Cited by 543Extracellular vesicles in diseaseNanoparticle-Based Drug DeliveryBarrier Structure and Function Studies

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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Qu, Mengke, Lin, Qing, Huang, Luyi, Fu, Yao, Wang, Luyao, He, Shanshan, Fu, Yu, Yang, Shengyong, Zhang, Zhirong, Zhang, Ling, Sun, Xun·2018·Journal of Controlled Release

DOI 10.1016/j.jconrel.2018.08.035

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Abstract

Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood-brain barrier blocks passage of most drugs. Here we find exosomes from blood showing natural brain targeting ability which involved the transferrin-transferrin receptor interaction. Thus, we develop a biocompatible platform based on blood exosomes for delivering drugs across the blood-brain barrier. Blood exosomes show sizes between 40 and 200 nm and spherical morphology, and dopamine can be efficiently loaded into blood exosomes by a saturated solution incubation method. Further in vitro and in vivo studies demonstrates these exosomes successfully delivered dopamine to brain, including the striatum and substantia nigra. Brain distribution of dopamine increased >15-fold by using the blood exosomes as delivery system. Dopamine-loaded exosomes show much better therapeutic efficacy in a PD mouse model and lower systemic toxicity than free dopamine after intravenous administration. These results suggest that blood exosomes can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.

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Authors: Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., & Sun, X.
Affiliations: Sichuan University (CN)
Corresponding author: Zhang, Ling
Sun, Xun
ORCID: Lin, Qing
Huang, Luyi
Fu, Yao
Wang, Luyao
He, Shanshan
Fu, Yu
Yang, Shengyong
Zhang, Zhirong
Zhang, Ling
Sun, Xun
Venue: Journal of Controlled Release
Publisher: Elsevier BV
Published: 2018-10
Volume: 287
Pages: 156-166
ISSN: 0168-3659 (ISSN-L)
DOI: 10.1016/j.jconrel.2018.08.035
OpenAlex: W2888790211
Cited by: 543
References: 43
Citations by year: 2026: 44 · 2025: 72 · 2024: 106 · 2023: 99 · 2022: 81 · 2021: 63 · 2020: 48 · 2019: 27 · 2018: 3
FWCI: 12.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Journal of Controlled Release (publishedVersion)
PubMed (publishedVersion)
Funders: Graduate Student's Research and Innovation Fund of Sichuan University
National Natural Science Foundation of China (81690261)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords: Parkinson's disease, blood exosomes, blood-brain barrier, transferrin receptor, brain targeting, striatum, substantia nigra, brain drug delivery, neurodegenerative disease treatment
MeSH terms: Animals, Brain, Dopamine, Drug Carriers, Parkinson Disease, Dopamine Agents, Drug Delivery Systems, Mice, Exosomes

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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

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