The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Challenges in the development and establishment of exosome-based drug delivery systems
Abstract
Exosomes are extracellular vesicles released from cells and are characterized by a lipid bilayer membrane encapsulating a variety of biological molecules such as nucleic acids or proteins within the lumen or the lipid-bilayer. Under physiological environments, exosomes mediate cell-to-cell communication and cargo transport. Therefore, exosomes have been explored as drug delivery vehicles for improving therapeutic outcomes. Although recent studies have demonstrated promising advances with exosome-based drug delivery systems, several challenges severely hinder further development of exosomes for clinical applications. This review summarizes and emphasizes some of the technical challenges related to the isolation, characterization, and stability testing of exosomes. More importantly, challenges related specifically to the application of exosomes for drug delivery such as cell-uptake, drug loading, drug release, and in vivo distribution will be examined in this article.
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Cites
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Cited by
Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Zhang, Y., Liu, Q., Zhang, X., Huang, H., Tang, S., Chai, Y., Xu, Z., Li, M., Chen, X., Liu, J., et al. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01472-z · Cited by 306
Artificial exosomes for translational nanomedicine
Li, Y.-J., Wu, J.-Y., Liu, J., Xu, W., Qiu, X., Huang, S., Hu, X.-B., & Xiang, D.-X. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00986-2 · Cited by 303
Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297
Exosome-Based Drug Delivery: Translation from Bench to Clinic
Koh, H. B., Kim, H. J., Kang, S.-W., & Yoo, T.-H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082042 · Cited by 259
Engineered Exosome for Drug Delivery: Recent Development and Clinical Applications
Tian, J., Han, Z., Song, D., Peng, Y., Xiong, M., Chen, Z., Duan, S., & Zhang, L. (2023) · International Journal of Nanomedicine · doi:10.2147/ijn.s444582 · Cited by 246
Metadata
- Authors
- Wang, J., Chen, D., & Ho, E. A.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 329
- Pages
- 894-906
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W3092740363
- Cited by
- 382
- References
- 100
- FWCI
- 9.96
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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