Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson’s disease

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930

Regulated portals of entry into the cell

Conner, S. D., & Schmid, S. L. (2003) · Nature · doi:10.1038/nature01451 · Cited by 3,959

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715

Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor

Pan, B., & Johnstone, R. M. (1983) · Cell · doi:10.1016/0092-8674(83)90040-5 · Cited by 2,042

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,841

Molecular Pathways of Neurodegeneration in Parkinson's Disease

Dawson, T. M., & Dawson, V. L. (2003) · Science · doi:10.1126/science.1087753 · Cited by 1,674

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

Ohno, S.-I., Takanashi, M., Sudo, K., Ueda, S., Ishikawa, A., Matsuyama, N., Fujita, K., Mizutani, T., Ohgi, T., Ochiya, T., et al. (2013) · Molecular Therapy · doi:10.1038/mt.2012.180 · Cited by 1,666

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W. E., Miller, D., & Zhang, H. (2010) · Molecular Therapy · doi:10.1038/mt.2010.105 · Cited by 1,579

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Kim, M. S., Haney, M. J., Zhao, Y., Mahajan, V., Deygen, I., Klyachko, N. L., Inskoe, E., Piroyan, A., Sokolsky, M., Okolie, O., et al. (2016) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2015.10.012 · Cited by 1,410

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

Zhuang, X., Xiang, X., Grizzle, W., Sun, D., Zhang, S., Axtell, R. C., Ju, S., Mu, J., Zhang, L., Steinman, L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.164 · Cited by 1,356

The biology , function , and biomedical applications of exosomes

Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770

Strategies for delivering therapeutics across the blood–brain barrier

Terstappen, G. C., Meyer, A. H., Bell, R. D., & Zhang, W. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00139-y · Cited by 1,138

Exosomes─Nature’s Lipid Nanoparticles, a Rising Star in Drug Delivery and Diagnostics

Tenchov, R., Sasso, J. M., Wang, X., Liaw, W., Chen, C., & Zhou, Q. A. (2022) · ACS Nano · doi:10.1021/acsnano.2c08774 · Cited by 642

Unlocking the promise of mRNA therapeutics

Rohner, E., Yang, R., Foo, K. S., Goedel, A., & Chien, K. R. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01491-z · Cited by 612

Biodistribution of extracellular vesicles following administration into animals: A systematic review

Kang, M., Jordan, V., Blenkiron, C., & Chamley, L. (2021) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12085 · Cited by 519

Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis

Zhao, L., Gu, C., Gan, Y. H., Shao, L., Chen, H., & Zhu, H. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.005 · Cited by 448

Current Strategies for Exosome Cargo Loading and Targeting Delivery

Zeng, H., Guo, S., Ren, X., Wu, Z., Liu, S., & Yao, X. (2023) · Cells · doi:10.3390/cells12101416 · Cited by 464

Cell-cell communication: New insights and clinical implications

Su, J., Song, Y., Zhu, Z., Huang, X., Fan, J., Qiao, J., & Mao, F. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01888-z · Cited by 433

Dosing extracellular vesicles

Gupta, D., Zickler, A. M., & Andaloussi, S. E. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113961 · Cited by 438

Intranasal Delivery of Mesenchymal Stem Cell Derived Exosomes Loaded with Phosphatase and Tensin Homolog siRNA Repairs Complete Spinal Cord Injury

Guo, S., Perets, N., Betzer, O., Ben-Shaul, S., Sheinin, A., Michaelevski, I., Popovtzer, R., Offen, D., & Levenberg, S. (2019) · ACS Nano · doi:10.1021/acsnano.9b01892 · Cited by 424

Exosome detection via the ultrafast-isolation system: EXODUS

Chen, Y., Zhu, Q., Cheng, L., Wang, Y., Li, M., Yang, Q., Hu, L., Lou, D., Li, J., Dong, X., et al. (2021) · Nature Methods · doi:10.1038/s41592-020-01034-x · Cited by 423

Exosomes: The next generation of endogenous nanomaterials for advanced drug delivery and therapy

Liao, W., Du, Y., Zhang, C., Pan, F., Yao, Y., Zhang, T., & Peng, Q. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.12.045 · Cited by 418

A Comprehensive Review on Factors Influences Biogenesis, Functions, Therapeutic and Clinical Implications of Exosomes

Gurunathan, S., Kang, M.-H., & Kim, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s291956 · Cited by 397

Curcumin-primed exosomes potently ameliorate cognitive function in AD mice by inhibiting hyperphosphorylation of the Tau protein through the AKT/GSK-3β pathway

Wang, H., Sui, H., Zheng, Y., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2019) · Nanoscale · doi:10.1039/c9nr01255a · Cited by 324

M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization

Li, H., Feng, Y., Zheng, X. C., Jia, M., Mei, Z., Wang, Y., Zhang, Z., Zhou, M., & Li, C. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.019 · Cited by 266

Potential Use of Exosomes as Diagnostic Biomarkers and in Targeted Drug Delivery: Progress in Clinical and Preclinical Applications

Huda, M. N., Nafiujjaman, M., Deaguero, I. G., Okonkwo, J., Hill, M. L., Kim, T. H., & Nurunnabi, M. (2021) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.1c00217 · Cited by 268

Immune Exosomes Loading Self-Assembled Nanomicelles Traverse the Blood–Brain Barrier for Chemo-immunotherapy against Glioblastoma

Cui, J., Wang, X., Li, J., Zhu, A., Du, Y., Zeng, W., Guo, Y., Di, L., & Wang, R. (2023) · ACS Nano · doi:10.1021/acsnano.2c10219 · Cited by 254

Designer Exosomes: A New Platform for Biotechnology Therapeutics

Jafari, D., Shajari, S., Jafari, R., Mardi, N., Gomari, H., Ganji, F., Moghadam, M. F., & Samadikuchaksaraei, A. (2020) · BioDrugs · doi:10.1007/s40259-020-00434-x · Cited by 255

Brain delivery of quercetin-loaded exosomes improved cognitive function in AD mice by inhibiting phosphorylated tau-mediated neurofibrillary tangles

Qi, Y., Guo, L., Jiang, Y., Shi, Y., Sui, H., & Zhao, L. (2020) · Drug Delivery · doi:10.1080/10717544.2020.1762262 · Cited by 239

Exosomes based strategies for brain drug delivery

Rehman, F. U., Liu, Y., Zheng, M., & Shi, B. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121949 · Cited by 240

Engineered exosomes: desirable target-tracking characteristics for cerebrovascular and neurodegenerative disease therapies

Xu, M., Feng, T., Liu, B., Qiu, F., Xu, Y., Zhao, Y., & Zheng, Y. (2021) · Theranostics · doi:10.7150/thno.62330 · Cited by 229

Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis.

Wei, Z.-X., Xie, G.-J., Mao, X., Zou, X.-P., Liao, Y.-J., Liu, Q.-S., Wang, H., & Cheng, Y. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0622-2 · Cited by 227

A Historical Review of Brain Drug Delivery

Pardridge, W. M. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061283 · Cited by 219

Extracellular vesicles as a drug delivery system: A systematic review of preclinical studies

de Castilla, P. E. M., Tong, L., Huang, C., Sofias, A. M., Pastorin, G., Chen, X. S., Storm, G., Schiffelers, R. M., & Wang, J. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.011 · Cited by 219

Exosomes as Naturally Occurring Vehicles for Delivery of Biopharmaceuticals: Insights from Drug Delivery to Clinical Perspectives

Butreddy, A., Kommineni, N., & Dudhipala, N. R. (2021) · Nanomaterials · doi:10.3390/nano11061481 · Cited by 215

Exosome-based nanocarriers as bio-inspired and versatile vehicles for drug delivery: recent advances and challenges

Zhang, M., Zang, X., Wang, M., Li, Z., Qiao, M., Hu, H., & Chen, D. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00170k · Cited by 216

Mesenchymal stem cell-derived exosome: a promising alternative in the therapy of Alzheimer’s disease

Guo, M., Yin, Z., Chen, F., & Lei, P. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00670-x · Cited by 205

Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis

Yan, F., Zhong, Z., Wang, Y., Feng, Y., Mei, Z., Li, H., Chen, X., Cai, L., & Li, C. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00675-6 · Cited by 197

Exosomes as drug delivery systems: A brief overview and progress update

Patil, S. M., Sawant, S. S., & Kunda, N. K. (2020) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2020.07.026 · Cited by 198

Exosome: a significant nano-scale drug delivery carrier

Peng, H., Ji, W., Zhao, R., Yang, J., Lü, Z., Li, Y., & Zhang, X. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb01499k · Cited by 192

Overcoming the blood–brain barrier for the therapy of malignant brain tumor: current status and prospects of drug delivery approaches

Mitusova, K. A., Peltek, O. O., Karpov, T. E., Muslimov, A. R., Zyuzin, M. V., & Timin, A. S. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01610-7 · Cited by 193

Exosomes as natural nanocarrier-based drug delivery system: recent insights and future perspectives

Sen, S., Xavier, J., Kumar, N., Ahmad, M. Z., & Ranjan, O. P. (2023) · 3 Biotech · doi:10.1007/s13205-023-03521-2 · Cited by 195

How to decrease pharmaceuticals in the environment? A review

Caban, M., & Stepnowski, P. (2021) · Environmental Chemistry Letters · doi:10.1007/s10311-021-01194-y · Cited by 195

Recent Advancements in the Loading and Modification of Therapeutic Exosomes

Xu, M., Yang, Q., Sun, X., & Wang, Y. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.586130 · Cited by 183

Insights into Exosome Transport through the Blood–Brain Barrier and the Potential Therapeutical Applications in Brain Diseases

Abdelsalam, M., Ahmed, M., Osaid, Z., Hamoudi, R., & Harati, R. (2023) · Pharmaceuticals · doi:10.3390/ph16040571 · Cited by 181

Exosomal delivery of therapeutic modulators through the blood–brain barrier; promise and pitfalls

Heidarzadeh, M., Özdemir, Y., Kaya, M., Abriz, A. E., Zarebkohan, A., Rahbarghazi‬, R., & Sokullu, E. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00650-0 · Cited by 183

Exosomes as New Generation Vehicles for Drug Delivery: Biomedical Applications and Future Perspectives

Rajput, A., Varshney, A., Bajaj, R., & Pokharkar, V. (2022) · Molecules · doi:10.3390/molecules27217289 · Cited by 172

Cell-derived nanovesicle-mediated drug delivery to the brain: Principles and strategies for vesicle engineering

Liang, Y., Iqbal, Z., Lu, J., Wang, J., Zhang, H., Chen, X., Duan, L., & Xia, J. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2022.10.008 · Cited by 162

ADSCs-derived extracellular vesicles alleviate neuronal damage, promote neurogenesis and rescue memory loss in mice with Alzheimer's disease

Ma, X., Huang, M., Zheng, M., Dai, C., Song, Q., Zhang, Q., Li, Q., Gu, X. Q., Chen, H., Jiang, G., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.019 · Cited by 163

Encapsulation and assessment of therapeutic cargo in engineered exosomes: a systematic review

Chen, Z., Xiong, M., Tian, J., Song, D., Duan, S., & Zhang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02259-6 · Cited by 163

Mitochondrial Dysfunction and Aging: Insights from the Analysis of Extracellular Vesicles

Picca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Coelho‐Júnior, H. J., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040805 · Cited by 161

Exosomes from different cells: Characteristics, modifications, and therapeutic applications

Li, M., Li, S., Du, C., Zhang, Y., Li, Y., Chu, L., Han, X., Galons, H., Zhang, Y., Sun, H., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112784 · Cited by 157

Exosomes Engineering and Their Roles as Therapy Delivery Tools, Therapeutic Targets, and Biomarkers

Kučuk, N., Primožič, M., Knez, Ž., & Leitgeb, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179543 · Cited by 161

Exosome as drug delivery system: Current advancements

Sharma, V., & Mukhopadhyay, C. D. (2024) · Extracellular Vesicle · doi:10.1016/j.vesic.2023.100032 · Cited by 156

Nanostructured particles assembled from natural building blocks for advanced therapies

Ju, Y., Liao, H., Richardson, J. J., Guo, J., & Caruso, F. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00343g · Cited by 157

Recent Advancements of Nanomedicine in Neurodegenerative Disorders Theranostics

Mukherjee, S., Madamsetty, V. S., Bhattacharya, D., Roy Chowdhury, S., Paul, M. K., & Mukherjee, A. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202003054 · Cited by 152

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 156

Genome-Wide, Integrative Analysis Implicates Exosome-Derived MicroRNA Dysregulation in Schizophrenia

Du, Y., Yu, Y., Hu, Y., Li, X., Wei, Z., Pan, R., Li, X.-S., Zheng, G.-E., Qin, X., Liu, Q., et al. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sby191 · Cited by 155

Curcumin-laden exosomes target ischemic brain tissue and alleviate cerebral ischemia-reperfusion injury by inhibiting ROS-mediated mitochondrial apoptosis

He, R., Jiang, Y., Shi, Y., Liang, J., & Zhao, L. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111314 · Cited by 147

Separation, characterization, and standardization of extracellular vesicles for drug delivery applications

Buschmann, D., Mussack, V., & Byrd, J. B. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.027 · Cited by 156

The Emerging Role of Neural Cell-Derived Exosomes in Intercellular Communication in Health and Neurodegenerative Diseases

Huo, L., Du, X., Li, X., Liu, S., & Xu, Y. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.738442 · Cited by 149

Exosomes in Parkinson disease

Pinnell, J. R., Cui, M., & Tieu, K. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15288 · Cited by 146

Harnessing Exosomes for the Development of Brain Drug Delivery Systems

Zheng, M., Huang, M., Ma, X., Chen, H., & Gao, X. (2019) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.9b00085 · Cited by 136

Extracellular Vesicle-Based Therapeutics: Preclinical and Clinical Investigations

Klyachko, N. L., Arzt, C. J., Li, S. M., Gololobova, O. A., & Batrakova, E. V. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121171 · Cited by 133

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

Burnouf, T., Agrahari, V., & Agrahari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s225453 · Cited by 130

Recent progresses in exosome-based systems for targeted drug delivery to the brain

Bashyal, S., Chhitij, T., & Lee, S. K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.011 · Cited by 130

Potential Roles of Exosomes in Parkinson’s Disease: From Pathogenesis, Diagnosis, and Treatment to Prognosis

Yu, H., Sun, T., An, J., Wen, L., Liu, F., Bu, Z., Cui, Y., & Feng, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00086 · Cited by 130

Exosome-powered neuropharmaceutics: unlocking the blood-brain barrier for next-gen therapies

Mehdizadeh, S., Mamaghani, M., Hassanikia, S., Pilehvar‐Soltanahmadi, Y., & Ertaş, Y. N. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03352-8 · Cited by 138

Extracellular vesicles as bioactive nanotherapeutics: An emerging paradigm for regenerative medicine

Li, M., Fang, F., Sun, M., Zhang, Y., Hu, M., & Zhang, J. (2022) · Theranostics · doi:10.7150/thno.72812 · Cited by 121

Extracellular vesicles in tumor immunity: mechanisms and novel insights

Kuang, L., Wu, L., & Li, Y. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02233-w · Cited by 135

Extracellular Vesicle- and Extracellular Vesicle Mimetics-Based Drug Delivery Systems: New Perspectives, Challenges, and Clinical Developments

Gangadaran, P., & Ahn, B. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050442 · Cited by 119

Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy

Zhan, Q., Yi, K., Cui, X., Li, X., Yang, S., Wang, Q., Fang, C., Tan, Y., Li, L., Xu, C., et al. (2022) · Neuro-Oncology · doi:10.1093/neuonc/noac071 · Cited by 103

MicroRNA-124-3p-enriched small extracellular vesicles as a therapeutic approach for Parkinson’s disease

Esteves, M., de Abreu, R. C., Fernandes, H., Serra-Almeida, C., Martins, P. A. T., Barão, M., Cristóvão, A. C., Saraiva, C., Ferreira, R., Ferreira, L., et al. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.06.003 · Cited by 121

Engineering Exosomes for Therapeutic Applications: Decoding Biogenesis, Content Modification, and Cargo Loading Strategies

Bahadorani, M., Nasiri, M., Dellinger, K., Aravamudhan, S., & Zadegan, R. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s464249 · Cited by 121

Nanoformulation properties, characterization, and behavior in complex biological matrices: Challenges and opportunities for brain-targeted drug delivery applications and enhanced translational potential

Agrahari, V., Burnouf, P., Burnouf, T., & Agrahari, V. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.02.008 · Cited by 115

Exosomes as Drug Delivery Systems: Endogenous Nanovehicles for Treatment of Systemic Lupus Erythematosus

Ortega, A., Martínez-Arroyo, O., Forner, M. J., & Cortés, R. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics13010003 · Cited by 113

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110

Extracellular Vesicles in neural cell interaction and CNS homeostasis

Schnatz, A., Müller, C., Brahmer, A., & Krämer‐Albers, E. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00035 · Cited by 108

Anti-Parkinsonian Therapy: Strategies for Crossing the Blood–Brain Barrier and Nano-Biological Effects of Nanomaterials

Cheng, G., Liu, Y., Ma, R., Cheng, G., Guan, Y., Chen, X., Wu, Z., & Chen, T. (2022) · Nano-Micro Letters · doi:10.1007/s40820-022-00847-z · Cited by 113

Current Knowledge and Future Perspectives of Exosomes as Nanocarriers in Diagnosis and Treatment of Diseases

Zou, Z., Han, L., Xu, G., Hu, Y., Zhang, W., & Tian, K. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s417422 · Cited by 115

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

Rong, S., Wang, L., Peng, Z., Liao, Y., Li, D., Yang, X., Nussler, A. K., Liu, L., Bao, W., & Yang, W. Q. (2020) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12536 · Cited by 110

Engineered extracellular vesicles as intelligent nanosystems for next-generation nanomedicine

Fan, Z., Jiang, C., Wang, Y., Wang, K., Marsh, J., Zhang, D., Chen, X., & Nie, L. (2022) · Nanoscale Horizons · doi:10.1039/d2nh00070a · Cited by 103

Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy

Khatami, S. H., Karami, N., Taheri‐Anganeh, M., Taghvimi, S., Tondro, G., Khorsand, M., Fard, E. S., Sedighimehr, N., Kazemi, M., Jaberi, K. R., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03365-0 · Cited by 109

Injectable Supramolecular Ureidopyrimidinone Hydrogels Provide Sustained Release of Extracellular Vesicle Therapeutics

Mol, E. A., Lei, Z., Roefs, M. T., Bakker, M. H., Goumans, M., Doevendans, P. A., Dankers, P. Y. W., Vader, P., & Sluijter, J. P. G. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201900847 · Cited by 101

Extracellular Vesicles as Nanotherapeutics for Parkinson’s Disease

Leggio, L., Paternò, G., Vivarelli, S., L’Episcopo, F., Tirolo, C., Raciti, G., Pappalardo, F., Giachino, C., Caniglia, S., Serapide, M. F., et al. (2020) · Biomolecules · doi:10.3390/biom10091327 · Cited by 100

Exosomes as therapeutic and drug delivery vehicle for neurodegenerative diseases

Nouri, Z., Barfar, A., Perseh, S., Motasadizadeh, H., Maghsoudian, S., Fatahi, Y., Nouri, K., Yektakasmaei, M. P., Dinarvand, R., & Atyabi, F. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02681-4 · Cited by 103

Ultrasound Facilitates Naturally Equipped Exosomes Derived from Macrophages and Blood Serum for Orthotopic Glioma Treatment

Bai, L., Liu, Y., Guo, K., Zhang, K., Liu, Q., Wang, P., & Wang, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b00893 · Cited by 96

Biological characteristics of exosomes and genetically engineered exosomes for the targeted delivery of therapeutic agents

Yan, L., Lu, Y., & Li, X. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1641508 · Cited by 99

Factors Affecting Extracellular Vesicles Based Drug Delivery Systems

Gaurav, I., Thakur, A., Iyaswamy, A., Wang, X., Chen, X., & Yang, Z. (2021) · Molecules · doi:10.3390/molecules26061544 · Cited by 97

Nanoengineering facilitating the target mission: targeted extracellular vesicles delivery systems design

Song, H., Chen, X., Hao, Y., Wang, J., Xie, Q., & Wang, X. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01638-9 · Cited by 98

Extracellular vesicles, from the pathogenesis to the therapy of neurodegenerative diseases

Xia, X., Wang, Y., & Zheng, J. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00330-0 · Cited by 97

The application of exosomes and Exosome-nanoparticle in treating brain disorders

Salarpour, S., Barani, M., Pardakhty, A., Khatami, M., & Chauhan, N. P. S. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.118549 · Cited by 92

Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine

Lin, Q., Qu, M., Zhou, B., Patra, H. K., Sun, Z., Luo, Q., Yang, W., Wu, Y., Zhang, Y., Li, L., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.08.037 · Cited by 88

Blood TfR+ exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy

Yang, L., Han, D., Zhan, Q., Li, X., Shan, P., Hu, Y., Ding, H., Wang, Y., Zhang, L., Zhang, Y., et al. (2019) · Theranostics · doi:10.7150/thno.37220 · Cited by 90

Potential Role of Exosomes in Cancer Metastasis

Tian, W., Liu, S., & Li, B. (2019) · BioMed Research International · doi:10.1155/2019/4649705 · Cited by 90

Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

Chiangjong, W., Netsirisawan, P., Hongeng, S., & Chutipongtanate, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761362 · Cited by 87

Biomimetic drug-delivery systems for the management of brain diseases

Chen, Y., Wei, C., Lyu, Y., Chen, H., Jiang, G., & Gao, X. (2019) · Biomaterials Science · doi:10.1039/c9bm01395d · Cited by 87

Extracellular Vesicles for the Diagnosis and Treatment of Parkinson’s Disease

Upadhya, R., & Shetty, A. K. (2021) · Aging and Disease · doi:10.14336/ad.2021.0516 · Cited by 87

Lipid-Based Nanovesicular Drug Delivery Systems

Limongi, T., Susa, F., Marini, M., Allione, M., Torre, B., Pisano, R., & Fabrizio, E. M. D. (2021) · Nanomaterials · doi:10.3390/nano11123391 · Cited by 90

Molecular Biomarkers and Their Implications for the Early Diagnosis of Selected Neurodegenerative Diseases

Doroszkiewicz, J., Groblewska, M., & Mroczko, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094610 · Cited by 88

Exosomes as cell-derivative carriers in the diagnosis and treatment of central nervous system diseases

Shetgaonkar, G. G., Marques, S. M., DCruz, C. E. M., Vibhavari, R. J. A., Kumar, L., & Shirodkar, R. K. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01026-0 · Cited by 400

Overcoming the blood-brain barrier: Exosomes as theranostic nanocarriers for precision neuroimaging

Li, C., Qin, S., Wen, Y., Zhao, W. G., Huang, Y., & Liu, J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.002 · Cited by 86

Exosomes Interactions with the Blood–Brain Barrier: Implications for Cerebral Disorders and Therapeutics

Osaid, Z., Haider, M. A., Hamoudi, R., & Harati, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115635 · Cited by 89

Biogenesis, Composition and Potential Therapeutic Applications of Mesenchymal Stem Cells Derived Exosomes in Various Diseases

Yuan, Y., Wang, J., Zhang, Y., Li, L., Reza, A. M. M. T., & Gurunathan, S. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s407029 · Cited by 85

The exosome: a review of current therapeutic roles and capabilities in human reproduction

Dimik, M., Abeysinghe, P., Logan, J., & Mitchell, M. D. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01225-3 · Cited by 86

Extracellular Vesicles as Drug Transporters

Nowak, M., Górczyńska, J., Kołodzińska, K., Rubin, J., & Choromańska, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241210267 · Cited by 84

Extracellular vesicles for the treatment of central nervous system diseases

Gratpain, V., Mwema, A., Labrak, Y., Muccioli, G. G., Pesch, V. V., & Rieux, A. D. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.05.006 · Cited by 79

Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances

Najm, A., Niculescu, A.-G., Grumezescu, A. M., & Beuran, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084300 · Cited by 86

Mitochondrial-Derived Vesicles as Candidate Biomarkers in Parkinson’s Disease: Rationale, Design and Methods of the EXosomes in PArkiNson Disease (EXPAND) Study

Picca, A., Guerra, F., Calvani, R., Bucci, C., Monaco, M. R. L., Bentivoglio, A. R., Landi, F., Bernabei, R., & Marzetti, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102373 · Cited by 79

Native and Bioengineered Exosomes for Ischemic Stroke Therapy

Khan, H. L., Pan, J., Li, Y.-F., Zhang, Z., & Yang, G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.619565 · Cited by 79

Applications of Exosomes in Targeted Drug Delivery for the Treatment of Parkinson’s Disease: A Review of Recent Advances and Clinical Challenges

Kumar, B., Pandey, M., Fayaz, F., Izneid, T. A., Pottoo, F. H., Manchanda, S., Sharma, A., & Sahoo, P. K. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666201019112557 · Cited by 11

Potential Therapeutic Applications and Developments of Exosomes in Parkinson’s Disease

Luo, S., Du, L., & Cui, Y. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00195 · Cited by 34

Exosomes: Cellular capsules for drug delivery in Parkinson’s disease

Samal, J., Demir, S., & Pandit, A. S. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-50922-0.00006-7 · Cited by 4

Plant-derived exosomes as cell homogeneous nanoplatforms for brain biomacromolecules delivery ameliorate mitochondrial dysfunction against Parkinson’s disease

Xu, Y., Yan, G., Zhao, J., Ren, Y., Xiao, Q., Tan, M., & Peng, L. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102438 · Cited by 80

Research progress on exosome-mediated vascular endothelial growth factor–nerve growth factor cotransplantation in the treatment of Parkinson’s disease

Yan, W., Meng, X., & Li, X. (2025) · Journal of Aging and Rehabilitation · doi:10.1097/jagr.0000000000000024