Ultrasound-Responsive Carriers for Therapeutic Applications

Thermal ablation of tumours: biological mechanisms and advances in therapy

Chu, K. F., & Dupuy, D. E. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3672 · Cited by 1,990 · see citing works

Ultrasound Microbubble Contrast Agents: Fundamentals and Application to Gene and Drug Delivery

Ferrara, K. W., Pollard, R. E., & Borden, M. A. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095852 · Cited by 1,259 · see citing works

Ultrasound-Enhanced Systemic Thrombolysis for Acute Ischemic Stroke

Alexandrov, A. V., Molina, C. A., Grotta, J. C., Garami, Z. F., Ford, S. R., Álvarez‐Sabín, J., Montaner, J., Saqqur, M., Demchuk, A. M., Moyé, L. A., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041175 · Cited by 1,043 · see citing works

Echocardiography of the Aortic Root

Gramiak, R., & Shah, P. M. (1968) · Investigative Radiology · doi:10.1097/00004424-196809000-00011 · Cited by 935 · see citing works

Chemical Design and Synthesis of Functionalized Probes for Imaging and Treating Tumor Hypoxia

Liu, J., Bu, W., & Shi, J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00525 · Cited by 840 · see citing works

Ultrasound-Mediated Transdermal Protein Delivery

Mitragotri, S., Blankschtein, D., & Langer, R. (1995) · Science · doi:10.1126/science.7638603 · Cited by 794 · see citing works

Clinical trial of blood-brain barrier disruption by pulsed ultrasound

Carpentier, A., Canney, M., Vignot, A., Reina, V., Beccaria, K., Horodyckid, C., Karachi, C., Leclercq, D., Lafon, C., Chapelon, J.-Y., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6086 · Cited by 757 · see citing works

Enzyme-responsive nanomaterials for controlled drug delivery

Hu, Q., Katti, P. S., & Gu, Z. (2014) · Nanoscale · doi:10.1039/c4nr04249b · Cited by 683 · see citing works

Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy

Wang, C., Cheng, L., & Liu, Z. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.09.069 · Cited by 666 · see citing works

Microbubble compositions, properties and biomedical applications

Sirsi, S. R., & Borden, M. A. (2009) · Bubble Science Engineering & Technology · doi:10.1179/175889709x446507 · Cited by 596 · see citing works

Redox-responsive polymers for drug delivery: from molecular design to applications

Huo, M., Yuan, J., Tao, L., & Wei, Y. (2014) · Polym. Chem. · doi:10.1039/c3py01192e · Cited by 561 · see citing works

Controlled and targeted tumor chemotherapy by ultrasound-activated nanoemulsions/microbubbles

Rapoport, N. Y., Kennedy, A., Shea, J., Scaife, C. L., & Nam, K.-H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.05.026 · Cited by 552 · see citing works

State-of-the-art materials for ultrasound-triggered drug delivery

Sirsi, S. R., & Borden, M. A. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.12.010 · Cited by 492 · see citing works

Polymer-Grafted Mesoporous Silica Nanoparticles as Ultrasound-Responsive Drug Carriers

Paris, J. L., Cabañas, M. V., Manzano, M., & Vallet‐Regí, M. (2015) · ACS Nano · doi:10.1021/acsnano.5b04378 · Cited by 484 · see citing works

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

Abrahao, A., Meng, Y., Llinas, M., Huang, Y., Hamani, C., Mainprize, T., Aubert, I., Heyn, C., Black, S. E., Hynynen, K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12426-9 · Cited by 476 · see citing works

Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy

Huebsch, N., Kearney, C. J., Zhao, X., Kim, J., Cezar, C. A., Suo, Z., & Mooney, D. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1405469111 · Cited by 453 · see citing works

Microbubble Administration Accelerates Clot Lysis During Continuous 2-MHz Ultrasound Monitoring in Stroke Patients Treated With Intravenous Tissue Plasminogen Activator

Molina, C. A., Ribó, M., Rubiera, M., Montaner, J., Santamarina, E., Delgado‐Mederos, R., Arenillas, J. F., Huertas, R., Purroy, F. F., Delgado, P., et al. (2005) · Stroke · doi:10.1161/01.str.0000199064.94588.39 · Cited by 451 · see citing works

Ultrasound-mediated transdermal drug delivery: Mechanisms, scope, and emerging trends

Polat, B. E., Hart, D. P., Langer, R., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.006 · Cited by 447 · see citing works

Echocardiographic Destruction of Albumin Microbubbles Directs Gene Delivery to the Myocardium

Shohet, R. V., Chen, S., Zhou, Y.-T., Wang, Z., Meidell, R. S., Unger, R. H., & Grayburn, P. A. (2000) · Circulation · doi:10.1161/01.cir.101.22.2554 · Cited by 446 · see citing works

A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer

Dimcevski, G. G., Kotopoulis, S., Bjånes, T. K., Hoem, D., Schjøtt, J. D., Gjertsen, B. T., Biermann, M., Molven, A., Sørbye, H., McCormack, E., et al. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.10.007 · Cited by 430 · see citing works

Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions

Rapoport, N. Y., Nam, K. H., Gupta, R., Gao, Z., Mohan, P., Payne, A., Todd, N., Liu, X., Kim, T., Shea, J., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.01.022 · Cited by 424 · see citing works

Sonogenetics is a non-invasive approach to activating neurons in Caenorhabditis elegans

Ibsen, S. D., Tong, A., Schutt, C. E., Esener, S. C., & Chalasani, S. H. (2015) · Nature Communications · doi:10.1038/ncomms9264 · Cited by 377 · see citing works

Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice

Choi, J. J., Pernot, M., Small, S. A., & Konofagou, E. E. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.07.018 · Cited by 356 · see citing works

Albumin Microbubble Echo-Contrast Material as an Enhancer for Ultrasound Accelerated Thrombolysis

Tachibana, K., & Tachibana, S. (1995) · Circulation · doi:10.1161/01.cir.92.5.1148 · Cited by 345 · see citing works

Dissolution Behavior of Lipid Monolayer-Coated, Air-Filled Microbubbles: Effect of Lipid Hydrophobic Chain Length

(2002) · doi:10.1021/la026082h · Cited by 343 · see citing works

Liposomes in ultrasonic drug and gene delivery

Huang, S. L. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.003 · Cited by 339 · see citing works

Acoustic radiation force in vivo: a mechanism to assist targeting of microbubbles

Dayton, P. A., Klibanov, A. L., Brandenburger, G. H., & Ferrara, K. W. (1999) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(99)00062-9 · Cited by 332 · see citing works

A Thermoresponsive Bubble-Generating Liposomal System for Triggering Localized Extracellular Drug Delivery

Chen, K., Liang, H., Chen, H., Wang, Y., Cheng, P., Liu, H.-L., Younan Xia, A., & Sung, H. (2012) · ACS Nano · doi:10.1021/nn304474j · Cited by 280 · see citing works

Acoustically active liposomes for drug encapsulation and ultrasound-triggered release

Huang, S.-L., & MacDonald, R. C. (2004) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2004.07.003 · Cited by 268 · see citing works

Acoustically Active Lipospheres Containing Paclitaxel

Unger, E. C., McCreery, T. P., Sweitzer, R. H., Caldwell, V. E., & WU, Y. (1998) · Investigative Radiology · doi:10.1097/00004424-199812000-00007 · Cited by 267 · see citing works

pH-Controlled Gas-Generating Mineralized Nanoparticles: A Theranostic Agent for Ultrasound Imaging and Therapy of Cancers

Min, K. H., Min, H. S., Lee, H. J., Park, D. J., Yhee, J. Y., Kim, K., Kwon, I. C., Jeong, S. Y., Silvestre, Ó. F., Chen, X. S., et al. (2015) · ACS Nano · doi:10.1021/nn506210a · Cited by 265 · see citing works

Ultrasound radiation force enables targeted deposition of model drug carriers loaded on microbubbles

Lum, A. F. H., Borden, M. A., Dayton, P. A., et al. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.11.006 · Cited by 262 · see citing works

Ultrasound-triggered drug delivery for cancer treatment using drug delivery systems: From theoretical considerations to practical applications

Boissenot, T., Bordat, A., Fattal, E., & Tsapis, N. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.026 · Cited by 262 · see citing works

Phase‐shift, stimuli‐responsive perfluorocarbon nanodroplets for drug delivery to cancer

Rapoport, N. Y. (2012) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1176 · Cited by 251 · see citing works

EFFECT OF ULTRASOUND ON THE PRODUCTION OF IL-8, BASIC FGF AND VEGF

Reher, P., Doan, N., Bradnock, B., et al. (1999) · Cytokine · doi:10.1006/cyto.1998.0444 · Cited by 249 · see citing works

Endogenous pH-responsive nanoparticles with programmable size changes for targeted tumor therapy and imaging applications

Wu, W., Luo, L., Wang, Y., Wu, Q., Dai, H.-B., Li, J., Durkan, C., Wang, N., & Wang, G. (2018) · Theranostics · doi:10.7150/thno.23459 · Cited by 247 · see citing works

Paclitaxel-liposome–microbubble complexes as ultrasound-triggered therapeutic drug delivery carriers

Yan, F., Li, L., Deng, Z., Jin, Q., Chen, J., Yang, W., Yeh, C., Wu, J., Shandas, R., Liu, X., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.12.025 · Cited by 239 · see citing works

A preliminary evaluation of the effects of primary and secondary radiation forces on acoustic contrast agents

Dayton, P. A., Morgan, K. E., Klibanov, A. L., et al. (1997) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/58.656630 · Cited by 232 · see citing works

Drug Release from Phase-Changeable Nanodroplets Triggered by Low-Intensity Focused Ultrasound

Cao, Y., Chen, Y., Yu, T., Guo, Y., Liu, F., Yao, Y., Li, P., Wang, D., Wang, Z., Chen, Y., et al. (2018) · Theranostics · doi:10.7150/thno.21492 · Cited by 229 · see citing works

SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

Fan, C.-H., Ting, C.-Y., Lin, H.-J., Wang, C.-H., Liu, H.-L., Yen, T.-C., & Yeh, C.-K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.099 · Cited by 225 · see citing works

Acoustically-active microbubbles conjugated to liposomes: Characterization of a proposed drug delivery vehicle

Kheirolomoom, A., Dayton, P. A., Lum, A. F. H., Little, E. L., Paoli, E. E., Zheng, H., & Ferrara, K. W. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.12.015 · Cited by 225 · see citing works

Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by Ultrasound-Targeted microbubble destruction

Chen, S., Shohet, R. V., Bekeredjian, R., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00627-2 · Cited by 213 · see citing works

Nanoscale theranostics for physical stimulus-responsive cancer therapies

Chen, Q., Ke, H., Dai, Z., & Liu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.09.018 · Cited by 209 · see citing works

Mechanisms of Microbubble-Facilitated Sonoporation for Drug and Gene Delivery

Fan, Z., Kumon, R. E., & Deng, C. X. (2014) · Therapeutic Delivery · doi:10.4155/tde.14.10 · Cited by 195 · see citing works

Multifunctional Photonic Nanomaterials for Diagnostic, Therapeutic, and Theranostic Applications

Kim, H., Beack, S., Han, S., Shin, M., Lee, T., Park, Y., Kim, K. S., Yetisen, A. K., Yun, S. H., Kwon, W., et al. (2018) · Advanced Materials · doi:10.1002/adma.201701460 · Cited by 191 · see citing works

A Temperature-Responsive Copolymer Hydrogel in Controlled Drug Delivery

Dai, H., Chen, Q., Qin, H., et al. (2006) · Macromolecules · doi:10.1021/ma060486p · Cited by 187 · see citing works

State-of-the-art of microbubble-assisted blood-brain barrier disruption

Song, K.-H., Harvey, B. K., & Borden, M. A. (2018) · Theranostics · doi:10.7150/thno.26869 · Cited by 181 · see citing works

Tumor-penetrating codelivery of siRNA and paclitaxel with ultrasound-responsive nanobubbles hetero-assembled from polymeric micelles and liposomes

Yin, T., Wang, P., Li, J., Wang, Y., Zheng, B., Zheng, R., Cheng, D., & Shuai, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.072 · Cited by 171 · see citing works

Radiation-Force Assisted Targeting Facilitates Ultrasonic Molecular Imaging

Zhao, S., Borden, M. A., Bloch, S. H., et al. (2004) · Molecular Imaging · doi:10.1162/1535350042380317 · Cited by 169 · see citing works

Intracellular delivery and calcium transients generated in sonoporation facilitated by microbubbles

Fan, Z., Kumon, R. E., Park, J. H., et al. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.09.031 · Cited by 167 · see citing works

Endogenous Catalytic Generation of O2 Bubbles for In Situ Ultrasound-Guided High Intensity Focused Ultrasound Ablation

Liu, T., Zhang, N., Wang, Z., Wu, M., Chen, Y., Ma, M., Chen, H., & Shi, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b03772 · Cited by 163 · see citing works

Microbubble Dissolution in a Multigas Environment

Kwan, J. J., & Borden, M. A. (2010) · Langmuir · doi:10.1021/la904088p · Cited by 161 · see citing works

Self-assembled liposome-loaded microbubbles: The missing link for safe and efficient ultrasound triggered drug-delivery

Geers, B., Lentacker, I., Sanders, N. N., et al. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.02.024 · Cited by 160 · see citing works

Optical observation of contrast agent destruction

Chomas, J. E., Dayton, P. A., May, D. J., et al. (2000) · Applied Physics Letters · doi:10.1063/1.1287519 · Cited by 157 · see citing works

Therapeutic effects of paclitaxel-containing ultrasound contrast agents

Tartis, M., McCallan, J. L., Lum, A. F. H., LaBell, R., Stieger‐Vanegas, S. M., Matsunaga, T. O., & Ferrara, K. W. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.03.017 · Cited by 148 · see citing works

Ultrasound-triggered local anaesthesia

Rwei, A. Y., Paris, J. L., Wang, B., Wang, W., Axon, C. D., Vallet‐Regí, M., Langer, R., & Kohane, D. S. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0117-6 · Cited by 148 · see citing works

Sonoporation-Enhanced Chemotherapy Significantly Reduces Primary Tumour Burden in an Orthotopic Pancreatic Cancer Xenograft

Kotopoulis, S., Delalande, A., Popa, M. L., et al. (2013) · Molecular Imaging and Biology · doi:10.1007/s11307-013-0672-5 · Cited by 147 · see citing works

Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

Poon, C., McMahon, D., & Hynynen, K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.014 · Cited by 147 · see citing works

Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Fan, C., Ting, C.-Y., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.048 · Cited by 145 · see citing works

A reversible light-operated nanovalve on mesoporous silica nanoparticles

Tarn, D., Ferris, D. P., Barnes, J. C., Ambrogio, M. W., Stoddart, J. F., & Zink, J. I. (2014) · Nanoscale · doi:10.1039/c3nr06049g · Cited by 137 · see citing works

A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

Epstein-Barash, H., Orbey, G., Polat, B. E., Ewoldt, R. H., Feshitan, J. A., Langer, R., Borden, M. A., & Kohane, D. S. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.03.008 · Cited by 136 · see citing works

The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging

Cai, W. B., Yang, H. L., Zhang, J., et al. (2015) · Scientific Reports · doi:10.1038/srep13725 · Cited by 136 · see citing works

Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles

Escoffre, J., Piron, J., Novell, A., et al. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100397p · Cited by 131 · see citing works

In situ bone tissue engineering via ultrasound-mediated gene delivery to endogenous progenitor cells in mini-pigs

Bez, M., Sheyn, D., Tawackoli, W., Avalos, P., Shapiro, G., Giaconi, J., Da, X., David, S. B., Gavrity, J., Awad, H. A., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3128 · Cited by 129 · see citing works

Microbubble Formulations: Synthesis, Stability, Modeling and Biomedical Applications

Upadhyay, A., & Dalvi, S. V. (2018) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.09.022 · Cited by 129 · see citing works

Magnetic field activated lipid–polymer hybrid nanoparticles for stimuli-responsive drug release

Kong, S. D., Sartor, M., Hu, C. J., Zhang, W., Zhang, L., & Jin, S. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.11.006 · Cited by 125 · see citing works

Cavitation-Enhanced Extravasation for Drug Delivery

Arvanitis, C., Bazán‐Peregrino, M., Rifai, B., Seymour, L. W., & Coussios, C. C. (2011) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2011.08.004 · Cited by 123 · see citing works

Ultrasound-Responsive Materials for Drug/Gene Delivery

Cai, X., Jiang, Y. Q., Lin, M., Zhang, J., Guo, H., Yang, F., Leung, W., & Xu, C. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01650 · Cited by 121 · see citing works

Sonofragmentation: Effect of Ultrasound Frequency and Power on Particle Breakage

Jordens, J., Appermont, T., Gielen, B., et al. (2016) · Crystal Growth & Design · doi:10.1021/acs.cgd.6b00088 · Cited by 120 · see citing works

Dynamics and fragmentation of thick-shelled microbubbles

May, D. J., Allen, J. S., & Ferrara, K. W. (2002) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2002.1041081 · Cited by 117 · see citing works

Nanobubble Liposome Complexes for Diagnostic Imaging and Ultrasound-Triggered Drug Delivery in Cancers: A Theranostic Approach

Prabhakar, A., & Banerjee, R. (2019) · ACS Omega · doi:10.1021/acsomega.9b01924 · Cited by 116 · see citing works

Low-Intensity Ultrasound-Exposed Microbubbles Provoke Local Hyperpolarization of the Cell Membrane Via Activation of BKCa Channels

Juffermans, L. J. M., Kamp, O., Dijkmans, P. A., et al. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.09.010 · Cited by 115 · see citing works

Gemcitabine loaded microbubbles for targeted chemo-sonodynamic therapy of pancreatic cancer

Nesbitt, H., Sheng, Y., Kamila, S., Logan, K. A., Thomas, K. G., Callan, B., Taylor, M., Love, M., O’Rourke, D. M., Kelly, P., et al. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.04.018 · Cited by 108 · see citing works

Folate-conjugated gene-carrying microbubbles with focused ultrasound for concurrent blood-brain barrier opening and local gene delivery

Fan, C., Chang, E.-L., Ting, C.-Y., Lin, Y., Liao, E., Huang, C.-Y., Chang, Y., Chan, H., Wei, K., & Yeh, C. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.017 · Cited by 104 · see citing works

Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis

Kim, J., Lindsey, B. D., Chang, W.-Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03492-4 · Cited by 101 · see citing works

Ultrasound-Mediated Local Drug and Gene Delivery Using Nanocarriers

Zhou, Q.-L., Chen, Z., Wáng, Y. X. J., Yang, F., Lin, Y., & Liao, Y. (2014) · BioMed Research International · doi:10.1155/2014/963891 · Cited by 99 · see citing works

A Review of Thermo- and Ultrasound-Responsive Polymeric Systems for Delivery of Chemotherapeutic Agents

Zardad, A.-Z., Choonara, Y. E., du Toit, L. C., Kumar, P., Mabrouk, M., Kondiah, P. P. D., & Pillay, V. (2016) · Polymers · doi:10.3390/polym8100359 · Cited by 98 · see citing works

Drug-loaded bubbles with matched focused ultrasound excitation for concurrent blood–brain barrier opening and brain-tumor drug delivery

Fan, C., Ting, C.-Y., Chang, Y., Wei, K., Liu, H.-L., & Yeh, C. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.12.026 · Cited by 96 · see citing works

Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections

Lattwein, K. R., Shekhar, H., Kouijzer, J. J. P., van Wamel, W. J. B., Holland, C. K., & Kooiman, K. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.09.011 · Cited by 95 · see citing works

Near-infrared light-activatable polymeric nanoformulations for combined therapy and imaging of cancer

Yue, X., Zhang, Q., & Dai, Z. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.04.007 · Cited by 93 · see citing works

A novel strategy utilizing ultrasound for antigen delivery in dendritic cell-based cancer immunotherapy

Suzuki, R., Oda, Y., Utoguchi, N., Namai, E., Taira, Y., Okada, N., Kadowaki, N., Kodama, T., Tachibana, K., & Maruyama, K. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2008.10.015 · Cited by 89 · see citing works

Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment

Luo, W., Wen, G., Li, Y., et al. (2017) · Theranostics · doi:10.7150/thno.16677 · Cited by 89 · see citing works

Inertial cavitation to non-invasively trigger and monitor intratumoral release of drug from intravenously delivered liposomes

Graham, S., Carlisle, R. C., Choi, J. J., Stevenson, M., Shah, A. R., Myers, R. S., Fisher, K. D., Bazán‐Peregrino, M., Seymour, L. W., & Coussios, C. C. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.12.016 · Cited by 86 · see citing works

Magnetic hyperthermia and pH-responsive effective drug delivery to the sub-cellular level of human breast cancer cells by modified CoFe2O4 nanoparticles

Oh, Y., Santhamoorthy, M., Manivasagan, P., Bharathiraja, S., & Oh, J. (2016) · Biochimie · doi:10.1016/j.biochi.2016.11.012 · Cited by 86 · see citing works

PBCA-based polymeric microbubbles for molecular imaging and drug delivery

Koczera, P., Appold, L., Shi, Y., Liu, M., Dasgupta, A., Pathak, V., Ojha, T., Fokong, S., Wu, Z., van Zandvoort, M., et al. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.03.006 · Cited by 85 · see citing works

Review of ultrasound mediated drug delivery for cancer treatment: updates from pre-clinical studies

Couture, O., Foley, J. L., Kassell, N. F., Larrat, B., & Aubry, J. (2014) · Translational Cancer Research · doi:10.21037/3354 · Cited by 84 · see citing works

Acoustic droplet–hydrogel composites for spatial and temporal control of growth factor delivery and scaffold stiffness

Fabiilli, M. L., Wilson, C. G. M., Padilla, F. R., et al. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.03.027 · Cited by 82 · see citing works

Safety evaluation of frequent application of microbubble-enhanced focused ultrasound blood-brain-barrier opening

Tsai, H., Tsai, C.-H., Chen, W., Inserra, C., Wei, K., & Liu, H.-L. (2018) · Scientific Reports · doi:10.1038/s41598-018-35677-w · Cited by 82 · see citing works

Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery

Min, H. S., Son, S., You, D. G., Lee, T. W., Lee, J., Lee, S., Yhee, J. Y., Lee, J., Han, M. H., Park, J. H., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.049 · Cited by 81 · see citing works

Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome–microbubble complexes assisted by ultrasound

Deng, Z., Yan, F., Jin, Q., Li, F., Wu, J., Liu, X., & Zheng, H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.018 · Cited by 80 · see citing works

Ultrasound-mediated transdermal in vivo transport of insulin with low-profile cymbal arrays

Smith, N. B., Lee, S., & Shung, K. K. (2003) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(03)00908-6 · Cited by 79 · see citing works

Polymer-Stabilized Perfluorobutane Nanodroplets for Ultrasound Imaging Agents

Huang, Y., Vezeridis, A. M., Wang, J., Wang, Z., Thompson, M. P., Mattrey, R. F., & Gianneschi, N. C. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b08800 · Cited by 76 · see citing works

Ultrasound-Mediated Destruction of LHRHa-Targeted and Paclitaxel-Loaded Lipid Microbubbles for the Treatment of Intraperitoneal Ovarian Cancer Xenografts

Pu, C., Chang, S., Sun, J., Zhu, S., Liu, H., Zhu, Y., Wang, Z., & Xu, R. X. (2013) · Molecular Pharmaceutics · doi:10.1021/mp400523h · Cited by 75 · see citing works

Ultrasound-Mediated Release of Hydrophilic and Lipophilic Agents From Echogenic Liposomes

Kopechek, J. A., Abruzzo, T. M., Wang, B., et al. (2008) · Journal of Ultrasound in Medicine · doi:10.7863/jum.2008.27.11.1597 · Cited by 71 · see citing works

Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery

Paul, S., Nahire, R., Mallik, S., et al. (2014) · Computational Mechanics · doi:10.1007/s00466-013-0962-4 · Cited by 70 · see citing works

Circulating Magnetic Microbubbles for Localized Real-Time Control of Drug Delivery by Ultrasonography-Guided Magnetic Targeting and Ultrasound

Chertok, B., & Langer, R. (2017) · Theranostics · doi:10.7150/thno.20781 · Cited by 67 · see citing works

Ultrasound-mediated targeted drug delivery: recent success and remaining challenges

Castle, J. W., Butts, M. D., Healey, A., Kent, K., Marino, M., & Feinstein, S. B. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00265.2012 · Cited by 64 · see citing works

Superhydrophobic silica nanoparticles as ultrasound contrast agents

Jin, Q., Lin, C.-Y., Kang, S., et al. (2016) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2016.12.001 · Cited by 62 · see citing works

Intra-articular drug delivery from an optimized topical patch containing teriflunomide and lornoxicam for rheumatoid arthritis treatment: Does the topical patch really enhance a local treatment?

Xi, H., Cun, D., Xiang, R., et al. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.03.028 · Cited by 61 · see citing works

Exploitation of sub-micron cavitation nuclei to enhance ultrasound-mediated transdermal transport and penetration of vaccines

Bhatnagar, S., Kwan, J. J., Shah, A. R., Coussios, C. C., & Carlisle, R. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.07.016 · Cited by 61 · see citing works

Ultrasound-triggered thrombolysis using urokinase-loaded nanogels

Jin, H., Tan, H., Zhao, L., Sun, W., Zhu, L., Sun, Y., Hao, H.-J., Haiying, X., Liu, L., Qu, X., et al. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.06.001 · Cited by 59 · see citing works

Investigating the acoustic release of doxorubicin from targeted micelles

Husseini, G. A., Velluto, D., Kherbeck, L., Pitt, W. G., Hubbell, J. A., & Christensen, D. A. (2012) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2012.05.025 · Cited by 59 · see citing works

Lipid Coated Microbubbles and Low Intensity Pulsed Ultrasound Enhance Chondrogenesis of Human Mesenchymal Stem Cells in 3D Printed Scaffolds

Aliabouzar, M., Zhang, L. G., & Sarkar, K. (2016) · Scientific Reports · doi:10.1038/srep37728 · Cited by 58 · see citing works

Ultrasound triggered image-guided drug delivery to inhibit vascular reconstruction via paclitaxel-loaded microbubbles

Zhu, X., Guo, J., He, C., et al. (2016) · Scientific Reports · doi:10.1038/srep21683 · Cited by 57 · see citing works

Ultrasound responsive block copolymer micelle of poly(ethylene glycol)–poly(propylene glycol) obtained through click reaction

Li, F., Xie, C. L., Cheng, Z., & Xia, H. (2015) · Ultrasonics Sonochemistry · doi:10.1016/j.ultsonch.2015.11.023 · Cited by 50 · see citing works

Photosensitizer-loaded bubble-generating mineralized nanoparticles for ultrasound imaging and photodynamic therapy

Park, D. J., Min, K. H., Lee, H. J., et al. (2016) · Journal of Materials Chemistry B · doi:10.1039/c5tb02338f · Cited by 49 · see citing works

Blood-brain barrier disruption induced by diagnostic ultrasound combined with microbubbles in mice

Zhao, B., Chen, Y., Liu, J., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23527 · Cited by 49 · see citing works

Microbubbles as biocompatible porogens for hydrogel scaffolds

Lima, E. G., Durney, K. M., Sirsi, S. R., et al. (2012) · Acta Biomaterialia · doi:10.1016/j.actbio.2012.07.007 · Cited by 46 · see citing works

Lung Surfactant Microbubbles Increase Lipophilic Drug Payload for Ultrasound-Targeted Delivery

Sirsi, S. R., Fung, C., Garg, S., et al. (2013) · Theranostics · doi:10.7150/thno.5616 · Cited by 44 · see citing works

Gas‐Stabilizing Gold Nanocones for Acoustically Mediated Drug Delivery

Mannaris, C., Teo, B. M., Seth, A., et al. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800184 · Cited by 44 · see citing works

Pro-apoptotic liposomes-nanobubble conjugate synergistic with paclitaxel: a platform for ultrasound responsive image-guided drug delivery

Chandan, R., & Banerjee, R. (2018) · Scientific Reports · doi:10.1038/s41598-018-21084-8 · Cited by 44 · see citing works

Controlled bone formation using ultrasound-triggered release of BMP-2 from liposomes

Crasto, G. J., Kartner, N., Reznik, N., Spatafora, M. V., Chen, H., Williams, R., Burns, P. N., Clokie, C. M. L., Manolson, M. F., & Peel, S. A. F. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.032 · Cited by 42 · see citing works

Sonothrombolysis with Magnetically Targeted Microbubbles

Victor, M. D. S., Barnsley, L. C., Carugo, D., Owen, J., Coussios, C. C., & Stride, E. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2018.12.014 · Cited by 42 · see citing works

Ultrasound-Sensitive Liposomes for Triggered Macromolecular Drug Delivery: Formulation and In Vitro Characterization

de Matos, M. B. C., Deckers, R., van Elburg, B., et al. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01463 · Cited by 41 · see citing works

Ultrasound‐Induced Disruption of Amphiphilic Block Copolymer Micelles

Xuan, J., Pelletier, M., Xia, H., & Zhao, Y. (2011) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201000624 · Cited by 39 · see citing works

Ultrasound-Mediated Destruction of LHRHa-Targeted and Paclitaxel-Loaded Lipid Microbubbles Induces Proliferation Inhibition and Apoptosis in Ovarian Cancer Cells

Liu, H., Chang, S., Sun, J., Zhu, S., Pu, C., Zhu, Y., Wang, Z., & Xu, R. X. (2013) · Molecular Pharmaceutics · doi:10.1021/mp4005244 · Cited by 39 · see citing works

Fast release behavior of block copolymer micelles under high intensity focused ultrasound/redox combined stimulus

Tong, R., Xia, H., & Lu, X. (2012) · Journal of Materials Chemistry B · doi:10.1039/c2tb00222a · Cited by 38 · see citing works

Efficacy of Combined Ultrasound-and-Microbubbles-Mediated Diclofenac Gel Delivery to Enhance Transdermal Permeation in Adjuvant-Induced Rheumatoid Arthritis in the Rat

Liao, A., Chung, H.-Y., Chen, W., et al. (2016) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2016.03.031 · Cited by 38 · see citing works

Contrast-enhanced ultrasound imaging in vivo with laser-activated nanodroplets

Yoon, H., Yarmoska, S. K., Hannah, A. S., et al. (2017) · Medical Physics · doi:10.1002/mp.12269 · Cited by 35 · see citing works

Enhancement Effect of Ultrasound-Induced Microbubble Cavitation on Branched Polyethylenimine-Mediated VEGF165 Transfection With Varied N/P Ratio

Zhang, C., Cao, H., Li, Q., et al. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.08.025 · Cited by 34 · see citing works

The synergistic bactericidal effect of vancomycin on UTMD treated biofilm involves damage to bacterial cells and enhancement of metabolic activities

Hu, J., Zhang, N., Li, L., Zhang, N., Ma, Y., Zhao, C., Wu, Q., Li, Y., He, N., & Wang, X. (2018) · Scientific Reports · doi:10.1038/s41598-017-18496-3 · Cited by 34 · see citing works

Microwave-activated nanodroplet vaporization for highly efficient tumor ablation with real-time monitoring performance

Xu, J., Chen, Y., Deng, L., Liu, J., Cao, Y., Li, P., Ran, H., Zheng, Y., & Wang, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.08.034 · Cited by 33 · see citing works

Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects

Khokhlova, T. D., Haider, Y. A., & Hwang, J. H. (2015) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x15592584 · Cited by 32 · see citing works

Phase-transitional Fe3O4/perfluorohexane Microspheres for Magnetic Droplet Vaporization

Wang, R., Yang, Z., Zhang, P., et al. (2017) · Theranostics · doi:10.7150/thno.17251 · Cited by 32 · see citing works

Effect of Ultrasound on the Permeability of Vascular Wall to Nano-emulsion Droplets

Thakkar, D., Gupta, R., Monson, K. L., & Rapoport, N. Y. (2013) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2013.04.008 · Cited by 31 · see citing works

In Vitro Investigation of the Individual Contributions of Ultrasound-Induced Stable and Inertial Cavitation in Targeted Drug Delivery

Gourevich, D., Volovick, A., Dogadkin, O., Wang, L., Mulvana, H., Medan, Y., Melzer, A., & Cochran, S. (2015) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2015.03.016 · Cited by 29 · see citing works

A tumor responsive self healing prodrug hydrogel enables synergistic action of doxorubicin and miltefosine for focal combination chemotherapy

Balakrishnan, B., Joshi, N., Thorat, K., et al. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00454h · Cited by 25 · see citing works

An in vitro proof-of-principle study of sonobactericide

Lattwein, K. R., Shekhar, H., van Wamel, W. J. B., Gonzalez, T., Herr, A. B., Holland, C. K., & Kooiman, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-21648-8 · Cited by 24 · see citing works

Localized in Vivo Model Drug Delivery with Intravascular Ultrasound and Microbubbles

Kilroy, J. P., Klibanov, A. L., Wamhoff, B. R., et al. (2014) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2014.04.007 · Cited by 22 · see citing works

Determination of microbubble cavitation threshold pressure as function of shell chemistry

Dicker, S., Mleczko, M. J., Schmitz, G., et al. (2010) · Bubble Science Engineering & Technology · doi:10.1179/1758897910y.0000000001 · Cited by 20 · see citing works

Microbubble‐enhanced ultrasound exposure promotes uptake of methotrexate into synovial cells and enhanced antiinflammatory effects in the knees of rabbits with antigen‐induced arthritis

Nakaya, H., Shimizu, T., Isobe, K., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21154 · Cited by 20 · see citing works

Synthesis, Acoustic Stability, and Pharmacologic Activities of Papaverine-Loaded Echogenic Liposomes for Ultrasound Controlled Drug Delivery

Kee, P. H., Abruzzo, T. A., Smith, D. A. B., et al. (2008) · Journal of Liposome Research · doi:10.1080/08982100802354558 · Cited by 20 · see citing works

Intracranial Non-thermal Ablation Mediated by Transcranial Focused Ultrasound and Phase-Shift Nanoemulsions

Peng, C., Sun, T., Vykhodtseva, N. I., et al. (2019) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2019.04.010 · Cited by 18 · see citing works

Optimization of Acoustic Liposomes for Improved In Vitro and In Vivo Stability

Sax, N., & Kodama, T. (2012) · Pharmaceutical Research · doi:10.1007/s11095-012-0864-8 · Cited by 15 · see citing works

Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles

Kilroy, J. P., Dhanaliwala, A. H., Klibanov, A. L., et al. (2015) · Annals of Biomedical Engineering · doi:10.1007/s10439-015-1315-6 · Cited by 15 · see citing works

Kinetics of albumin microbubble dissolution in aqueous media

Khan, A. H., & Dalvi, S. V. (2020) · Soft Matter · doi:10.1039/c9sm01516g · Cited by 14 · see citing works

Microbubble destruction by dual-high-frequency ultrasound excitation

Yeh, C., Su, S.-Y., & Shen, C.-C. (2009) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2009.1145 · Cited by 13 · see citing works

DNA-loaded microbubbles with crosslinked bovine serum albumin shells for ultrasound-promoted gene delivery and transfection

Du, J., Zhao, X., Li, B., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.10.036 · Cited by 12 · see citing works

Targeting property and toxicity of a novel ultrasound contrast agent microbubble carrying the targeting and drug-loaded complex FA-CNTs-PTX on MCF7 cells

Zhang, J., Zhang, Y., Liu, J., et al. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.06.027 · Cited by 9 · see citing works

Longitudinal Functional Assessment of Brain Injury Induced by High-Intensity Ultrasound Pulse Sequences

Ye, M., Solarana, K., Rafi, H., Patel, S., Nabili, M., Liu, Y., Huang, S., Fisher, J. A. N., Krauthamer, V., Myers, M. R., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-51876-5 · Cited by 6 · see citing works

Therapeutic ultrasound microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasonic assisted chemotherapy in breast cancer cells

Yan, F., Li, X., Jin, Q., et al. (2010) · IEEE International Ultrasonics Symposium · doi:10.1109/ultsym.2010.5935604 · Cited by 1 · see citing works

Engineering stable and biocompatible microbubble formulations for biomedical applications

Upadhyay, A. K. (2018) · Cited by 1 · see citing works

Smart nanoparticles for cancer therapy

Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works

Ultrasound-assisted tissue engineering

Melde, K., Athanassiadis, A. G., Missirlis, D., Shi, M., Seneca, S., & Fischer, P. (2024) · Nature Reviews Bioengineering · doi:10.1038/s44222-024-00166-5 · Cited by 59 · see citing works

Ultrasound-Mediated Transdermal Drug Delivery

Kost, J., & Langer, R. (1993) · Springer eBooks · doi:10.1007/978-1-4899-1262-6_4 · Cited by 10 · see citing works

Characterizations of Liquid Crystals as A Transdermal Drug Delivery System

Kadhum, W. R. (2022) · doi:10.54026/aroic/1013

Topical and Transdermal Delivery Using Prodrugs: Mechanism of Enhancement

Sloan, K. B., Wasdo, S. C., & Majumdar, S. (2010) · Methods and principles in medicinal chemistry · doi:10.1002/9783527633166.ch7 · Cited by 2 · see citing works

Defects generated in human stratum corneum specimens by ultrasound

Wu, J., Chappelow, J., Yang, J., et al. (1998) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(98)00049-0 · Cited by 61 · see citing works

Strategies to improve the potential of transdermal devices by enhancing the skin permeation of therapeutic entities

Nair, S. S. (2019) · Journal of Drug Delivery and Therapeutics · doi:10.22270/jddt.v9i3-s.2896 · Cited by 3 · see citing works