Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain
Open accessAbstract
In this study, exosomes used to encapsulate curcumin (Exo-cur) or a signal transducer and activator of transcription 3 (Stat3) inhibitor, i.e., JSI124 (Exo-JSI124) were delivered noninvasively to microglia cells via an intranasal route. The results generated from three inflammation-mediated disease models, i.e., a lipopolysaccharide (LPS)-induced brain inflammation model, experimental autoimmune encephalitis and a GL26 brain tumor model, showed that mice treated intranasally with Exo-cur or Exo-JSI124 are protected from LPS-induced brain inflammation, the progression of myelin oligodendrocyte glycoprotein (MOG) peptide induced experimental autoimmune encephalomyelitis (EAE), and had significantly delayed brain tumor growth in the GL26 tumor model. Intranasal administration of Exo-cur or Exo-JSI124 led to rapid delivery of exosome encapsulated drug to the brain that was selectively taken up by microglial cells, and subsequently induced apoptosis of microglial cells. Our results demonstrate that this strategy may provide a noninvasive and novel therapeutic approach for treating brain inflammatory-related diseases.
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Intranasal injections successfully deliver exosomes to the brain of mice.
“Other researchers used intranasal injections to successfully deliver exosomes to the brain of mice [236].”
From Alzheimer's Disease: Treatment Strategies and Their Limitations. (2022) · cites this paper as [236]
EVs can deliver miRNAs for treatment of various diseases.
“Several studies have reported and reviewed the potential of EVs in the delivery of miRNAs for the treatment of various diseases (Zhuang et al., 2011; Vader et al., 2016; Rufino-Ramos et al., 2017; Osorio-Querejeta et al., 2018, 2020; Long et al., 2020).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Zhuang et al., 2011
Finding an effective and less invasive method for delivery of microRNA-based drugs into the brain remains a major challenge.
“Finding an effective and less invasive method for the delivery of microRNA-based drugs into the brain remains a major challenge in the field (Zhuang et al., 2011).”
From Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia (2020) · cites this paper as Zhuang et al., 2011
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- Authors
- Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., Miller, D., & Zhang, H.-G.
- Affiliations
- University of Louisville (US)
- University of Alabama at Birmingham (US)
- Stanford Medicine (US)
- Corresponding author
- Zhang, Huang-Ge
- ORCID
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 19
- Issue
- 10
- Pages
- 1769-1779
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC3188748
- OpenAlex
- W2124304994
- Cited by
- 1,356
- References
- 1
- Citations by year
- 2026: 50 · 2025: 98 · 2024: 132 · 2023: 109 · 2022: 148 · 2021: 164 · 2020: 148 · 2019: 117 · 2018: 84 · 2017: 71 · 2016: 68 · 2015: 62 · 2014: 45 · 2013: 32 · 2012: 23
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute (R01CA107181, R01CA116092, R01CA137037)
- National Center for Complementary and Integrative Health (R01AT004294)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- exosomes, intranasal drug delivery, neuroinflammation, curcumin, microglia, experimental autoimmune encephalomyelitis, brain tumors, anti-inflammatory therapy, microglial apoptosis
- MeSH terms
- Administration, Intranasal, Animals, Anti-Inflammatory Agents, Brain Neoplasms, Drug Carriers, Encephalomyelitis, Autoimmune, Experimental, Humans, Microglia, Mice, Exosomes
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