The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization
Abstract
Imbalance between the activities of pro-inflammatory M1 and anti-inflammatory M2 macrophages in rheumatoid arthritis (RA) induces synovial inflammation and autoimmunity, leading to joint damage. Here we encapsulated a plasmid DNA encoding the anti-inflammatory cytokine interleukin-10 (IL-10 pDNA) and the chemotherapeutic drug betamethasone sodium phosphate (BSP) into biomimetic vector M2 exosomes (M2 Exo) derived from M2-type macrophages. We demonstrate that the loaded exosomes target and reduce inflammation for combined therapy against RA. The in vitro efficiency of the M2 Exo/pDNA/BSP co-delivery system was attributed to the synergistic effect of IL-10 pDNA and BSP, which also promoted M1-to-M2 macrophage polarization by reducing the secretion of pro-inflammatory cytokines (IL-1β, TNF-α) and increasing the expression of IL-10 cytokine. In a mouse model of RA, M2 Exo/pDNA/BSP showed good accumulation at inflamed joint sites, high anti-inflammatory activity, and potent therapeutic effect. The delivery system was non-toxic both in vitro and in vivo. Thus, this system may serve as a promising biocompatible drug carrier and anti-inflammatory agent for RA treatment based on M1-to-M2 macrophage re-polarization.
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Cites
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
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Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages
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Cited by
Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications
Mondal, J., Pillarisetti, S., Junnuthula, V., Saha, M., Hwang, S. R., Park, I.-K., & Lee, Y.-K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.12.027 · Cited by 416
Controlling the biodistribution and clearance of nanomedicines
Cabral, H., Li, J., Miyata, K., & Kataoka, K. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00138-1 · Cited by 303
Exosome-Based Drug Delivery: Translation from Bench to Clinic
Koh, H. B., Kim, H. J., Kang, S.-W., & Yoo, T.-H. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15082042 · Cited by 259
Metadata
- Authors
- Li, H., Feng, Y., Zheng, X., Jia, M., Mei, Z., Wang, Y., Zhang, Z., Zhou, M., & Li, C.
- Venue
- Journal of Controlled Release
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 341
- Pages
- 16-30
- ISSN
- 0168-3659 (ISSN-L)
- OpenAlex
- W3212827607
- Cited by
- 259
- References
- 52
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, H., Feng, Y., Zheng, X., Jia, M., Mei, Z., Wang, Y., Zhang, Z., Zhou, M., & Li, C. (2022). M2-type exosomes nanoparticles for rheumatoid arthritis therapy via macrophage re-polarization. Journal of Controlled Release. https://doi.org/10.1016/j.jconrel.2021.11.019
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