Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review
Abstract
As the mainstay in the treatment of various cancers, chemotherapy plays a vital role, but still faces many challenges, such as poor tumour selectivity and multidrug resistance (MDR). Targeted drug delivery using nanotechnology has provided a new strategy for addressing the limitations of the conventional chemotherapy. In the last decade, the volume of research published in this area has increased tremendously, especially with functional nano drug delivery systems (nanocarriers). Coupling a specific stimuli-triggered drug release mechanism with these delivery systems is one of the most prevalent approaches for improving therapeutic outcomes. Among the various stimuli, pH triggered delivery is regarded as the most general strategy, targeting the acidic extracellular microenvironment and intracellular organelles of solid tumours. In this review, we discuss recent advances in the development of pH-sensitive nanocarriers for tumour-targeted drug delivery. The review focuses on the chemical design of pH-sensitive biomaterials, which are used to fabricate nanocarriers for extracellular and/or intracellular tumour site-specific drug release. The pH-responsive biomaterials bring forth conformational changes in these nanocarriers through various mechanisms such as protonation, charge reversal or cleavage of a chemical bond, facilitating tumour specific cell uptake or drug release. A greater understanding of these mechanisms will help to design more efficient drug delivery systems to address the challenges encountered in conventional chemotherapy.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Acidic pH caused protonation leads to hydrophilic-hydrophobic phase transition for anionic polymers, and hydrophobic-hydrophilic phase transition for cationic polymers, inducing deformation of amphiphilic structures leading to drug release.
“Acidic pH caused protonation leads to hydrophilic-hydrophobic phase transition for the anionic polymers, and hydrophobic- hydrophilic phase transition for cationic polymers, inducing deformation of amphiphilic structures leading to drug release [136].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [136]
Two basic perceptions define the mechanism of pH-responsive nanoparticles: cleavage of chemical bonds and nanocarrier protonation.
“Generally, two basic perceptions define the mechanism of the pH-responsive nanoparticles, such as the cleavage of chemical bonds and nanocarrier protonation.138”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [138]
Cites
Matsumura, Y., & Maeda, H. (1986) · PubMed · Cited by 6,771 · see citing works
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
Moghimi, S. M., Hunter, A. C., & Murray, J. C. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01494-7 · Cited by 3,521 · see citing works
On Respiratory Impairment in Cancer Cells
Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works
(1989) · PubMed · Cited by 3,343 · see citing works
Thermo- and pH-responsive polymers in drug delivery☆
SCHMALJOHANN, D. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.09.020 · Cited by 3,023 · see citing works
Danhier, F., Féron, O., & Véronique Préat, A. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.08.027 · Cited by 2,827 · see citing works
A review of stimuli-responsive nanocarriers for drug and gene delivery
Ganta, S., Devalapally, H., Shahiwala, A., & Amiji, M. M. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.017 · Cited by 2,157 · see citing works
New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?
Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951 · see citing works
Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications
WICKI, A. N., Witzigmann, D., Balasubramanian, V., & Huwyler, J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.12.030 · Cited by 1,912 · see citing works
Lipid polymorphism and the functional roles of lipids in biological membranes
Cullis, P. R., & KRUIJFF, B. D. (1979) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(79)90012-1 · Cited by 1,865 · see citing works
Hypoxia signalling in cancer and approaches to enforce tumour regression
Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676 · see citing works
Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997) · Nature Medicine · doi:10.1038/nm0297-177 · Cited by 1,629 · see citing works
Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
Forgac, M. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2272 · Cited by 1,626 · see citing works
Acidity Generated by the Tumor Microenvironment Drives Local Invasion
Estrella, V. C., Chen, T., Lloyd, M. C., Wojtkowiak, J. W., Cornnell, H. H., Ibrahim‐Hashim, A., Bailey, K. M., Balagurunathan, Y., Rothberg, J. M., Sloane, B. F., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2796 · Cited by 1,404 · see citing works
Moghimi, S. M., & Szebeni, J. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00033-x · Cited by 1,228 · see citing works
pH-Sensitive nano-systems for drug delivery in cancer therapy
Liu, J., Huang, Y., Kumar, A., Tan, A., Jin, S., Mozhi, A., & Liang, X.-J. (2014) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.11.009 · Cited by 1,121 · see citing works
Fleige, E., Quadir, M., & Haag, R. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2012.01.020 · Cited by 1,114 · see citing works
Dhar, S., Gu, F., Langer, R., Farokhzad, O. C., & Lippard, S. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809154105 · Cited by 994 · see citing works
The relevance of tumour pH to the treatment of malignant disease
Wike-Hooley, J. L., HAVEMAN, J., & Reinhold, H. S. (1984) · Radiotherapy and Oncology · doi:10.1016/s0167-8140(84)80077-8 · Cited by 904 · see citing works
The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
Cardone, R. A., Casavola, V., & Reshkin, S. J. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1713 · Cited by 897 · see citing works
Novel applications of liposomes
Lasiç, D. D. (1998) · Trends in biotechnology · doi:10.1016/s0167-7799(98)01220-7 · Cited by 865 · see citing works
Nanomedicine therapeutic approaches to overcome cancer drug resistance
Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733 · see citing works
Regulation of intracellular pH in eukaryotic cells
Madshus, I. H. (1988) · Biochemical Journal · doi:10.1042/bj2500001 · Cited by 645 · see citing works
Disrupting proton dynamics and energy metabolism for cancer therapy
Parks, S. K., Chiche, J., & Pouysségur, J. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3579 · Cited by 613 · see citing works
Griffiths, J. R. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.326 · Cited by 595 · see citing works
Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
Torchilin, V. (2009) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.026 · Cited by 583 · see citing works
Smart hybrid materials by conjugation of responsive polymers to biomacromolecules
Cobo, I., Li, M., Sumerlin, B. S., & Perrier, S. (2014) · Nature Materials · doi:10.1038/nmat4106 · Cited by 574 · see citing works
Hamaguchi, T., Matsumura, Y., Suzuki, M., Shimizu, K., Goda, R., Nakamura, I., Nakatomi, I., Yokoyama, M., Kataoka, K., & Kakizoe, T. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602479 · Cited by 565 · see citing works
MRI of the tumor microenvironment
Gillies, R. J., Raghunand, N., Karczmar, G. S., & Bhujwalla, Z. M. (2002) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.10181 · Cited by 553 · see citing works
pH-Responsive Copolymer Assemblies for Controlled Release of Doxorubicin
Gillies, E. R., & Fréchet, J. M. J. (2005) · Bioconjugate Chemistry · doi:10.1021/bc049851c · Cited by 551 · see citing works
Polymer vesicles in vivo: correlations with PEG molecular weight
Photos, P. J., Bacakova, L., Discher, B., Bates, F. S., & Discher, D. E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00201-3 · Cited by 527 · see citing works
Hatakeyama, H., Akita, H., & Harashima, H. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b13-00059 · Cited by 500 · see citing works
Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
Ishida, T., & Kiwada, H. (2007) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2007.11.005 · Cited by 496 · see citing works
pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
Felber, A. E., Dufresne, M.-H., & Leroux, J. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.09.006 · Cited by 480 · see citing works
Stimuli‐Responsive Polymersomes as Nanocarriers for Drug and Gene Delivery
Onaca, O., Enea, R., Hughes, D. W., & Meier, W. P. (2008) · Macromolecular Bioscience · doi:10.1002/mabi.200800248 · Cited by 464 · see citing works
Wyman, T. B., Nicol, F., Zelphati, O., Scaria, P. V., Plank, C., & Szoka, F. C. (1997) · Biochemistry · doi:10.1021/bi9618474 · Cited by 454 · see citing works
Fukumura, D., Duda, D. G., Munn, L. L., & JAIN, R. K. (2010) · Microcirculation · doi:10.1111/j.1549-8719.2010.00029.x · Cited by 452 · see citing works
Poly(l-histidine)–PEG block copolymer micelles and pH-induced destabilization
Lee, E. S., Shin, H. J., Na, K., & Bae, Y. H. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00205-0 · Cited by 452 · see citing works
Natural and Synthetic Biomedical Polymers
(2014) · Elsevier eBooks · doi:10.1016/c2011-0-07330-1 · Cited by 445 · see citing works
Prabaharan, M., Grailer, J. J., Pilla, S., Steeber, D. A., & Gong, S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.07.020 · Cited by 378 · see citing works
Poly(ortho esters): synthesis, characterization, properties and uses
Heller, J., Barr, J., Ng, S. Y., Abdellauoi, K. S., & Gurny, R. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(02)00055-8 · Cited by 372 · see citing works
Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
Yin, Q., Shen, J., Zhang, Z., Yu, H., & Li, Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.04.011 · Cited by 366 · see citing works
Tumor pH controls the <i>in vivo</i> efficacy of weak acid and base chemotherapeutics
Gerweck, L. E., Vijayappa, S., & Kozin, S. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0024 · Cited by 362 · see citing works
Jiang, T., Zhang, Z.-H., Zhang, Y., Lv, H., Zhou, J., Li, C., Hou, L., & Zhang, Q. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.09.027 · Cited by 361 · see citing works
Prodrugs for improving tumor targetability and efficiency
Mahato, R., Tai, W., & Cheng, K. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.02.002 · Cited by 355 · see citing works
Transferrin-Containing, Cyclodextrin Polymer-Based Particles for Tumor-Targeted Gene Delivery
Bellocq, N. C., Pun, S. H., Jensen, G. S., & Davis, M. E. (2003) · Bioconjugate Chemistry · doi:10.1021/bc034125f · Cited by 350 · see citing works
Etrych, T., Jelínková, M., Řı́hová, B., & Ulbrich, K. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00281-4 · Cited by 340 · see citing works
Stimuli-sensitive nanopreparations for combination cancer therapy
Jhaveri, A. M., Deshpande, P. P., & Torchilin, V. P. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.002 · Cited by 335 · see citing works
Nanopreparations to overcome multidrug resistance in cancer
Patel, N. R., Pattni, B. S., Abouzeid, A. H., & Torchilin, V. P. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.08.004 · Cited by 334 · see citing works
Acetals as pH-Sensitive Linkages for Drug Delivery
Gillies, E. R., Goodwin, A. P., & Fréchet, J. M. J. (2004) · Bioconjugate Chemistry · doi:10.1021/bc049853x · Cited by 332 · see citing works
Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
Yoo, H. S., Lee, E. A., & Park, T. G. (2002) · Journal of Controlled Release · doi:10.1016/s0168-3659(02)00088-3 · Cited by 324 · see citing works
Seddon, J. M., Cevc, G., & Marsh, D. (1983) · Biochemistry · doi:10.1021/bi00274a045 · Cited by 313 · see citing works
Nanotechnology applied to overcome tumor drug resistance
Gao, Z., Zhang, L., & Sun, Y. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.051 · Cited by 303 · see citing works
The pH-dependent bilayer destabilization by an amphipathic peptide
Subbarao, N. K., Parente, R. A., Szoka, F. C., Nádasdi, L., & Pongracz, K. (1987) · Biochemistry · doi:10.1021/bi00385a002 · Cited by 297 · see citing works
Min, K. H., Kim, J.-H., Bae, S. M., Shin, H., Kim, M.-S., Park, S.-J., Lee, H., Park, R., Kim, I.-S., Kim, K., et al. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.02.024 · Cited by 287 · see citing works
Shen, W., & Ryser, H. J. ‐. (1981) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(81)91644-2 · Cited by 278 · see citing works
Hamad, I. M., Al-Hanbali, O. A., Hunter, A. C., Rutt, K. J., Andresen, T. L., & Moghimi, S. M. (2010) · ACS Nano · doi:10.1021/nn101990a · Cited by 276 · see citing works
Material properties in complement activation
Moghimi, S. M., Andersen, A. J., Ahmadvand, D., Wibroe, P. P., Andresen, T. L., & Hunter, A. C. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.06.002 · Cited by 270 · see citing works
Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy
Zhang, C., Wang, W., Liu, T., Wu, Y., Guo, H. B., Wang, P., Tian, Q., Wang, Y., & Yuan, Z. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.11.045 · Cited by 268 · see citing works
Pathania, D., Millard, M., & Neamati, N. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.05.010 · Cited by 265 · see citing works
Zhu, S., Hong, M., Tang, G., Qian, L., Lin, J., Jiang, Y., & Pei, Y. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.10.044 · Cited by 264 · see citing works
Polyketal Nanoparticles: A New pH-Sensitive Biodegradable Drug Delivery Vehicle
Heffernan, M. J., & Murthy, N. (2005) · Bioconjugate Chemistry · doi:10.1021/bc050176w · Cited by 257 · see citing works
Hatakeyama, H., Ito, E., Akita, H., Oishi, M., Nagasaki, Y., Futaki, S., & Harashima, H. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.06.008 · Cited by 255 · see citing works
Nanotechnology in Drug Delivery
Marco, A., & Manet Ilse G., J. (2008) · Springer eBooks · doi:10.1007/978-0-387-77667-5 · Cited by 247 · see citing works
A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery
Paliwal, S. R., Paliwal, R., & Vyas, S. P. (2014) · Drug Delivery · doi:10.3109/10717544.2014.882469 · Cited by 242 · see citing works
Smart Polymers and their Applications
(2014) · Elsevier eBooks · doi:10.1016/c2013-0-16347-7 · Cited by 242 · see citing works
Kato, K., Chin, K., Yoshikawa, T., Yamaguchi, K., Tsuji, Y., Esaki, T., Sakai, K., Kimura, M., Hamaguchi, T., Shimada, Y., et al. (2012) · Investigational New Drugs · doi:10.1007/s10637-011-9709-2 · Cited by 237 · see citing works
Kanapathipillai, M., Brock, A., & Ingber, D. E. (2014) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.05.005 · Cited by 234 · see citing works
Steric Stabilization of Fusogenic Liposomes by a Low-pH Sensitive PEG−Diortho Ester−Lipid Conjugate
Guo, X. D., & Szoka, F. C. (2001) · Bioconjugate Chemistry · doi:10.1021/bc000110v · Cited by 233 · see citing works
Protecting groups in organic synthesis. Part 8. Conversion of aldehydes into geminal diacetates
Kochhar, K. S., Bal, B. S., DESHPANDE, R. P., Rajadhyaksha, S. N., & Pinnick, H. W. (1983) · The Journal of Organic Chemistry · doi:10.1021/jo00158a036 · Cited by 231 · see citing works
Lin, S. B., Du, F., Wang, Y., Ji, S., Liang, D., Yu, L. M., & Li, Z. (2007) · Biomacromolecules · doi:10.1021/bm7008747 · Cited by 225 · see citing works
Liu, Y., Wang, W., Yang, J., Zhou, C., & Sun, J. (2013) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2013.07.021 · Cited by 224 · see citing works
Oxime Linkage: A Robust Tool for the Design of pH-Sensitive Polymeric Drug Carriers
Jin, Y., Song, L., Su, Y., Zhu, L., Pang, Y., Qiu, F., Tong, G., Yan, D., Zhu, B., & Zhu, X. (2011) · Biomacromolecules · doi:10.1021/bm200956u · Cited by 216 · see citing works
Kierstead, P. H., Okochi, H., Venditto, V. J., Chuong, T. C., Kivimae, S., Fréchet, J. M. J., & Szoka, F. C. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.023 · Cited by 210 · see citing works
Shin, J. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00232-3 · Cited by 209 · see citing works
Proton-induced fusion of oleic acid-phosphatidylethanolamine liposomes
Düzgüneş, N., Straubinger, R. M., Baldwin, P. A., Friend, D. S., & Papahadjopoulos, D. (1985) · Biochemistry · doi:10.1021/bi00334a004 · Cited by 206 · see citing works
Tang, R., Ji, W., Panus, D., Palumbo, R. N., & Wang, C. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.12.005 · Cited by 202 · see citing works
Towards Membrane Protein Design: pH-sensitive Topology of Histidine-containing Polypeptides
Bechinger, B. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0614 · Cited by 201 · see citing works
Moghimi, S. M., Hamad, I. M., Andresen, T. L., Jørgensen, K., & Szebeni, J. (2006) · The FASEB Journal · doi:10.1096/fj.06-6186fje · Cited by 201 · see citing works
Yuba, E., Harada, A., Sakanishi, Y., Watarai, S., & Kono, K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2012.12.031 · Cited by 196 · see citing works
Shenoy, D. B., Little, S. R., Langer, R., & Amiji, M. M. (2005) · Molecular Pharmaceutics · doi:10.1021/mp0500420 · Cited by 193 · see citing works
Deng, H., Liu, J., Zhao, X., Zhang, Y., Liu, J., Xu, S., Deng, L., Dong, A., & Zhang, J. (2014) · Biomacromolecules · doi:10.1021/bm501290t · Cited by 185 · see citing works
Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds
Sun, T., Wang, Y., Wang, F., Du, J., Mao, C., Sun, C., Tang, R.-Z., Liu, Y., Zhu, J., Zhu, Y., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.10.011 · Cited by 175 · see citing works
Wu, Y., Chen, W., Meng, F., Wang, Z., Cheng, R., Deng, C., Liu, H., & Zhong, Z. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.07.011 · Cited by 172 · see citing works
Yin, H., Lee, E. S., Kim, D., Lee, K. H., Oh, K. T., & Bae, Y. H. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.11.014 · Cited by 168 · see citing works
Cancer research: past, present and future
Cao, Y., DePinho, R. A., Ernst, M., & Vousden, K. H. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3138 · Cited by 167 · see citing works
Ding, C., Gu, J., Qu, X., & Yang, Z. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800563g · Cited by 162 · see citing works
DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials
Kratz, F. (2007) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.16.6.855 · Cited by 158 · see citing works
Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles
Yan, X., & Gemeinhart, R. A. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.05.005 · Cited by 158 · see citing works
Anti-PEG IgM Response against PEGylated Liposomes in Mice and Rats
Ichihara, M., Shimizu, T., Imoto, A., Hashiguchi, Y., Uehara, Y., Ishida, T., & Kiwada, H. (2010) · Pharmaceutics · doi:10.3390/pharmaceutics3010001 · Cited by 157 · see citing works
Classification of stimuli–responsive polymers as anticancer drug delivery systems
Taghizadeh, B., Taranejoo, S., Monemian, S., Moghaddam, Z. S., Daliri, K., Derakhshankhah, H., & Derakhshani, Z. (2014) · Drug Delivery · doi:10.3109/10717544.2014.887157 · Cited by 154 · see citing works
Masson, C., Garinot, M., Mignet, N., Wetzer, B., Mailhe, P., Scherman, D., & Bessodes, M. (2004) · Journal of Controlled Release · doi:10.1016/j.jconrel.2004.07.016 · Cited by 152 · see citing works
A pH‐Responsive Superamphiphile Based on Dynamic Covalent Bonds
Wang, C., Wang, G., Wang, Z., & Zhang, X. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201003502 · Cited by 151 · see citing works
Polyacetal−Doxorubicin Conjugates Designed for pH-Dependent Degradation
Tomlinson, R. D., Heller, J., Brocchini, S., & Duncan, R. (2003) · Bioconjugate Chemistry · doi:10.1021/bc030028a · Cited by 151 · see citing works
On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes
Simões, S., Slepushkin, V., Düzgüneş, N., & de Lima, M. C. P. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00389-3 · Cited by 148 · see citing works
Improving the evaluation of new cancer treatments: challenges and opportunities
Rothenberg, M. L., Carbone, D. P., & Johnson, D. H. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1047 · Cited by 147 · see citing works
Remaut, K., Lucas, B., Braeckmans, K., Demeester, J., & Smedt, S. C. D. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.10.029 · Cited by 146 · see citing works
Poly(ortho esters)From Concept to Reality
Heller, J., & Barr, J. (2004) · Biomacromolecules · doi:10.1021/bm040049n · Cited by 140 · see citing works
Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes
Wang, C. Y., & Huang, L. (1984) · Biochemistry · doi:10.1021/bi00314a026 · Cited by 139 · see citing works
Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel
Alani, A. W. G., Bae, Y., Rao, D. A., & Kwon, G. S. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.038 · Cited by 134 · see citing works
Shi, J., Liu, Y., Wang, L., Gao, J., Zhang, J., Yu, X., Ma, R., Liu, R., & Zhang, Z. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.10.037 · Cited by 131 · see citing works
A pH‐Responsive Drug‐Delivery Platform Based on Glycol Chitosan–Coated Liposomes
Yan, L., Crayton, S. H., Thawani, J. P., Amirshaghaghi, A., Tsourkas, A., & Cheng, Z. (2015) · Small · doi:10.1002/smll.201501412 · Cited by 129 · see citing works
“Smart” Drug Carriers: PEGylated TATp-Modified pH-Sensitive Liposomes
Kale, A. A., & Torchilin, V. P. (2007) · Journal of Liposome Research · doi:10.1080/08982100701525035 · Cited by 129 · see citing works
Denny, W. A., & Wilson, W. R. (1986) · Journal of Medicinal Chemistry · doi:10.1021/jm00156a001 · Cited by 128 · see citing works
Self-citationA Biodegradable pH-sensitive Micelle System for Targeting Acidic Solid Tumors
Sethuraman, V. A., Lee, M. C., & Bae, Y. H. (2007) · Pharmaceutical Research · doi:10.1007/s11095-007-9480-4 · Cited by 128 · see citing works
Liu, Y., Feng, L., Liu, T., Zhang, L., Yao, Y., Yu, D., Wang, L., & Zhang, N. (2014) · Nanoscale · doi:10.1039/c3nr05647c · Cited by 126 · see citing works
pH-responsive polymers: properties, synthesis and applications
Reyes‐Ortega, F. (2014) · Elsevier eBooks · doi:10.1533/9780857097026.1.45 · Cited by 123 · see citing works
Hu, J., Miura, S., Na, K., & Bae, Y. H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.007 · Cited by 123 · see citing works
Takahashi, A., Yamamoto, Y., Yasunaga, M., Koga, Y., Kuroda, J., Takigahira, M., Harada, M., Saito, H., Hayashi, T., Kato, Y., et al. (2013) · Cancer Science · doi:10.1111/cas.12153 · Cited by 122 · see citing works
Wu, W., Liu, J., Cao, S., Tan, H. S., Li, J., Xu, F., & Zhang, X. (2011) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2011.06.015 · Cited by 121 · see citing works
Liposomal cancer therapy: exploiting tumor characteristics
Kaasgaard, T., & Andresen, T. L. (2010) · Expert Opinion on Drug Delivery · doi:10.1517/17425240903427940 · Cited by 120 · see citing works
Sadighian, S., Rostamizadeh, K., Hosseini‐Monfared, H., & Hamidi, M. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.03.001 · Cited by 118 · see citing works
Guo, X. D., MacKay, J. A., & Szoka, F. C. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74986-8 · Cited by 116 · see citing works
Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA
Sakurai, Y., Hatakeyama, H., Sato, Y., Akita, H., Takayama, K., Kobayashi, S., Futaki, S., & Harashima, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.047 · Cited by 114 · see citing works
Pu, Y., Chang, S., Yuan, H., Wang, G., He, B., & Gu, Z. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.082 · Cited by 114 · see citing works
Johnson, R. P., Jeong, Y., John, J. V., Chung, C., Kang, D. H., Selvaraj, M., Suh, H., & Kim, I. (2013) · Biomacromolecules · doi:10.1021/bm400089m · Cited by 112 · see citing works
Lai, M., Düzgüneş, N., & Szoka, F. C. (1985) · Biochemistry · doi:10.1021/bi00328a012 · Cited by 111 · see citing works
Wang, L., Liu, G., Wang, X., Hu, J., Zhang, G., & Liu, S. (2015) · Macromolecules · doi:10.1021/acs.macromol.5b01709 · Cited by 110 · see citing works
Nakamura, H., Etrych, T., Chytil, P., Ohkubo, M., Fang, J. Q., Ulbrich, K., & Maeda, H. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.011 · Cited by 109 · see citing works
Chiang, Y., & Lo, C.-L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.03.046 · Cited by 108 · see citing works
Sakaguchi, N., Kojima, C., Harada, A., & Kono, K. (2008) · Bioconjugate Chemistry · doi:10.1021/bc7004736 · Cited by 106 · see citing works
Wang, M., Hu, H., Sun, Y., Qiu, L., Zhang, J., Guan, G., Zhao, X., Qiao, M., Cheng, L., Cheng, L., et al. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.09.006 · Cited by 104 · see citing works
Moghimi, S. M. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00204-5 · Cited by 103 · see citing works
Multifunctional drug delivery system for targeting tumor and its acidic microenvironment
Shen, M., Huang, Y., Han, L., Qin, J., Fang, X., Wang, J., & Yang, V. C.-M. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.05.013 · Cited by 103 · see citing works
Li, Z., Qiu, L., Chen, Q., Hao, T., Qiao, M., Zhao, H., Zhang, J., Hu, H., Zhao, X., Chen, D., et al. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.09.014 · Cited by 102 · see citing works
Li, Y., Liu, R., Yang, J., Shi, Y., Ma, G., Zhang, Z., & Zhang, X. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.11.010 · Cited by 102 · see citing works
Heller, J. (2005) · Springer eBooks · doi:10.1007/bfb0027551 · Cited by 101 · see citing works
Shalviri, A., Raval, G., Prasad, P., Chan, C., Liu, Q., Heerklotz, H. H., Rauth, A. M., & Wu, X. Y. (2012) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2012.09.001 · Cited by 101 · see citing works
Yang, S. R., Lee, H. J., & Kim, J.-D. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.05.016 · Cited by 101 · see citing works
Xu, Q., Huang, W., Jiang, L., Lei, Z., Li, X., & Deng, H. (2013) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2013.05.007 · Cited by 100 · see citing works
Improved anti‐tumor activity of stabilized anthracycline polymeric micelle formulation, NC‐6300
Harada, M., Bobe, I., Saito, H., Shibata, N., Tanaka, R., Hayashi, T., & Kato, Y. (2010) · Cancer Science · doi:10.1111/j.1349-7006.2010.01745.x · Cited by 99 · see citing works
pH‐Responsive PEG‐Poly(β‐amino ester) Block Copolymer Micelles with a Sharp Transition
Kim, M.-S., Hwang, S. J., Han, J. K., Choi, E. K., Park, H. J., Kim, J. S., & Lee, D. S. (2006) · Macromolecular Rapid Communications · doi:10.1002/marc.200500769 · Cited by 98 · see citing works
Human tumour pH and its variation
Wike-Hooley, J. L., Berg, A. P. V. D., van der Zee, J., & Reinhold, H. S. (1985) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(85)90216-0 · Cited by 97 · see citing works
Chytil, P., Etrych, T., Koňák, Č., Šírová, M., Mrkvan, T., Řı́hová, B., & Ulbrich, K. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.028 · Cited by 97 · see citing works
Na, K., Lee, E. S., & Bae, Y. H. (2007) · Bioconjugate Chemistry · doi:10.1021/bc070052e · Cited by 94 · see citing works
Peptide-Mediated Release of Folate-Targeted Liposome Contents from Endosomal Compartments1
Vogel, K., Wang, S. S., Lee, R. J., Chmielewski, J. A., & Low, P. S. (1996) · Journal of the American Chemical Society · doi:10.1021/ja952725m · Cited by 91 · see citing works
A Multifunctional Envelope-type Nanodevice for Use in Nanomedicine: Concept and Applications
Nakamura, T., Akita, H., Yamada, Y., Hatakeyama, H., & Harashima, H. (2012) · Accounts of Chemical Research · doi:10.1021/ar200254s · Cited by 91 · see citing works
Lin, Y.-L., Jiang, G., Birrell, L. K., & ElSayed, M. E. H. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.05.048 · Cited by 90 · see citing works
Deslongchamps, P., Dory, Y. L., & Li, S. (2000) · Tetrahedron · doi:10.1016/s0040-4020(00)00270-2 · Cited by 90 · see citing works
pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system
Hong, M.-S., Lim, S., Oh, Y., & Kim, C. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357021771913 · Cited by 88 · see citing works
Zhou, Z., Li, L., Yang, Y., Xu, X., & Huang, Y. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.04.059 · Cited by 86 · see citing works
Jain, N. K., Tare, M., Mishra, V. K., & Tripathi, P. K. (2014) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2014.09.006 · Cited by 82 · see citing works
Oxidation of fatigue fracture surfaces at low crack growth rates
Benoit, D. R., Namdar-Irani, R., & Tixier, R. (1980) · Materials Science and Engineering · doi:10.1016/0025-5416(80)90063-4 · Cited by 81 · see citing works
Chang, G., Li, C., Lu, W., & Ding, J. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.201000117 · Cited by 81 · see citing works
The Drug Discovery by NanoMedicine and its Clinical Experience
Matsumura, Y. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu046 · Cited by 80 · see citing works
Thambi, T., Deepagan, V. G., Yoo, C., & Park, J. H. (2011) · Polymer · doi:10.1016/j.polymer.2011.08.024 · Cited by 79 · see citing works
Moghimi, S. M., Hamad, I. M., Bünger, R., Andresen, T. L., Jørgensen, K., Hunter, A. C., Baranji, L., Rosivall, L., & Szebeni, J. (2006) · Journal of Liposome Research · doi:10.1080/08982100600848801 · Cited by 79 · see citing works
Chen, D., Shen, Y., Liu, Mu, M., Liang, L., Wang, & Sun (2011) · International Journal of Nanomedicine · doi:10.2147/ijn.s24344 · Cited by 78 · see citing works
Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo
Sawant, R. R., & Torchilin, V. P. (2009) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2009.02.022 · Cited by 78 · see citing works
Kang, X., Dai, Y., Ma, P., Yang, D., Li, C., Hou, Z., Cheng, Z., & Lin, J. (2012) · Chemistry - A European Journal · doi:10.1002/chem.201202433 · Cited by 78 · see citing works
Jiang, T., Li, Y., Lv, Y., Cheng, Y.-J., He, F., & Zhuo, R. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.06.054 · Cited by 77 · see citing works
Etrych, T., Šubr, V., Laga, R., Řı́hová, B., & Ulbrich, K. (2014) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2014.02.016 · Cited by 76 · see citing works
Boomer, J. A., Qualls, M. M., Inerowicz, H. D., Haynes, R. H., Patri, V. S., Kim, J.-M., & Thompson, D. H. (2008) · Bioconjugate Chemistry · doi:10.1021/bc800239b · Cited by 75 · see citing works
Li, R., Feng, F., Wang, Y., Yang, X., Yang, X., & Yang, V. C.-M. (2014) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2014.05.008 · Cited by 73 · see citing works
Complement activation by PEGylated liposomes containing prednisolone
van den Hoven, J. M., Nemes, R., Metselaar, J. M., Nuijen, B., Beijnen, J. H., Storm, G., & Szebeni, J. (2013) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2013.03.007 · Cited by 72 · see citing works
Polymeric microspheres composed of pH/temperature-sensitive polymer complex
Kim, E. J., Cho, S. H., & Yuk, S. H. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00439-7 · Cited by 71 · see citing works
Rostovtseva, T. K., Gurnev, P. A., Chen, M.-Y., & Bezrukov, S. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.378778 · Cited by 70 · see citing works
Hong, W., Chen, D., Li, J., Gu, J.-C., Hu, H., Zhao, X., & Qiao, M. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.12.033 · Cited by 70 · see citing works
Hami, Z., Amini, M., Ghazi‐Khansari, M., Rezayat, S. M., & Gilani, K. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.01.015 · Cited by 70 · see citing works
Ouahab, A., Cheraga, N., Onoja, V., Shen, Y., & Tu, J. (2014) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2014.03.009 · Cited by 69 · see citing works
Kakinoki, A., Kaneo, Y., Ikeda, Y., Tanaka, T., & Fujita, K. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.103 · Cited by 69 · see citing works
Szabó, I., Manea, M., Orbán, E., Csámpai, A., Bősze, S. E., Szabó, R., Tejeda, M., Gaál, D., Kapuvári, B., Przybylski, M., et al. (2009) · Bioconjugate Chemistry · doi:10.1021/bc800542u · Cited by 66 · see citing works
Chen, D. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s31757 · Cited by 64 · see citing works
Hoffmann, S. R. K., Vystrčilová, L., Ulbrich, K., Etrych, T., Caysa, H., Mueller, T., & Mäder, K. (2012) · Biomacromolecules · doi:10.1021/bm2015027 · Cited by 64 · see citing works
Lebrecht, D., Geist, A., Ketelsen, U., Haberstroh, J., Setzer, B., Kratz, F., & Walker, U. A. (2006) · International Journal of Cancer · doi:10.1002/ijc.22409 · Cited by 60 · see citing works
Verbaan, F. J., Klouwenberg, P. M. C. K., van Steenis, J. H., Snel, C. J., Boerman, O. C., Hennink, W. E., & Storm, G. (2005) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2005.07.018 · Cited by 59 · see citing works
Ding, D., Wang, J., Zhu, Z., Li, R., Wu, W., Liu, B., & Jiang, X. (2012) · ACS Applied Materials & Interfaces · doi:10.1021/am300138z · Cited by 57 · see citing works
Polymer Micelles with Hydrazone-Ester Dual Linkers for Tunable Release of Dexamethasone
Howard, M. D., Ponta, A., Eckman, A. M., Jay, M., & Bae, Y. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0470-1 · Cited by 57 · see citing works
Tang, R., Ji, W., & Wang, C. (2011) · Polymer · doi:10.1016/j.polymer.2010.12.057 · Cited by 57 · see citing works
Oliveira, M. C., Leite, E., Souza, Carvalho-Junior, Coelho, Lana, Â. M. Q., & Cassali, G. D. (2012) · International Journal of Nanomedicine · doi:10.2147/ijn.s34652 · Cited by 55 · see citing works
Xu, H., Paxton, J. W., & Wu, Z. (2015) · Pharmaceutical Research · doi:10.1007/s11095-015-1635-0 · Cited by 54 · see citing works
Self-citationDeng, Y., Yang, P., Ma, Zhao, She, Wang, Li, X., & Wang (2013) · International Journal of Nanomedicine · doi:10.2147/ijn.s41701 · Cited by 54 · see citing works
Shin, J., Shum, P., Grey, J., Fujiwara, S., Malhotra, G. S., González-Bonet, A., Hyun, S., Moase, E. H., Allen, T. M., & Thompson, D. H. (2012) · Molecular Pharmaceutics · doi:10.1021/mp300326z · Cited by 53 · see citing works
Zhou, Y.-Y., Du, Y., Wang, L., Yuan, H., Zhou, J., & Hu, F. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.04.025 · Cited by 53 · see citing works
Bersani, S., Vila-Caballer, M., Brazzale, C., Barattin, M., & Salmaso, S. (2014) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2014.08.005 · Cited by 53 · see citing works
Fei, L., Yap, L.-P., Conti, P. S., Shen, W., & Zaro, J. L. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.01.047 · Cited by 53 · see citing works
Synthesis and In vitro efficacy of acid-Sensitive poly(ethylene glycol) paclitaxel conjugates
Rodrigues, P. C. A., Scheuermann, K., Stockmar, C., Maier, G., Fiebig, H., Unger, C., Mülhaupt, R., & Kratz, F. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/s0960-894x(02)01002-8 · Cited by 52 · see citing works
Acid-Triggered Transformation of Diortho Ester Phosphocholine Liposome
Huang, Z. R., Guo, X., Li, W., MacKay, J. A., & Szoka, F. C. (2005) · Journal of the American Chemical Society · doi:10.1021/ja057024w · Cited by 51 · see citing works
Ma, H., Shiraishi, K., Minowa, T., Kawano, K., Yokoyama, M., Hattori, Y., & Maitani, Y. (2009) · Pharmaceutical Research · doi:10.1007/s11095-009-0018-9 · Cited by 51 · see citing works
Preparation of polyacetals by the reaction of divinyl ethers and polyols
Heller, J., Penhale, D. W. H., & Helwing, R. F. (1980) · Journal of Polymer Science Polymer Letters Edition · doi:10.1002/pol.1980.130180410 · Cited by 51 · see citing works
Facile Synthesis of Acid-Labile Polymers with Pendent Ortho Esters
Cheng, J., Ji, R., Gao, S., Du, F., & Li, Z. (2011) · Biomacromolecules · doi:10.1021/bm201410c · Cited by 51 · see citing works
Chytil, P., Hoffmann, S. R. K., Schindler, L., Kostka, L., Ulbrich, K., Caysa, H., Mueller, T., Mäder, K., & Etrych, T. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.05.008 · Cited by 50 · see citing works
Hu, Y., Wang, J., Zhang, H., Jiang, G., & Kan, C. (2014) · Materials Science and Engineering C · doi:10.1016/j.msec.2014.08.061 · Cited by 50 · see citing works
Zhang, W., Wang, G., See, E., Shaw, J., Baguley, B. C., Liu, J., Amirapu, S., & Wu, Z. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.02.026 · Cited by 49 · see citing works
Self-citationKim, H.-K., den Bossche, J. V., Hyun, S., & Thompson, D. H. (2012) · Bioconjugate Chemistry · doi:10.1021/bc300266y · Cited by 49 · see citing works
Martin, N. K., Robey, I., Gaffney, E. A., Gillies, R. J., Gatenby, R. A., & Maini, P. K. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.58 · Cited by 48 · see citing works
STIMULI-SENSITIVE PARTICLES FOR DRUG DELIVERY
Grainger, S. J., & ElSayed, M. E. H. (2010) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789814295680_0008 · Cited by 45 · see citing works
Cui, Y., Wu, Z., Liu, X., Ni, R., Zhu, X.-X., Ma, L., & Liu, J. (2010) · AAPS PharmSciTech · doi:10.1208/s12249-010-9454-4 · Cited by 41 · see citing works
Self-citationJäger, E., Jäger, A., Etrych, T., Giacomelli, F. C., Chytil, P., Jigounov, A., Putaux, J., Řı́hová, B., Ulbrich, K., & Štěpánek, P. (2012) · Soft Matter · doi:10.1039/c2sm26150b · Cited by 39 · see citing works
Liu, H., Liu, M., Ma, L., & Chen, J. (2009) · European Polymer Journal · doi:10.1016/j.eurpolymj.2009.03.019 · Cited by 39 · see citing works
Chiang, Y., Cheng, Y.-T., Lu, C.-Y., Yen, Y.-W., Yu, L.-Y., Yu, K.-S., Lyu, S.-Y., Yang, C.-Y., & Lo, C.-L. (2013) · Chemistry of Materials · doi:10.1021/cm402614k · Cited by 37 · see citing works
pH-responsive polymer–drug conjugates as multifunctional micelles for cancer-drug delivery
Kang, Y., Ha, W., Liu, Y., Ma, Y., Fan, M., Ding, L., Zhang, S., & Li, B. (2014) · Nanotechnology · doi:10.1088/0957-4484/25/33/335101 · Cited by 35 · see citing works
Zhao, X., Liu, P., Song, Q., Gong, N., Yang, L., & Wu, W. D. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb00600g · Cited by 34 · see citing works
In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
Liu, J., Li, H., Chen, D., Jin, X., Zhao, X., Zhang, C., & Ping, Q. N. (2010) · Drug Delivery · doi:10.3109/10717544.2010.520355 · Cited by 34 · see citing works
Kim, H.-K., Thompson, D. H., Jang, H. S., Chung, Y. J., & den Bossche, J. V. (2013) · ACS Applied Materials & Interfaces · doi:10.1021/am400977t · Cited by 32 · see citing works
Kim, J. H., Oh, Y. T., Lee, K. S., Yun, J. M., Park, B. T., & Oh, K. T. (2011) · Macromolecular Research · doi:10.1007/s13233-011-0502-z · Cited by 31 · see citing works
Kostková, H., Etrych, T., Řı́hová, B., Kostka, L., Starovoytová, L., Kovář, M., & Ulbrich, K. (2013) · Macromolecular Bioscience · doi:10.1002/mabi.201300288 · Cited by 29 · see citing works
Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery
Chen, H., Zhang, H., Thor, D., Rahimian, R., & Guo, X. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.03.013 · Cited by 28 · see citing works
Novel pH-Sensitive Biodegradable Polymeric Drug Delivery Systems Based on Ketal Polymers
Chen, D., & Wang, H. (2014) · Journal of Nanoscience and Nanotechnology · doi:10.1166/jnn.2014.9190 · Cited by 27 · see citing works
Lv, Y., Huang, H., Yang, B., Liu, H., Li, Y., & Wang, J. (2014) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2014.04.082 · Cited by 27 · see citing works
Flagged first, then by citations
2 of the 213 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,891 · see citing works
Smart nanoparticles for cancer therapy
Sun, L., Liu, H., Ye, Y., Lei, Y., Islam, R., Tan, S., Tong, R., Miao, Y.-B., & Cai, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01642-x · Cited by 1,073 · see citing works
“138 Chemical bonds of pH-responsive linkers disassemble at acidic pH and release the drug in the tumor microenvironment.”
BackgroundTumour acidosis: from the passenger to the driver's seat
Corbet, C., & Féron, O. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2017.77 · Cited by 998 · see citing works
Advances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 869 · see citing works
Metal-organic frameworks for stimuli-responsive drug delivery
Wang, Y., Yan, J., Wen, N., Xiong, H., Cai, S., He, Q., Hu, Y., Peng, D., Liu, Z., & Liu, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119619 · Cited by 670 · see citing works
Preparation and application of pH-responsive drug delivery systems
Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645 · see citing works
Formulation of Poloxamers for Drug Delivery
Bodratti, A. M., & Alexandridis, P. (2018) · Journal of Functional Biomaterials · doi:10.3390/jfb9010011 · Cited by 590 · see citing works
Theranostic Fluorescent Probes
Sharma, A. K., Verwilst, P., Li, M., Ma, D., Singh, N., Yoo, J., Kim, Y., Yang, Y., Zhu, J., Huang, H., et al. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00778 · Cited by 510 · see citing works
Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy
Peng, S., Xiao, F., Chen, M., & Gao, H. (2021) · Advanced Science · doi:10.1002/advs.202103836 · Cited by 446 · see citing works
The acidic tumor microenvironment: a target for smart cancer nano-theranostics
Feng, L., Dong, Z., Tao, D., Zhang, Y., & Liu, Z. (2017) · National Science Review · doi:10.1093/nsr/nwx062 · Cited by 428 · see citing works
Stimuli-responsive polymeric micelles for drug delivery and cancer therapy
Zhou, Q., Zhang, L., Yang, T., & Wu, H. Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s158696 · Cited by 415 · see citing works
“31 Accordingly, the difference in pH has been widely exploited to achieve tumor site-or organelle-specific activation of pH-responsive PMs and on-demand drug release.”
Cyclodextrin‐Based Multistimuli‐Responsive Supramolecular Assemblies and Their Biological Functions
Zhang, Y., Liu, Y., & Liu, Y. (2019) · Advanced Materials · doi:10.1002/adma.201806158 · Cited by 402 · see citing works
Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics
Zhao, S., Yu, X., Qian, Y., Chen, W., & Shen, J. (2020) · Theranostics · doi:10.7150/thno.42564 · Cited by 391 · see citing works
“Moreover, the diverse nanostructures and surface modification of nanomaterials should endow themselves with the tumor-targeting ability by EPR effect or other interactions affiliated to the features of tumor tissues [18-21].”
BackgroundOverchuk, M., & Zheng, G. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.10.024 · Cited by 383 · see citing works
Ramasamy, T., Ruttala, H. B., Gupta, B., Poudel, B. K., Choi, H., Yong, C. S., & Kim, J. O. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.04.043 · Cited by 373 · see citing works
“cargo, including internalization beyond biological barriers such as the blood brain barrier or interaction with receptors on cellular surfaces [9].”
BackgroundBioinspired Diselenide‐Bridged Mesoporous Silica Nanoparticles for Dual‐Responsive Protein Delivery
Shao, D., Li, M., Wang, Z., Zheng, X., Lao, Y., Chang, Z., Zhang, F., Lu, M., Yue, J., Hu, H., et al. (2018) · Advanced Materials · doi:10.1002/adma.201801198 · Cited by 366 · see citing works
Contact Lens Materials: A Materials Science Perspective
Musgrave, C. S. A., & Fang, F. (2019) · Materials · doi:10.3390/ma12020261 · Cited by 356 · see citing works
“Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery; a review, 152, Copyright 2016, with permission from Elsevier [210].”
BackgroundInfluentialCurrent Multistage Drug Delivery Systems Based on the Tumor Microenvironment
Chen, B., Dai, W., He, B., Zhang, H., Wang, X., Wang, Y., & Zhang, Q. (2017) · Theranostics · doi:10.7150/thno.16684 · Cited by 347 · see citing works
“Among various chemotherapeutics, anthracyclines such as DOX, are the most popular model drugs for hydrazone conjugation, as previously reviewed by Wu et al [135].”
BackgroundpH-Responsive Polymer Nanomaterials for Tumor Therapy
Chu, S., Shi, X., Tian, Y., & Gao, F. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.855019 · Cited by 315 · see citing works
Use of magnetic fields and nanoparticles to trigger drug release and improve tumor targeting
Liu, J. F., Jang, B., Issadore, D., & Tsourkas, A. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1571 · Cited by 290 · see citing works
<scp>pH</scp> ‐sensitive polymers: Classification and some fine potential applications
Ofridam, F., Tarhini, M., Lebaz, N., Gagnière, É., Mangin, D., & Elaissari, A. (2021) · Polymers for Advanced Technologies · doi:10.1002/pat.5230 · Cited by 286 · see citing works
Stealth nanoparticles in oncology: Facing the PEG dilemma
Zalba, S., ten Hagen, T. L. M., Burgui, C., & Garrido, M. J. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.09.002 · Cited by 282 · see citing works
pH-Responsive Nanocarriers in Cancer Therapy
AlSawaftah, N., Awad, N. S., Pitt, W. G., & Husseini, G. A. (2022) · Polymers · doi:10.3390/polym14050936 · Cited by 273 · see citing works
“This will result in vesicular destabilization [38,43].”
BackgroundInfluentialInfection microenvironment-related antibacterial nanotherapeutic strategies
Wang, Z., Liu, X., Duan, Y., & Huang, Y. P. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121249 · Cited by 269 · see citing works
Wang, Z., Deng, X., Ding, J., Zhou, W., Zheng, X., & Tang, G. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.11.003 · Cited by 271 · see citing works
A review of drug release mechanisms from nanocarrier systems
Ding, C., & Li, Z. (2017) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.03.130 · Cited by 269 · see citing works
pH-sensitive biomaterials for drug delivery
Zhuo, S., Zhang, F., Yu, J., Zhang, X., Yang, G., & Liu, X. (2020) · Molecules · doi:10.3390/molecules25235649 · Cited by 247 · see citing works
Wu, W., Luo, L., Wang, Y., Wu, Q., Dai, H.-B., Li, J., Durkan, C., Wang, N., & Wang, G. (2018) · Theranostics · doi:10.7150/thno.23459 · Cited by 247 · see citing works
“The ideal nanocarrier must tightly retain the encapsulated drug without premature release during transport but must show burst release once inside tumor cells to overcome multidrug resistance and subsequently efficiently induce tumor cells apoptosis [70, 105, 196-200].”
BackgroundMethodYang, Y., Li, M., Pan, G., Chen, J., & Guo, B. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202214089 · Cited by 243 · see citing works
Wang, Z., Ye, Q., Yu, S., & Akhavan, B. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300105 · Cited by 244 · see citing works
Schubert, J., & Chanana, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180601101859 · Cited by 236 · see citing works
“smart properties like responsiveness [23] (pH, [24-27]”
Internal stimuli-responsive nanocarriers for drug delivery: Design strategies and applications
Liu, M., Du, H., Zhang, W., & Zhai, G. (2017) · Materials Science and Engineering: C · doi:10.1016/j.msec.2016.11.030 · Cited by 235 · see citing works
Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
Zhou, L., Wang, H., & Li, Y. (2018) · Theranostics · doi:10.7150/thno.22679 · Cited by 232 · see citing works
“These nanomedicines remain stable at physiological pH, but collapse in an acidic microenvironment due to hydrolysis of acid labile bonds or protonation of chemical groups, resulting in release of their cargo into the cytosol, which promotes cytoplasmic drug concentrations to exceed the capacity of the efflux transport…”
BackgroundApplication of polydopamine in tumor targeted drug delivery system and its drug release behavior
Wang, Z., Duan, Y., & Duan, Y. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.009 · Cited by 231 · see citing works
Lu, J., Sun, J., Li, F., Wang, J., Liu, J., Kim, D., Fan, C., Hyeon, T., & Ling, D. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04169 · Cited by 230 · see citing works
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches
Ashrafizadeh, M., Delfi, M., Zarrabi, A., Bigham, A., Sharifi, E., Rabiee, N., Paiva‐Santos, A. C., Kumar, A. P., Tan, S. C., Hushmandi, K., et al. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.08.001 · Cited by 233 · see citing works
Chi, Y., Yin, X., Sun, K., Feng, S., Liu, J., Chen, D., Guo, C., & Wu, Z. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.06.027 · Cited by 220 · see citing works
“This acid-triggered HA shedding may facilitate the liposomes for ‘endosome escape’, allowing drug content to be released to cytoplasm [25].”
BackgroundSelf-citationRational Design of Cancer Nanomedicine for Simultaneous Stealth Surface and Enhanced Cellular Uptake
Jin, Q., Deng, Y., Chen, X., & Ji, J. (2019) · ACS Nano · doi:10.1021/acsnano.8b07746 · Cited by 219 · see citing works
Small‐Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery
Li, G., Sun, B., Li, Y., Luo, C., He, Z., & Sun, J. (2021) · Small · doi:10.1002/smll.202101460 · Cited by 207 · see citing works
Pei, P., Sun, C., Tao, W., Li, J., Yang, X., & Wang, J. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.10.010 · Cited by 206 · see citing works
Gong, C., Yu, X., You, B., Wu, Y. F., Wang, R., Han, L., Wang, Y., Gao, S., & Yuan, Y. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-00649-8 · Cited by 205 · see citing works
Zhou, Y., Chen, X., Cao, J., & Gao, H. (2020) · Journal of Materials Chemistry B · doi:10.1039/d0tb00649a · Cited by 213 · see citing works
Gold Complexes in Anticancer Therapy: From New Design Principles to Particle‐Based Delivery Systems
Moreno‐Alcántar, G., Picchetti, P., & Casini, A. (2023) · Angewandte Chemie International Edition · doi:10.1002/anie.202218000 · Cited by 204 · see citing works
Stimuli-responsive nano-assemblies for remotely controlled drug delivery
Li, F., Qin, Y., Lee, J., Liao, H., Wang, N., Davis, T. P., Qiao, R., & Ling, D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.03.051 · Cited by 197 · see citing works
Current Advances in Stimuli-Responsive Hydrogels as Smart Drug Delivery Carriers
Zhang, Y., & Wu, B. M. (2023) · Gels · doi:10.3390/gels9100838 · Cited by 202 · see citing works
“Biological fluid pH is a significant chemical property that holds immense potential in the drug delivery field. pH-responsive hydrogel and nanogels have been developed as intelligent drug delivery carriers, capable of exhibiting swelling or shrinking behavior in response to changes in pH [71–74].”
BackgroundZheng, M., Pan, M., Zhang, W., Lin, H., Wu, S., Lu, C. T., Tang, S., Liu, D., & Cai, J. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.001 · Cited by 196 · see citing works
“Several pH-responsive chemical bonds such as imine, hydrazone, boronate, oxime, amide, ether, and orthoester bonds have been incorporated into drug delivery systems to facilitate rapid bond breakage and accelerated drug release at tumor pH [191].”
BackgroundZhang, L., Wu, S., Qin, Y., Fan, F., Zhang, Z., Huang, C., Ji, W., Lu, L., Wang, C., Sun, H., et al. (2019) · Nano Letters · doi:10.1021/acs.nanolett.9b00030 · Cited by 192 · see citing works
pH-Sensitive nanoscale materials as robust drug delivery systems for cancer therapy
Shi, Z., Li, Q., & Mei, L. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.03.001 · Cited by 188 · see citing works
pH-Sensitive nanogels for drug delivery in cancer therapy
Li, Z., Huang, J. C., & Wu, J. (2020) · Biomaterials Science · doi:10.1039/d0bm01729a · Cited by 186 · see citing works
Functional biomaterials towards flexible electronics and sensors
Sun, Q., Qian, B., Uto, K., Chen, J., Liu, X., & Minari, T. (2018) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2018.08.018 · Cited by 175 · see citing works
A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells
Zhang, M., Xu, C., Wen, L., Han, M. K., Xiao, B., Zhou, J., Zhang, Y., Zhang, Z., Viennois, É., & Merlin, D. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1681 · Cited by 172 · see citing works
“The reported DDS have involved polymeric nanoparticles (3), liposomes (4), dendrimers (5), inorganic nanoparticles (6), and protein nanoparticles (7).”
BackgroundSeverely polarized extracellular acidity around tumour cells
Feng, Q., Bennett, Z. T., Grichuk, A., Pantoja, R., Huang, T., Faubert, B., Huang, G., Chen, M., DeBerardinis, R. J., Sumer, B. D., et al. (2024) · Nature Biomedical Engineering · doi:10.1038/s41551-024-01178-7 · Cited by 176 · see citing works
“For tumour-targeted therapy that exploits acidic pH for therapeutic development 50,51 or drug delivery 54 , a lower pH threshold (for example, pH <5.5) should be considered.”
InfluentialZhang, W., Yu, Z., Wu, M. Y., Ren, J., Xia, H.-F., Sa, G., Zhu, J., Pang, D., Zhao, Y., & Chen, G. (2016) · ACS Nano · doi:10.1021/acsnano.6b05630 · Cited by 170 · see citing works
Alsehli, M. (2020) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2020.01.004 · Cited by 171 · see citing works
“amines) are widely used for fabricating pH-responsive nanocarriers to induce the disruption of polymeric micelles in acidic media at the interior and/or exterior of tumor cells (Kanamala et al., 2016; Wang et al., 2018).”
BackgroundSmart Nanocarriers as an Emerging Platform for Cancer Therapy: A Review
Kenchegowda, M., Rahamathulla, M., Hani, U., Begum, M. Y., Guruswamy, S., Osmani, R. A. M., Gowrav, M. P., Alshehri, S., Ghoneim, M. M., Alshlowi, A., et al. (2021) · Molecules · doi:10.3390/molecules27010146 · Cited by 174 · see citing works
Leveraging Physiology for Precision Drug Delivery
Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169 · see citing works
“To control the timing of drug release or activation, DDSs incorporating stimuli-responsive moieties were designed (247) for different types of physiological factors, such as glucose levels (281, 436, 496), pH gradients (189, 236, 317, 401), redox gradients (121, 171, 266, 335), overexpressed enzymes (23, 161), and ATP…”
BackgroundGold Nanoparticles in Cancer Theranostics
Gao, Q., Zhang, J., Gao, J., Zhang, Z., Zhu, H., & Wang, D. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.647905 · Cited by 168 · see citing works
Stimuli-Responsive Polymeric Nanoplatforms for Cancer Therapy
Chang, D., Ma, Y., Xu, X., Xie, J., & Ju, S. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.707319 · Cited by 169 · see citing works
Programming Stimuli-Responsive Behavior into Biomaterials
Badeau, B. A., & DeForest, C. A. (2019) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-060418-052324 · Cited by 163 · see citing works
“As such, pH-responsive therapeutic carriers have been employed to achieve tumor- or intracellular-specific delivery (18).”
BackgroundKong, X., Qi, Y., Wang, X., Jiang, R., Wang, J., Fang, Y., Gao, J., & Hwang, K. C. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101070 · Cited by 163 · see citing works
“On the basis of the significant decrease of pH values in tumor tissues and cells, the design of pH responsive nano drug delivery systems has become a hot research topic in tumor therapy [176-178].”
BackgroundNanogels for intracellular delivery of biotherapeutics
Li, D., van Nostrum, C. F., Mastrobattista, E., Vermonden, T., & Hennink, W. E. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.020 · Cited by 161 · see citing works
Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156 · see citing works
“Acidic pH caused protonation leads to hydrophilic-hydrophobic phase transition for the anionic polymers, and hydrophobichydrophilic phase transition for cationic polymers, inducing deformation of amphiphilic structures leading to drug release [136].”
BackgroundHan, X., Alu, A., Liu, H., Shi, Y., Wei, X., Cai, L., & Wei, Y. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.01.011 · Cited by 159 · see citing works
“These ligands include specific antibodies, aptamers, peptides, and other ligands [30,36].”
BackgroundXie, S., Zhao, L., Song, X., Tang, M., Mo, C., & Li, X. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.10.041 · Cited by 153 · see citing works
Targeted contrast agents and activatable probes for photoacoustic imaging of cancer
Zhao, Z., Swartchick, C. B., & Chan, J. (2022) · Chemical Society Reviews · doi:10.1039/d0cs00771d · Cited by 154 · see citing works
Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy
Moosavian, S. A., Bianconi, V., Pirro, M., & Sahebkar, A. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.09.025 · Cited by 146 · see citing works
Stimuli-responsive nanoscale drug delivery systems for cancer therapy
Li, L., Yang, W., & Xu, D. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1519029 · Cited by 143 · see citing works
Chen, X., Gao, H., Deng, Y., Jin, Q., Ji, J., & Ding, D. (2020) · ACS Nano · doi:10.1021/acsnano.0c02197 · Cited by 142 · see citing works
Li, R., Peng, F., Cai, J., Yang, D., & Zhang, P. (2019) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2019.06.003 · Cited by 139 · see citing works
Lalu, L., Tambe, V., Pradhan, D., Nayak, K., Bagchi, S., Maheshwari, R., Kalia, K., & Tekade, R. K. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.035 · Cited by 137 · see citing works
“As evinced from several investigations, they usually elicit zero order kinetic of drug release pattern with characteristic rapid release accompanied by sustained release [37].”
Polymer-based drug delivery systems for cancer treatment
Guo, X., Wang, L., Xiao, W., & Zhou, S. (2016) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.28252 · Cited by 137 · see citing works
Jia, Q., Li, Z., Guo, C., Huang, X., Song, Y., Zhou, N., Wang, M., Zhang, Z., He, L., & Du, M. (2019) · Nanoscale · doi:10.1039/c9nr06195a · Cited by 134 · see citing works
Kong, C., Li, Y., Liu, Z., Ye, J., Wang, Z., Zhang, L., Kong, W., Liu, H., Liu, C., Pang, H., et al. (2019) · ACS Nano · doi:10.1021/acsnano.8b08246 · Cited by 132 · see citing works
Prodrug strategy for cancer cell-specific targeting: A recent overview
Zhang, X., Li, X., You, Q., & Zhang, X. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.08.010 · Cited by 131 · see citing works
Fontes, M. D. L., Meneguin, A. B., Tercjak, A., Gutierrez, J., Cury, B. S. F., dos Santos, A. M., Ribeiro, S. J. L., & Barud, H. D. S. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.09.061 · Cited by 130 · see citing works
Stimuli-responsive nanocarriers for delivery of bone therapeutics – Barriers and progresses
Lavrador, P., Gaspar, V. M., & Mano, J. F. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.021 · Cited by 130 · see citing works
“The first one involves the design of nanocarriers with a pH-sensitive release profile resulting from existence of carboxylic acids or amines (including tertiary amines) within the nanocarrier backbone/structure [14,106].”
Stimuli-responsive polymer-doxorubicin conjugate: Antitumor mechanism and potential as nano-prodrug
Chen, K., Cai, H., Zhang, H., Zhu, H., Gu, Z., Gong, Q., & Luo, K. (2018) · Acta Biomaterialia · doi:10.1016/j.actbio.2018.11.050 · Cited by 128 · see citing works
Li, R., & Xie, Y. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.02.020 · Cited by 127 · see citing works
Nanogels: Synthesis, properties, and recent biomedical applications
Duan, Q., Zhu, Y., Jia, H., Wang, S., & Wu, F. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101167 · Cited by 123 · see citing works
Advances in pH-responsive drug delivery systems
Mu, Y., Gong, L., Peng, T., Yao, J., & Lin, Z. (2021) · OpenNano · doi:10.1016/j.onano.2021.100031 · Cited by 122 · see citing works
Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery
Askari, E., Seyfoori, A., Amereh, M., Gharaie, S. S., Ghazali, H. S., Ghazali, Z. S., Khunjush, B., & Akbari, M. (2020) · Gels · doi:10.3390/gels6020014 · Cited by 121 · see citing works
Mills, J. A., Liu, F., Jarrett, T. R., Fletcher, N. L., & Thurecht, K. J. (2022) · Biomaterials Science · doi:10.1039/d2bm00181k · Cited by 124 · see citing works
Wang, X., Yang, Y., Zhuang, Y., Gao, P., Yang, F., Shen, H. Y., Guo, H., & Wu, D. (2016) · Biomacromolecules · doi:10.1021/acs.biomac.6b00744 · Cited by 120 · see citing works
Responsive crosslinked polymer nanogels for imaging and therapeutics delivery
Ekkelenkamp, A. E., Elzes, M. R., Engbersen, J. F. J., & Paulusse, J. M. J. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02239e · Cited by 119 · see citing works
Dimeric prodrug-based nanomedicines for cancer therapy
Li, S., Shan, X., Wang, Y., Chen, Q., Sun, J., He, Z., Sun, B., & Luo, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.07.036 · Cited by 116 · see citing works
Stimuli-Responsive Functional Micro-/Nanorobots: A Review
Zhou, Y., Ye, M., Hu, C., Qian, H., Nelson, B. J., & Wang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c01942 · Cited by 118 · see citing works
Yang, W. J., Zhou, P., Liang, L., Cao, Y., Qiao, J., Li, X., Teng, Z., & Wang, L. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04394 · Cited by 115 · see citing works
Safe approaches for camptothecin delivery: Structural analogues and nanomedicines
Botella, P., & Rivero-Buceta, E. M. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.12.023 · Cited by 114 · see citing works
“This factor, together with the lower pH values inside endosomes, suggests that enhancing endosomal escape is the most realistic objective for pH-sensitive nanocarriers in the short term [166].”
BackgroundJia, D., Ma, X., Lu, Y., Li, X., Hou, S., Gao, Y., Xue, P., Kang, Y., & Xu, Z. (2020) · Chinese Chemical Letters · doi:10.1016/j.cclet.2020.11.052 · Cited by 112 · see citing works
Song, Z., Chen, X., You, X., Huang, K., Dhinakar, A., Gu, Z., & Wu, J. (2017) · Biomaterials Science · doi:10.1039/c7bm00730b · Cited by 110 · see citing works
Li, Q., Sun, L., Hou, M., Chen, Q., Yang, R., Zhang, L., Xu, Z., Kang, Y., & Xue, P. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b19667 · Cited by 110 · see citing works
Yang, Y., Wang, Z., Peng, Y., Ding, J., & Zhou, W. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00010 · Cited by 109 · see citing works
Cao, Z., Li, W., Liu, R., Li, X., Li, H., Liu, L., Chen, Y., Lv, C., & Liu, Y. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109340 · Cited by 109 · see citing works
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review
Yan, Y., & Ding, H. (2020) · Nanomaterials · doi:10.3390/nano10081613 · Cited by 108 · see citing works
Devnarain, N., Osman, N., Fasiku, V. O., Makhathini, S. S., Salih, M., Ibrahim, U. H., & Govender, T. (2020) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1664 · Cited by 106 · see citing works
Photosensitive drug delivery systems for cancer therapy: Mechanisms and applications
Pan, P., Svirskis, D. M., Rees, S. W. P., Barker, D. L. A., Waterhouse, G. I. N., & Wu, Z. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.08.053 · Cited by 105 · see citing works
Self-citationGe, Y., Zhang, T., Zhou, L., Ding, W., Liang, H., Hu, Z., Chen, Q. K., Dong, J., Xue, F., Yin, X., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121407 · Cited by 105 · see citing works
Chemotherapeutic drug delivery by tumoral extracellular matrix targeting
Raavé, R., van Kuppevelt, T. H., & Daamen, W. F. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.01.029 · Cited by 106 · see citing works
Tang, S., Meng, Q., Sun, H., Su, J., Yin, Q., Zhang, Z., Yu, H., Chen, L., Gu, W., & Li, Y. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.06.005 · Cited by 104 · see citing works
Song, Q., Jia, J., Niu, X., Zheng, C., Zhao, H., Sun, L., Zhang, H., Wang, L., Zhang, Z., & Zhang, Y. (2019) · Nanoscale · doi:10.1039/c9nr03802g · Cited by 103 · see citing works
- Authors
- Kanamala, M., Wilson, W. R., Yang, M., Palmer, B. D., & Wu, Z.
- Affiliations
- University of Auckland (NZ)
- Corresponding author
- Wu, Zimei
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 85
- Pages
- 152-167
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W2288119981
- Cited by
- 1,004
- References
- 213
- Citations by year
- 2026: 65 · 2025: 96 · 2024: 78 · 2023: 85 · 2022: 99 · 2021: 117 · 2020: 129 · 2019: 113 · 2018: 108 · 2017: 77 · 2016: 37
- FWCI
- 5.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials (publishedVersion)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Funders
- Royal Society of New Zealand (UOA1201)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- pH-responsive nanocarriers, tumour-targeted drug delivery, stimuli-responsive drug release, intracellular drug release, protonation, charge reversal, bond cleavage, tumor selectivity, multidrug resistance, chemotherapy
- MeSH terms
- Animals, Biocompatible Materials, Clinical Trials as Topic, Disease Models, Animal, Humans, Hydrogen-Ion Concentration, Neoplasms, Drug Delivery Systems, Nanotechnology, Nanostructures, Drug Liberation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review