Cited by 403Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery

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Progress in brain targeting drug delivery system by nasal route

Khan, Abdur Rauf, Liu, Mengrui, Khan, Muhammad Wasim, Zhai, Guangxi·2017·Journal of Controlled Release

DOI 10.1016/j.jconrel.2017.09.001

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Abstract

The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route. Novel DDSs such as nanoparticles (NPs), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (CNS). Complex geometry of the nasal cavity presented a big challenge to effective delivery of drugs beyond the nasal valve. Recently, pharmaceutical firms utilized latest and emerging nasal drug delivery technologies to overcome these barriers. This review aims to describe the latest development of brain targeted DDSs via nasal administration.Chemical compounds studied in this article Carbopol 934p (PubChem CID: 6581) Carboxy methylcellulose (PubChem CID: 24748) Penetratin (PubChem CID: 101111470) Poly lactic-co-glycolic acid (PubChem CID: 23111554) Tween 80 (PubChem CID: 5284448).

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Authors: Khan, A. R., Liu, M., Khan, M. W., & Zhai, G.
Affiliations: Shandong University (CN)
Corresponding author: Zhai, Guangxi
ORCID: Khan, Abdur Rauf
Liu, Mengrui
Khan, Muhammad Wasim
Zhai, Guangxi
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2017-12
Volume: 268
Pages: 364-389
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2017.09.001
OpenAlex: W2750980441
Cited by: 402
References: 286
Citations by year: 2026: 23 · 2025: 54 · 2024: 61 · 2023: 50 · 2022: 60 · 2021: 56 · 2020: 41 · 2019: 36 · 2018: 20 · 2017: 1
FWCI: 2.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: China-Australia Centre for Health Sciences Research (2016GJ01)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: intranasal drug delivery, blood-brain barrier, olfactory pathway, trigeminal pathway, nanoparticles, liposomes, polymeric micelles, nasal mucosa, neurotherapeutics, Carbopol 934P, carboxymethyl cellulose, penetratin, PLGA, Tween 80
MeSH terms: Administration, Intranasal, Animals, Brain, Humans, Drug Delivery Systems

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