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Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease
Abstract
Parkinson's disease (PD), one of the most common movement and neurodegenerative disorders, is challenging to treat, largely because the blood-brain barrier blocks passage of most drugs. Here we find exosomes from blood showing natural brain targeting ability which involved the transferrin-transferrin receptor interaction. Thus, we develop a biocompatible platform based on blood exosomes for delivering drugs across the blood-brain barrier. Blood exosomes show sizes between 40 and 200 nm and spherical morphology, and dopamine can be efficiently loaded into blood exosomes by a saturated solution incubation method. Further in vitro and in vivo studies demonstrates these exosomes successfully delivered dopamine to brain, including the striatum and substantia nigra. Brain distribution of dopamine increased >15-fold by using the blood exosomes as delivery system. Dopamine-loaded exosomes show much better therapeutic efficacy in a PD mouse model and lower systemic toxicity than free dopamine after intravenous administration. These results suggest that blood exosomes can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.
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“In a mouse Parkinson’s disease (PD) model, exosomes with pre-loaded dopamine exhibited better performance than free dopamine after intravenous injection [74].”
From The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System (2022) · cites this paper as [74]
Citations
Cites
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930
Regulated portals of entry into the cell
Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,959
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042
Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,841
Molecular Pathways of Neurodegeneration in Parkinson's Disease
Dawson, T. M., & Dawson, V. L. (2003) · Science · doi:10.1126/science.1087753 · Cited by 1,674
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666
Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., et al. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,410
Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356
Self-citationTargeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
Qian, Z., Li, H., Sun, H., & Ho, K. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.4.561 · Cited by 1,035
Proteomic and Biochemical Analyses of Human B Cell-derived Exosomes
Wubbolts, R., Leckie, R. S., Veenhuizen, P. T. M., Schwarzmann, G., Möbius, W., Hoernschemeyer, J., Slot, J.-W., Geuze, H. J., & Stoorvogel, W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207550200 · Cited by 886
Kojima, R., Bojar, D., Rizzi, G., Hamri, G. C.-E., El-Baba, M. D., Saxena, P., Ausländer, S., Tan, K. R., & Fussenegger, M. (2018) · Nature Communications · doi:10.1038/s41467-018-03733-8 · Cited by 748
A new blood–brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
Nakagawa, S., Deli, M. A., Kawaguchi, H., Shimizudani, T., Shimono, T., Kittel, Á., Tanaka, K., & Niwa, M. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2008.12.002 · Cited by 728
Johnsen, K. B., Gudbergsson, J. M., Skov, M. N., Pilgaard, L., Moos, T., & Duroux, M. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.005 · Cited by 704
Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier
Fishman, J. B., Rubin, J. B., Handrahan, J. V., Connor, J. R., & Fine, R. E. (1987) · Journal of Neuroscience Research · doi:10.1002/jnr.490180206 · Cited by 550
Asanuma, M., Miyazaki, I., & Ogawa, N. (2003) · Neurotoxicity Research · doi:10.1007/bf03033137 · Cited by 518
Exosomes: Looking back three decades and into the future
Harding, C. V., Heuser, J. E., & Stahl, P. D. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201212113 · Cited by 480
Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy
Qi, H., Liu, C., Long, L., Ren, Y., Zhang, S., Chang, X., Qian, X., Jia, H., Zhao, J., Sun, J., et al. (2016) · ACS Nano · doi:10.1021/acsnano.5b06939 · Cited by 459
The Pharmacology of l-DOPA-Induced Dyskinesia in Parkinson’s Disease
Huot, P., Johnston, T. H., Koprich, J. B., Fox, S. H., & Brotchie, J. M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005678 · Cited by 335
Exosomes purified from a single cell type have diverse morphology
Zabeo, D., Cvjetkovic, A., Lässer, C., Schorb, M., Lötvall, J. O., & Höög, J. L. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1329476 · Cited by 304
Dopamine and adult neurogenesis
Borta, A., & Höglinger, G. U. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04241.x · Cited by 192
Ingato, D., Lee, J. U., Sim, S. J., & Kwon, Y. J. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.09.016 · Cited by 177
Vidal, M., Sainte‐Marie, J., Philippot, J. R., & Bienvenüe, A. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041400308 · Cited by 172
Eckenroth, B. E., Steere, A. N., Chasteen, N. D., Everse, S. J., & Mason, A. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105786108 · Cited by 160
Exosomes: A new delivery system for tumor antigens in cancer immunotherapy
Cho, J., Yeo, D.-J., Son, H., Kim, H., Jung, D., Ko, J., Koh, J. S., Kim, Y.-N., & Kim, C. (2004) · International Journal of Cancer · doi:10.1002/ijc.20757 · Cited by 160
Grealish, S., Mattsson, B., Draxler, P., & Björklund, A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07265.x · Cited by 147
Exosome release by reticulocytes—An integral part of the red blood cell differentiation system
Blanc, L., Gassart, A. D., Géminard, C., Bette‐Bobillo, P., & Vidal, M. (2005) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2005.04.008 · Cited by 111
Saks, V. A., Ventura‐Clapier, R., Huchua, Z. A., Preobrazhenskiĭ, A. N., & Emelin, I. V. (1984) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(84)90115-0 · Cited by 85
Rhein protects against acetaminophen-induced hepatic and renal toxicity
Zhao, Y., Zhou, G., Yang, H., Wang, J., Shan, L., Li, R., & Xiao, X. (2011) · Food and Chemical Toxicology · doi:10.1016/j.fct.2011.04.011 · Cited by 84
Drug Delivery Systems for Imaging and Therapy of Parkinson';s Disease
Silindir‐Gunay, M., Özer, A. Y., & Chalon, S. (2015) · Current Neuropharmacology · doi:10.2174/1570159x14666151230124904 · Cited by 83
Gao, H., Yang, Z. H., Zhang, S., Pang, Z., Liu, Q., & Jiang, X. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.11.003 · Cited by 79
Ross, D. W., Ayscue, L. H., Watson, J. S., & BENTLEY, S. A. (1988) · American Journal of Clinical Pathology · doi:10.1093/ajcp/90.3.262 · Cited by 72
Pharmacokinetics of dopamine in infants and children
Eldadah, M. K., Schwartz, P. H., HARRISON, R., & Newth, C. J. L. (1991) · Critical Care Medicine · doi:10.1097/00003246-199108000-00006 · Cited by 42
Regional striatal DOPA transport and decarboxylase activity in Parkinson's disease.
Kuwabara, H., Cumming, P. D., Yasuhara, Y., Léger, G. C., Guttman, M., Dikšić, M., Evans, A. C., & GJEDDE, A. H. (1995) · PubMed · Cited by 40
Monitoring of Respiration and Circulation
Blom, J. A. (2003) · CRC Press eBooks · doi:10.1201/9780203503287 · Cited by 35
Endocytosis and exocytosis of protein in capillary endothelium
Williams, S. K., Greener, D. A., & Solenski, N. J. (1984) · Journal of Cellular Physiology · doi:10.1002/jcp.1041200208 · Cited by 26
Li, Y., Zhou, Y., Qi, B., Gong, T., Sun, X., Fu, Y. S., & Zhang, Z. (2014) · Molecular Pharmaceutics · doi:10.1021/mp500352p · Cited by 24
Self-citationSoliman, A. M., Fathalla, A., & Moustafa, A. A. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.04.057 · Cited by 22
Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential
Zhdanov, A. V., Aviello, G., Knaus, U. G., & Papkovsky, D. B. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.10.023 · Cited by 19
Current treatments in Parkinson's including the proposal of an innovative dopamine microimplant
Velázquez-Paniagua, M., Vázquez-Álvarez, A. M., Valverde-Aguilar, G., & Aragón, P. V. (2015) · Revista Médica Del Hospital General De México · doi:10.1016/j.hgmx.2015.10.006 · Cited by 7
Practical guidelines for examination of adults with asymptomatic hypertransaminasaemia
Bruguera, M. (2017) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2016.03.011 · Cited by 4
DISTRIBUTION OF SIX TF C (TRANSFERRIN) SUBTYPES IN CORD BLOODS AND BLOOD DONORS
Nicholls, C., & Mulley, J. (1982) · Immunology and Cell Biology · doi:10.1038/icb.1982.48 · Cited by 3
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Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138
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Metadata
- Authors
- Qu, M., Lin, Q., Huang, L., Fu, Y., Wang, L., He, S., Fu, Y., Yang, S., Zhang, Z., Zhang, L., & Sun, X.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Zhang, Ling
- Sun, Xun
- ORCID
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 287
- Pages
- 156-166
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W2888790211
- Cited by
- 543
- References
- 43
- Citations by year
- 2026: 44 · 2025: 72 · 2024: 106 · 2023: 99 · 2022: 81 · 2021: 63 · 2020: 48 · 2019: 27 · 2018: 3
- FWCI
- 12.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Controlled Release (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Graduate Student's Research and Innovation Fund of Sichuan University
- National Natural Science Foundation of China (81690261)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Parkinson's disease, blood exosomes, blood-brain barrier, transferrin receptor, brain targeting, striatum, substantia nigra, brain drug delivery, neurodegenerative disease treatment
- MeSH terms
- Animals, Brain, Dopamine, Drug Carriers, Parkinson Disease, Dopamine Agents, Drug Delivery Systems, Mice, Exosomes
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