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Engineered exosome as targeted lncRNA MEG3 delivery vehicles for osteosarcoma therapy

Huang, Xin, Wu, Wei, Jing, Doudou, Yang, Lingkai, Guo, Haoyu, Wang, Lutong, Zhang, Weiyue, Pu, Feifei, Shao, Zengwu·2022·Journal of Controlled Release
DOI 10.1016/j.jconrel.2022.01.026
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Abstract

Exosomes as nanosized membrane vesicles, could targeted deliver therapeutic agents by modification with target ligands. Exosome-derived non-coding RNAs play a vital role in the development of tumors. Previous evidences reveal that long non-coding RNA maternally expressed gene 3 (lncRNA MEG3) has anti-tumor properties. Whereas, the inhibitory effects of exosome-derived lncRNA MEG3 in osteosarcoma (OS) remain largely unknown. In this study, we utilize the engineering technology to combine exosome and lncRNA for tumor-targeting therapy of OS. We elucidated the anti-OS effects of lncRNA MEG3, and then prepared the c(RGDyK)-modified and MEG3-loaded exosomes (cRGD-Exo-MEG3). The engineered exosomes cRGD-Exo-MEG3 could deliver more efficiently to OS cells both in vitro and in vivo. In this way, cRGD-Exo-MEG3 facilitate the anti-OS effects of MEG3 significantly, with the help of enhanced tumor-targeting therapy. This study elucidates that engineered exosomes as targeted lncRNA MEG3 delivery vehicles have potentially therapeutic effects for OS.

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Metadata

Authors
Huang, X., Wu, W., Jing, D., Yang, L., Guo, H., Wang, L., Zhang, W., Pu, F., & Shao, Z.
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2022-03
Volume
343
Pages
107-117
ISSN
0168-3659
DOI
10.1016/j.jconrel.2022.01.026
Cited by
188
References
3
Language
en
Licence
Funders
  • National Natural Science Foundation of China (91649204)
  • National Key Research and Development Program of China (2016YFC1100100)

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