Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Inflammation and cancer

Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111 · see citing works

Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells

Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

Théry, C., Witwer, K. W., Aikawa, E., Alcaraz, M. J., Anderson, J. D., Andriantsitohaina, R., Antoniou, A., Arab, T., Archer, F., Atkin‐Smith, G. K., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535750 · Cited by 11,099 · see citing works

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works

Microenvironmental regulation of tumor progression and metastasis

Quail, D. F., & Joyce, J. A. (2013) · Nature Medicine · doi:10.1038/nm.3394 · Cited by 7,994 · see citing works

Angiogenesis in cancer, vascular, rheumatoid and other disease

Folkman, J. (1995) · Nature Medicine · doi:10.1038/nm0195-27 · Cited by 7,627 · see citing works

Cancer immunotherapy using checkpoint blockade

Ribas, A., & Wolchok, J. D. (2018) · Science · doi:10.1126/science.aar4060 · Cited by 6,791 · see citing works

Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids

Théry, C., Amigorena, S., Raposo, G., & Clayton, A. (2006) · Current Protocols in Cell Biology · doi:10.1002/0471143030.cb0322s30 · Cited by 5,766 · see citing works

Molecular mechanisms and clinical applications of angiogenesis

Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467 · see citing works

Tumour exosome integrins determine organotropic metastasis

Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H., Gainche, L., Curry, W. T., Carter, B. S., Krichevsky, A. M., & Breakefield, X. O. (2008) · Nature Cell Biology · doi:10.1038/ncb1800 · Cited by 5,001 · see citing works

The immune contexture in human tumours: impact on clinical outcome

Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981 · see citing works

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Tirosh, I., Izar, B., Prakadan, S. M., Wadsworth, M. H., Treacy, D., Trombetta, J. J., Rotem, A., Rodman, C., Lian, C., Murphy, G., et al. (2016) · Science · doi:10.1126/science.aad0501 · Cited by 4,944 · see citing works

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617 · see citing works

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works

Innate and adaptive immune cells in the tumor microenvironment

Gajewski, T. F., Schreiber, H., & Fu, Y.-X. (2013) · Nature Immunology · doi:10.1038/ni.2703 · Cited by 4,148 · see citing works

Membrane vesicles as conveyors of immune responses

Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,869 · see citing works

Stromal Fibroblasts Present in Invasive Human Breast Carcinomas Promote Tumor Growth and Angiogenesis through Elevated SDF-1/CXCL12 Secretion

Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., & Weinberg, R. A. (2005) · Cell · doi:10.1016/j.cell.2005.02.034 · Cited by 3,759 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer

Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

Chen, G., Huang, A. C., Zhang, W., Zhang, G., Wu, M., Xu, W., Yu, Z., Yang, J., Wang, B., Sun, H., et al. (2018) · Nature · doi:10.1038/s41586-018-0392-8 · Cited by 2,813 · see citing works

Influence of tumour micro-environment heterogeneity on therapeutic response

Junttila, M. R., & de Sauvage, F. J. (2013) · Nature · doi:10.1038/nature12626 · Cited by 2,694 · see citing works

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Costa-Silva, B., Aiello, N. M., Ocean, A. J., Singh, S., Zhang, H., Thakur, B. K., Becker, A., Hoshino, A., Mark, M. T., Molina, H., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3169 · Cited by 2,692 · see citing works

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

Özdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Kamerkar, S., LeBleu, V. S., Sugimoto, H., Yang, S., Ruivo, C. F., Melo, S. A., Lee, J. J., & Kalluri, R. (2017) · Nature · doi:10.1038/nature22341 · Cited by 2,639 · see citing works

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

Newman, A. M., Bratman, S. V., To, J., Wynne, J. F., Eclov, N. C. W., Modlin, L. A., Liu, C. L., Neal, J. W., Wakelee, H. A., Merritt, R. E., et al. (2014) · Nature Medicine · doi:10.1038/nm.3519 · Cited by 2,220 · see citing works

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works

Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

Al-Nedawi, K. N. I., Meehan, B., Micallef, J., Lhotak, V., May, L. L., Guha, A., & Rak, J. W. (2008) · Nature Cell Biology · doi:10.1038/ncb1725 · Cited by 2,037 · see citing works

The extracellular matrix modulates the hallmarks of cancer

Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,014 · see citing works

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

Becker, A., Thakur, B. K., Weiss, J. M., Kim, H. S., Peinado, H., & Lyden, D. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.009 · Cited by 2,003 · see citing works

Progress in Exosome Isolation Techniques

Li, P., Kaslan, M., Lee, S. H., Yao, J. D., & Gao, Z. (2017) · Theranostics · doi:10.7150/thno.18133 · Cited by 1,970 · see citing works

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

Friedl, P., & Alexander, S. (2011) · Cell · doi:10.1016/j.cell.2011.11.016 · Cited by 1,940 · see citing works

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works

The biology and function of exosomes in cancer

Kalluri, R. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81135 · Cited by 1,849 · see citing works

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G. J., Wei, J., & Nie, G. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.11.083 · Cited by 1,809 · see citing works

Biogenesis and secretion of exosomes

Kowal, J., Tkach, M., & Théry, C. (2014) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.05.004 · Cited by 1,781 · see citing works

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

Kranz, L. M., Diken, M., Haas, H., Kreiter, S., Loquai, C., Reuter, K. C., Meng, M., Fritz, D., Vascotto, F., Hefesha, H., et al. (2016) · Nature · doi:10.1038/nature18300 · Cited by 1,771 · see citing works

Phenotype molding of stromal cells in the lung tumor microenvironment

Lambrechts, D., Wauters, E., Boeckx, B., Aibar, S., Nittner, D., Burton, O., Bassez, A., Decaluwé, H., Pircher, A., Van den Eynde, K., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0096-5 · Cited by 1,648 · see citing works

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

Zhang, H., Freitas, D. P., Kim, H. S., Fabijanic, K. I., Li, Z., Chen, H., Mark, M. T., Molina, H., Benito‐Martín, A., Bojmar, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0040-4 · Cited by 1,623 · see citing works

Double-stranded DNA in exosomes: a novel biomarker in cancer detection

Thakur, B. K., Zhang, H., Becker, A., Matei, I. R., Huang, Y., Costa‐Silva, B., Zheng, Y., Hoshino, A., Brazier, H., Xiang, J., et al. (2014) · Cell Research · doi:10.1038/cr.2014.44 · Cited by 1,592 · see citing works

MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response

Fabbri, M., Paone, A., Calore, F., Galli, R., Gaudio, E., Santhanam, R., Lovat, F., Fadda, P., Mao, C., Nuovo, G. J., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209414109 · Cited by 1,558 · see citing works

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515 · see citing works

Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis

Zhou, W., Fong, M. Y., Min, Y., Somlo, G., Liu, L., Palomares, M. R., Yu, Y., Chow, A., O’Connor, S. T. F., Chin, A. R., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.03.007 · Cited by 1,476 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · cited 1× · see citing works

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,237 · see citing works

Engineering exosomes as refined biological nanoplatforms for drug delivery

Luan, X., Sansanaphongpricha, K., Myers, I., Chen, H., Yuan, H., & Sun, D. (2017) · Acta Pharmacologica Sinica · doi:10.1038/aps.2017.12 · Cited by 1,171 · see citing works

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,102 · see citing works

Integrated digital error suppression for improved detection of circulating tumor DNA

Newman, A. M., Lovejoy, A. F., Klass, D. M., Kurtz, D. M., Chabon, J. J., Scherer, F., Stehr, H., Liu, C. L., Bratman, S. V., Say, C., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3520 · Cited by 1,091 · see citing works

Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth

Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

Li, H., Courtois, E. T., Sengupta, D., Tan, Y., Chen, K. H., Goh, J. J. L., Kong, S. L., Chua, C., Hon, L. K., Tan, W. S., et al. (2017) · Nature Genetics · doi:10.1038/ng.3818 · Cited by 1,080 · see citing works

Isolation of exosomes from whole blood by integrating acoustics and microfluidics

Wu, M., Ouyang, Y., Wang, Z., Zhang, R., Huang, P., Chen, C., Li, H., Li, P., Quinn, D., Dao, M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1709210114 · Cited by 958 · see citing works

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works

Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery

Yeo, R. W. Y., Lai, R. C., Zhang, B., Tan, S. S., Yin, Y., Teh, B. J., & Lim, S. K. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.07.001 · Cited by 816 · see citing works

Molecular lipidomics of exosomes released by PC-3 prostate cancer cells

Llorente, A., Skotland, T., Sylvänne, T., Kauhanen, D., Róg, T., Orłowski, A., Vattulainen, I., Ekroos, K., & Sandvig, K. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.011 · Cited by 771 · see citing works

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

Boelens, M., Wu, T. J., Nabet, B., Xu, B.-H., Qiu, Y., Yoon, T., Azzam, D. J., Victor, C. T.-S., Wiemann, B., Ishwaran, H., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.051 · Cited by 768 · see citing works

Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer

Sansone, P., Savini, C., Kurelac, I., Chang, Q., Amato, L. B., Strillacci, A., Степанова, А., Iommarini, L., Mastroleo, C., Daly, L., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704862114 · Cited by 732 · see citing works

ExtraPEG: A Polyethylene Glycol-Based Method for Enrichment of Extracellular Vesicles

Rider, M. A., Hurwitz, S. N., & Meckes, D. G. (2016) · Scientific Reports · doi:10.1038/srep23978 · Cited by 699 · see citing works

Cancer-associated fibroblasts neutralize the anti-tumor effect of CSF1 receptor blockade by inducing PMN-MDSC infiltration of tumors

Kumar, V., Donthireddy, L., Marvel, D., Condamine, T., Wang, F., Lavilla-Alonso, S., Hashimoto, A., Vonteddu, P., Behera, R., Goins, M. A., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.10.005 · Cited by 653 · see citing works

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

Liu, Y., Gu, Y. H., Han, Y., Zhang, Q., Jiang, Z., Zhang, X., Huang, B., Xu, X., Zheng, J., & Cao, X. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.06.021 · Cited by 642 · see citing works

Cellular stress conditions are reflected in the protein and RNA content of endothelial cell‐derived exosomes

de Jong, O. G., Verhaar, M. C., Chen, Y., Vader, P., Gremmels, H., Posthuma, G., Schiffelers, R. M., Guček, M., & van Balkom, B. W. M. (2012) · Journal of Extracellular Vesicles · doi:10.3402/jev.v1i0.18396 · Cited by 634 · see citing works

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

Ding, B.-S., Cao, Z., Lis, R., Nolan, D. J., Guo, P., Simons, M., Penfold, M. E., Shido, K., Rabbany, S. Y., & Rafii, S. (2014) · Nature · doi:10.1038/nature12681 · Cited by 626 · see citing works

Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

Armstrong, J. P. K., Holme, M. N., & Stevens, M. M. (2017) · ACS Nano · doi:10.1021/acsnano.6b07607 · Cited by 605 · see citing works

Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies

Patel, S. A., & Minn, A. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.007 · Cited by 574 · see citing works

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M. L., Spring, L. M., Tazzyman, S. J., Lambein, L., Poissonnier, A., Ferraro, G. B., Baer, C., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0256-3 · Cited by 533 · see citing works

Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity

Li, J., Liu, K., Liu, Y., Xu, Y., Zhang, F., Yang, H., Liu, J., Pan, T., Chen, J., Wu, M., et al. (2013) · Nature Immunology · doi:10.1038/ni.2647 · Cited by 508 · see citing works

Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts

Paggetti, J., Haderk, F., Seiffert, M., Janji, B., Distler, U., Ammerlaan, W., Kim, Y. J., Adam, J., Lichter, P., Solary, É., et al. (2015) · Blood · doi:10.1182/blood-2014-12-618025 · Cited by 475 · see citing works

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities

McMillin, D. W., Negri, J. M., & Mitsiades, C. S. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3870 · Cited by 474 · see citing works

Short-Range Exosomal Transfer of Viral RNA from Infected Cells to Plasmacytoid Dendritic Cells Triggers Innate Immunity

Dreux, M., Garaigorta, U., Boyd, B. S., Décembre, É., Chung, J., Whitten-Bauer, C., Wieland, S. F., & Chisari, F. V. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.08.010 · Cited by 471 · see citing works

RNA in extracellular vesicles

Kim, K. M., Abdelmohsen, K., Mustapić, M., Kapogiannis, D., & Gorospe, M. (2017) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1413 · Cited by 456 · see citing works

Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis

Melo, S. A., Sugimoto, H., O'Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L., Melo, C., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 453 · see citing works

Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer

Nabet, B. Y., Qiu, Y., Shabason, J. E., Wu, T. J., Yoon, T., Kim, B. C., Benci, J. L., DeMichele, A. M., Tchou, J. C., Marcotrigiano, J., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.031 · Cited by 453 · see citing works

Leukemia cell to endothelial cell communication via exosomal miRNAs

Umezu, T., Ohyashiki, K., Kuroda, M., & Ohyashiki, J. H. (2012) · Oncogene · doi:10.1038/onc.2012.295 · Cited by 446 · see citing works

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

Rodda, L. B., Lu, E., Bennett, M. L., Sokol, C. L., Wang, X., Luther, S. A., Barres, B. A., Luster, A. D., Ye, C., & Cyster, J. G. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.006 · Cited by 441 · see citing works

The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity

Moroishi, T., Hayashi, T., Pan, W., Fujita, Y., Holt, M. V., Qin, J., Carson, D. A., & Guan, K. (2016) · Cell · doi:10.1016/j.cell.2016.11.005 · Cited by 435 · see citing works

Tumor exosomes inhibit differentiation of bone marrow dendritic cells

Yu, S., Liu, C., Su, K., Wang, J., Liu, Y., Zhang, L., Li, C., Cong, Y., Kimberly, R., Grizzle, W. E., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6867 · Cited by 425 · see citing works

The Exosome Total Isolation Chip

Liu, F., Vermesh, O., Mani, V., Ge, T. J., Madsen, S. J., Sabour, A. F., Hsu, E., Gowrishankar, G., Kanada, M., Jokerst, J. V., et al. (2017) · ACS Nano · doi:10.1021/acsnano.7b04878 · Cited by 398 · see citing works

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

Scherz-Shouval, R., Santagata, S., Mendillo, M. L., Sholl, L. M., Ben-Aharon, I., Beck, A. H., Dias-Santagata, D., Koeva, M., Stemmer, S. M., Whitesell, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.045 · Cited by 386 · see citing works

Fibroblast-Derived Exosomes Contribute to Chemoresistance through Priming Cancer Stem Cells in Colorectal Cancer

Hu, Y.-B., Yan, C., Mu, L., Huang, K., Li, X.-L., Tao, D., Wu, Y.-Q., & Qin, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125625 · Cited by 328 · see citing works

Gastric cancer exosomes promote tumour cell proliferation through PI3K/Akt and MAPK/ERK activation

Qu, J.-L., Qu, X.-J., Zhao, M.-F., Teng, Y.-E., Zhang, Y., Hou, K., Jiang, Y.-H., Yang, X., & Liu, Y.-P. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2009.04.006 · Cited by 303 · see citing works

Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

Minn, A. J., & Wherry, E. J. (2016) · Cell · doi:10.1016/j.cell.2016.03.031 · Cited by 272 · see citing works

Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis

LeBleu, V. S., Teng, Y., O’Connell, J. T., Charytan, D. M., Muller, G. A., Müller, C. A., Sugimoto, H., & Kalluri, R. (2013) · Nature Medicine · doi:10.1038/nm.2989 · Cited by 260 · see citing works

Contribution of MyD88 to the Tumor Exosome-Mediated Induction of Myeloid Derived Suppressor Cells

Liu, Y., Xiang, X., Zhuang, X., Zhang, S., Liu, C., Cheng, Z., Michalek, S., Grizzle, W. E., & Zhang, H. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090777 · Cited by 217 · see citing works

Isolation of syncytiotrophoblast microvesicles and exosomes and their characterisation by multicolour flow cytometry and fluorescence Nanoparticle Tracking Analysis

Dragovic, R., Collett, G. P., Hole, P., Ferguson, D. J. P., Redman, C. W. G., Sargent, I. L., & Tannetta, D. (2015) · Methods · doi:10.1016/j.ymeth.2015.03.028 · Cited by 191 · see citing works

Sensing of latent EBV infection through exosomal transfer of 5′pppRNA

Baglio, S. R., van Eijndhoven, M. A. J., Koppers‐Lalic, D., Berenguer, J., Lougheed, S. M., Gibbs, S., Léveillé, N., Rinkel, R. N. P. M., Hopmans, E. S., Swaminathan, S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1518130113 · Cited by 161 · see citing works

Mass spectrometry of extracellular vesicles

Pòcsfalvi, G., Stanly, C., Vilasi, A., Fiume, I., Capasso, G., Turiák, L., Buzás, E. I., & Vékey, K. (2015) · Mass Spectrometry Reviews · doi:10.1002/mas.21457 · Cited by 152 · see citing works

Essential role of Notch signaling in apoptosis of human pancreatic tumoral cells mediated by exosomal nanoparticles

Ristorcelli, E., Béraud, E., Mathieu, S., Lombardo, D., & Vérine, A. (2009) · International Journal of Cancer · doi:10.1002/ijc.24375 · Cited by 115 · see citing works

Harnessing Tumor Evolution to Circumvent Resistance

McNamara, K. L., & Curtis, C. N. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.05.007 · Cited by 66 · see citing works

Towards mechanisms and standardization in extracellular vesicle and extracellular RNA studies: results of a worldwide survey

Soekmadji, C., Hill, A. F., Wauben, M. H. M., et al. (2018) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2018.1535745 · Cited by 49 · see citing works

Bioinformatics Tools for Extracellular Vesicles Research

Keerthikumar, S., Gangoda, L., Gho, Y. S., et al. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-6728-5_13 · Cited by 21 · see citing works

Exosomes: key players in cancer and potential therapeutic strategy

Dai, J., Su, Y., Zhong, S., Cong, L., Liu, B., Yang, J., Tao, Y., He, Z., Chen, C., & Jiang, Y. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00261-0 · Cited by 1,186 · see citing works

Role of Glutathione in Cancer: From Mechanisms to Therapies

Kennedy, L., Sandhu, J. K., Harper, M.-E., & Cuperlovic-Culf, M. (2020) · Biomolecules · doi:10.3390/biom10101429 · Cited by 880 · see citing works

Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential

Lin, Z., Wu, Y., Xu, Y., Li, G., Li, Z., & Liu, T. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01650-5 · Cited by 297 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles to the Rescue of Renal Injury

Birtwistle, L., Chen, X.-M., & Pollock, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126596 · Cited by 113 · see citing works

The Therapeutic Potential and Clinical Significance of Exosomes as Carriers of Drug Delivery System

Li, T., Li, X., Han, G., Liang, M., Yang, Z., Zhang, C., Huang, S., Tai, S., & Yu, S. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010021 · Cited by 110 · see citing works

Role of the tumor microenvironment in cancer hallmarks and targeted therapy (Review)

Naser, R., Fakhoury, I., El‑Fouani, A., Abi‑Habib, R., & El‑Sibai, M. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5471 · Cited by 61 · see citing works

Modular Hydrogel Vaccine for Programmable and Coordinate Elicitation of Cancer Immunotherapy

Ji, P., Sun, W., Zhang, S., Xing, Y., Wang, C., Wei, M., Li, Q., Ji, G., & Yang, G. (2023) · Advanced Science · doi:10.1002/advs.202301789 · Cited by 57 · see citing works

Endoplasmic Reticulum Stress and Tumor Microenvironment in Bladder Cancer: The Missing Link

Nie, Z., Chen, M., Wen, X., Gao, Y., Huang, D., Cao, H., Peng, Y., Guo, N., Ni, J., & Zhang, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.683940 · Cited by 43 · see citing works

miR-200a targets Gelsolin: A novel mechanism regulating secretion of microvesicles in hepatocellular carcinoma cells

Xu, Y., Zhang, Y.-F., Wang, L., Zhao, R., Qiao, Y., Han, D., Sun, Q., Dong, N., Liu, Y.-C., Wu, D.-T., et al. (2017) · Oncology Report · doi:10.3892/or.2017.5506 · Cited by 25 · see citing works

Inhibitory effect of microvesicles collected from stored blood on platelet aggregation

Daveloose, D., Wolf, C., Jeanguillaume, C., et al. (1981) · Thrombosis Research · doi:10.1016/0049-3848(81)90321-2 · Cited by 5 · see citing works

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles

Clancy, J. W., Sedgwick, A., Rossé, C., Muralidharan-Chari, V., Raposo, G., Method, M., Chavrier, P., & D’Souza‐Schorey, C. (2015) · Nature Communications · doi:10.1038/ncomms7919 · Cited by 189 · see citing works

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

Bastos-Amador, P., Royo, F., González, E., Conde‐Vancells, J., Palomo-Diez, L., Borràs, F. E., & Falcón‐Pérez, J. M. (2012) · Journal of Proteomics · doi:10.1016/j.jprot.2012.03.054 · Cited by 97 · see citing works

The bioactive content of CTCL cell line-derived exosomes and small microvesicles: First study in CTCL

Moyal, L., Gorovitz, B., Arkin, C., et al. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.07.151