Preparation and application of pH-responsive drug delivery systems

New developments in liposomal drug delivery

Pattni, B. S., Chupin, V. V., & Torchilin, V. P. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00046 · Cited by 1,600

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

Karimi, M., Ghasemi, A., Zangabad, P. S., Rahighi, R., Basri, S. M. M., Mirshekari, H., Amiri, M., Shafaei, Z., Aslani, A., Bozorgomid, M., et al. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00798d · Cited by 1,557

pH-Sensitive nano-systems for drug delivery in cancer therapy

Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121

Dual-Dynamic-Bond Cross-Linked Antibacterial Adhesive Hydrogel Sealants with On-Demand Removability for Post-Wound-Closure and Infected Wound Healing

Liang, Y., Li, Z., Huang, Y. P., Yu, R., & Guo, B. (2021) · ACS Nano · doi:10.1021/acsnano.1c00204 · Cited by 1,089

Tumour acidosis: from the passenger to the driver's seat

Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 1,028

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.01.061 · Cited by 1,004

Ph sensitive hydrogels in drug delivery: brief history, properties, swelling, and release mechanism, material selection and applications

Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844

Mesoporous silica nanoparticles for drug and gene delivery

Zhou, Y., Quan, G., Wu, Q., Zhang, X., Niu, B., Wu, B., Huang, Y., Pan, X., & Wu, C. (2018) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2018.01.007 · Cited by 726

Polymeric Conjugates for Drug Delivery

Larson, N., & Ghandehari, H. (2012) · Chemistry of Materials · doi:10.1021/cm2031569 · Cited by 580

Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics

Radovic‐Moreno, A. F., Lu, T. K., Puscasu, V. A., Yoon, S.-S., Langer, R., & Farokhzad, O. C. (2012) · ACS Nano · doi:10.1021/nn3008383 · Cited by 552

Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions

Yin, J., Huang, L., Wu, L., Li, J., James, T. D., & Lin, W. (2021) · Chemical Society Reviews · doi:10.1039/d1cs00645b · Cited by 551

A pH-activatable nanoparticle with signal-amplification capabilities for non-invasive imaging of tumour malignancy

Mi, P., Kokuryo, D., Cabral, H., Wu, H., Terada, Y., Saga, T., Aoki, I., Nishiyama, N., & Kataoka, K. (2016) · Nature Nanotechnology · doi:10.1038/nnano.2016.72 · Cited by 521

Polyphenol-Mediated Assembly for Particle Engineering

Zhou, J., Lin, Z., Ju, Y., Rahim, M. A., Richardson, J. J., & Caruso, F. (2020) · Accounts of Chemical Research · doi:10.1021/acs.accounts.0c00150 · Cited by 503

Surface Charge Switchable Supramolecular Nanocarriers for Nitric Oxide Synergistic Photodynamic Eradication of Biofilms

Hu, D., Deng, Y., Jia, F., Jin, Q., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b05493 · Cited by 490

Recent progress on semiconducting polymer nanoparticles for molecular imaging and cancer phototherapy

Li, J., Rao, J., & Pu, K. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.11.025 · Cited by 472

Injectable antibacterial conductive hydrogels with dual response to an electric field and pH for localized “smart” drug release

Qu, J., Zhao, X., Ma, P. X., & Guo, B. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.03.018 · Cited by 468

Chitosan Nanoparticles at the Biological Interface: Implications for Drug Delivery

Aibani, N., Rai, R., Patel, P., Cuddihy, G., & Wasan, E. K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101686 · Cited by 419

Recent advances in dendrimer-based nanovectors for tumor-targeted drug and gene delivery

Kesharwani, P., & Iyer, A. K. (2014) · Drug Discovery Today · doi:10.1016/j.drudis.2014.12.012 · Cited by 387

pH- and ion-sensitive polymers for drug delivery

Yoshida, T., Lai, T. C., Kwon, G. S., & Sako, K. (2013) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2013.821978 · Cited by 367

Inflammation-Responsive Drug-Loaded Hydrogels with Sequential Hemostasis, Antibacterial, and Anti-Inflammatory Behavior for Chronically Infected Diabetic Wound Treatment

Wang, Y., Wu, Y., Long, L., Yang, L., Fu, D., Hu, C., Kong, Q., & Wang, Y. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c09889 · Cited by 356

Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis

Lei, Y., Wang, Y., Shen, J., Cai, Z., Zhao, C., Chen, H., Luo, X., Hu, N., Cui, W., & Huang, W. (2022) · Science Advances · doi:10.1126/sciadv.abl6449 · Cited by 349

Facile synthesis of pH-responsive sodium alginate/carboxymethyl chitosan hydrogel beads promoted by hydrogen bond

Jing, H., Huang, X., Du, X., Mo, L., Ma, C., & Wang, H. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118993 · Cited by 321

Nanoparticle-mediated targeted drug delivery for breast cancer treatment

Liyanage, P. Y., Hettiarachchi, S. D., Zhou, Y., Ouhtit, A., Seven, E. S., Oztan, C. Y., Çelik, E., & Leblanc, R. M. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.04.006 · Cited by 294

Injectable Microfluidic Hydrogel Microspheres for Cell and Drug Delivery

Zhao, Z., Wang, Z., Li, G., Cai, Z., Wu, J., Wang, L., Deng, L., Cai, M., & Cui, W. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103339 · Cited by 282

New Advances in General Biomedical Applications of PAMAM Dendrimers

de Araújo, R. V., Santos, S. D. S., Ferreira, E. I., & Giarolla, J. (2018) · Molecules · doi:10.3390/molecules23112849 · Cited by 279

Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer

Zhang, Y., Yang, C., Wang, W., Liu, J., Liu, Q., Huang, F., Chu, L., Gao, H., Liu, Q., Kong, D., et al. (2016) · Scientific Reports · doi:10.1038/srep21225 · Cited by 276

Harnessing Endogenous Stimuli for Responsive Materials in Theranostics

Cook, A. B., & Decuzzi, P. (2021) · ACS Nano · doi:10.1021/acsnano.0c09115 · Cited by 273

Mechanisms of drug release in pH-sensitive micelles for tumour targeted drug delivery system: A review

Wang, Z., Deng, X., Ding, J., Zhou, W., Zheng, X., & Tang, G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.003 · Cited by 271

Hyaluronic acid and albumin based nanoparticles for drug delivery

Lei, C., Liu, X.-R., Chen, Q., Li, Y., Zhou, J., Zhou, L.-Y., & Zou, T. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.033 · Cited by 271

Effects of Dietary n–3 and n–6 Polyunsaturated Fatty Acids in Inflammation and Cancerogenesis

Liput, K. P., Lepczyński, A., Ogłuszka, M., Nawrocka, A., Poławska, E., Grzesiak, A., Ślaska, B., Pareek, C. S., Czarnik, U., & Pierzchała, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136965 · Cited by 271

Increased Gold Nanoparticle Retention in Brain Tumors by in Situ Enzyme-Induced Aggregation

Ruan, S., Hu, C., Tang, X., Cun, X., Xiao, W., Shi, K., He, Q., & Gao, H. (2016) · ACS Nano · doi:10.1021/acsnano.6b05070 · Cited by 263

Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages

Guo, R., Su, Q., Zhang, J., Dong, A., Lin, C., & Zhang, J. (2017) · Biomacromolecules · doi:10.1021/acs.biomac.7b00089 · Cited by 260

pH-sensitive biomaterials for drug delivery

Zhuo, S., Zhang, F., Yu, J., Zhang, X., Yang, G., & Liu, X. (2020) · Molecules · doi:10.3390/molecules25235649 · Cited by 247

Biofilm‐Sensitive Photodynamic Nanoparticles for Enhanced Penetration and Antibacterial Efficiency

Wu, S., Chen, X., Zhu, Y., Zheng, L., Zhang, L., Hu, Y., Yu, B., Wang, Y., & Xu, F. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202103591 · Cited by 243

Targeted delivery of quercetin via pH-responsive zinc oxide nanoparticles for breast cancer therapy

Sadhukhan, P., Kundu, M., Chatterjee, S., Ghosh, N., Manna, P., Das, J., & Sil, P. C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.02.096 · Cited by 226

Macromolecular metamorphosis via stimulus-induced transformations of polymer architecture

Sun, H., Kabb, C. P., Dai, Y., Hill, M. R., Ghiviriga, I., Bapat, A. P., & Sumerlin, B. S. (2017) · Nature Chemistry · doi:10.1038/nchem.2730 · Cited by 220

Imaging small molecule-induced endosomal escape of siRNA

Rietz, H. D., Hedlund, H., Wilhelmson, S., Nordenfelt, P., & Wittrup, A. (2020) · Nature Communications · doi:10.1038/s41467-020-15300-1 · Cited by 209

Injectable and Self-Healing Nanocomposite Hydrogels with Ultrasensitive pH-Responsiveness and Tunable Mechanical Properties: Implications for Controlled Drug Delivery

Wu, M. Y., Chen, J., Huang, W., Yan, B., Peng, Q., Liu, J., Chen, L., & Zeng, H. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00347 · Cited by 201

Biologically derived metal organic frameworks

Anderson, S. L., & Stylianou, K. C. (2017) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2017.07.012 · Cited by 197

Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery

Jiang, L., Zhou, S., Zhang, X., Li, C., Ji, S., Mao, H. Z., & Jiang, X. (2021) · Nature Communications · doi:10.1038/s41467-021-22594-2 · Cited by 195

Paclitaxel-loaded pH responsive hydrogel based on self-assembled peptides for tumor targeting

Raza, F., Zhu, Y., Chen, L., You, X., Zhang, J., Asifullah, K., Khan, M. W., Hasnat, M., Zafar, H., Wu, J., et al. (2019) · Biomaterials Science · doi:10.1039/c9bm00139e · Cited by 194

pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy

Shi, Z., Li, Q., & Mei, L. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.001 · Cited by 193

PEG- b -PCL Copolymer Micelles with the Ability of pH-Controlled Negative-to-Positive Charge Reversal for Intracellular Delivery of Doxorubicin

Deng, H., Liu, J., Zhao, X., Zhang, Y., Liu, J., Xu, S., Deng, L., Dong, A., & Zhang, J. (2014) · Biomacromolecules · doi:10.1021/bm501290t · Cited by 186

pH-Sensitive nanogels for drug delivery in cancer therapy

Li, Z., Huang, J. C., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01729a · Cited by 186

Emerging Nano-Formulations and Nanomedicines Applications for Ocular Drug Delivery

Khiev, D., Mohamed, Z. A., Vichare, R., Paulson, R. J., Bhatia, S., Mohapatra, S., Lobo, G. P., Valapala, M., Kerur, N., Passaglia, C. L., et al. (2021) · Nanomaterials · doi:10.3390/nano11010173 · Cited by 182

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Ramírez-García, P. D., Retamal, J. S., Shenoy, P. A., Imlach, W. L., Sykes, M., Truong, N. P., Constandil, L., Pélissier, T., Nowell, C. J., Khor, S. Y., et al. (2019) · Nature Nanotechnology · doi:10.1038/s41565-019-0568-x · Cited by 161

NMR Insights into Dendrimer-Based Host–Guest Systems

Hu, J., Xu, T., & Cheng, Y. (2012) · Chemical Reviews · doi:10.1021/cr200333h · Cited by 160

Properties and in vitro drug release of pH- and temperature-sensitive double cross-linked interpenetrating polymer network hydrogels based on hyaluronic acid/poly (N-isopropylacrylamide) for transdermal delivery of luteolin

Kim, A. R., Lee, S. L., & Park, S. N. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.06.061 · Cited by 159

Enhanced effect of pH-sensitive mixed copolymer micelles for overcoming multidrug resistance of doxorubicin

Qiu, L., Qiao, M., Chen, Q., Tian, C., Long, M., Wang, M., Li, Z., Hu, W. S., Li, G., Cheng, L., et al. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.08.008 · Cited by 153

Facile preparation of pH-sensitive chitosan microspheres for delivery of curcumin; characterization, drug release kinetics and evaluation of anticancer activity

Pooresmaeil, M., & Namazi, H. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.183 · Cited by 153

Acetal containing polymers as pH-responsive nano-drug delivery systems

Gannimani, R., Walvekar, P., Naidu, V. R., Aminabhavi, T. M., & Govender, T. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.044 · Cited by 149

Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release

Gu, Z., Dong, Y., Xu, S., Wang, L., & Liu, Z. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202012956 · Cited by 146

pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury

Zhang, C. Y., Lin, W., Gao, J., Shi, X., Davaritouchaee, M., Nielsen, A. E., Mancini, R. J., & Wang, Z. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04051 · Cited by 143

GSH-sensitive polymeric prodrug: Synthesis and loading with photosensitizers as nanoscale chemo-photodynamic anti-cancer nanomedicine

Luo, L., Qi, Y., Zhong, H., Jiang, S., Zhang, H., Cai, H., Wu, Y., Gu, Z., Gong, Q., & Luo, K. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.05.003 · Cited by 143

A pH/ROS dual-responsive and targeting nanotherapy for vascular inflammatory diseases

Zhang, R., Liu, R., Liu, C., Pan, L., Qi, Y., Cheng, J., Guo, J., Jia, Y., Ding, J., Zhang, J., et al. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119605 · Cited by 142

A transistor-like pH-sensitive nanodetergent for selective cancer therapy

Liu, M., Huang, L., Zhang, W., Wang, X., Geng, Y., Zhang, Y., Wang, L., Zhang, W., Zhang, Y., Xiao, S., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01085-5 · Cited by 138

Graphene quantum dot cross-linked carboxymethyl cellulose nanocomposite hydrogel for pH-sensitive oral anticancer drug delivery with potential bioimaging properties

Rakhshaei, R., Namazi, H., Hamishehkar, H., & Rahimi, M. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.10.118 · Cited by 136

pH-Sensitive Nanoformulated Triptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma

Ling, D., Xia, H., Park, W., Hackett, M., Song, C., Na, K., Hui, K. M., & Hyeon, T. (2014) · ACS Nano · doi:10.1021/nn502074x · Cited by 135

Stepwise pH-responsive nanoparticles containing charge-reversible pullulan-based shells and poly(β-amino ester)/poly(lactic-co-glycolic acid) cores as carriers of anticancer drugs for combination therapy on hepatocellular carcinoma

Zhang, C., An, T., Wang, D., Wan, G., Zhang, M., Wang, H., Zhang, S., Li, R., Yang, X., & Wang, Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.030 · Cited by 133

Doxorubicin-Conjugated PAMAM Dendrimers for pH-Responsive Drug Release and Folic Acid-Targeted Cancer Therapy

Zhang, M., Zhu, J., Zheng, Y. F., Guo, R., Wang, S., Mignani, S. M., Caminade, A., Majoral, J., & Shi, X. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030162 · Cited by 130

pH-responsive cationic liposome for endosomal escape mediated drug delivery

Rayamajhi, S., Marchitto, J., Nguyen, T. D. T., Marasini, R., Celia, C., & Aryal, S. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.110804 · Cited by 128

Targeted therapeutic effects of oral inulin-modified double-layered nanoparticles containing chemotherapeutics on orthotopic colon cancer

Hou, Y., Jin, J., Duan, H., Liu, C., Chen, L., Huang, W., Gao, Z., & Jin, M. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121440 · Cited by 127

Ferroptosis/pyroptosis dual-inductive combinational anti-cancer therapy achieved by transferrin decorated nanoMOF

Xu, R. F., Yang, J., Qian, Y., Deng, H., Wang, Z., Ma, S., Wei, Y., Yang, N., & Shen, Q. (2021) · Nanoscale Horizons · doi:10.1039/d0nh00674b · Cited by 125

Mesoporous Silica Nanoparticles with pH-Sensitive Nanovalves for Delivery of Moxifloxacin Provide Improved Treatment of Lethal Pneumonic Tularemia

Li, Z., Clemens, D. L., Lee, B., Dillon, B. J., Horwitz, M. A., & Zink, J. I. (2015) · ACS Nano · doi:10.1021/acsnano.5b04306 · Cited by 123

Incorporating Cu-based metal-organic framework/drug nanohybrids into gelatin microsphere for ibuprofen oral delivery

Javanbakht, S., Nezhad‐Mokhtari, P., Shaabani, A., Arsalani, N., & Ghorbani, M. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.11.028 · Cited by 122

Nanobuffering of pH-Responsive Polymers: A Known but Sometimes Overlooked Phenomenon and Its Biological Applications

Tao, W., Wang, J., Parak, W. J., Farokhzad, O. C., & Shi, J. (2019) · ACS Nano · doi:10.1021/acsnano.9b01696 · Cited by 118

Co-delivery of doxorubicin and curcumin by a pH-sensitive, injectable, and in situ hydrogel composed of chitosan, graphene, and cellulose nanowhisker

Omidi, S., Pirhayati, M., & Kakanejadifard, A. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115745 · Cited by 118

Nanomedicine-based drug delivery towards tumor biological and immunological microenvironment

Li, J., & Burgess, D. J. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.05.008 · Cited by 118

Dual-Sensitive Nanomicelles Enhancing Systemic Delivery of Therapeutically Active Antibodies Specifically into the Brain

Xie, J., Gonzalez‐Carter, D., Tockary, T. A., Nakamura, N., Xue, Y., Nakakido, M., Akiba, H., Dirisala, A., Liu, X., Toh, K., et al. (2020) · ACS Nano · doi:10.1021/acsnano.9b09991 · Cited by 117

An update on actively targeted liposomes in advanced drug delivery to glioma

Mojarad-Jabali, S., Farshbaf, M., Walker, P. R., Hemmati, S., Fatahi, Y., Zakeri‐Milani, P., Sarfraz, M., & Valizadeh, H. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120645 · Cited by 117

Mineralization of pH-Sensitive Doxorubicin Prodrug in ZIF-8 to Enable Targeted Delivery to Solid Tumors

Yan, J., Liu, C., Wu, Q., Zhou, J., Xu, X., Zhang, L., Wang, D., Yang, F., & Zhang, H. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c02599 · Cited by 116

ZnO-Based Nanoplatforms for Labeling and Treatment of Mouse Tumors without Detectable Toxic Side Effects

Ye, D.-X., Ma, Y., Zhao, W., Cao, H., Kong, J., Xiong, H., & Möhwald, H. (2016) · ACS Nano · doi:10.1021/acsnano.5b07846 · Cited by 115

Encapsulation of tissue plasminogen activator in pH-sensitive self-assembled antioxidant nanoparticles for ischemic stroke treatment – Synergistic effect of thrombolysis and antioxidant –

Mei, T., Kim, A., Vong, L. B., Marushima, A., Puentes, S., Matsumaru, Y., Matsumura, A., & Nagasaki, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.05.020 · Cited by 115

Dendrimer-Au Nanoparticle Network Covered Alumina Membrane for Ion Rectification and Enhanced Bioanalysis

Wang, C., Zhao, X., Liu, F., Chen, Y., Xia, X., & Li, J. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b05066 · Cited by 115

Dimeric prodrug-based nanomedicines for cancer therapy

Li, S., Shan, X., Wang, Y., Chen, Q., Sun, J., He, Z., Sun, B., & Luo, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.036 · Cited by 115

Stimuli-responsive polymeric prodrug-based nanomedicine delivering nifuroxazide and doxorubicin against primary breast cancer and pulmonary metastasis

Luo, L., Xu, F., Peng, H., Luo, Y., Tian, X., Battaglia, G., Zhang, H., Gong, Q., Gu, Z., & Luo, K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.017 · Cited by 114

Advances in pH‐Sensitive Polymers for Smart Insulin Delivery

Xie, J., Li, A., & Li, J. (2017) · Macromolecular Rapid Communications · doi:10.1002/marc.201700413 · Cited by 108

A natural drug entry channel in the ferritin nanocage

Jiang, B., Chen, X., Sun, G., Chen, X., Yin, Y., Jin, Y., Mi, Q., Ma, L., Yang, Y., Yan, X., et al. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100948 · Cited by 108

Hydrogel containing minocycline and zinc oxide-loaded serum albumin nanopartical for periodontitis application: preparation, characterization and evaluation

Mou, J., Liu, Z., Liu, J., Lu, J., Zhu, W.-T., & Pei, D. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1571121 · Cited by 106

Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

He, W., Mei, Q., Li, J., Zhai, Y., Chen, Y., Wang, R., Lu, E., Zhang, X., Zhang, Z., & Sha, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00231 · Cited by 106

A pH‐Mediated Electronic Wound Dressing for Controlled Drug Delivery

Kiaee, G., Mostafalu, P., Samandari, M., & Sonkusale, S. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800396 · Cited by 105

Non-small cell lung cancer combination therapy: Hyaluronic acid modified, epidermal growth factor receptor targeted, pH sensitive lipid-polymer hybrid nanoparticles for the delivery of erlotinib plus bevacizumab

Pang, J., Xing, H., Sun, Y., Feng, S., & Wang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.109861 · Cited by 105

Construction of an environmentally friendly octenylsuccinic anhydride modified pH-sensitive chitosan nanoparticle drug delivery system to alleviate inflammation and oxidative stress

Yu, Z., Ma, L., Ye, S., Li, G., & Zhang, M. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115972 · Cited by 104

Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy

Narayan, R., Gadag, S., Cheruku, S. P., Raichur, A. M., Day, C. M., Garg, S., Manandhar, S., Pai, K. S. R., Suresh, A., Mehta, C. H., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.117893 · Cited by 103

Drug Delivery System Based on pH-Sensitive Biocompatible Poly(2-vinyl pyridine)-b-poly(ethylene oxide) Nanomicelles Loaded with Curcumin and 5-Fluorouracil

Iurciuc, C. E., Cretan, M. S., Purcar, V., Popa, M., Daraba, O. M., Atanase, L. I., & Ochiuz, L. (2020) · Polymers · doi:10.3390/polym12071450 · Cited by 101

Self-healable hydrogel on tumor cell as drug delivery system for localized and effective therapy

Chang, G., Chen, Y., Li, Y., Li, S., Huang, F., Shen, Y., & Xie, A. (2015) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.12.077 · Cited by 100

pH and thermal dual-responsive poly(NIPAM-co-GMA)-coated magnetic nanoparticles via surface-initiated RAFT polymerization for controlled drug delivery

Pourjavadi, A., Kohestanian, M., & Streb, C. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110418 · Cited by 100

pH-Responsive nanoparticles based on cholesterol/imidazole modified oxidized-starch for targeted anticancer drug delivery

Xu, Y., Zi, Y., Lei, J., Mo, X., Shao, Z., Wu, Y., Tian, Y., Li, D., & Mu, C. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115858 · Cited by 100

pH-Sensitive carboxymethyl chitosan-modified cationic liposomes for sorafenib and siRNA co-delivery

Zhang, N., Su, Z., Liang, Y., & Yao, Y. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s90524 · Cited by 99

Modular Acid-Activatable Acetone-Based Ketal-Linked Nanomedicine by Dexamethasone Prodrugs for Enhanced Anti-Rheumatoid Arthritis with Low Side Effects

Xu, Y., Mu, J., Xu, Z., Zhong, H., Chen, Z., Ni, Q., Liang, X., & Guo, S. (2020) · Nano Letters · doi:10.1021/acs.nanolett.9b05340 · Cited by 99

Stimuli‐Sensitive Linear–Dendritic Block Copolymer–Drug Prodrug as a Nanoplatform for Tumor Combination Therapy

Cai, H., Tan, P., Chen, X., Kopytynski, M., Pan, D., Zheng, X., Gu, L., Gong, Q., Tian, X., Gu, Z., et al. (2021) · Advanced Materials · doi:10.1002/adma.202108049 · Cited by 99

Supramolecular design and applications of polyphenol-based architecture: A review

Liang, H., Zhou, B., Wu, D., Li, J., & Li, B. (2019) · Advances in Colloid and Interface Science · doi:10.1016/j.cis.2019.102019 · Cited by 98

Platinum complexes of curcumin delivered by dual-responsive polymeric nanoparticles improve chemotherapeutic efficacy based on the enhanced anti-metastasis activity and reduce side effects

Chen, Y., Chen, C., Zhang, X., He, C., Zhao, P., Li, M., Fan, T., Yan, R., Lu, Y., Lee, R. J., et al. (2019) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2019.10.011 · Cited by 98

Intra-articular delivery of celastrol by hollow mesoporous silica nanoparticles for pH-sensitive anti-inflammatory therapy against knee osteoarthritis

Jin, T., Wu, D., Liu, X., Xu, J.-T., Ma, B., Ji, Y. S., Jin, Y.-Y., Wu, S., Wu, T., & Ma, K. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00651-0 · Cited by 98

Biomineralized Metal–Organic Framework Nanoparticles Enable Enzymatic Rolling Circle Amplification in Living Cells for Ultrasensitive MicroRNA Imaging

Zhang, J., He, M., Nie, C., He, M., Pan, Q., Liu, C., Hu, Y., Yi, J., Chen, T., & Chu, X. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b01343 · Cited by 97

Curcumin-incorporated crosslinked sodium alginate-g-poly (N-isopropyl acrylamide) thermo-responsive hydrogel as an in-situ forming injectable dressing for wound healing: In vitro characterization and in vivo evaluation

Zakerikhoob, M., Abbasi, S. Z., Yousefi, G., Mokhtari, M., & Noorbakhsh, M. S. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118434 · Cited by 96

Colon-targeted dexamethasone microcrystals with pH-sensitive chitosan/alginate/Eudragit S multilayers for the treatment of inflammatory bowel disease

Oshi, M. A., Naeem, M., Bae, J., Kim, J., Lee, J., Hasan, N., Kim, W., Im, E., Jung, Y., & Yoo, J. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.06.107 · Cited by 93

Smart Shear-Thinning Hydrogels as Injectable Drug Delivery Systems

Gharaie, S. S., Dabiri, S. M. H., & Akbari, M. (2018) · Polymers · doi:10.3390/polym10121317 · Cited by 91

pH-responsive silica nanoparticles for the treatment of skin wound infections

Pan, F., Giovannini, G., Zhang, S., Altenried, S., Zuber, F., Chen, Q., Boesel, L. F., & Ren, Q. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.04.009 · Cited by 91

Design and Engineering of Hypoxia and Acidic pH Dual‐Stimuli‐Responsive Intelligent Fluorescent Nanoprobe for Precise Tumor Imaging

Chen, S., Chen, M., Yang, J., Zeng, X., Zhou, Y., Yang, S., Yang, R., Yuan, Q., & Zheng, J. (2021) · Small · doi:10.1002/smll.202100243 · Cited by 90

A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer

Chen, C., Yao, W., Sun, W., Guo, T., Lv, H., Wang, X., Ying, H., Wang, Y., & Wang, P. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.09.058 · Cited by 89

Layer-by-layer pH-sensitive nanoparticles for drug delivery and controlled release with improved therapeutic efficacy in vivo

Men, W., Zhu, P., Dong, S., Liu, W., Zhou, K. L., Bai, Y., Liu, X., Gong, S., & Zhang, S. (2020) · Drug Delivery · doi:10.1080/10717544.2019.1709922 · Cited by 89

Tumor targeted delivery of umbelliferone via a smart mesoporous silica nanoparticles controlled-release drug delivery system for increased anticancer efficiency

Kundu, M., Chatterjee, S., Ghosh, N., Manna, P., Das, J., & Sil, P. C. (2020) · Materials Science and Engineering: C · doi:10.1016/j.msec.2020.111239 · Cited by 89

A dual pH-sensitive liposomal system with charge-reversal and NO generation for overcoming multidrug resistance in cancer

Chen, M., Song, F., Liu, Y., Tian, J. H., Liu, C., Li, R., & Zhang, Q. (2018) · Nanoscale · doi:10.1039/c8nr06218h · Cited by 86

Biodegradable and pH Sensitive Peptide Based Hydrogel as Controlled Release System for Antibacterial Wound Dressing Application

Zhu, J., Han, H., Ye, T.-T., Li, F., Wang, X., Yu, J., & Wu, D. (2018) · Molecules · doi:10.3390/molecules23123383 · Cited by 85

Targeting the Cell Membrane by Charge-Reversal Amphiphilic Pillar[5]arene for the Selective Killing of Cancer Cells

Chang, Y., Chen, J., Yang, J., Lin, T., Zeng, L., Xu, J., Hou, J., & Zhang, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b13492 · Cited by 83

Tumor-pH-Sensitive PLLA-Based Microsphere with Acid Cleavable Acetal Bonds on the Backbone for Efficient Localized Chemotherapy

Li, J., Zhang, X., Zhao, M., Wu, L., Luo, K., Pu, Y., & He, B. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00734 · Cited by 82

Acid‐Labile Acyclic Cucurbit[n]uril Molecular Containers for Controlled Release

Mao, D., Liang, Y., Liu, Y., Zhou, X., Ma, J., Jiang, B., Liu, J., & Ma, D. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201707164 · Cited by 81

Branched Polymer‐Based Redox/Enzyme‐Activatable Photodynamic Nanoagent to Trigger STING‐Dependent Immune Responses for Enhanced Therapeutic Effect

Luo, Q., Duan, Z., Li, X., Gu, L., Ren, L. F., Zhu, H., Tian, X., Chen, R., Zhang, H., Gong, Q., et al. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202110408 · Cited by 81

Charge-convertible polymers for improved tumor targeting and enhanced therapy

Li, Y., Yang, H. Y., Thambi, T., Park, J. H., & Lee, D. S. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119299 · Cited by 78

Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery

Xi, Z., Ahmad, E., Zhang, W., Li, J., Wang, A., Faridoon, Wang, N., Zhu, C., Huang, W., Xu, L., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.11.045 · Cited by 78

LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo

He, C., Zhang, Z., Ding, Y., Xue, K., Wang, X., Yang, R., An, Y., Liu, D., Hu, C., & Tang, Q. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00751-x · Cited by 77

Enhancing siRNA-based cancer therapy using a new pH-responsive activatable cell-penetrating peptide-modified liposomal system

Xiang, B., Jia, X., Qi, J., Yang, L., Sun, W., Yan, X., Yang, S., De-ying, C., Du, Q., & Qi, X. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s129574 · Cited by 76

Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy

Jiajiang, X., Fan, Z., Li, Y., Zhang, Y., Yu, F., Su, G., Xie, L., & Hou, Z. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s152312 · Cited by 76

Doxorubicin-conjugated pH-responsive gold nanorods for combined photothermal therapy and chemotherapy of cancer

Chen, J., Li, X., Zhao, X., Wu, Q., Zhu, H., Mao, Z., & Gao, C. (2018) · Bioactive Materials · doi:10.1016/j.bioactmat.2018.05.003 · Cited by 76

pH-sensitive ternary Fe3O4/GQDs@G hybrid microspheres; Synthesis, characterization and drug delivery application

Pooresmaeil, M., & Namazi, H. (2020) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2020.156419 · Cited by 75

Targeting the Hypoxic and Acidic Tumor Microenvironment with pH-Sensitive Peptides

Dharmaratne, N. U., Kaplan, A. R., & Glazer, P. M. (2021) · Cells · doi:10.3390/cells10030541 · Cited by 75

pH dependent silver nanoparticles releasing titanium implant: A novel therapeutic approach to control peri-implant infection

Dong, Y., Ye, H., Liu, Y., Xu, L., Wu, Z., Hu, X., Ma, J., Pathak, J. L., Liu, J., & Wu, G. (2017) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2017.06.034 · Cited by 74

Recent progress of organic small molecule-based fluorescent probes for intracellular pH sensing

Wen, Y., Jing, N., Huo, F., & Yin, C. (2021) · The Analyst · doi:10.1039/d1an01621k · Cited by 74

pH/ROS dual-responsive supramolecular polypeptide prodrug nanomedicine based on host-guest recognition for cancer therapy

Ding, Y., Wang, C., Ma, Y., Zhu, L., Lü, B., Wang, Y., Wang, J., Chen, T., Dong, C., & Yao, Y. S. (2022) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.03.004 · Cited by 74

Molecular dynamics study on the encapsulation and release of anti-cancer drug doxorubicin by chitosan

Li, J., Ying, S., Ren, H., Dai, J., Zhang, L., Liang, L., Wang, Q., Shen, Q., & Shen, J. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119241 · Cited by 73

A two-step precise targeting nanoplatform for tumor therapy via the alkyl radicals activated by the microenvironment of organelles

Wang, L., Niu, X., Song, Q., Jia, J., Hao, Y., Zheng, C., Ding, K., Xiao, H., Liu, X., Zhang, Z., et al. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.017 · Cited by 72

In vitro/vivo evaluation of novel mitochondrial targeting charge-reversal polysaccharide-based antitumor nanoparticle

Fang, L., Lin, H., Wu, Z., Wang, Z., Fan, X., Cheng, Z., Hou, X., & Chen, D. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.115930 · Cited by 72

Cell-specific and pH-sensitive nanostructure hydrogel based on chitosan as a photosensitizer carrier for selective photodynamic therapy

Belali, S., Karimi, A. R., & Hadizadeh, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.12.169 · Cited by 71

Core–shell tecto dendrimers formed via host–guest supramolecular assembly as pH-responsive intelligent carriers for enhanced anticancer drug delivery

Wang, J., Li, D., Fan, Y., Shi, M., Yang, Y.-X., Wang, L., Peng, Y., Shen, M., & Shi, X. (2019) · Nanoscale · doi:10.1039/c9nr08309j · Cited by 71

Polymersomes Eradicating Intracellular Bacteria

Fenaroli, F., Robertson, J. D., Scarpa, E., Gouveia, V. M., Guglielmo, C. D., Pace, C. D., Elks, P. M., Poma, A., Evangelopoulos, D., Canseco, J. O., et al. (2020) · ACS Nano · doi:10.1021/acsnano.0c01870 · Cited by 71

PH-sensitive starch-based hydrogels: synthesis and effect of molecular components on drug release behavior

Quintanilla de Stéfano, J. C., Abundis-Correa, V., Herrera-Flores, S. D., & Alvarez, A. J. (2020) · Polymers · doi:10.3390/polym12091974 · Cited by 70

pH sensitive liposomes assisted specific and improved breast cancer therapy using co-delivery of SIRT1 shRNA and Docetaxel

Swami, R., Kumar, Y., Chaudhari, D., Katiyar, S. S., Kuche, K., Katare, P. B., Banerjee, S., & Jain, S. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111664 · Cited by 70

pH-Sensitive Peptide Hydrogels as a Combination Drug Delivery System for Cancer Treatment

Liu, Y., Ran, Y., Ge, Y., Raza, F., Li, S., Zafar, H., Wu, Y., Paiva‐Santos, A. C., Yu, C., Sun, M., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14030652 · Cited by 70

pH-sensitive zwitterionic coating of gold nanocages improves tumor targeting and photothermal treatment efficacy

Piao, J., Gao, F., Li, Y., Yu, L., Liu, D., Tan, Z., Xiong, Y., Yang, L., & You, Y. (2017) · Nano Research · doi:10.1007/s12274-017-1736-7 · Cited by 69

Mussel-Derived, Cancer-Targeting Peptide as pH-Sensitive Prodrug Nanocarrier

Ma, Y., He, P., Tian, X., Liu, G.-L., Zeng, X., & Pan, G. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b09031 · Cited by 69

Chinese quince seed gum and poly ( N,N -diethylacryl amide-co-methacrylic acid) based pH-sensitive hydrogel for use in drug delivery

Xie, A., Yin, H., Liu, H., Zhu, C., & Yang, Y. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.01.007 · Cited by 68

Chitosan coated pH-responsive metal-polyphenol delivery platform for melanoma chemotherapy

Mu, M., Liang, X., Chuan, D., Zhao, S., Wei, Y., Fan, R., Tong, A., Zhao, N., Han, B. R., & Guo, G. F. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118000 · Cited by 68

pH gradient difference around ischemic brain tissue can serve as a trigger for delivering polyethylene glycol-conjugated urokinase nanogels

Cui, W., Liu, R., Jin, H., Lv, P., Sun, Y., Men, X., Yang, S., Qu, X., Yang, Z., & Huang, Y. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.01.028 · Cited by 67

Paclitaxel-loaded folate-coated long circulating and pH-sensitive liposomes as a potential drug delivery system: A biodistribution study

Monteiro, L. O. F., Fernandes, R. S., Oda, C. M. R., Lopes, S. C. D. A., Townsend, D. M., Cardoso, V. N., Oliveira, M. C., Leite, E. A., Rubello, D., & de Barros, A. L. B. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.135 · Cited by 67

Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system

Jafarzadeh-Holagh, S., Hashemi‐Najafabadi, S., Shaki, H., & Vasheghani‐Farahani, E. (2018) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2018.02.076 · Cited by 67

A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic hyperthermia tumor therapy

Zhou, X., Wang, L., Xu, Y., Du, W., Cai, X., Wang, F., Ling, Y., Chen, H., Wang, Z., Hu, B. Q., et al. (2018) · RSC Advances · doi:10.1039/c8ra00215k · Cited by 66

pH-dependent delivery of chlorhexidine from PGA grafted mesoporous silica nanoparticles at resin-dentin interface

Akram, Z., Aati, S. Y., Ngo, H., & Fawzy, A. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00788-6 · Cited by 66

Glucosamine-conjugated graphene quantum dots as versatile and pH-sensitive nanocarriers for enhanced delivery of curcumin targeting to breast cancer

Ghanbari, N., Salehi, Z., Khodadadi, A. A., Shokrgozar, M. A., & Saboury, A. A. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111809 · Cited by 66

Colon-targeted delivery of tacrolimus using pH-responsive polymeric nanoparticles for murine colitis therapy

Cai, X., Wang, X., He, M., Wang, Y., Lan, M., Zhao, Y., & Gao, F. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120836 · Cited by 66

Development of doxorubicin hydrochloride loaded pH-sensitive liposomes: Investigation on the impact of chemical nature of lipids and liposome composition on pH-sensitivity

Rehman, A. U., Omran, Z., Anton, H., Mély, Y., Akram, S., Vandamme, T., & Anton, N. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.11.001 · Cited by 65

Dendrimer grafted persistent luminescent nanoplatform for aptamer guided tumor imaging and acid-responsive drug delivery

Zhang, H.-J., Zhao, X., Chen, L., Yang, C., & Yan, X. (2020) · Talanta · doi:10.1016/j.talanta.2020.121209 · Cited by 65

Formulation of pH-sensitive chlorhexidine-loaded/mesoporous silica nanoparticles modified experimental dentin adhesive

Akram, Z., Daood, U., Aati, S. Y., Ngo, H., & Fawzy, A. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.111894 · Cited by 65

Integrin αvβ3-targeted liposomal drug delivery system for enhanced lung cancer therapy

Fu, S., Zhao, Y., Sun, J., Yang, T., Zhi, D., Zhang, E. X., Zhong, F., Zhen, Y., Zhang, S., & Zhang, S. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111623 · Cited by 65

Methotrexate-Loaded Gelatin and Polyvinyl Alcohol (Gel/PVA) Hydrogel as a pH-Sensitive Matrix

Akhlaq, M., Azad, A. K., Ullah, I., Nawaz, A., Safdar, M. M., Bhattacharya, T., Uddin, A. B. M. H., Abbas, S. A., Mathews, A., Kundu, S. K., et al. (2021) · Polymers · doi:10.3390/polym13142300 · Cited by 65

pH-Sensitive nanoparticles based on amphiphilic imidazole/cholesterol modified hydroxyethyl starch for tumor chemotherapy

Xu, Z., Yang, D., Long, T., Yuan, L., Qiu, S., Li, D., Mu, C., & Ge, L. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118827 · Cited by 65

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Wu, S., Chou, H., Yuh, C., Mekuria, S. L., Kao, Y., & Tsai, H. (2017) · Advanced Science · doi:10.1002/advs.201700339 · Cited by 63

Co-delivery of doxorubicin and imatinib by pH sensitive cleavable PEGylated nanoliposomes with folate-mediated targeting to overcome multidrug resistance

Chen, Y., Cheng, Y., Zhao, P., Zhang, S., Li, M., He, C., Zhang, X., Yang, T., Yan, R., Ye, P., et al. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.03.024 · Cited by 63

Co-delivery of DOX and PDTC by pH-sensitive nanoparticles to overcome multidrug resistance in breast cancer

Cheng, X., Li, D., Sun, M., He, L., Zheng, Y., Wang, X., & Tang, R. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.05.042 · Cited by 63

Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy

Chen, K., Chang, C., Liu, Z., Zhou, Y., Xu, Q., Li, C., Huang, Z., Xu, H., Xu, P., & Lü, B. (2020) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2020.111166 · Cited by 63

Live-Cell Surface-Enhanced Raman Spectroscopy Imaging of Intracellular pH: From Two Dimensions to Three Dimensions

Zhang, Y., de Aberasturi, D. J., Henriksen‐Lacey, M., Langer, J., & Liz‐Marzán, L. M. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01487 · Cited by 63

Furin Enzyme and pH Synergistically Triggered Aggregation of Gold Nanoparticles for Activated Photoacoustic Imaging and Photothermal Therapy of Tumors

Cheng, X., Zhou, X., Xu, J., Sun, R., Xia, H., Ding, J., Chin, Y. E., Chai, Z., Shi, H., & Gao, M. (2021) · Analytical Chemistry · doi:10.1021/acs.analchem.1c01713 · Cited by 63

Design and characterization of a novel pH-sensitive biocompatible and multifunctional nanocarrier for in vitro paclitaxel release

Vajedi, F. S., Dehghani, H., & Zarrabi, A. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111627 · Cited by 62

Facile preparation of pH/reduction dual-stimuli responsive dextran nanogel as environment-sensitive carrier of doxorubicin

Yu, K., Xiyao, Y., He, L., Zheng, R., Min, J., Su, H., Shan, S., & Jia, Q. (2020) · Polymer · doi:10.1016/j.polymer.2020.122585 · Cited by 60

PEG-Benzaldehyde-Hydrazone-Lipid Based PEG-Sheddable pH-Sensitive Liposomes: Abilities for Endosomal Escape and Long Circulation

Kanamala, M., Palmer, B. D., Ghandehari, H., Wilson, W. R., & Wu, Z. (2018) · Pharmaceutical Research · doi:10.1007/s11095-018-2429-y · Cited by 59

Micelle-Embedded Layer-by-Layer Coating with Catechol and Phenylboronic Acid for Tunable Drug Loading, Sustained Release, Mild Tissue Response, and Selective Cell Fate for Re-endothelialization

Jiang, L., Zhuang, W., Li, L., Zhang, B., Yang, L., Liu, D., Yu, H., Luo, R., & Wang, Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b01253 · Cited by 59

Transient swelling response of pH-sensitive hydrogels: A monophasic constitutive model and numerical implementation

Bayat, M. R., Dolatabadi, R., & Baghani, M. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119030 · Cited by 59

pH responsive cross-linked polymeric matrices based on natural polymers: effect of process variables on swelling characterization and drug delivery properties

Naeem, F., Khan, S., Jalil, A., Ranjha, N. M., Riaz, A., Haider, M. S., Sarwar, S., Saher, F., & Afzal, S. (2017) · BioImpacts · doi:10.15171/bi.2017.21 · Cited by 58

Delivery of anticancer drug using pH-sensitive micelles from triblock copolymer MPEG-b-PBAE-b-PLA

Yang, C., Xue, Z., Liu, Y., Xiao, J., Chen, J., Zhang, L., Guo, J., & Lin, W. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.12.003 · Cited by 58

A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy

Do, T. T. A., Grijalvo, S., Imae, T., García, M. J. N., & Rodríguez‐Abreu, C. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118366 · Cited by 58

Overcoming Multidrug Resistance by Codelivery of MDR1-Targeting siRNA and Doxorubicin Using EphA10-Mediated pH-Sensitive Lipoplexes: In Vitro and In Vivo Evaluation

Zhang, J., Du, Z., Pan, S., Shi, M., Li, J., Yang, C., Hu, H., Qiao, M., Chen, D., & Zhao, X. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b01806 · Cited by 56

A bio-responsive 6-mercaptopurine/doxorubicin based “Click Chemistry” polymeric prodrug for cancer therapy

Liao, J., Peng, H., Wei, X., Song, Y., Liu, C., Li, D., Yin, Y., Xiong, X., Zheng, H. S., & Wang, Q. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110461 · Cited by 56

Construction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer

Zeng, X., Zhang, Y., Xu, X., Chen, Z., Ma, L., Wang, Y., Guo, X., Li, J., & Wang, X. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2048132 · Cited by 56

DOX-Conjugated keratin nanoparticles for pH-Sensitive drug delivery

Liu, P., Wu, Q., Li, Y., Li, P., Yuan, J., Meng, X., & Xiao, Y. (2019) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2019.06.057 · Cited by 55

Manganese/iron-based nanoprobes for photodynamic/chemotherapy combination therapy of tumor guided by multimodal imaging

Fan, S., Zhang, Y., Tan, H., Xue, C., He, Y., Wei, X., Zha, Y., Niu, J., Liu, Y., Cheng, Y., et al. (2021) · Nanoscale · doi:10.1039/d0nr08831e · Cited by 55

A pH-sensitive semi-interpenetrating polymer network hydrogels constructed by konjac glucomannan and poly (γ-glutamic acid): Synthesis, characterization and swelling behavior

Zhu, C., Tang, N., Gan, J., Zhang, X., Li, Y., Jia, X. T., & Cheng, Y. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.06.046 · Cited by 54

Ultra-pH-sensitive sensor for visualization of lysosomal autophagy, drug-induced pH alteration and malignant tumors microenvironment

Zhang, T., Huo, F., Zhang, W., Chao, J., & Yin, C. (2021) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2021.130393 · Cited by 54

pH/H2O2 Dual-Responsive Chiral Mesoporous Silica Nanorods Coated with a Biocompatible Active Targeting Ligand for Cancer Therapy

Wang, Y., Wang, J., Gou, K., Kang, W., Guo, X., Zhu, K., Li, S., & Li, H. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c08532 · Cited by 54

Dual responsive aerogel made from thermo/pH sensitive graft copolymer alginate-g-P(NIPAM-co-NHMAM) for drug controlled release

Shao, L., Cao, Y., Li, Z., Hu, W., Li, S., & Lu, L. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.03.166 · Cited by 53

Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters

Yan, J., Wu, Q., Zhao, Z., Wu, J., Ye, H., Liang, Q., Zhou, Z., Hou, M., Li, X., Liu, Y., et al. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120166 · Cited by 53

A pH-sensitive oxidized-dextran based double drug-loaded hydrogel with high antibacterial properties

Zhang, M., Chen, G., Lei, M., Lei, J., Li, D., & Zheng, H. S. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.03.169 · Cited by 53

Recent Advances in pH- or/and Photo-Responsive Nanovehicles

Shin, Y., Husni, P., Kang, K., Lee, D., Lee, S., Lee, E. S., Youn, Y. S., & Oh, K. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13050725 · Cited by 53

Angiopep-2-Modified Carboxymethyl Chitosan-Based pH/Reduction Dual-Stimuli-Responsive Nanogels for Enhanced Targeting Glioblastoma

Song, P., Song, N., Li, L., Wu, M., Lu, Z., & Zhao, X. (2021) · Biomacromolecules · doi:10.1021/acs.biomac.1c00314 · Cited by 53

NIR/pH dual-responsive polysaccharide-encapsulated gold nanorods for enhanced chemo-photothermal therapy of breast cancer

Xu, W., Wang, J., Qian, J., Hou, G., Wang, Y., Ji, L., & Suo, A. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.109854 · Cited by 52

Aerosol-Assisted Synthesis of Tailor-Made Hollow Mesoporous Silica Microspheres for Controlled Release of Antibacterial and Anticancer Agents

Poostforooshan, J., Belbekhouche, S., Shaban, M., Alphonse, V., Habert, D., Bousserrhıne, N., Courty, J., & Weber, A. P. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b20510 · Cited by 52

Incorporation of Graphene Quantum Dots, Iron, and Doxorubicin in/on Ferritin Nanocages for Bimodal Imaging and Drug Delivery

Nasrollahi, F., Sana, B., Paramelle, D., Ahadian, S., Khademhosseini, A., & Lim, S. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900183 · Cited by 52

Tryptophan-functionalized graphene quantum dots with enhanced curcumin loading capacity and pH-sensitive release

Ghanbari, N., Salehi, Z., Khodadadi, A. A., Shokrgozar, M. A., Saboury, A. A., & Farzaneh, F. (2020) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2020.102137 · Cited by 52

Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications

Zhao, X., Shi, A., Ma, Q., Yan, X., Bian, L., Zhang, P., & Wu, J. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00928-y · Cited by 51

Doxorubicin-Loaded Carbon Dots Lipid-Coated Calcium Phosphate Nanoparticles for Visual Targeted Delivery and Therapy of Tumor

Zhang, J., Zhang, H., Jiang, J., Cui, N., Xiao, X., Wang, T., Wang, X., He, Y., & Wang, D. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s229154 · Cited by 50

Biodegradable theranostic nanoplatforms of albumin-biomineralized nanocomposites modified hollow mesoporous organosilica for photoacoustic imaging guided tumor synergistic therapy

Li, D., Zhang, T., Min, C., Huang, H., Tan, D., & Gu, W. (2020) · Chemical Engineering Journal · doi:10.1016/j.cej.2020.124253 · Cited by 50

Targeting Acidic Diseased Tissues by pH-Triggered Membrane-Associated Peptide Folding

Reshetnyak, Y. K., Moshnikova, A., Andreev, O. A., & Engelman, D. M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00335 · Cited by 50

Development of an M cell targeted nanocomposite system for effective oral protein delivery: preparation, in vitro and in vivo characterization

Song, J. G., Lee, S. H., & Han, H. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00750-y · Cited by 50

Stimuli-responsive composite hydrogels with three-dimensional stability prepared using oxidized cellulose nanofibers and chitosan

Pedige, M. P. H., Asoh, T., Hsu, Y., & Uyama, H. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118907 · Cited by 50

Pharmacokinetic evaluation of quetiapine fumarate controlled release hybrid hydrogel: a healthier treatment of schizophrenia

Akhlaq, M., Maryam, F., Elaı̈ssari, A., Ullah, H., Adeel, M., Hussain, A., Ramzan, M., Ullah, O., Danish, M. Z., Iftikhar, S., et al. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1458922 · Cited by 49

Synthesis and characterization of multi stimuli-responsive block copolymer-silica hybrid nanocomposite with core-shell structure via RAFT polymerization

Pourjavadi, A., Rahemipoor, S., & Kohestanian, M. (2019) · Composites Science and Technology · doi:10.1016/j.compscitech.2019.107951 · Cited by 49

pH-sensitive bromelain nanoparticles by ortho ester crosslinkage for enhanced doxorubicin penetration in solid tumor

Wang, X., Xu, J., Xu, X., Qin, F., & Tang, R. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111004 · Cited by 49

pH-sensitive and bubble-generating mesoporous silica-based nanoparticles for enhanced tumor combination therapy

Zhang, Z., Huang, C., Zhang, L., Guo, Q., Qin, Y., Fan, F., Li, B., Xiao, B., Zhu, D., & Zhang, L. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.08.013 · Cited by 49

Hemoglobin as a Smart pH-Sensitive Nanocarrier To Achieve Aggregation Enhanced Tumor Retention

Li, H., Chen, Y., Li, Z., Xu, L. L., Jin, Q., & Ji, J. (2018) · Biomacromolecules · doi:10.1021/acs.biomac.8b00241 · Cited by 48

Bacterial infection microenvironment sensitive prodrug micelles with enhanced photodynamic activities for infection control

Wang, S., Fang, Y., Zhang, Z., Jin, Q., & Ji, J. (2021) · Colloids and Interface Science Communications · doi:10.1016/j.colcom.2020.100354 · Cited by 48

Effect of pH-sensitive nanoparticles on inhibiting oral biofilms

Peng, X., Han, Q., Zhou, X., Chen, Y., Huang, X., Guo, X., Peng, R., Wang, H., Peng, X., & Cheng, L. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2037788 · Cited by 48

A Dendritic Polymer‐Based Nanosystem Mediates Drug Penetration and Irreversible Endoplasmic Reticulum Stresses in Tumor via Neighboring Effect

Zheng, X., Pan, D., Zhu, G., Zhang, L., Bhamra, A., Chen, R., Zhang, H., Gong, Q., Gu, Z., & Luo, K. (2022) · Advanced Materials · doi:10.1002/adma.202201200 · Cited by 48

Synthesis and characterization of a novel biocompatible pseudo-hexagonal NaCa-layered double metal hydroxides for smart pH-responsive drug release of dacarbazine and enhanced anticancer activity in malignant melanoma

Asiabi, H., Yamini, Y., Alipour, M. A., Shamsayei, M., & Hosseinkhani, S. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2018.12.017 · Cited by 47

Novel redox-sensitive thiolated TPGS based nanoparticles for EGFR targeted lung cancer therapy

Viswanadh, M. K., Agrawal, N., Shaik, A., Jha, A., Poddar, S., Mahto, S. K., & Muthu, M. S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120652 · Cited by 47

Chitosan for constructing stable polymer-inorganic suspensions and multifunctional membranes for wound healing

Wang, L., Du, L., Wang, M., Wang, X., Tian, S., Yan, C., Wang, X., Zhang, J., Nie, J., & Ma, G. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119209 · Cited by 47

Biodegradable pH-sensitive prospidine-loaded dextran phosphate based hydrogels for local tumor therapy

Solomevich, S. O., Bychkovsky, P. M., Yurkshtovich, T. L., Golub, N. V., Мирчук, П. Ю., Ревтович, М. Ю., & Шмак, А. И. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.115308 · Cited by 46

Self‐Stabilized Supramolecular Assemblies Constructed from PEGylated Dendritic Peptide Conjugate for Augmenting Tumor Retention and Therapy

Zheng, X., Pan, D., Chen, X., Wu, L., Chen, M., Wang, W., Zhang, H., Gong, Q., Gu, Z., & Luo, K. (2021) · Advanced Science · doi:10.1002/advs.202102741 · Cited by 46

Codelivery of Shikonin and siTGF-β for enhanced triple negative breast cancer chemo-immunotherapy

Li, J., Zhao, M. F., Liang, W., Wu, S., Wang, Z., & Wang, D. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.015 · Cited by 46

Artificial intelligence aids in development of nanomedicines for cancer management

Tan, P., Chen, X., Zhang, H., Wei, Q., & Luo, K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.01.005 · Cited by 256

Bioactive compound encapsulation: Characteristics, applications in food systems, and implications for human health

Rezagholizade-shirvan, A., Soltani, M., Shokri, S., Radfar, R., Arab, M., & Shamloo, E. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.101953 · Cited by 240

Recent advances and clinical translation of liposomal delivery systems in cancer therapy

Chen, J., Hu, S., Sun, M., Shi, J., Zhang, H., Yu, H., & Yang, Z. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2023.106688 · Cited by 233

Current research trends of nanomedicines

Liu, Q., Zou, J., Chen, Z., He, W., & Wu, W. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.05.018 · Cited by 223

Solubilization techniques used for poorly water-soluble drugs

Xie, B., Liu, Y., Li, X., Yang, P., & He, W. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.08.027 · Cited by 241

pH-Responsive Micro/Nano Drug Delivery

Nouri, B., Montazer, M., & Malek, R. M. A. (2024) · CRC Press eBooks · doi:10.1201/9781003468424-15

pH-sensitive drug delivery systems

Ghaffar, A., Yameen, B., Latif, M., & Malik, M. I. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816960-5.00014-8 · Cited by 23

Ph-responsive drug delivery systems as intelligent carriers for targeted drug therapy: brief history, properties, synthesis, mechanism and application

Bami, M. S., Raeisi Estabragh, M. A., Khazaeli, P., Ohadi, M., & Dehghannoudeh, G. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102987 · Cited by 101

Microenvironment-Activated Smart Drug Delivery System: An Integrated Review of pH-Responsive Polymers, Nanocarriers and Dual-Stimuli Innovation

Vanitha S*, B. A. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20839250

pH-Sensitive Nanomaterials for Smart Release of Drugs

Meher, M. K., & Poluri, K. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817830-0.00002-3 · Cited by 10