Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment
Open accessAbstract
Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, significantly increased the transduction ratio and the infectious titer when compared with the virus and paclitaxel alone. We demonstrated that the obtained EV formulation reduced the in vivo tumor growth in animal xenograft model of human lung cancer. Indeed, we found that combined treatment of oncolytic adenovirus and paclitaxel encapsulated in EV has enhanced anticancer effects both in vitro and in vivo in lung cancer models. Transcriptomic comparison carried out on the explanted xenografts from the different treatment groups revealed that only 5.3% of the differentially expressed genes were overlapping indicating that a de novo genetic program is triggered by the presence of the encapsulated paclitaxel: this novel genetic program might be responsible of the observed enhanced antitumor effect. Our work provides a promising approach combining anticancer drugs and viral therapies by intravenous EV delivery as a strategy for the lung cancer treatment.
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Lung tumor cell-derived exosomes can effectively carry oncolytic virus and PTX, enhancing antitumor effects in nude mice.
“Similarly, Garofalo et al. showed lung tumor cell-derived exosomes can effectively carry the oncolytic virus and chemotherapeutic drugs (PTX), thus enhancing the antitumor effects in nude mice [57].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [57]
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Cites
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482 · see citing works
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709 · see citing works
limma powers differential expression analyses for RNA-sequencing and microarray studies
Ritchie, M. E., Phipson, B., Wu, D., Hu, Y., Law, C. W., Shi, W., & Smyth, G. K. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv007 · Cited by 40,458 · see citing works
HTSeq—a Python framework to work with high-throughput sequencing data
Anders, S., Pyl, P. T., & Huber, W. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btu638 · Cited by 21,464 · see citing works
Trapnell, C., Roberts, A., Goff, L. A., Pertea, G. M., Kim, D., Kelley, D. R., Pimentel, H., Salzberg, S. L., Rinn, J. L., & Pachter, L. S. (2012) · Nature Protocols · doi:10.1038/nprot.2012.016 · Cited by 11,930 · see citing works
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works
Genesis: cluster analysis of microarray data
Sturn, A., Quackenbush, J., & Trajanoski, Z. (2002) · Bioinformatics · doi:10.1093/bioinformatics/18.1.207 · Cited by 1,761 · see citing works
Applying extracellular vesicles based therapeutics in clinical trials – an ISEV position paper
Lener, T., Gimona, M., Aigner, L., Börger, V., Buzás, E. I., Camussi, G., Chaput, N., Chatterjee, D., Court, F. A., Portillo, H. A. D., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.30087 · Cited by 1,615 · see citing works
Extracellular vesicles for drug delivery.
Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,237 · see citing works
Exosomes/microvesicles as a mechanism of cell-to-cell communication
Camussi, G., Deregibus, M. C., Bruno, S., Cantaluppi, V., & Biancone, L. (2010) · Kidney International · doi:10.1038/ki.2010.278 · Cited by 1,179 · see citing works
Khuri, F. R., Nemunaitis, J. J., Ganly, I., Arseneau, J. C., Tannock, I. F., Romel, L., Gore, M. E., Ironside, J. A. D., MacDougall, R. H., Heise, C. C., et al. (2000) · Nature Medicine · doi:10.1038/78638 · Cited by 1,099 · see citing works
Alberg, A. J., & Samet, J. M. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00046-8 · Cited by 1,060 · see citing works
Lung cancer: Biology and treatment options
Lemjabbar‐Alaoui, H., Hassan, O. U., Yang, Y., & Buchanan, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2015.08.002 · Cited by 1,024 · see citing works
Alberg, A. J., Brock, M. V., & Samet, J. M. (2003) · Elsevier eBooks · doi:10.1016/b978-1-4557-3383-5.00052-x · Cited by 784 · see citing works
Oncolytic virus therapy: A new era of cancer treatment at dawn
Fukuhara, H., Ino, Y., & Todo, T. (2016) · Cancer Science · doi:10.1111/cas.13027 · Cited by 776 · see citing works
Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
Takahashi, A., Okada, R., Nagao, K., Kawamata, Y., Hanyu, A., Yoshimoto, S., Takasugi, M., Watanabe, S., Kanemaki, M. T., Obuse, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms15287 · Cited by 761 · see citing works
Albumin-bound paclitaxel: a next-generation taxane
Gradishar, W. J. (2006) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.7.8.1041 · Cited by 706 · see citing works
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
Kooijmans, S. A. A., Fliervoet, L. A. L., van der Meel, R., Fens, M. H. A. M., Heijnen, H. F. G., Henegouwen, P. M. P. V. B. E., Vader, P., & Schiffelers, R. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.009 · Cited by 629 · see citing works
Saari, H., Lázaro-Ibáñez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P., & Yliperttula, M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.031 · Cited by 613 · see citing works
Self-citationRe-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics
Armstrong, J. P. K., Holme, M. N., & Stevens, M. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b07607 · Cited by 605 · see citing works
Hu, J. C. C., Coffin, R. S., Davis, C. J., Graham, N. J., Groves, N., GUEST, P. J., Harrington, K. J., James, N. D., Love, C., McNeish, I. A., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0759 · Cited by 571 · see citing works
Delivery of chemotherapeutic drugs in tumour cell-derived microparticles
Tang, K., Zhang, Y., Zhang, H., Xu, P., Liu, J., Ma, J., Lv, M., Li, D., Katirai, F., Shen, G.-X., et al. (2012) · Nature Communications · doi:10.1038/ncomms2282 · Cited by 453 · see citing works
Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity
Ferguson, S. W., & Nguyen, J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.037 · Cited by 419 · see citing works
Extracellular vesicles: emerging targets for cancer therapy
Vader, P., Breakefield, X. O., & Wood, M. J. A. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.03.002 · Cited by 417 · see citing works
Paclitaxel: What has been done and the challenges remain ahead.
Bernabeu, E., Cagel, M., Lagomarsino, E., Moretton, M., & Chiappetta, D. (2017) · International journal of pharmaceutics · doi:10.1016/j.ijpharm.2017.05.016 · Cited by 376 · see citing works
Treatment of Cancer Patients With a Serotype 5/3 Chimeric Oncolytic Adenovirus Expressing GMCSF
Koski, A., Kangasniemi, L., Escutenaire, S., Pesonen, S. A., Cerullo, V., Diaconu, I., Nokisalmi, P., Raki, M., Rajecki, M., Guse, K., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.161 · Cited by 243 · see citing works
Self-citationForget, P., Vandenhende, J., Berlière, M., Machiels, J., Nussbaum, B., Legrand, C., & Kock, M. D. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181d2ad07 · Cited by 233 · see citing works
Witwer, K. W., Soekmadji, C., Hill, A. F., Wauben, M. H. M., Buzás, E. I., Vizio, D. D., Falcón‐Pérez, J. M., Gardiner, C., Hochberg, F. H., Kurochkin, I. V., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1396823 · Cited by 233 · see citing works
Synergy between angiostatin and endostatin: inhibition of ovarian cancer growth.
Yokoyama, Y., Dhanabal, M., Griffioen, A. W., Sukhatme, V. P., & Ramakrishnan, S. (2000) · PubMed · Cited by 228 · see citing works
Jung, J., Mori, T., Kobayashi, C., Matsunaga, Y., Yoda, T., Feig, M., & Sugita, Y. (2015) · Wiley Interdisciplinary Reviews. Computational Molecular Science · doi:10.1002/wcms.1220 · Cited by 222 · see citing works
Intelligent Design: Combination Therapy With Oncolytic Viruses
Ottolino‐Perry, K., Diallo, J., Lichty, B. D., Bell, J. C., & McCart, J. A. (2009) · Molecular Therapy · doi:10.1038/mt.2009.283 · Cited by 211 · see citing works
Ranki, T., Pesonen, S. A., Hemminki, A., Partanen, K. P. L., Kairemo, K., Alanko, T., Lundin, J. E., Linder, N., Turkki, R., Ristimaki, A. P., et al. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0121-5 · Cited by 201 · see citing works
Current Issues and Future Directions of Oncolytic Adenoviruses
Yamamoto, M., & Curiel, D. T. (2009) · Molecular Therapy · doi:10.1038/mt.2009.266 · Cited by 197 · see citing works
Deubiquitinase USP37 Is Activated by CDK2 to Antagonize APCCDH1 and Promote S Phase Entry
Huang, X., Summers, M. K., Pham, V. C., Lill, J. R., Liu, J., Lee, G., Kirkpatrick, D. S., Jackson, P. K., Fang, G., & Dixit, V. M. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.027 · Cited by 158 · see citing works
Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
Ohno, S., Drummen, G. P. C., & Kuroda, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17020172 · Cited by 150 · see citing works
Gadgeel, S. M., Ramalingam, S. S., & Kalemkerian, G. P. (2012) · Radiologic Clinics of North America · doi:10.1016/j.rcl.2012.06.003 · Cited by 139 · see citing works
Going viral: a review of replication-selective oncolytic adenoviruses
Larson, C., Oronsky, B. T., Scicinski, J. J., Fanger, G. R., Stirn, M., Oronsky, A. L., & Reid, T. R. (2015) · Oncotarget · doi:10.18632/oncotarget.5116 · Cited by 137 · see citing works
Rizvi, N. A., Riely, G. J., Azzoli, C. G., Miller, V. A., Ng, K., Fiore, J. J., Chia, G., Brower, M., Heelan, R. T., Hawkins, M., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.8605 · Cited by 121 · see citing works
Toyoizumi, T., Mick, R., Abbas, A. E., Kang, E. H., Kaiser, L. R., & Molnar-Kimber, K. L. (1999) · Human Gene Therapy · doi:10.1089/10430349950016410 · Cited by 120 · see citing works
Oncolytic viruses: finally delivering
Seymour, L. W., & Fisher, K. D. (2016) · British Journal of Cancer · doi:10.1038/bjc.2015.481 · Cited by 118 · see citing works
Cancer Specific Viruses and the Development of ONYX-015
McCormick, F. P. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.216 · Cited by 106 · see citing works
Li, R., Xiaohua, T., Li, Y., Zhang, H., Ma, R., Ji, T., Dong, W., Tong, T., Liu, Y., Chen, D., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.02.025 · Cited by 100 · see citing works
Cerullo, V., Diaconu, I., Romano, V. C., Hirvinen, M., Ugolini, M., Escutenaire, S., Holm, L., Kipar, A., Kanerva, A., & Hemminki, A. (2012) · Molecular Therapy · doi:10.1038/mt.2012.137 · Cited by 97 · see citing works
Self-citationCapasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D. S., Kuryk, Ł., Sarvela, T., Vitale, A., Antopolsky, M. L., Magarkar, A., Viitala, T., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1105429 · Cited by 87 · see citing works
Self-citationRecent advances in oncolytic adenovirus therapies for cancer
Shaw, A. R., & Suzuki, M. (2016) · Current Opinion in Virology · doi:10.1016/j.coviro.2016.06.009 · Cited by 87 · see citing works
Enhanced Histopathology of the Immune System
Elmore, S. A. (2011) · Toxicologic Pathology · doi:10.1177/0192623311427571 · Cited by 84 · see citing works
DNA Polymerase ε: A Polymerase of Unusual Size (and Complexity)
Pursell, Z. F., & Kunkel, T. A. (2008) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)00004-4 · Cited by 79 · see citing works
Vile, R. G., Ando, D. G., & Kirn, D. H. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700548 · Cited by 77 · see citing works
Sze, D. Y., Reid, T. R., & Rose, S. C. (2013) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2013.05.040 · Cited by 66 · see citing works
Extracellular vesicles – A promising avenue for the detection and treatment of infectious diseases?
Fuhrmann, G., Neuer, A. L., & Herrmann, I. K. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.04.005 · Cited by 60 · see citing works
Striking out at disseminated metastases: the systemic delivery of oncolytic viruses.
Fisher, K. (2006) · PubMed · Cited by 59 · see citing works
Kuryk, Ł., Haavisto, E., Garofalo, M., Capasso, C., Hirvinen, M., Pesonen, S. A., Ranki, T., Vassilev, L., & Cerullo, V. (2016) · International Journal of Cancer · doi:10.1002/ijc.30228 · Cited by 57 · see citing works
Self-citationVassilev, L., Ranki, T., Joensuu, T. K., Jäger, E., Karbach, J., Wahle, C., Partanen, K. P. L., Kairemo, K., Alanko, T., Turkki, R., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1017702 · Cited by 56 · see citing works
Mendez, N., Herrera, V., Zhang, L., Hedjran, F., Feuer, R., Blair, S. L., Trogler, W. C., Reid, T. R., & Kummel, A. C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.010 · Cited by 55 · see citing works
Ingemarsdotter, C. K., Baird, S. K., Connell, C. M., Öberg, D., Halldén, G., & McNeish, I. A. (2010) · Oncogene · doi:10.1038/onc.2010.335 · Cited by 54 · see citing works
Cheong, S. C., Wang, Y., Meng, J.-H., Hill, R., Sweeney, K. G., Kirn, D. H., Lemoine, N. R., & Halldén, G. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701099 · Cited by 52 · see citing works
Ranki, T., Joensuu, T. K., Jäger, E., Karbach, J., Wahle, C., Kairemo, K., Alanko, T., Partanen, K. P. L., Turkki, R., Linder, N., et al. (2014) · OncoImmunology · doi:10.4161/21624011.2014.958937 · Cited by 49 · see citing works
Zhong, Z., Shi, S., Han, J., Zhang, Z., & Sun, X. (2009) · Molecular Pharmaceutics · doi:10.1021/mp900151k · Cited by 44 · see citing works
Hassan, M. A., Braam, S. R., & Kruyt, F. A. E. (2006) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700984 · Cited by 44 · see citing works
Oncolytic Adenovirus Loaded with L-carnosine as Novel Strategy to Enhance the Antitumor Activity
Garofalo, M., Iovine, B., Kuryk, Ł., Capasso, C., Hirvinen, M., Vitale, A., Yliperttula, M. L., Bevilacqua, M. A., & Cerullo, V. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0559 · Cited by 44 · see citing works
Self-citationKuryk, Ł., Vassilev, L., Ranki, T., Hemminki, A., Karioja‐Kallio, A., Levälampi, O., Vuolanto, A., Cerullo, V., & Pesonen, S. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182715 · Cited by 40 · see citing works
Self-citationCerullo, V., Vähä-Koskela, M. J. V., & Hemminki, A. (2012) · OncoImmunology · doi:10.4161/onci.20172 · Cited by 34 · see citing works
Self-citationCai, X., Luo, J., Yang, X., Deng, H., Zhang, J., Li, S., Wei, H., Yang, C. Z., Xu, L., Jin, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4416 · Cited by 33 · see citing works
Oncolytic virotherapy: the questions and the promise
Aurelian, L. (2013) · Oncolytic Virotherapy · doi:10.2147/ov.s39609 · Cited by 29 · see citing works
Farzad, L., Cerullo, V., Yagyu, S., Bertin, T., Hemminki, A., Rooney, C. M., Lee, B., & Suzuki, M. (2014) · Molecular Therapy — Oncolytics · doi:10.1038/mto.2014.8 · Cited by 29 · see citing works
Self-citationTso, K.-Y., Lee, S. D., Lo, K. W., & Yip, K. Y.-L. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1172 · Cited by 26 · see citing works
Sharma, P., Kolawole, A. O., Wiltshire, S. M., Frondorf, K. A., & Excoffon, K. J. D. A. (2011) · Journal of General Virology · doi:10.1099/vir.0.036269-0 · Cited by 23 · see citing works
Intratumoral injection of taxol in vivo suppresses A549 tumor showing cytoplasmic vacuolization
Wang, C., & Chen, T. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24012 · Cited by 20 · see citing works
Niu, X. (2011) · Oncology Letters · doi:10.3892/ol.2011.334 · Cited by 20 · see citing works
Chen, H., Huang, X., Wang, S., Zheng, X., Lin, J., Li, P., & Lin, L. (2015) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.1000-9604.2014.12.17 · Cited by 19 · see citing works
Li, R., Wan, B., Zhou, J., Wang, Y., Luo, T., Gu, X., Chen, F., & Yu, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045932 · Cited by 18 · see citing works
Inactivation of Adenovirus Type 5 by Caustics
Jannat, R., Hsu, D. S., & Maheshwari, G. (2005) · Biotechnology Progress · doi:10.1021/bp049812f · Cited by 14 · see citing works
Xu, S., Tian, Y., Hu, Y., Zhang, N., Hu, S., Song, D., Wu, Z., Wang, Y., Cui, Y., & Tang, H. (2016) · Scientific Reports · doi:10.1038/srep28057 · Cited by 14 · see citing works
Weeklynab-Paclitaxel in Metastatic Breast Cancer – Summary and Results of an Expert Panel Discussion
Jackisch, C., Lück, H., Untch, M., Bischoff, J., Müller, V., Schmidt, M., Thill, M., & Kiechle, M. B. (2012) · Breast Care · doi:10.1159/000338273 · Cited by 7 · see citing works
Flagged first, then by citations
2 of the 77 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- D.P. Eisenberg, NIH Public Access, 8 (2007), pp. 603-615.
- C. Bertoli, J.M. Skotheim, R.A.M. De Bruin, G. Street, HHS Public Access, 14 (2015), pp. 518-528, http://dx.doi.org/10.1038/nrm3629.Control. · DOI
Cited by
Sorted by citations
Advances and challenges in the treatment of lung cancer
Li, Y., Yan, B., & He, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115891 · Cited by 492 · see citing works
Oncolytic Viruses and the Immune System: The Dynamic Duo
de Matos, A. L., Franco, L. S., & McFadden, G. (2020) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2020.01.001 · Cited by 273 · see citing works
Preservation of biomaterials and cells by freeze-drying: Change of paradigm
Merivaara, A., Zini, J., Koivunotko, E., Valkonen, S., Korhonen, O., Fernandes, F. M., & Yliperttula, M. L. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.06.042 · Cited by 225 · see citing works
Self-citationExtracellular vesicles as a drug delivery system: A systematic review of preclinical studies
de Castilla, P. E. M., Tong, L., Huang, C., Sofias, A. M., Pastorin, G., Chen, X. S., Storm, G., Schiffelers, R. M., & Wang, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.011 · Cited by 214 · see citing works
Garofalo, M., Villa, A. M., Rizzi, N., Kuryk, Ł., Rinner, B., Cerullo, V., Yliperttula, M. L., Mazzaferro, V., & Ciana, P. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.12.022 · Cited by 134 · see citing works
Self-citationExtracellular Vesicles as Natural, Safe and Efficient Drug Delivery Systems
Villa, F., Quarto, R., & Tasso, R. (2019) · Pharmaceutics · doi:10.3390/pharmaceutics11110557 · Cited by 127 · see citing works
Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine
Li, M., Fang, F., Sun, M., Zhang, Y., Hu, M., & Zhang, J. (2022) · Theranostics · doi:10.7150/thno.72812 · Cited by 122 · see citing works
Current Perspectives on Taxanes: Focus on Their Bioactivity, Delivery and Combination Therapy
Škubník, J., Pavlíčková, V. S., Ruml, T., & Rimpelová, S. (2021) · Plants · doi:10.3390/plants10030569 · Cited by 114 · see citing works
The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System
Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works
Customized materials-assisted microorganisms in tumor therapeutics
Chen, Q., Qiao, J., Liu, X., Zhang, C., & Zhang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01571g · Cited by 109 · see citing works
Perspective on Adenoviruses: Epidemiology, Pathogenicity, and Gene Therapy
Crenshaw, B. J., Jones, L. B., Bell, C. R., Kumar, S., & Matthews, Q. L. (2019) · Biomedicines · doi:10.3390/biomedicines7030061 · Cited by 106 · see citing works
Kuryk, Ł., Møller, A. W., & Jaderberg, M. E. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1532763 · Cited by 99 · see citing works
Garofalo, M., Villa, A. M., Rizzi, N., Kuryk, Ł., Mazzaferro, V., & Ciana, P. (2018) · Viruses · doi:10.3390/v10100558 · Cited by 91 · see citing works
Self-citationExtracellular Vesicles and Viruses: Two Intertwined Entities
Moulin, C., Crupi, M. J. F., Ilkow, C. S., Bell, J. C., & Boulton, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021036 · Cited by 91 · see citing works
Application of engineered extracellular vesicles for targeted tumor therapy
Zhang, F., Guo, J. J., Zhang, Z., Duan, M., Wang, G., Qian, Y., Zhao, H., Yang, Z., & Jiang, X. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-022-00798-y · Cited by 85 · see citing works
From Conventional Therapies to Immunotherapy: Melanoma Treatment in Review
Kuryk, Ł., Bertinato, L., Staniszewska, M., Pancer, K. W., Wieczorek, M., Salmaso, S., Caliceti, P., & Garofalo, M. (2020) · Cancers · doi:10.3390/cancers12103057 · Cited by 81 · see citing works
Self-citationde Jong, B., Barros, E., Hoenderop, J. G. J., & Rigalli, J. P. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111006 · Cited by 71 · see citing works
Tumor-derived extracellular vesicles as messengers of natural products in cancer treatment
Xu, Y., Feng, K., Zhao, H., Di, L., Wang, L., & Wang, R. (2022) · Theranostics · doi:10.7150/thno.67775 · Cited by 69 · see citing works
Logozzi, M., Mizzoni, D., Bocca, B., Raimo, R. D., Petrucci, F., Caimi, S., Alimonti, A., Falchi, M., Cappello, F., Campanella, C., et al. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.02.014 · Cited by 67 · see citing works
Development of oncolytic virotherapy: from genetic modification to combination therapy
Lan, Q., Xia, S., Wang, Q., Xu, W., Huang, H., Jiang, S., & Lu, L. (2020) · Frontiers of Medicine · doi:10.1007/s11684-020-0750-4 · Cited by 66 · see citing works
Heterologous and cross-species tropism of cancer-derived extracellular vesicles
Garofalo, M., Villa, A. M., Crescenti, D., Marzagalli, M., Kuryk, Ł., Limonta, P., Mazzaferro, V., & Ciana, P. (2019) · Theranostics · doi:10.7150/thno.34824 · Cited by 65 · see citing works
Self-citationKim, M. W., Kwon, S., Choi, J. H., & Lee, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123859 · Cited by 64 · see citing works
Extracellular vesicles provide a capsid‐free vector for oncolytic adenoviral DNA delivery
Saari, H., Turunen, T. A., Lõhmus, A., Turunen, M. P., Jalasvuori, M., Butcher, S. J., Ylä‐Herttuala, S., Viitala, T., Cerullo, V., Siljander, P. R. M., et al. (2020) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2020.1747206 · Cited by 62 · see citing works
Self-citationIpinmoroti, A. O., & Matthews, Q. L. (2020) · Pathogens · doi:10.3390/pathogens9121056 · Cited by 60 · see citing works
Jayasinghe, M. K., Tan, M., Peng, B., Yang, Y., Sethi, G., Pirisinu, M., & Le, M. T. N. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.02.010 · Cited by 60 · see citing works
Combination of Anti-Cancer Drugs with Molecular Chaperone Inhibitors
Shevtsov, M. A., Multhoff, G., Mikhaylova, E. R., Shibata, A., Guzhova, I. V., & Margulis, B. A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215284 · Cited by 59 · see citing works
Recent advances in oncolytic virus-based cancer therapy
Fu, L., Wang, S., Cai, M., Wang, X., Chen, J., Tong, X., Chen, X., & Mou, X. (2019) · Virus Research · doi:10.1016/j.virusres.2019.197675 · Cited by 57 · see citing works
Transplantation of autologous extracellular vesicles for cancer-specific targeting
Villa, A. M., Garofalo, M., Crescenti, D., Rizzi, N., Brunialti, E., Vingiani, A., Belotti, P., Sposito, C., Franzè, S., Cilurzo, F., et al. (2020) · Theranostics · doi:10.7150/thno.51344 · Cited by 55 · see citing works
Self-citationSalmond, N., & Williams, K. C. (2021) · Nanoscale Advances · doi:10.1039/d0na00676a · Cited by 55 · see citing works
Li, H., Xu, W., Li, F., Zeng, R., Zhang, X., Wang, X., Zhao, S., Weng, J., Zhu, L., & Sun, L. (2022) · Drug Delivery · doi:10.1080/10717544.2021.2023697 · Cited by 54 · see citing works
Kim, J., Sestito, L. F., Im, S., Kim, W. J., & Thomas, S. N. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201908788 · Cited by 54 · see citing works
Expanding the Spectrum of Adenoviral Vectors for Cancer Therapy
Gao, J. J., Zhang, W., & Ehrhardt, A. (2020) · Cancers · doi:10.3390/cancers12051139 · Cited by 54 · see citing works
Role of extracellular vesicles in chronic lung disease
Trappe, A., Donnelly, S. C., McNally, P., & Coppinger, J. A. (2021) · Thorax · doi:10.1136/thoraxjnl-2020-216370 · Cited by 52 · see citing works
Kuryk, Ł., Møller, A. W., & Jaderberg, M. E. (2019) · Journal of Medical Virology · doi:10.1002/jmv.25501 · Cited by 47 · see citing works
Kuryk, Ł., & Møller, A. W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25677 · Cited by 44 · see citing works
Deng, S., Iscaro, A., Zambito, G., Mijit, E., Minicucci, M., Essand, M., Löwik, C. W. G. M., Muthana, M., Censi, R., Mezzanotte, L., et al. (2021) · Nanomaterials · doi:10.3390/nano11010144 · Cited by 43 · see citing works
Wang, M., Lv, C.-Y., Li, S., Wang, J.-K., Luo, W., Zhao, P., Liu, X., Wang, Z., Jiao, Y., Sun, H., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00907-3 · Cited by 42 · see citing works
Zhang, Y., Wu, J., Zhang, H., Wei, J., & Wu, J. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.574007 · Cited by 40 · see citing works
Cloaked Viruses and Viral Factors in Cutting Edge Exosome-Based Therapies
Dogrammatzis, C., Waisner, H., & Kalamvoki, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00376 · Cited by 39 · see citing works
Garofalo, M., Grazioso, G., Cavalli, A., & Sgrignani, J. (2020) · Molecules · doi:10.3390/molecules25071756 · Cited by 37 · see citing works
Self-citationMechanisms of extracellular vesicle uptake and implications for the design of cancer therapeutics
Jackson, S. R., Flemming, J. P., Karagoz, K., Wermuth, P. J., & Mahoney, M. G. (2024) · Journal of Extracellular Biology · doi:10.1002/jex2.70017 · Cited by 37 · see citing works
Zocchi, M. R., Tosetti, F., Benelli, R., & Poggi, A. D. (2020) · Cancers · doi:10.3390/cancers12071886 · Cited by 34 · see citing works
Microbial dysbiosis and epigenetics modulation in cancer development – A chemopreventive approach
Haque, S., Raina, R., Afroze, N., Hussain, A., Alsulimani, A., Singh, V., Mishra, B. N., Kaul, S., & Kharwar, R. N. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.024 · Cited by 35 · see citing works
Cheng, C. (2024) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.4c00185 · Cited by 33 · see citing works
Yin, Z., Fan, J., Xu, J., Wu, F., Yang, L., Zhou, M. L., Liao, T., Duan, L., Wang, S., Geng, W., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02024 · Cited by 32 · see citing works
From Immunosuppression to Immunomodulation - Turning Cold Tumours into Hot
Garofalo, M., Pancer, K. W., Wieczorek, M., Staniszewska, M., Salmaso, S., Caliceti, P., & Kuryk, Ł. (2022) · Journal of Cancer · doi:10.7150/jca.71992 · Cited by 32 · see citing works
Self-citationNF-κB Signaling in Targeting Tumor Cells by Oncolytic Viruses—Therapeutic Perspectives
Struzik, J., & Szulc‐Dąbrowska, L. (2018) · Cancers · doi:10.3390/cancers10110426 · Cited by 31 · see citing works
Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer
Kugeratski, F. G., McAndrews, K. M., & Kalluri, R. (2021) · Endocrinology · doi:10.1210/endocr/bqaa250 · Cited by 28 · see citing works
Formulation-optimized oncolytic viruses: Advancing systemic delivery and immune amplification
Ma, N., Gao, J., Pang, X., Wu, K., Yang, S., Wei, H. L., & Hao, Y. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113822 · Cited by 27 · see citing works
Chatterjee, S., Kordbacheh, R., & Sin, J. (2024) · Microorganisms · doi:10.3390/microorganisms12020274 · Cited by 26 · see citing works
Emerging delivery strategy for oncolytic virotherapy
Zhu, J., Ma, J., Huang, M., Deng, H., & Shi, G. (2024) · Molecular Therapy Oncology · doi:10.1016/j.omton.2024.200809 · Cited by 25 · see citing works
Strategies for Small Extracellular Vesicle-Based Cancer Immunotherapy
Chen, Y., Tang, S., Cai, F., & Wan, Y. (2024) · Research · doi:10.34133/research.0421 · Cited by 25 · see citing works
Membrane Derived Vesicles as Biomimetic Carriers for Targeted Drug Delivery System
Zhang, L.-Y., Yang, X., Wang, S., Chen, H., Pan, H., & Hu, Z. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200922113054 · Cited by 25 · see citing works
Targeting Cancer Stem Cells: New Perspectives for a Cure to Cancer
Aramini, B., Masciale, V., Grisendi, G., Banchelli, F., D’Amico, R., Dominici, M., & Haider, K. H. (2022) · Springer eBooks · doi:10.1007/978-981-16-6016-0_31-1 · Cited by 25 · see citing works
Lung cancer and oncolytic virotherapy——enemy's enemy
Li, Z., Feiyue, Z., Li, G., & Haifeng, L. (2022) · Translational Oncology · doi:10.1016/j.tranon.2022.101563 · Cited by 25 · see citing works
Progress in oncolytic viruses modified with nanomaterials for intravenous application
Chen, L., Ma, Z., Chen, X., Xie, Y., Ouyang, D., Song, S., Zhao, X., & Liu, F. (2023) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2023.0275 · Cited by 23 · see citing works
Novel Insights Into Mesothelioma Therapy: Emerging Avenues and Future Prospects
Kuryk, L., Rodella, G., Staniszewska, M., Pancer, K., Wieczorek, M., Salmaso, S., Caliceti, P., & Garofalo, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.916839 · Cited by 22 · see citing works
Self-citationExtracellular vesicles: A new frontier in deciphering the mechanisms of traditional Chinese medicine
Wang, K., He, S., Wang, Y., Guo, S., Zhang, F., Wang, Y., Dong, W., Zhang, L., Wang, X., & Yu, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107890 · Cited by 26 · see citing works
Cancer-derived EVs show tropism for tissues at early stage of neoplastic transformation
Garofalo, M., Villa, A. M., Brunialti, E., Crescenti, D., Dell'Omo, G., Kuryk, Ł., Vingiani, A., Mazzaferro, V., & Ciana, P. (2020) · Nanotheranostics · doi:10.7150/ntno.47226 · Cited by 21 · see citing works
Self-citationInhalable dry powders of microRNA-laden extracellular vesicles prepared by thin-film freeze-drying
AboulFotouh, K., Almanza, G., Yu, Y., Joyce, R., Davenport, G. J., Cano, C., Williams, R. O., Zanetti, M., & Cui, Z. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.123757 · Cited by 21 · see citing works
Mathlouthi, S., Kuryk, Ł., Prygiel, M., Lupo, M. G., Zasada, A. A., Pesce, C., Ferri, N., Rinner, B., Salmaso, S., & Garofalo, M. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.10.057 · Cited by 21 · see citing works
Self-citationOptimization of Early Steps in Oncolytic Adenovirus ONCOS-401 Production in T-175 and HYPERFlasks
Kuryk, Ł., Møller, A. W., Vuolanto, A., Pesonen, S. A., Garofalo, M., Cerullo, V., & Jaderberg, M. E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030621 · Cited by 21 · see citing works
Self-citationViral warfare: unleashing engineered oncolytic viruses to outsmart cancer’s defenses
Omolekan, T. O., Folahan, J. T., Tesfay, M. Z., Mohan, H., Dutta, O., Rahimian, L., Ferdous, K. U., Ghavimi, R., Cios, A., Beng, T. K., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1618751 · Cited by 20 · see citing works
An Overview on Taxol Production Technology and Its Applications as Anticancer Agent
Sharma, A., Bhatia, S. K., Banyal, A., Chanana, I., Kumar, A., Chand, D., Kulshrestha, S., & Kumar, P. (2022) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-022-0063-3 · Cited by 20 · see citing works
Exosomes as Novel Delivery Systems for Application in Traditional Chinese Medicine
Chen, Q., Wu, D., Wang, Y., & Chen, Z. (2022) · Molecules · doi:10.3390/molecules27227789 · Cited by 20 · see citing works
Liguori, G. L., & Kralj‐Iglič, V. (2023) · Cancers · doi:10.3390/cancers15184425 · Cited by 20 · see citing works
Haque, S., Kodidela, S., Gerth, K. A., Hatami, E., Verma, N., & Kumar, S. (2020) · Cells · doi:10.3390/cells9040864 · Cited by 19 · see citing works
A cell-laden hydrogel as prophylactic vaccine and anti-PD-L1 amplifier against autologous tumors
Li, J., Yan, Y., Zhang, P., Ding, J., Huang, Y., Jin, Y., & Li, L. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.027 · Cited by 18 · see citing works
Combining Oncolytic Viruses and Small Molecule Therapeutics: Mutual Benefits
Spiesschaert, B., Angerer, K., Park, J., & Wollmann, G. (2021) · Cancers · doi:10.3390/cancers13143386 · Cited by 18 · see citing works
Exosomes: special nano-therapeutic carrier for cancers, overview on anticancer drugs
Rezakhani, L., Fekri, K., Rostaminasab, G., & Rahmati, S. (2022) · Medical Oncology · doi:10.1007/s12032-022-01887-6 · Cited by 17 · see citing works
Systemic Delivery Strategies for Oncolytic Viruses: Advancing Targeted and Efficient Tumor Therapy
Xia, Y., Li, D., Yang, K., & Ou, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146900 · Cited by 16 · see citing works
Critical Roles of Tumor Extracellular Vesicles in the Microenvironment of Thoracic Cancers
Kara-Terki, L., Treps, L., Blanquart, C., & Fradin, D. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176024 · Cited by 16 · see citing works
Modulating osteoclasts with nanoparticles: A path for osteoporosis management?
Rouco, H., García‐García, P., Briffault, E., & Díaz‐Rodríguez, P. (2023) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1885 · Cited by 16 · see citing works
Zeng, M., Zhang, W., Li, Y., & Li, Y. (2024) · Biomarker Research · doi:10.1186/s40364-024-00581-1 · Cited by 17 · see citing works
Oncolytic Virus Therapy Alters the Secretome of Targeted Glioblastoma Cells
Godlewski, J. A., Farhath, M. M., Ricklefs, F. L., Passaro, C., Kiel, K., Nakashima, H., Chiocca, E. A., & Bronisz, A. (2021) · Cancers · doi:10.3390/cancers13061287 · Cited by 15 · see citing works
Islam, S. M. B. U., Lee, B., Jiang, F., Kim, E., Ahn, S., & Hwang, T.-H. (2020) · Cancers · doi:10.3390/cancers12010228 · Cited by 15 · see citing works
Muhammad, S. A., Mohammed, J. S., & Rabiu, S. (2023) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.2c00878 · Cited by 14 · see citing works
Safarzadeh, M., Saadat, N., Abbasi-Molaei, S., & Rastegari‐Pouyani, M. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02283-z · Cited by 14 · see citing works
Extracellular Vesicles for Cancer Therapy: Impact of Host Immune Response
Gilligan, K., & Dwyer, R. M. (2020) · Cells · doi:10.3390/cells9010224 · Cited by 14 · see citing works
Shao, M., Rodrigues, J. D. S., Sousa‐Oliveira, I., Moradialvand, M., Asadollahi, P., Veiga, F., Hameed, H., Jha, N. K., Sillanpää, M. E. T., Sethi, G., et al. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102395 · Cited by 13 · see citing works
Zhang, W., Wang, J., Ngo, C. H. L., Li, L., & Wang, Y. (2025) · Advanced NanoBiomed Research · doi:10.1002/anbr.202500008 · Cited by 12 · see citing works
Nanotechnology and nano-sized tools: Newer approaches to circumvent oncolytic adenovirus limitations
Shirazi, M. M. A., Saedi, T. A., Moghaddam, Z. S., Nemati, M., شیری, ر., Negahdari, B., & Goradel, N. H. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108611 · Cited by 12 · see citing works
Delivery systems for enhancing oncolytic adenoviruses efficacy
Zhou, Y., Zhang, Y.-N., Yang, X., Wang, S., & Hu, P.-Y. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119971 · Cited by 12 · see citing works
Exploring AI tools and multi-omics for precision medicine in lung cancer therapy
Sahu, A., Nema, P., Rajak, D., Purohit, A., Rawal, R., Soni, V., & Kashaw, S. K. (2025) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2025.06.001 · Cited by 13 · see citing works
Oncolytic Viruses in Lung Cancer Treatment: A Review Article
Sakhi, H., Arabi, M., Ghaemi, A., Movafagh, A., & Sheikhpour, M. (2023) · Immunotherapy · doi:10.2217/imt-2023-0124 · Cited by 11 · see citing works
Combination therapy with oncolytic viruses for lung cancer treatment
Sun, L., Zhao, Q., & Miao, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1524079 · Cited by 11 · see citing works
Ipinmoroti, A. O., Crenshaw, B. J., Pandit, R., Kumar, S., Sims, B., & Matthews, Q. L. (2021) · Journal of Immunology Research · doi:10.1155/2021/2958394 · Cited by 11 · see citing works
Hochheuser, C., Kunze, N. Y., Tytgat, G. A. M., Voermans, C., & Timmerman, I. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11030161 · Cited by 11 · see citing works
Metzner, C., & Zaruba, M. (2021) · Viruses · doi:10.3390/v13071238 · Cited by 11 · see citing works
Nanoengineering‐armed oncolytic viruses drive antitumor response: progress and challenges
Zhang, Y., Shi, X., Shen, Y., Dong, X., He, R., Chen, G., Zhang, Y., Tan, H., & Zhang, K. (2024) · MedComm · doi:10.1002/mco2.755 · Cited by 10 · see citing works
Kadbhane, A., Patel, M., Srivastava, S., Singh, P. K., Madan, J., Singh, S. B., & Khatri, D. K. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102526 · Cited by 10 · see citing works
Kiaheyrati, N., Babaei, A., Ranji, R., Bahadoran, E., Taheri, S., & Farokhpour, Z. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122734 · Cited by 10 · see citing works
Jamieson, T. R., Poutou, J., & Ilkow, C. S. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.07.004 · Cited by 10 · see citing works
Drug target therapy and emerging clinical relevance of exosomes in meningeal tumors
Sharma, S., Rana, R., Prakash, P., & Ganguly, N. K. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04715-1 · Cited by 9 · see citing works
Owliaee, I., Khaledian, M., Boroujeni, A. K., & Shojaeian, A. (2023) · Infectious Agents and Cancer · doi:10.1186/s13027-023-00549-0 · Cited by 8 · see citing works
Therapeutic potential of oncolytic viruses in the era of precision oncology.
Kingsak, M., Meethong, T., Jongkhumkrong, J., Li, C., & Wang, Q. (2023) · PubMed Central · doi:10.12336/biomatertransl.2023.02.003 · Cited by 8 · see citing works
Muhammad, S. A., Mohammed, J. S., & Rabiu, S. (2022) · Pharmaceutical Nanotechnology · doi:10.2174/2211738510666220930155253 · Cited by 8 · see citing works
Sun, J., Ma, S., Xu, J., Abudureyimu, M., An, Y., Xu, J., Zhang, S.-H., Zhang, Z., Guo, C.-X., Liu, B.-L., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114514 · Cited by 7 · see citing works
Wang, X., Fan, R., Wang, G., Han, B., Zhou, L., Tong, A., Zou, B., & Guo, G. (2025) · Drug Resistance Updates · doi:10.1016/j.drup.2025.101345 · Cited by 7 · see citing works
Taheri, B., Zarei‐Behjani, Z., Babaei, A., & Moradkhan, F. M. (2023) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-023-00295-0 · Cited by 7 · see citing works
- Authors
- Garofalo, M., Saari, H., Somersalo, P., Crescenti, D., Kuryk, L., Aksela, L., Capasso, C., Madetoja, M., Koskinen, K., Oksanen, T., Mäkitie, A., Jalasvuori, M., Cerullo, V., Ciana, P., & Yliperttula, M.
- Affiliations
- University of Helsinki (FI)
- University of Milan (IT)
- University of Jyväskylä (FI)
- Corresponding author
- Garofalo, M.
- Yliperttula, M.
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 283
- Pages
- 223-234
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2806319473
- Cited by
- 138
- References
- 77
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 17 · 2021: 22 · 2020: 28 · 2019: 9 · 2018: 5
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Controlled Release (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Työväentutkimus Vuosikirja (submittedVersion)
- Jyväskylä University Digital Archive (University of Jyväskylä) (submittedVersion, cc-by)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- Funders
- Post doc pool foundation (016947-3)
- Italian Association for Cancer Research (IG-11903)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- oncolytic adenovirus, paclitaxel, extracellular vesicles, lung cancer, combination cancer therapy, intravenous drug delivery, xenograft tumor growth, gene expression profiling, differentially expressed genes, viral therapy
- MeSH terms
- Extracellular Vesicles, Animals, Antineoplastic Agents, Phytogenic, Combined Modality Therapy, Female, Humans, Liver, Lung Neoplasms, Mice, Inbred BALB C, Mice, Nude, Spleen, Paclitaxel, Cell Line, Tumor, Oncolytic Viruses
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