Cited by 403Advanced Drug Delivery SystemsNanoparticle-Based Drug DeliveryInhalation and Respiratory Drug Delivery

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Progress in brain targeting drug delivery system by nasal route

Khan, Abdur Rauf, Liu, Mengrui, Khan, Muhammad Wasim, Zhai, Guangxi·2017·Journal of Controlled Release

DOI 10.1016/j.jconrel.2017.09.001

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Abstract

The blood-brain barrier (BBB) restricts the transport of potential therapeutic moieties to the brain. Direct targeting the brain via olfactory and trigeminal neural pathways by passing the BBB has gained an important consideration for delivery of wide range of therapeutics to brain. Intranasal route of transportation directly delivers the drugs to brain without systemic absorption, thus avoiding the side effects and enhancing the efficacy of neurotherapeutics. Over the last several decades, different drug delivery systems (DDSs) have been studied for targeting the brain by the nasal route. Novel DDSs such as nanoparticles (NPs), liposomes and polymeric micelles have gained potential as useful tools for targeting the brain without toxicity in nasal mucosa and central nervous system (CNS). Complex geometry of the nasal cavity presented a big challenge to effective delivery of drugs beyond the nasal valve. Recently, pharmaceutical firms utilized latest and emerging nasal drug delivery technologies to overcome these barriers. This review aims to describe the latest development of brain targeted DDSs via nasal administration.Chemical compounds studied in this article Carbopol 934p (PubChem CID: 6581) Carboxy methylcellulose (PubChem CID: 24748) Penetratin (PubChem CID: 101111470) Poly lactic-co-glycolic acid (PubChem CID: 23111554) Tween 80 (PubChem CID: 5284448).

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RETRACTED ARTICLE Development and evaluation of tripalmitin emulsomes for the treatment of experimental visceral leishmaniasis
Pal, A., Gupta, S., Jaiswal, A. K., Dube, A., & Vyas, S. P. (2011) · Journal of Liposome Research · doi:10.3109/08982104.2011.592495 · Cited by 39
Retracted
Recent advances with liposomes as pharmaceutical carriers
Torchilin, V. P. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1632 · Cited by 5,282
Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier
Makadia, H. K., & Siegel, S. J. (2011) · Polymers · doi:10.3390/polym3031377 · Cited by 4,816 · cited 2×
“Most of the research over last several years was focused on polymeric NPs based on poly (lactic acid) (PLA), poly (D.L-lactide-co-glycolide) (PLGA) and poly (glycolic acid) (PGA) for brain targeted delivery [85].”
Background
The blood-brain barrier
Daneman, R., & Prat, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020412 · Cited by 3,437
Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis
Rejman, J., Oberle, V., Zuhorn, I. S., & Hoekstra, D. (2004) · Biochemical Journal · doi:10.1042/bj20031253 · Cited by 2,872
The blood-brain barrier: Bottleneck in brain drug development
Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798
Nanostructured lipid matrices for improved microencapsulation of drugs
Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00180-1 · Cited by 1,256
Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment: A Pilot Clinical Trial
Craft, S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.233 · Cited by 1,253
Intranasal delivery of biologics to the central nervous system
Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214
Nasal drug delivery—possibilities, problems and solutions
Illum, L. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00363-2 · Cited by 1,139

Show all 286 references

Research works printed but not linked: 10

Prados, 2003, A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma, Neuro-Oncology, 5, 96, 10.1093/neuonc/5.2.96 · DOI
Sanjay, 2011, Der Pharmac. Sin., 2, 94
Huang, 1996, Microsphere transport pathways in the rabbit nasal mucosa, Int. J. Pharm. Adv., 1, 298
Aswathy, 2013, Emulsomes: a novel liposoomal formulation for sustained drug delivery, Int. Res. J. Pharm., 3, 192
Desai, 2012, Evaluation of brain targeting for the nasal delivery of midazolam, Int. J. Pharm. Sci. Rev. Res., 12, 109
Kanazawa, 2011, Cell-penetrating peptide-modified block copolymer micelles promote direct brain delivery via intranasal administration, Pharm. Res., 28, 2130, 10.1007/s11095-011-0440-7 · DOI · Paper page
Patel, 2012, Nanocarriers as novel nose-to-brain targeted drug delivery platforms, Indian J. Nov. Drug Deliv, 4, 243
Abdelbary, 2013, Brain targeting of olanzapine via intranasal delivery of core-shell difunctional block copolymer mixed nanomicellar carriers: in-vitro characterization, ex-vivo estimation of nasal toxicity and in-vivo biodistribution studies, Int. J. Pharm., 452
Haruta, 2012, Meeting the needs for nasal delivery devices for powder formulations, Drug Dev. Deliv., 12, 22
Suman, 1999, Comparison of nasal deposition and clearance of aerosol generated by nebulizer and an aqueous spray pump, Pharm. Res., 16, 1648, 10.1023/A:1011933410898 · DOI

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Authors: Khan, A. R., Liu, M., Khan, M. W., & Zhai, G.
Affiliations: Shandong University (CN)
Corresponding author: Zhai, Guangxi
ORCID: Khan, Abdur Rauf
Liu, Mengrui
Khan, Muhammad Wasim
Zhai, Guangxi
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2017-12
Volume: 268
Pages: 364-389
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2017.09.001
OpenAlex: W2750980441
Cited by: 402
References: 286
Citations by year: 2026: 23 · 2025: 54 · 2024: 61 · 2023: 50 · 2022: 60 · 2021: 56 · 2020: 41 · 2019: 36 · 2018: 20 · 2017: 1
FWCI: 2.87
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: China-Australia Centre for Health Sciences Research (2016GJ01)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: intranasal drug delivery, blood-brain barrier, olfactory pathway, trigeminal pathway, nanoparticles, liposomes, polymeric micelles, nasal mucosa, neurotherapeutics, Carbopol 934P, carboxymethyl cellulose, penetratin, PLGA, Tween 80
MeSH terms: Administration, Intranasal, Animals, Brain, Humans, Drug Delivery Systems

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