Cited by 347Drug Solubulity and Delivery SystemsNanoparticle-Based Drug DeliveryAdvancements in Transdermal Drug Delivery

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Drug nanocrystals: in vivo performances.

Gao, Lei, Liu, Guiyang, Ma, Jianli, Wang, Xiaoqing, Zhou, Liang, Li, Xiang·2012·Journal of Controlled Release

DOI 10.1016/j.jconrel.2012.03.013

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Abstract

Over the past few decades, there has been a considerable research interest in drug nanocrystal system as a pharmaceutical approach for poorly soluble drugs. At the beginning lots of works have been done to study various technologies associated with production of drug nanocrystals and their in vitro physical and chemical properties, such as morphology, formulation composition, stabilities, crystalline structure and enhanced solubility and dissolution velocity. Recently, in vivo behaviors of the nanocrystals have been generally studied in animals (including human), and the results proved that drug nanocrystals could be used as a versatile formulation to alter and improve the pharmacokinetic, pharmacodynamic and targeting properties of poorly soluble drugs. In this paper, in vivo performances of drug nanocrystals exhibited in animals in different administration route were reviewed, and the advantages of drug nanocrystals in the aspect of safety, pharmacodynamics, pharmacokinetics and targeting delivery were discussed in detail.

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A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,781
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521
Nanoparticles in cancer therapy and diagnosis
Brigger, I., Dubernet, C., & Couvreur, P. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00044-3 · Cited by 3,040
Nanomedicine: current status and future prospects
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2747rev · Cited by 2,029
Nanosuspensions in drug delivery
Rabinow, B. E. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1494 · Cited by 1,529
Targeted drug delivery via the folate receptor
Sudimack, J. J., & Lee, R. J. (2000) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(99)00062-9 · Cited by 1,477
Nanosuspensions as particulate drug formulations in therapy
Müller, R. H., Jacobs, C., & Kayser, O. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00118-6 · Cited by 1,370
Inhaling medicines: delivering drugs to the body through the lungs
Patton, J. S., & Byron, P. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2153 · Cited by 1,370
Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., & Préat, V. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.08.013 · Cited by 1,305
Nanosizing: a formulation approach for poorly-water-soluble compounds
Merisko-Liversidge, E. M., Liversidge, G. G., & Cooper, E. R. (2003) · European Journal of Pharmaceutical Sciences · doi:10.1016/s0928-0987(02)00251-8 · Cited by 1,270

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Lipinski, 2002, Poor aqueous solubility — an industry wide problem in drug discovery, Am. Pharm. Rev., 5, 82
des Rieux, 2006, Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach, J. Control. Release, 116, 1, 10.1016/j.jconrel.2006.08.013 · DOI · Paper page
Dressman, 2000, In vitro–in vivo correlations for lipophilic, poorly water-soluble drugs, Eur. J. Pharm. Sci., 11, S73, 10.1016/S0928-0987(00)00181-0 · DOI
Clement, 1992, Tissue distribution and plasma clearance of a novel microcrystalline-coated flurbiprofen formulation, Pharmacologist, 34, 204

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Authors: Gao, L., Liu, G., Ma, J., Wang, X., Zhou, L., & Li, X.
Affiliations: First Affiliated Hospital of Chinese PLA General Hospital (CN)
Corresponding author: Gao, Lei
Liu, Guiyang
ORCID: Gao, Lei
Liu, Guiyang
Ma, Jianli
Wang, Xiaoqing
Zhou, Liang
Li, Xiang
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2012-06
Volume: 160
Issue: 3
Pages: 418-430
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2012.03.013
OpenAlex: W2041317416
Cited by: 347
References: 159
Citations by year: 2026: 13 · 2025: 20 · 2024: 20 · 2023: 23 · 2022: 31 · 2021: 29 · 2020: 36 · 2019: 26 · 2018: 27 · 2017: 28 · 2016: 36 · 2015: 18 · 2014: 19 · 2013: 19 · 2012: 2
FWCI: 2.30
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords: drug nanocrystals, poorly water-soluble drugs, pharmacokinetics, pharmacodynamics, targeted drug delivery, in vivo performance, route of administration, dissolution enhancement
MeSH terms: Animals, Drug Administration Routes, Pharmaceutical Preparations, Humans, Pharmacokinetics, Drug Delivery Systems, Nanoparticles

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Drug nanocrystals: in vivo performances.

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