PBCA-based polymeric microbubbles for molecular imaging and drug delivery
Open accessAbstract
Microbubbles (MB) are routinely used as contrast agents for ultrasound (US) imaging. We describe different types of targeted and drug-loaded poly(n-butyl cyanoacrylate) (PBCA) MB, and demonstrate their suitability for multiple biomedical applications, including molecular US imaging and US-mediated drug delivery. Molecular imaging of angiogenic tumor blood vessels and inflamed atherosclerotic endothelium is performed by modifying the surface of PBCA MB with peptides and antibodies recognizing E-selectin and VCAM-1. Stable and inertial cavitation of PBCA MB enables sonoporation and permeabilization of blood vessels in tumors and in the brain, which can be employed for direct and indirect drug delivery. Direct drug delivery is based on US-induced release of (model) drug molecules from the MB shell. Indirect drug delivery refers to US- and MB-mediated enhancement of extravasation and penetration of co-administered drugs and drug delivery systems. These findings are in line with recently reported pioneering proof-of-principle studies showing the usefulness of (phospholipid) MB for molecular US imaging and sonoporation-enhanced drug delivery in patients. They aim to exemplify the potential and the broad applicability of combining MB with US to improve disease diagnosis and therapy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Immunity, Inflammation, and Cancer
Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
Role of the Vascular Endothelial Growth Factor Pathway in Tumor Growth and Angiogenesis
Hicklin, D. J., & Ellis, L. M. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2005.06.081 · Cited by 3,010 · see citing works
Role of integrins in cell invasion and migration
Hood, J. D., & Cheresh, D. A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc727 · Cited by 1,781 · see citing works
Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress
Lammers, T., Kiessling, F., Hennink, W. E., & Storm, G. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.09.063 · Cited by 1,324 · see citing works
Microbubbles in medical imaging: current applications and future directions
Lindner, J. (2004) · Nature reviews. Drug discovery · doi:10.1038/nrd1417 · Cited by 875 · see citing works
Understanding ultrasound induced sonoporation: Definitions and underlying mechanisms
Lentacker, I., Cock, I. D., Deckers, R., Smedt, S. C. D., & MOONEN, C. T. W. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.008 · Cited by 824 · see citing works
Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation
van Wamel, A. J. E. T., Kooiman, K., Harteveld, M., Emmer, M., ten Cate, F. J., Versluis, M., & de Jong, N. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.007 · Cited by 597 · see citing works
Microbubble compositions, properties and biomedical applications
Sirsi, S. R., & Borden, M. A. (2009) · Bubble Science Engineering & Technology · doi:10.1179/175889709x446507 · Cited by 596 · see citing works
Mulvagh, S. L., Rakowski, H., Vannan, M. A., Abdelmoneim, S. S., Becher, H. H., Bierig, S. M., Burns, P. N., Castelló, R., Coon, P. D., Hagen, M. E., et al. (2008) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2008.09.009 · Cited by 490 · see citing works
Lindner, J. R., Song, J. S., Christiansen, J., Klibanov, A. L., Xu, F. L., & Ley, K. F. (2001) · Circulation · doi:10.1161/hc4201.097061 · Cited by 442 · see citing works
Dimcevski, G. G., Kotopoulis, S., Bjånes, T. K., Hoem, D., Schjøtt, J. D., Gjertsen, B. T., Biermann, M., Molven, A., Sørbye, H., McCormack, E., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.007 · Cited by 430 · see citing works
Karshafian, R., Bevan, P. D., Williams, R., Samac, S., & Burns, P. N. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2008.10.013 · Cited by 356 · see citing works
Encapsulated ultrasound microbubbles: Therapeutic application in drug/gene delivery
Liu, Y., Miyoshi, H., & Nakamura, M. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.05.018 · Cited by 318 · see citing works
Local drug and gene delivery through microbubbles
Unger, E. C., Hersh, E. M., Vannan, M. A., Matsunaga, T. O., & McCreery, T. P. (2001) · Progress in Cardiovascular Diseases · doi:10.1053/pcad.2001.26443 · Cited by 307 · see citing works
Ultrasound Microbubbles for Molecular Diagnosis, Therapy, and Theranostics
Kiessling, F. M., Fokong, S., Koczera, P., Lederle, W., & Lammers, T. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.099754 · Cited by 306 · see citing works
Wells, P. N. T. (2006) · Physics in Medicine and Biology · doi:10.1088/0031-9155/51/13/r06 · Cited by 286 · see citing works
Ting, C.-Y., Fan, C., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.096 · Cited by 283 · see citing works
Liu, H.-L., Fan, C., Ting, C.-Y., & Yeh, C. (2014) · Theranostics · doi:10.7150/thno.8074 · Cited by 275 · see citing works
Drug loaded microbubble design for ultrasound triggered delivery
Lentacker, I., Smedt, S. C. D., & Sanders, N. N. (2009) · Soft Matter · doi:10.1039/b823051j · Cited by 264 · see citing works
Recent advances in molecular, multimodal and theranostic ultrasound imaging
Kiessling, F. M., Fokong, S., Bzyl, J., Lederle, W., Palmowski, M., & Lammers, T. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.013 · Cited by 202 · see citing works
Strobel, D. D., Seitz, K., Blank, W., Schüler, A., Dietrich, C. F., von Herbay, A., Friedrich‐Rust, M., & Bernatik, T. (2009) · Ultraschall in der Medizin - European Journal of Ultrasound · doi:10.1055/s-0028-1109672 · Cited by 178 · see citing works
Sonoporation enhances liposome accumulation and penetration in tumors with low EPR
Theek, B., Baues, M., Ojha, T., Möckel, D., Veettil, S. K., Steitz, J., van Bloois, L., Storm, G., Kiessling, F. M., & Lammers, T. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.021 · Cited by 171 · see citing works
Palmowski, M., Huppert, J., Ladewig, G., Hauff, P., Reinhardt, M., Mueller, M. M., Woenne, E. C., Jenne, J. W., Mäurer, M., Kauffmann, G. W., et al. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-0409 · Cited by 170 · see citing works
Image-guided, targeted and triggered drug delivery to tumors using polymer-based microbubbles
Fokong, S., Theek, B., Wu, Z., Koczera, P., Appold, L. C., Jorge, S., Resch‐Genger, U., van Zandvoort, M. A. M. J., Storm, G., Kiessling, F. M., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.007 · Cited by 158 · see citing works
Theranostic USPIO‐Loaded Microbubbles for Mediating and Monitoring Blood‐Brain Barrier Permeation
Lammers, T., Koczera, P., Fokong, S., Gremse, F., Ehling, J., Vogt, M., Pich, A., Storm, G., van Zandvoort, M., & Kiessling, F. (2015) · Advanced Functional Materials · doi:10.1002/adfm.201401199 · Cited by 156 · see citing works
Self-citationUltrasound-mediated drug delivery to the brain: principles, progress and prospects
Dasgupta, A., Liu, M., Ojha, T., Storm, G., Kiessling, F. M., & Lammers, T. (2016) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2016.07.007 · Cited by 156 · see citing works
Doxorubicin and paclitaxel loaded microbubbles for ultrasound triggered drug delivery
Cochran, M. C., Eisenbrey, J., Ouma, R. O., Soulen, M., & Wheatley, M. (2011) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2011.05.030 · Cited by 149 · see citing works
Focused ultrasound and microbubbles for enhanced extravasation
Böhmer, M. R., Chlon, C., Raju, B. I., Chin, C. T., Shevchenko, T. I., & Klibanov, A. L. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.06.012 · Cited by 104 · see citing works
Sonochemotherapy: from bench to bedside
Lammertink, B., Bos, C., Deckers, R., Storm, G., MOONEN, C. T. W., & Escoffre, J. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00138 · Cited by 101 · see citing works
Kheirolomoom, A., Lai, C.-Y., Tam, S. M., Mahakian, L. M., Ingham, E. S., Watson, K. D., & Ferrara, K. W. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.019 · Cited by 90 · see citing works
Non-invasive imaging for studying anti-angiogenic therapy effects
Ehling, J., Lammers, T., & Kiessling, F. M. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-10-0721 · Cited by 83 · see citing works
Yang, F., Lin, Y.-S., Kang, K., & Chao, T. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.038 · Cited by 78 · see citing works
Palmowski, M., Huppert, J., Hauff, P., Reinhardt, M., Schreiner, K., Socher, M. A., Hallscheidt, P. J., Kauffmann, G. W., Semmler, W., & Kiessling, F. M. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0285 · Cited by 77 · see citing works
Staruch, R., Ganguly, M., Tannock, I. F., Hynynen, K., & Chopra, R. (2012) · International Journal of Hyperthermia · doi:10.3109/02656736.2012.736670 · Cited by 75 · see citing works
Characterization of cell membrane response to ultrasound activated microbubbles
Tran, T. A., Guennec, J. L., Bougnoux, P., Tranquart, F., & Bouakaz, A. (2008) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2008.615 · Cited by 74 · see citing works
Åslund, A., Berg, S., Hak, S., Mørch, Y. A., TORP, S. H., Sandvig, A., Widerøe, M., Hansen, R., & Davies, C. D. L. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.047 · Cited by 72 · see citing works
Eggen, S., Fagerland, S.-M. T., Mørch, Y. A., Hansen, R., Søvik, K. S., Berg, S., Furu, H., Bøhn, A. D., Lilledahl, M. B., Angelsen, A., et al. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.020 · Cited by 69 · see citing works
Palmowski, M., Morgenstern, B., Hauff, P., Reinhardt, M., Huppert, J., Mäurer, M., Woenne, E. C., Doerk, S., Ladewig, G., Jenne, J. W., et al. (2008) · Investigative Radiology · doi:10.1097/rli.0b013e31815a251b · Cited by 67 · see citing works
Eisenbrey, J. R., Soulen, M. C., & Wheatley, M. A. (2009) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2009.2030497 · Cited by 63 · see citing works
Disposition of Ultrasound Sensitive Polymeric Drug Carrier in a Rat Hepatocellular Carcinoma Model
Cochran, M. C., Eisenbrey, J. R., Soulen, M. C., Schultz, S. M., Ouma, R. O., White, S. B., Furth, E. E., & Wheatley, M. A. (2011) · Academic Radiology · doi:10.1016/j.acra.2011.06.013 · Cited by 62 · see citing works
Tiemann, K., Pohl, C., Schlosser, T. W., Goenechea, J., Bruce, M., Veltmann, C., Kuntz‐Hehner, S., Bangard, M., & Becher, H. H. (2000) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(00)00261-1 · Cited by 59 · see citing works
Palmowski, M., Peschke, P., Huppert, J., Hauff, P., Reinhardt, M., Mäurer, M., Karger, C. P., Scholz, M., Semmler, W., Huber, P. E., et al. (2009) · Neoplasia · doi:10.1593/neo.09540 · Cited by 52 · see citing works
Future Prospects for SonoVue and CPS
Cosgrove, D. O. (2004) · European Radiology Supplements · doi:10.1007/s10406-004-0084-3 · Cited by 51 · see citing works
Fokong, S., Fragoso, A., Rix, A., Curaj, A., Wu, Z., Lederle, W., Iranzo, O., Gätjens, J., Kiessling, F. M., & Palmowski, M. (2013) · Investigative Radiology · doi:10.1097/rli.0b013e31829d03ec · Cited by 48 · see citing works
Recruitment of endocytosis in sonopermeabilization-mediated drug delivery: a real-time study
Derieppe, M. P. P., Rojek, K. O., Escoffre, J., de Senneville, B. D., MOONEN, C. T. W., & Bos, C. (2015) · Physical Biology · doi:10.1088/1478-3975/12/4/046010 · Cited by 48 · see citing works
Baetke, S. C., Rix, A., Tranquart, F., Schneider, R., Lammers, T., Kiessling, F. M., & Lederle, W. (2015) · Radiology · doi:10.1148/radiol.2015142899 · Cited by 44 · see citing works
Cavalieri, F., Zhou, M., Tortora, M., Lucilla, B., & Ashokkumar, M. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212800099874 · Cited by 44 · see citing works
Wideband harmonic imaging: A novel contrast ultrasound imaging technique
Bauer, A., Hauff, P., Lazenby, J., Behren, P. L. V., Zomack, M., Reinhardt, M., & Schlief, R. (1999) · European Radiology · doi:10.1007/pl00014075 · Cited by 39 · see citing works
Curaj, A., Wu, Z., Fokong, S., Liehn, E. A., Weber, C., Burlacu, A., Lammers, T., van Zandvoort, M. A. M. J., & Kiessling, F. M. (2015) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304857 · Cited by 36 · see citing works
Reinhardt, M., Hauff, P., Linker, R. A., Briel, A., Gold, R., Rieckmann, P., Becker, G., Toyka, K. V., Mäurer, M., & Schirner, M. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.04.019 · Cited by 34 · see citing works
Rix, A., Fokong, S., Heringer, S., Pjontek, R., Kabelitz, L., Theek, B., Brockmann, M., Wiesmann, M., & Kiessling, F. M. (2016) · Investigative Radiology · doi:10.1097/rli.0000000000000282 · Cited by 33 · see citing works
Wu, Z., Curaj, A., Fokong, S., Liehn, E. A., Weber, C., Lammers, T., Kiessling, F. M., & van Zandvoort, M. A. M. J. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000805 · Cited by 32 · see citing works
In vivo molecular imaging of adhesion molecules in experimental autoimmune encephalomyelitis (EAE)
Linker, R. A., Reinhardt, M., Bendszus, M., Ladewig, G., Briel, A., Schirner, M., Mäurer, M., & Hauff, P. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.09.019 · Cited by 29 · see citing works
Low-Dose Molecular Ultrasound Imaging with E-Selectin-Targeted PBCA Microbubbles
Spivak, I., Rix, A., Schmitz, G., Fokong, S., Iranzo, O., Lederle, W., & Kiessling, F. M. (2015) · Molecular Imaging and Biology · doi:10.1007/s11307-015-0894-9 · Cited by 28 · see citing works
The in vitro stability of air-filled polybutylcyanoacrylate microparticles
Olbrich, C., Hauff, P., Scholle, F.-D., Schmidt, W., Bakowsky, U., Briel, A., & Schirner, M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2006.02.034 · Cited by 23 · see citing works
Ultrasound drug targeting to tumors with thermosensitive liposomes
Ernsting, M. J., Worthington, A. E., May, J. P., Tagami, T., Kolios, M. C., & Li, S. (2011) · IEEE International Ultrasonics Symposium · doi:10.1109/ultsym.2011.0001 · Cited by 16 · see citing works
Fluorescently labeled microbubbles for facilitating translational molecular ultrasound studies
Koczera, P., Wu, Z., Fokong, S., Theek, B., Appold, L. C., Jorge, S., Möckel, D., Liu, Z., Curaj, A., Storm, G., et al. (2012) · Drug Delivery and Translational Research · doi:10.1007/s13346-011-0056-9 · Cited by 16 · see citing works
Joseph, S., Olbrich, C., Kirsch, J., Hasbach, M., Briel, A., & Schirner, M. (2004) · Pharmaceutical Research · doi:10.1023/b:pham.0000029278.27038.5b · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tumor targeting via EPR: Strategies to enhance patient responses
Golombek, S. K., May, J.-N., Theek, B., Appold, L., Drude, N., Kiessling, F., & Lammers, T. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.007 · Cited by 1,262 · see citing works
Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
Dadfar, S. M., Roemhild, K., Drude, N. I., von Stillfried, S., Knüchel, R., Kiessling, F., & Lammers, T. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.01.005 · Cited by 1,181 · see citing works
PLGA-Based Nanoparticles in Cancer Treatment
Rezvantalab, S., Drude, N., Moraveji, M. K., Güvener, N., Koons, E. K., Shi, Y., Lammers, T., & Kiessling, F. M. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01260 · Cited by 612 · see citing works
Advances in nanomaterial-based targeted drug delivery systems
Cheng, X., Xie, Q., & Sun, Y. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1177151 · Cited by 419 · see citing works
Cell therapy trials for heart regeneration — lessons learned and future directions
Menasché, P. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0013-0 · Cited by 269 · see citing works
Ejigah, V., Owoseni, O., Backer, P. B., Ogundipe, O. D., Fisusi, F. A., & Adesina, S. K. (2022) · Polymers · doi:10.3390/polym14132601 · Cited by 241 · see citing works
Shields, C. W., Wang, L., Evans, M. A., & Mitragotri, S. (2019) · Advanced Materials · doi:10.1002/adma.201901633 · Cited by 190 · see citing works
Ultrasound-Based Micro-/Nanosystems for Biomedical Applications
Huang, H. F., Zheng, Y., Chang, M., Song, J., Xia, L., Wu, C., Jia, W., Ren, H., Feng, W., & Chen, Y. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00009 · Cited by 186 · see citing works
Multi‐Responsive Biodegradable Cationic Nanogels for Highly Efficient Treatment of Tumors
Li, X., Sun, H., Li, H., Hu, C., Luo, Y., Shi, X., & Pich, A. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202100227 · Cited by 165 · see citing works
Neurotheranostics as Personalized Medicines
Kevadiya, B. D., Ottemann, B. M., Thomas, M. B., Mukadam, I., Nigam, S., McMillan, J., Gorantla, S., Bronich, T. K., Edagwa, B., & Gendelman, H. E. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.10.011 · Cited by 124 · see citing works
Snipstad, S., Sulheim, E., Davies, C. D. L., MOONEN, C. T. W., Storm, G., Kiessling, F. M., Schmid, R., & Lammers, T. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1547279 · Cited by 119 · see citing works
Physical triggering strategies for drug delivery
Sun, T., Dasgupta, A., Zhao, Z., Nurunnabi, M., & Mitragotri, S. (2020) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2020.06.010 · Cited by 115 · see citing works
Ultrasound-Responsive Carriers for Therapeutic Applications
Chandan, R., Mehta, S., & Banerjee, R. (2020) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01979 · Cited by 113 · see citing works
Papachristodoulou, A., Signorell, R. D., Werner, B., Brambilla, D., Luciani, P., Çavuşoğlu, M., Grandjean, J., Silginer, M., Rudin, M., Martin, E., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.009 · Cited by 93 · see citing works
Köse, G., Darguzyte, M., & Kiessling, F. M. (2020) · Nanomaterials · doi:10.3390/nano10101935 · Cited by 75 · see citing works
Li, B., Aid, R., Labour, M.-N., Zenych, A., Juenet, M., Choqueux, C., Ollivier, V., Couture, O., Letourneur, D., & Chauvierre, C. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.12.023 · Cited by 75 · see citing works
Microbubbles for human diagnosis and therapy
Fournier, L., Taille, T. D. L., & Chauvierre, C. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122025 · Cited by 73 · see citing works
Polymeric materials for ultrasound imaging and therapy
Barmin, R. A., Moosavifar, M., Dasgupta, A., Herrmann, A., Kiessling, F. M., Pallares, R. M., & Lammers, T. (2023) · Chemical Science · doi:10.1039/d3sc04339h · Cited by 56 · see citing works
Etemadi, H., Buchanan, J. K., Kandile, N. G., & Plieger, P. G. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00938 · Cited by 52 · see citing works
Microbubble–Nanoparticle Complexes for Ultrasound-Enhanced Cargo Delivery
Chapla, R., Huynh, K. T., & Schutt, C. E. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112396 · Cited by 51 · see citing works
Mehta, S., Bongcaron, V., Nguyen, T. K., Jirwanka, Y., Maluenda, A. C., Walsh, A. P. G., Palasubramaniam, J., Hulett, M. D., Srivastava, R., Bobik, A., et al. (2022) · Small · doi:10.1002/smll.202200967 · Cited by 44 · see citing works
Transferrin Receptor‐Targeted Nonspherical Microbubbles for Blood–Brain Barrier Sonopermeation
Dasgupta, A., Sun, T., Rama, E., Motta, A., Zhang, Y., Power, C., Moeckel, D., Fletcher, S.-M. P., Moosavifar, M., Barmin, R. A., et al. (2023) · Advanced Materials · doi:10.1002/adma.202308150 · Cited by 44 · see citing works
Rudakovskaya, P. G., Barmin, R. A., Kuzmin, P. S., Fedotkina, E. P., Sencha, A. N., & Gorin, D. A. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061236 · Cited by 43 · see citing works
Nonspherical ultrasound microbubbles
Dasgupta, A., Sun, T., Palomba, R., Rama, E., Zhang, Y., Power, C., Moeckel, D., Liu, M., Sarode, A., Weiler, M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2218847120 · Cited by 40 · see citing works
Drug Loading in Poly(butyl cyanoacrylate)-Based Polymeric Microbubbles
Liu, M., Dasgupta, A., Koczera, P., Schipper, S., Rommel, D., Shi, Y., Kiessling, F. M., & Lammers, T. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00242 · Cited by 36 · see citing works
Sonoporation by microbubbles as gene therapy approach against liver cancer
Rinaldi, L., Folliero, V., Palomba, L., Zannella, C., Isticato, R., Francia, R. D., Berretta, M., de Sio, I., Adinolfi, L. E., Morelli, G., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.25875 · Cited by 34 · see citing works
Controllable polymerization of n-butyl cyanoacrylate using a high-gravity rotating packed bed
Liu, X., Jin, J., Chen, Y., Lu, B., Sun, Q., Wang, J., Chen, J., & Le, Y. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122400 · Cited by 33 · see citing works
Pathak, V., Nolte, T., Rama, E., Rix, A., Dadfar, S. M., Paefgen, V., Banala, S., Buhl, E. M., Weiler, M., Schulz, V., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120896 · Cited by 33 · see citing works
Shelf-Life Evaluation and Lyophilization of PBCA-Based Polymeric Microbubbles
Ojha, T., Pathak, V., Drude, N., Weiler, M., Rommel, D., Rütten, S., Geinitz, B., van Steenbergen, M. J., Storm, G., Kiessling, F. M., et al. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11090433 · Cited by 32 · see citing works
Theranostic Trigger‐Responsive Carbon Monoxide‐Generating Microbubbles
Pathak, V., Roemhild, K., Schipper, S., Groß‐Weege, N., Nolte, T., Ruetten, S., Buhl, E. M., Elshafei, A. S., Weiler, M., Märtin, L., et al. (2022) · Small · doi:10.1002/smll.202200924 · Cited by 30 · see citing works
Barmin, R. A., Dasgupta, A., Bastard, C., Laporte, L. D., Rütten, S., Weiler, M., Kiessling, F. M., Lammers, T., & Pallares, R. M. (2022) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00416 · Cited by 30 · see citing works
Ergen, C., Niemietz, P. M., Heymann, F., Baues, M., Gremse, F., Pola, R., van Bloois, L., Storm, G., Kiessling, F., Trautwein, C., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.03.025 · Cited by 27 · see citing works
Self-citationRecent advances in micro- and nano-bubbles for atherosclerosis applications
Wijaya, A., Maruf, A., Wu, W., & Wang, G. (2020) · Biomaterials Science · doi:10.1039/d0bm00762e · Cited by 25 · see citing works
Moosavifar, M., Barmin, R. A., Rama, E., Rix, A., Gumerov, R. A., Lisson, T., Bastard, C., Rütten, S., Avraham‐Radermacher, N., Koehler, J., et al. (2024) · Advanced Science · doi:10.1002/advs.202404385 · Cited by 23 · see citing works
Integration of microbubbles with biomaterials in tissue engineering for pharmaceutical purposes
Esmaeili, J., Rezaei, F. S., Beram, F. M., & Barati, A. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04189 · Cited by 20 · see citing works
Harnessing bubble behaviors for developing new analytical strategies
An, S., Ranaweera, R., & Luo, L. (2020) · The Analyst · doi:10.1039/d0an01497d · Cited by 21 · see citing works
Wischhusen, J. C., & Padilla, F. R. (2018) · IRBM · doi:10.1016/j.irbm.2018.10.007 · Cited by 20 · see citing works
Barmin, R. A., Dasgupta, A., Rix, A., Weiler, M., Appold, L. C., Rütten, S., Padilla, F. R., Kuehne, A. J. C., Pich, A., Laporte, L. D., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01021 · Cited by 19 · see citing works
Clinical translation and landscape of stimuli-responsive nanomedicines and microscale therapeutics
Kobzev, D., Kulyk, O., Barmin, R. A., Tatarets, A. L., Pallares, R. M., Kiessling, F. M., Lammers, T., & Peña, Q. (2026) · Chemical Society Reviews · doi:10.1039/d6cs00165c · Cited by 23 · see citing works
An overview on nanoplatforms for statins delivery: Perspectives for safe and effective therapy
Etemad, L., Salmasi, Z., Moosavian Kalat, S. A., Moshiri, M., Zamanian, J., Kesharwani, P., & Sahebkar, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116572 · Cited by 18 · see citing works
Zhang, T., Tang, Y., Zhang, W., Liu, S., Zhao, Y., Wang, W., Wang, J., Xu, L., & Liu, K. (2018) · Journal of Materials Chemistry B · doi:10.1039/c7tb03066e · Cited by 17 · see citing works
Fernandes, D. A. (2024) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.4c00137 · Cited by 17 · see citing works
Zhao, X., Ning, Q., Mo, Z., & Tang, S. (2019) · Artificial Cells, Nanomedicine, and Biotechnology · doi:10.1080/21691401.2019.1657875 · Cited by 16 · see citing works
Kaushik, A., Khan, A. H., Pratibha, N. A., Dalvi, S. V., & Shekhar, H. (2023) · The Journal of the Acoustical Society of America · doi:10.1121/10.0017682 · Cited by 13 · see citing works
Honari, A., & Sirsi, S. R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061705 · Cited by 13 · see citing works
Sonosensitive Cavitation Nuclei—A Customisable Platform Technology for Enhanced Therapeutic Delivery
Lyons, B., Balkaran, J. P. R., Dunn-Lawless, D. M., Lucian, V. M., Keller, S. B., O’Reilly, C. S., Hu, L., Rubasingham, J., Nair, M., Carlisle, R. C., et al. (2023) · Molecules · doi:10.3390/molecules28237733 · Cited by 14 · see citing works
mRNA Sonotransfection of Tumors with Polymeric Microbubbles: Co‐Formulation versus Co‐Administration
Chen, J., Wang, B., Wang, Y., Radermacher, H., Qi, J., Momoh, J., Lammers, T., Shi, Y., Rix, A., & Kiessling, F. M. (2024) · Advanced Science · doi:10.1002/advs.202306139 · Cited by 13 · see citing works
Estifeeva, T. M., Barmin, R. A., Rudakovskaya, P. G., Nechaeva, A. M., Luss, A. L., Mezhuev, Y. O., Chernyshev, V. S., Krivoborodov, E. G., Klimenko, O. A., Sindeeva, O. A., et al. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00331 · Cited by 13 · see citing works
Gusliakova, О. I., Kurochkin, M. A., Barmin, R. A., Сергеевна, П. Е., Estifeeva, T. M., Rudakovskaya, P. G., Sindeeva, O. A., Galushka, V. V., Vavaev, E. S., Komlev, A. S., et al. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213759 · Cited by 12 · see citing works
Wang, Y., Feng, J., & Lin, Y. (2021) · Nanotechnology · doi:10.1088/1361-6528/ac44e8 · Cited by 12 · see citing works
Barmin, R. A., Moosavifar, M., Zhang, R., Rütten, S., Thoröe‐Boveleth, S., Rama, E., Ojha, T., Kiessling, F. M., Lammers, T., & Pallares, R. M. (2024) · Journal of Materials Chemistry B · doi:10.1039/d3tb02950f · Cited by 10 · see citing works
Targeting and Modulation of Liver Myeloid Immune Cells by Hard‐Shell Microbubbles
Warzecha, K. T., Bartneck, M., Möckel, D., Appold, L. C., Ergen, C., Rawashdeh, W. A., Gremse, F., Niemietz, P. M., Jahnen‐Dechent, W., Trautwein, C., et al. (2018) · Advanced Biosystems · doi:10.1002/adbi.201800002 · Cited by 10 · see citing works
Xu, Y., Tang, L., Liu, Y., Qian, C., Chen, P., Xin, Y., Liu, H., & Qu, Y. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111642 · Cited by 9 · see citing works
Chen, J., Wang, B., Dasgupta, A., Porte, C., Eckardt, L., Qi, J., Weiler, M., Lammers, T., Rix, A., Shi, Y., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02806-9 · Cited by 8 · see citing works
Microbubble Shell Stiffness Engineering Enhances Ultrasound Imaging, Drug Delivery, and Sonoporation
Barmin, R. A., Moosavifar, M., Rama, E., Blöck, J., Rix, A., Petrovskii, V. S., Gumerov, R. A., Köhler, J., Pohl, M., Bastard, C., et al. (2025) · Advanced Materials · doi:10.1002/adma.202507655 · Cited by 8 · see citing works
Hark, C., Chen, J., Blöck, J., Buhl, E. M., Radermacher, H., Pola, R., Pechar, M., Etrych, T., Peña, Q., Rix, A., et al. (2024) · Drug Delivery and Translational Research · doi:10.1007/s13346-024-01561-6 · Cited by 8 · see citing works
Klibanov, A. L. (2020) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-030-42618-7_9 · Cited by 8 · see citing works
Li, X., Xia, S., Ji, R., Zhan, W., & Zhou, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.690152 · Cited by 8 · see citing works
Blöck, J., Li, H., Collado‐Lara, G., Kooiman, K., Rix, A., Chen, J., Hark, C., Radermacher, H., Porte, C., & Kiessling, F. M. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c01551 · Cited by 7 · see citing works
Ultrasound-activated poly(butyl cyanoacrylate) microbubbles enhance the therapeutic effect of Doxil
Blöck, J., Imschweiler, L., Mihyar, R., Chen, J., Barmin, R. A., Koletnik, S., Pallares, R. M., Lammers, T., Rix, A., & Kiessling, F. M. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107916 · Cited by 7 · see citing works
Multifunctional Ultrasound Microbubbles
Barmin, R. A., Moosavifar, M., Herrmann, A. P., Kiessling, F. M., Lammers, T., & Pallares, R. M. (2026) · Chemical Reviews · doi:10.1021/acs.chemrev.5c00280 · Cited by 7 · see citing works
Yolk-shell polyphosphazenes nanotheranostics for multimodal imaging guided effective phototherapy
Yan, K. Q., Mu, C., Wang, D., Jing, X., Zhang, N., & Meng, L. (2021) · Composites Communications · doi:10.1016/j.coco.2021.100950 · Cited by 7 · see citing works
Fernandes, A. C., Liu, M., Sorbo, T., Appold, L. C., Ilbert, M., Ferracci, G., Kiessling, F. M., Branco, R. J. F., Lammers, T., & Iranzo, O. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0244 · Cited by 7 · see citing works
Strategies to Maximize Anthracycline Drug Loading in Albumin Microbubbles
Liu, M., Dasgupta, A., Qu, N., Rama, E., Kiessling, F. M., & Lammers, T. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c01203 · Cited by 7 · see citing works
Olowosoke, C. B., Ibeh, R. C., Ibisanmi, T. A., & Chukwuemeka, P. O. (2025) · In Silico Research in Biomedicine · doi:10.1016/j.insi.2025.100083 · Cited by 5 · see citing works
Zou, Q., Deng, X., Wang, Z., Guo, S., Zong, Y., Qin, D., & Wan, M. (2025) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2025.107405 · Cited by 4 · see citing works
Lai, X., Xiong, Y., Guo, X., & Chen, C. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin26971 · Cited by 4 · see citing works
Recent advances in biofunctional ultrasound contrast agents with polymeric shells
Wang, B., Liu, Y., Feng, C., & Dong, J. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.107816 · Cited by 3 · see citing works
Polymeric nanoparticles as drug delivery systems for dementia
Esteruelas, G., Souto, E. B., Cano, A. C., Ettcheto, M., Espina, M., Camins, A., García, M. L., & Sánchez‐López, E. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824331-2.00006-6 · Cited by 3 · see citing works
Kumar, V., Madhavanunni, A. N., Nivetha, S., & Panicker, M. R. (2024) · IEEE South Asian Ultrasonics Symposium (SAUS) · doi:10.1109/saus61785.2024.10563527 · Cited by 3 · see citing works
Microbubble‐encapsulated Cobalt Nitrato Complexes for Ultrasound‐triggerable Nitric Oxide Delivery
Koczera, P., Thomas, F., Rama, E., Thoröe‐Boveleth, S., Kiessling, F. M., Lammers, T., & Herres‐Pawlis, S. (2024) · ChemMedChem · doi:10.1002/cmdc.202400232 · Cited by 3 · see citing works
Berg, S., Eggen, S., Caidahl, K., Dähne, L., & Hansen, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0276292 · Cited by 2 · see citing works
Size-Dependent Nonlinear Acoustic Responses and Stable Cavitation of Polymeric Microbubbles
Karimi, N., Moosavifar, M., Barmin, R. A., Appold, L. C., Bastard, C., Rütten, S., Assasa, M. N., Tani, A., Domenici, F., Paradossi, G., et al. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5c01981 · Cited by 2 · see citing works
Cardoso, B. J., Moosavifar, M., Barmin, R. A., Zhang, R., Bastard, C., Koehler, J., Rütten, S., Pohl, M., Thoröe‐Boveleth, S., Kraus, T., et al. (2025) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.5c01114 · Cited by 2 · see citing works
From Polymers to Functional Biomaterials
Weil, T., & Barz, M. (2017) · Macromolecular Bioscience · doi:10.1002/mabi.201700307 · Cited by 2 · see citing works
Zhang, J., Liu, Z., Chang, C., Hu, M., Teng, Y., Li, J., Zhang, X., & Chi, Y. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.576422 · Cited by 2 · see citing works
Rana, B., Singh, P., Varshney, S., Ali, S. W., Joshi, M., & Kale, R. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95366-5.00012-x · Cited by 1 · see citing works
Microchannels for microfluidic systems
Nasseri, B., Akar, S., & Naseri, E. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818791-3.00002-4 · Cited by 1 · see citing works
Hydrophilic Cargo-Loaded Microbubbles for Ultrasound-Triggered Local Delivery
Chow, S. (2020) · TSpace (University of Toronto)
Elwia, S. K., & Marei, Y. M. (2021) · Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology/Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology · doi:10.21608/eajbsc.2021.183298
Exploring the Generalizability of DeepNLCI in Out-of-Domain Scenarios
Lisson, T., Braccia, G., Fouad, M., & Schmitz, G. (2025) · IEEE International Ultrasonics Symposium · doi:10.1109/ius62464.2025.11201564
Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles
Chen, J., Wang, X., Fan, J., Wang, B., Fang, H., Wang, Y., Cui, H., Roufarshbaf, M., Savina, E., Valeske, A., et al. (2026) · Advanced Materials · doi:10.1002/adma.73639
Polymer platforms for cardiovascular disease applications
Yang, W.-J., Chen, M., Li, J., Duan, Y., Gao, H., Jin, Q., Wang, T., Zhang, Z. H., Yu, H., Jiang, B., et al. (2026) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2026.102154
Barmin, R. A., Saraolu, S. A., Gumerov, R. A., Li, Y., Moosavifar, M., Koehler, J., Pohl, M., Bastard, C., Rütten, S., Laporte, L. D., et al. (2026) · Green Chemistry · doi:10.1039/d6gc02897g
- Authors
- Koczera, P., Appold, L., Shi, Y., Liu, M., Dasgupta, A., Pathak, V., Ojha, T., Fokong, S., Wu, Z., van Zandvoort, M., Iranzo, O., Kuehne, A. J. C., Pich, A., Kiessling, F., & Lammers, T.
- Affiliations
- Universitätsklinikum Aachen (DE)
- RWTH Aachen University (DE)
- Utrecht University (NL)
- Centre National de la Recherche Scientifique (FR)
- DWI – Leibniz Institute for Interactive Materials (DE)
- Corresponding author
- Kiessling, Fabian
- Lammers, Twan
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 259
- Pages
- 128-135
- ISSN
- 0168-3659 (ISSN-L)
- PMC
- PMC5528138
- OpenAlex
- W2592211574
- Cited by
- 85
- References
- 60
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 10 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 10 · 2019: 6 · 2018: 12 · 2017: 1
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- University of Twente Research Information (publishedVersion, cc-by-nc-nd)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- University of Twente Research Information (submittedVersion, cc-by-nc-nd)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- German Research Foundation (LA 2937/1-2)
- European Research Council (ERC-StG-309495-NeoNaNo)
- German Center for Cardiovascular Research (FKZ 81X2800152)
- i3tm Seed Fund Program (SF_14-4-09-Sonoporation)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- microbubbles, ultrasound contrast agents, ultrasound molecular imaging, sonoporation, drug delivery, E-selectin, VCAM-1, targeted microbubbles, atherosclerosis, inertial cavitation, drug release, extravasation, brain drug delivery
- MeSH terms
- Ultrasonic Waves, Animals, Antibodies, Biotin, Brain, Carotid Arteries, Dextrans, Enbucrilate, Fluorescent Dyes, Humans, Male, Mice, Nude, Neoplasms, Neovascularization, Pathologic, Rhodamines, Ultrasonography, Drug Delivery Systems, Fluorescein-5-isothiocyanate, Vascular Cell Adhesion Molecule-1, E-Selectin, Streptavidin, Vascular Endothelial Growth Factor Receptor-2, Microbubbles, Cell Line, Tumor, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
