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Cited by 345

The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.

Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review

Open access
Ford Versypt, Ashlee N., Pack, Daniel W., Braatz, Richard D.·2013·Journal of Controlled Release

Abstract

PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles with mechanistic models are useful for understanding mechanisms and designing drug release particles.

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Registry

Crossref · 10.1016/j.jconrel.2012.10.015

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Metadata

Authors
Ford Versypt, A. N., Pack, D. W., & Braatz, R. D.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2013-01
Volume
165
Issue
1
Pages
29-37
ISSN
0168-3659 (ISSN-L)
OpenAlex
W1966070581
Cited by
345
References
84
FWCI
9.70
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review. https://app.cochat.ai/papers/10.1016/j.jconrel.2012.10.015
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Ford Versypt, A. N., Pack, D. W., & Braatz, R. D. (2013). Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2012.10.015

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.