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Hybrid nanoparticles for combination therapy of cancer
Open accessAbstract
Nanoparticle anticancer drug delivery enhances therapeutic efficacies and reduces side effects by improving pharmacokinetics and biodistributions of the drug payloads in animal models. Despite promising preclinical efficacy results, monotherapy nanomedicines have failed to produce enhanced response rates over conventional chemotherapy in human clinical trials. The discrepancy between preclinical data and clinical outcomes is believed to result from the less pronounced enhanced permeability and retention (EPR) effect in and the heterogeneity of human tumors as well as the intrinsic/acquired drug resistance to monotherapy over the treatment course. To address these issues, recent efforts have been devoted to developing nanocarriers that can efficiently deliver multiple therapeutics with controlled release properties and increased tumor deposition. In ideal scenarios, the drug or therapeutic modality combinations have different mechanisms of action to afford synergistic effects. In this review, we summarize recent progress in designing hybrid nanoparticles for the co-delivery of combination therapies, including multiple chemotherapeutics, chemotherapeutics and biologics, chemotherapeutics and photodynamic therapy, and chemotherapeutics and radiotherapy. The in vitro and in vivo anticancer effects are also discussed.
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“For instance, synthetic tunability enables the creation of smart nanoparticles that can simultaneously serve several therapeutic or imaging goals by co-encapsulating various therapeutic compounds with various release curves.22,23”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [23]
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Li, W., Zhang, X., Zhou, M., Tian, B., Yu, C., Jie, J., Hao, X., & Zhang, X. (2014) · Advanced Healthcare Materials · doi:10.1002/adhm.201300577 · Cited by 27
Flagged first, then by citations
2 of the 108 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nanotechnology for Multimodal Synergistic Cancer Therapy
Fan, W., Yung, B. C., Huang, P., & Chen, X. S. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00258 · Cited by 1,813
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
Tang, W., Fan, W., Lau, J., Deng, L., Shen, Z., & Chen, X. S. (2019) · Chemical Society Reviews · doi:10.1039/c8cs00805a · Cited by 610
Aggregation-Induced Emission (AIE), Life and Health
Wang, H., Li, Q., Alam, P., Bai, H., Bhalla, V., Bryce, M. R., Cao, M., Chen, C., Chen, S., Chen, X., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c03925 · Cited by 404
Wang, T., Wang, D., Yu, H., Wang, M., Liu, J., Feng, B., Zhou, F., Yin, Q., Zhang, Z., Huang, Y., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b07706 · Cited by 294
Metadata
- Authors
- He, C., Lu, J., & Lin, W.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Lin, Wenbin
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 219
- Pages
- 224-236
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC4656047
- OpenAlex
- W1770290865
- Cited by
- 174
- References
- 108
- Citations by year
- 2026: 16 · 2025: 28 · 2024: 19 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 9 · 2017: 20 · 2016: 12
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (U01-CA151455)
- University of Chicago Medicine Comprehensive Cancer Center (P30 CA014599)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
- Keywords
- hybrid nanostructures, combination cancer therapy, co-delivery, nanocarriers, drug resistance, enhanced permeability and retention effect, tumor heterogeneity, photodynamic therapy, radiotherapy, chemotherapeutics, biologics, controlled release, synergistic drug delivery
- MeSH terms
- Animals, Antineoplastic Agents, Drug Combinations, Ferric Compounds, Gold, Humans, Neoplasms, Organometallic Compounds, Polymers, Drug Delivery Systems, Organosilicon Compounds, Nanoparticles
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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