 · see citing works
Fasquelle, F., Carpentier, R., Demouveaux, B., Desseyn, J., & Betbeder, D. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00521 · Cited by 21 · see citing works
Singh, P., Sen, K., Sa, P., Khuntia, A., Raghav, S. K., Swain, R. K., & Sahoo, S. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155181 · Cited by 20 · see citing works
Li, C., Huang, Z., Liu, Z., Ci, L.-Q., Liu, Z., Liu, Y., Yan, X., & Lu, W. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s113658 · Cited by 20 · see citing works
Adenoviral vectors coated with cationic PEG derivatives for intravaginal vaccination against HIV-1
Xie, Z., Ji, Z., Zhang, Z., Gong, T., & Sun, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.05.056 · Cited by 19 · see citing works
Vaginal Nano‐Based Drug Delivery System
Wadetwar, R. N., & Kanojiya, P. S. (2021) · doi:10.1002/9781119711698.ch16 · Cited by 19 · see citing works
Farooq, U., Mirza, M. A., Alshetaili, A., Mohapatra, S., Jain, P., Hassan, N., Iqbal, Z., & Ali, A. (2024) · Nanoscale Advances · doi:10.1039/d3na00943b · Cited by 18 · see citing works
Nanomedicine for vaginal drug delivery
El‐Hammadi, M. M., & Arias, J. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-820466-5.00011-9 · Cited by 17 · see citing works
Engineered nanoparticles as a precise delivery system in cancer therapeutics
Sharma, R. K., Agrawal, U., Mody, N., Dubey, S., & Vyas, S. P. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-41532-3.00013-0 · Cited by 16 · see citing works
Understanding Mucosal Physiology and Rationale of Formulation Design for Improved Mucosal Immunity
Biswas, M., Nurunnabi, M., & Khatun, Z. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00395 · Cited by 16 · see citing works
Fang, L., Wang, L., Yao, Y., Zhang, J., Wu, X., Li, X., Wang, H., Zhang, X., Gong, X., & Chang, J. K. (2016) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2016.08.025 · Cited by 16 · see citing works
Liu, Z., Yang, H., Huang, R., Li, X., Sun, T., & Zhu, L. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00284-24 · Cited by 16 · see citing works
Atinderpal, K., Kapoor, N., Gupta, S., Tyag, A., Sharma, R. K., Ali, J., Gabrani, R., & Dang, S. (2018) · Indian Journal of Pharmaceutical Sciences · doi:10.4172/pharmaceutical-sciences.1000377 · Cited by 14 · see citing works
Awaad, A., & Seleem, A. A. (2015) · Biotechnic & Histochemistry · doi:10.3109/10520295.2015.1072770 · Cited by 14 · see citing works
Delivery and short-term maternal and fetal safety of vaginally administered PEG-PLGA nanoparticles
Irvin-Choy, N. S., Nelson, K. M., Gleghorn, J. P., & Day, E. S. (2023) · Drug Delivery and Translational Research · doi:10.1007/s13346-023-01369-w · Cited by 13 · see citing works
Gan, Y., Wu, N., Zhang, X., Li, F., Zhang, T., & Li, J. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87978 · Cited by 13 · see citing works
Li, G., Lin, D., Xie, X., Qin, L.-F., Wang, J.-T., & Liu, K. (2013) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(13)60007-2 · Cited by 13 · see citing works
Expanding opportunities to engineer mucosal vaccination with biomaterials
Haddad, H. F., Roe, E. F., & Collier, J. H. (2023) · Biomaterials Science · doi:10.1039/d2bm01694j · Cited by 13 · see citing works
Engineering Nanoparticles for Gynecologic Cancer Therapy
Murray, A. M., Swingle, K. L., & Mitchell, M. J. (2025) · ACS Nano · doi:10.1021/acsnano.5c07748 · Cited by 12 · see citing works
Nanotechnology for vaginal drug delivery and targeting
El‐Hammadi, M. M., & Arias, J. L. (2020) · Elsevier eBooks · doi:10.1016/b978-0-08-102985-5.00026-7 · Cited by 12 · see citing works
Sims, L. B., Frieboes, H. B., & Steinbach-Rankins, J. M. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s160044 · Cited by 11 · see citing works
Sims, L. B., Miller, H. A., Halwes, M. E., Steinbach-Rankins, J. M., & Frieboes, H. B. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.09.003 · Cited by 11 · see citing works
Mendoza, G., de Solorzano, I. O., Pintre, I. C., García-Salinas, S., Sebastián, V., Andreu, V., Gimeno, M., & Arruebo, M. (2018) · Nanoscale · doi:10.1039/c7nr07345c · Cited by 11 · see citing works
Engineering immunity in the mucosal niche against sexually transmitted infections
Ramanathan, R., & Woodrow, K. A. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1359 · Cited by 10 · see citing works
Nanomaterials Solutions for Contraception: Concerns, Advances, and Prospects
Su, Z., Diao, T., McGuire, H. M., Yao, C., Yang, L., Guo, B. K., Xu, X., He, B., & Zheng, Y. (2023) · ACS Nano · doi:10.1021/acsnano.3c04366 · Cited by 10 · see citing works
Krogstad, E. A., Rathbone, M. J., & Woodrow, K. A. (2013) · Advances in delivery science and technology · doi:10.1007/978-1-4614-9434-8_27 · Cited by 10 · see citing works
- Authors
- Cu, Y., Booth, C. J., & Saltzman, W. M.
- Affiliations
- Yale University (US)
- Corresponding author
- Saltzman, W. Mark
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 156
- Issue
- 2
- Pages
- 258-264
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC3220785
- OpenAlex
- W1967527831
- Cited by
- 129
- References
- 33
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 12 · 2016: 11 · 2015: 16 · 2014: 15 · 2013: 11 · 2012: 8
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Biomedical Imaging and Bioengineering (EB000487, R56EB000487, R01EB000487)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- PLGA nanoparticles, surface modification, avidin, PEGylation, vaginal mucus, mucoadhesion, nanoparticle biodistribution, vaginal tissue, mucosal drug delivery, STD prevention, polymeric nanoparticles
- MeSH terms
- Administration, Intravaginal, Animals, Avidin, Coumarins, Drug Carriers, Female, Mice, Inbred C57BL, Polyethylene Glycols, Polyglactin 910, Thiazoles, Vagina, Mice, Nanoparticles
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